Given usefulness of protein language models (LMs) in structure and functional inference, RNA LMs have received increased attentions in the last few years. However, these RNA models are often not compared against the same standard. Here, we divided RNA LMs into three classes (pretrained on multiple RNA types (especially noncoding RNAs), specific-purpose RNAs, and LMs that unify RNA with DNA or proteins or both) and compared 13 RNA LMs along with 3 DNA and 1 protein LMs as controls in zero-shot prediction of RNA secondary structure and functional classification. Results shows that the models doing well on secondary structure prediction often perform worse in function classification or vice versa, suggesting that more balanced unsupervised training is needed.

It remains debated how well any LM understands natural language or generates reliable metalinguistic judgments. Moreover, relatively little work has demonstrated that LMs can represent and respect subtle relationships between form and function proposed by linguists. We here focus on a particular such relationship established in recent work: English speakers' judgments about the information structure of canonical sentences predicts independently collected acceptability ratings on corresponding 'long distance dependency' [LDD] constructions, across a wide array of base constructions and multiple types of LDDs. To determine whether any LM captures this relationship, we probe GPT-4 on the same tasks used with humans and new extensions.Results reveal reliable metalinguistic skill on the information structure and acceptability tasks, replicating a striking interaction between the two, despite the zero-shot, explicit nature of the tasks, and little to no chance of contamination [Studies 1a, 1b]. Study 2 manipulates the information structure of base sentences and confirms a causal relationship: increasing the prominence of a constituent in a context sentence increases the subsequent acceptability ratings on an LDD construction. The findings suggest a tight relationship between natural and GPT-4 generated English, and between information structure and syntax, which begs for further exploration.

Currently, a considerable research effort is devoted to comparing LLMs to a group of human experts, where the term "expert" is often ill-defined or variable, at best, in a state of constantly updating LLM releases. Without proper safeguards in place, LLMs will threaten to cause harm to the established structure of safe delivery of patient care which has been carefully developed throughout history to keep the safety of the patient at the forefront. A key driver of LLM innovation is founded on community research efforts which, if continuing to operate under "humans versus LLMs" principles, will expedite this trend. Therefore, research efforts moving forward must focus on effectively characterizing the safe use of LLMs in clinical settings that persist across the rapid development of novel LLM models. In this communication, we demonstrate that rather than comparing LLMs to humans, there is a need to develop strategies enabling efficient work of humans with LLMs in an almost symbiotic manner.

The integration of Large Language Models (LLMs) and Federated Learning (FL) presents a promising solution for joint training on distributed data while preserving privacy and addressing data silo issues. However, this emerging field, known as Federated Large Language Models (FLLM), faces significant challenges, including communication and computation overheads, heterogeneity, privacy and security concerns. Current research has primarily focused on the feasibility of FLLM, but future trends are expected to emphasize enhancing system robustness and security. This paper provides a comprehensive review of the latest advancements in FLLM, examining challenges from four critical perspectives: feasibility, robustness, security, and future directions. We present an exhaustive survey of existing studies on FLLM feasibility, introduce methods to enhance robustness in the face of resource, data, and task heterogeneity, and analyze novel risks associated with this integration, including privacy threats and security challenges. We also review the latest developments in defense mechanisms and explore promising future research directions, such as few-shot learning, machine unlearning, and IP protection. This survey highlights the pressing need for further research to enhance system robustness and security while addressing the unique challenges posed by the integration of FL and LLM.

Large language models (LLMs) have transformed natural-language processing, yet their scale makes real-world deployment costly. Post-training quantization reduces memory and computation but often degrades accuracy, while quantization-aware training can recover performance at the cost of extra training. Pushing quantization to the ternary (2-bit) regime yields even larger savings but is notoriously unstable. Building on recent work showing that a bias-free, RMS-normalized Transformer with straight-through estimation can reach 1.58-bit precision, we demonstrate that simply inserting RMS normalization before every linear projection and applying a gradual, layer-wise quantization schedule stably fine-tunes full-precision checkpoints into ternary LLMs. Our approach matches or surpasses more elaborate knowledge-distillation pipelines on standard language-modeling benchmarks without adding model complexity. These results indicate that careful normalization alone can close much of the accuracy gap between ternary and full-precision LLMs, making ultra-low-bit inference practical.

