I was skeptical about ChatGPT and Claude at first. Then I started to come around--and I'm glad I did. Enter your email to receive alerts for this author. You can manage your newsletter subscriptions at any time. You're already subscribed to the aa_Alex_Kirshner newsletter.

I avoid AI tools because thinking is supposed to be hard. It's what makes us human Long before the age of multi-billion-dollar AI companies promising to disrupt the field of software development, I was learning to code the hard way. It was the mid-2000s, and I was a child with unmonitored access to the family computer. With the help of a basic text editor program, I learned how to make websites - first basic, then increasingly complex - from scratch. The results were never as beautiful or polished as in my imagination, but I could live with that, because I was learning a craft. The painstaking hours of debugging and poring over arcane documentation for projects that I eventually abandoned never felt wasted.

The lower prices could be aimed at undercutting the competition. DeepSeek is leaning hard into being the cost-effective choice for AI agents. According to its website, the Chinese startup is dropping the price for its latest flagship model, DeepSeek V4 Pro, to a fourth of its original price. This latest price update makes permanent the 75 percent discount promotion that was previously supposed to end on May 31, 2026. As seen on the website's pricing page, the DeepSeek V4 Pro prices now range from $0.003625 to $0.87 per one million tokens, compared to the previous range between $0.0145 to $3.48 for every million tokens.

The company has published an update about Project Glasswing, a month after its launch. Anthropic has published an initial report for Project Glasswing, the cybersecurity initiative it launched in April that aims to prevent AI cyberattacks with, well, AI. The initiative is powered by Claude Mythos Preview, the company's unreleased model, which Anthropic says has already helped its partners find more than ten thousand vulnerabilities overall just a month after Glasswing's launch. In addition, it says most of its partners have each found hundreds of critical-or high-severity vulnerabilities in their software using the model. The company said that its partners' rate of bug-finding has increased by more than a factor of ten.

Plus: Trump has postponed an AI order due to overregulation fears. Anthropic's Code with Claude showed off coding's future--whether you like it or not At Anthropic's developer event in London this week, Code with Claude, attendees were asked if they'd shipped code written entirely by Claude. Almost half the room raised their hands. Many admitted they hadn't even read the code before pushing it live. As tools like Claude Code get better, more and more developers are happy to hand their work off to AI. Anthropic says it wants to push automation as far as it will go. But not everyone is convinced that's the right approach.

Global affairs chief Chris Lehane wants to tone down the debate over AI's societal impacts--and get states to pass laws that won't derail OpenAI's meteoric rise. Three months ago, OpenAI cofounder Greg Brockman told me his concerns about a mounting public relations crisis facing artificial intelligence companies: Despite the popularity of tools like ChatGPT, an increasingly large share of the population said they viewed AI negatively. Since then, the backlash has only intensified. College commencement speakers are now getting booed for talking about AI in optimistic terms. Last month, someone threw a Molotov cocktail at OpenAI CEO Sam Altman's San Francisco home and wrote a manifesto advocating for crimes against AI executives.

Protein-protein interactions (PPIs) govern nearly all cellular processes, yet computational methods for identifying binding partners typically produce ranked predictions without mechanistic justification. This creates a fundamental barrier to adoption because biologists cannot assess whether predictions reflect genuine biochemical insight or spurious correlations. We present \textbf{Protein Thoughts}, a framework that reformulates PPI discovery as an interpretable search problem with explicit reasoning. The system decomposes binding evidence into four biologically meaningful signals: sequence similarity reflecting evolutionary relationships, structural complementarity capturing geometric fit, interface balance, and chemical compatibility encoding residue-level interactions. Rather than collapsing these signals into an opaque score, we preserve their individual contributions through a transparent value function that enables both ranking and auditing. To navigate large candidate spaces efficiently, we introduce hypothesis-guided entropy-regularized Tree-of-Thoughts search. A fine-tuned language model generates search directives from embedding-derived features, classifying candidates as high-priority, exploratory, or skippable. These directives condition a Boltzmann policy that balances exploitation with entropy-driven exploration, while hypothesis-aware pruning prevents premature abandonment of promising candidates. For candidates exhibiting score disagreement, hypothesis-conditioned embedding-space flow matching transports protein embeddings toward the binder manifold. On the SHS148k benchmark, Protein Thoughts achieves mean best-binder rank of 11.2 versus 47.7 for an entropic tree search baseline, a 76% improvement, and for binding prediction the trained value function achieves $91.08 \pm 0.19$ Micro-F1, outperforming existing PPI methods on the same dataset.