The intricate and multifaceted nature of vision language model (VLM) development, adaptation, and application necessitates the establishment of clear and standardized reporting protocols, particularly within the high-stakes context of healthcare. Defining these reporting standards is inherently challenging due to the diverse nature of studies involving VLMs, which vary significantly from the development of all new VLMs or finetuning for domain alignment to off-the-shelf use of VLM for targeted diagnosis and prediction tasks. In this position paper, we argue that traditional machine learning reporting standards and evaluation guidelines must be restructured to accommodate multiphase VLM studies; it also has to be organized for intuitive understanding of developers while maintaining rigorous standards for reproducibility. To facilitate community adoption, we propose a categorization framework for VLM studies and outline corresponding reporting standards that comprehensively address performance evaluation, data reporting protocols, and recommendations for manuscript composition. These guidelines are organized according to the proposed categorization scheme. Lastly, we present a checklist that consolidates reporting standards, offering a standardized tool to ensure consistency and quality in the publication of VLM-related research.

The rapid advancement of large language models has raised significant concerns regarding their potential misuse by malicious actors. As a result, developing effective detectors to mitigate these risks has become a critical priority. However, most existing detection methods focus excessively on detection accuracy, often neglecting the societal risks posed by high false positive rates (FPRs). This paper addresses this issue by leveraging Conformal Prediction (CP), which effectively constrains the upper bound of FPRs. While directly applying CP constrains FPRs, it also leads to a significant reduction in detection performance. To overcome this trade-off, this paper proposes a Zero-Shot Machine-Generated Text Detection Framework via Multiscaled Conformal Prediction (MCP), which both enforces the FPR constraint and improves detection performance. This paper also introduces RealDet, a high-quality dataset that spans a wide range of domains, ensuring realistic calibration and enabling superior detection performance when combined with MCP. Empirical evaluations demonstrate that MCP effectively constrains FPRs, significantly enhances detection performance, and increases robustness against adversarial attacks across multiple detectors and datasets.

Neural image compression, necessary in various machine-to-machine communication scenarios, suffers from its heavy encode-decode structures and inflexibility in switching between different compression levels. Consequently, it raises significant challenges in applying the neural image compression to edge devices that are developed for powerful servers with high computational and storage capacities. We take a step to solve the challenges by proposing a new transformer-based edge-compute-free image coding framework called Easz. Easz shifts the computational overhead to the server, and hence avoids the heavy encoding and model switching overhead on the edge. Easz utilizes a patch-erase algorithm to selectively remove image contents using a conditional uniform-based sampler. The erased pixels are reconstructed on the receiver side through a transformer-based framework. To further reduce the computational overhead on the receiver, we then introduce a lightweight transformer-based reconstruction structure to reduce the reconstruction load on the receiver side. Extensive evaluations conducted on a real-world testbed demonstrate multiple advantages of Easz over existing compression approaches, in terms of adaptability to different compression levels, computational efficiency, and image reconstruction quality.

We introduce GPTAQ, a novel finetuning-free quantization method for compressing large-scale transformer architectures. Unlike the previous GPTQ method, which independently calibrates each layer, we always match the quantized layer's output to the exact output in the full-precision model, resulting in a scheme that we call asymmetric calibration. Such a scheme can effectively reduce the quantization error accumulated in previous layers. We analyze this problem using optimal brain compression to derive a close-formed solution. The new solution explicitly minimizes the quantization error as well as the accumulated asymmetry error. Furthermore, we utilize various techniques to parallelize the solution calculation, including channel parallelization, neuron decomposition, and Cholesky reformulation for matrix fusion. As a result, GPTAQ is easy to implement, simply using 20 more lines of code than GPTQ but improving its performance under low-bit quantization. Remarkably, on a single GPU, we quantize a 405B language transformer as well as EVA-02, the rank first vision transformer that achieves 90% pretraining Imagenet accuracy. Code is available at Github.

This essay was adapted from Phil Christman's newsletter, the Tourist. Before 2023, my teaching year used to follow a predictable emotional arc. In September, I was always excited, not only about meeting a new crop of first-year writing students but even about the prep work. My lesson-planning sessions would take longer than intended and yet leave me feeling energized. I'd look forward to conference week--the one-on-one meetings I try to hold with every student, every term, at least once--and even to the first stack of papers.