Multimodal large language models (MLLMs) remain vulnerable to transfer-based targeted attacks, where perturbations optimized on open-source surrogate encoders can generalize to closed-source MLLMs. A key challenge for improving adversarial transferability is to effectively capture the intrinsic visual focus shared across different models, such that perturbations align with transferable semantic cues rather than surrogate-specific behaviors. However, existing methods suffer from spatial-domain feature redundancy and surrogate-specific gradient signals, thereby hindering cross-model transferability. In this paper, we propose FRA-Attack, which addresses both challenges from a unified frequency-domain regularization perspective. For feature alignment, a high-pass DCT objective on patch features suppresses redundant global structures and concentrates the loss on the high-frequency band that carries the MLLMs' intrinsic visual focus. For gradient optimization, we introduce Frequency-domain Gradient Regularization (FGR), a \textit{model-agnostic} low-pass regularizer that modulates the surrogate gradient using only the geometric frequency coordinate, \textit{i.e.}, no surrogate-derived statistic is involved, so that FGR is model-agnostic by construction, removing surrogate-specific high-frequency artifacts while preserving transferable low-frequency directions. Together, the two components form a unified frequency-domain treatment of transferability. Extensive experiments on $15$ flagship MLLMs across $7$ vendors show that FRA-Attack achieves superior cross-model transferability, particularly with state-of-the-art performance on GPT-5.4, Claude-Opus-4.6 and Gemini-3-flash.

Meta Is in Crisis, Google Search's Makeover, and AI Gets Booed by Graduates This week on, the team discusses Meta's recent layoffs and what they've been hearing from employees about the increasingly grim vibes at the company. They also talk about Elon Musk losing his lawsuit against OpenAI and share highlights from Google's annual conference--including an ambitious AI vision to change how people search the web. Finally, what do recent college graduates and women whose spouses work in AI have in common? Google Search Goes Agentic--and Doesn't Need You Anymore Write to us at [email protected] . You can always listen to this week's podcast through the audio player on this page, but if you want to subscribe for free to get every episode, here's how: If you're on an iPhone or iPad, open the app called Podcasts, or just tap this link . We spoke to more than a dozen employees and it turns out the job cuts are far from the only reason why Meta employees are really going through it. He lost his lawsuit against Sam Altman and OpenAI in really as full a way as you can, as dramatically as possible. I know, Zoë, you're looking forward to talking about that. We're going to get into why young adults might be using AI, but they have very complicated feelings about it. And later in the show, we're going to hear about why women married to AI bros have had enough . This week, the company is letting go of roughly 10 percent of its workforce, which is about 8,000 employees total. It's the latest round of job cuts, adding to the roughly 25,000 jobs that have been cut in the past few years as part of Mark Zuckerberg's Year of Efficiency that started in 2023 and now the latest AI-forward workplace, which he is trying to develop and impose. And while these latest cuts are not as big as some of the rounds of layoffs that have already happened, they're getting a ton of attention because Mark Zuckerberg, the CEO, has said that the reason they're happening, in part at least, in large part, is because the company is spending so much money on AI and data centers.

Watch a subscriber-only discussion exploring how AI might enter the physical world. AI companies want to build systems that understand the external world and overcome the limitations of LLMs. Recent developments have brought world models to the forefront of the AI discussion. Watch a conversation with editor in chief Mat Honan, senior AI editor Will Douglas Heaven, and AI reporter Grace Huckins exploring how AI might enter the physical world. A woman's uterus has been kept alive outside the body for the first time Jessica Hamzelou Want to understand the current state of AI? Check out these charts. Want to understand the current state of AI? Check out these charts.