This chapter explores the evolution, classification, and health implications of food processing, while emphasizing the transformative role of machine learning, artificial intelligence (AI), and data science in advancing food informatics. It begins with a historical overview and a critical review of traditional classification frameworks such as NOVA, Nutri-Score, and SIGA, highlighting their strengths and limitations, particularly the subjectivity and reproducibility challenges that hinder epidemiological research and public policy. To address these issues, the chapter presents novel computational approaches, including FoodProX, a random forest model trained on nutrient composition data to infer processing levels and generate a continuous FPro score. It also explores how large language models like BERT and BioBERT can semantically embed food descriptions and ingredient lists for predictive tasks, even in the presence of missing data. A key contribution of the chapter is a novel case study using the Open Food Facts database, showcasing how multimodal AI models can integrate structured and unstructured data to classify foods at scale, offering a new paradigm for food processing assessment in public health and research.

Open-source large language models (LLMs) still marginalise Moroccan Arabic (Darija), forcing practitioners either to bolt on heavyweight Arabic adapters or to sacrifice the very reasoning skills that make LLMs useful. We show that a rigorously quality-over-quantity alignment strategy can surface fluent Darija while safeguarding the backbone s cross-lingual reasoning at a sliver of the usual compute. We translate three compact instruction suites LIMA 1 K, DEITA 6 K and TULU 50 K into Darija, preserve 20 of the English originals, and add mathematics, coding and scientific prompts. A LoRA-tuned Gemma 3-4B trained on 5 K mixed instructions lifts DarijaMMLU from 32.8 to 42.7 ; adding the reasoning-dense TULU portion pushes it to 47.5 with no English regression. Scaling the identical recipe to Gemma 3-27B produces GemMaroc-27B, which matches Atlas-Chat on DarijaMMLU (61.6 ) and leaps ahead on Darija commonsense, scoring 60.5 on HellaSwag versus Atlas-Chat s 48.4 . Crucially, GemMaroc retains Gemma-27B s strong maths and general-reasoning ability, showing only minimal movement on GSM8K and English benchmarks. The entire model is trained in just 48 GPU.h, underscoring a Green AI pathway to inclusive, sustainable language technology. We release code, data and checkpoints to spur Darija-centric applications in education, public services and everyday digital interaction.

This paper investigates the underlying mechanisms of toxicity generation in Large Language Models (LLMs) and proposes an effective detoxification approach. Prior work typically considers the Feed-Forward Network (FFN) as the main source of toxicity, representing toxic regions as a set of toxic vectors or layer-wise subspaces. However, our in-depth analysis reveals that the global toxic subspace offers a more effective and comprehensive representation of toxic region within the model. Building on this insight, we propose GloSS (Global Toxic Subspace Suppression), a lightweight, four-stage method that mitigates toxicity by identifying and removing the global toxic subspace from the parameters of FFN. Experiments across a range of LLMs show that GloSS achieves state-of-the-art detoxification performance while preserving the models general capabilities, without requiring large-scale data or model retraining.

Speculative decoding accelerates Large Language Model (LLM) inference by employing a small speculative model (SSM) to generate multiple candidate tokens and verify them using the LLM in parallel. This technique has been widely integrated into LLM inference serving systems. However, inference requests typically exhibit uncertain execution time, which poses a significant challenge of efficiently scheduling requests in these systems. Existing work estimates execution time based solely on predicted output length, which could be inaccurate because execution time depends on both output length and token acceptance rate of verification by the LLM. In this paper, we propose a semi-clairvoyant request scheduling algorithm called Least-Attained/Perceived-Service for Speculative Decoding (LAPS-SD). Given a number of inference requests, LAPS-SD can effectively minimize average inference latency by adaptively scheduling requests according to their features during decoding. When the token acceptance rate is dynamic and execution time is difficult to estimate, LAPS-SD maintains multiple priority queues and allows request execution preemption across different queues. Once the token acceptance rate becomes stable, LAPS-SD can accurately estimate the execution time and schedule requests accordingly. Extensive experiments show that LAPS-SD reduces inference latency by approximately 39\% compared to state-of-the-art scheduling methods.

Mechanistic interpretability research seeks to reveal the inner workings of large language models, yet most work focuses on classification or generative tasks rather than summarization. This paper presents an interpretability framework for analyzing how GPT-like models adapt to summarization tasks. We conduct differential analysis between pre-trained and fine-tuned models, quantifying changes in attention patterns and internal activations. By identifying specific layers and attention heads that undergo significant transformation, we locate the "summarization circuit" within the model architecture. Our findings reveal that middle layers (particularly 2, 3, and 5) exhibit the most dramatic changes, with 62% of attention heads showing decreased entropy, indicating a shift toward focused information selection. We demonstrate that targeted LoRA adaptation of these identified circuits achieves significant performance improvement over standard LoRA fine-tuning while requiring fewer training epochs. This work bridges the gap between black-box evaluation and mechanistic understanding, providing insights into how neural networks perform information selection and compression during summarization.

Large language models use high-dimensional latent spaces to encode and process textual information. Much work has investigated how the conceptual content of words translates into geometrical relationships between their vector representations. Fewer studies analyze how the cumulative information of an entire prompt becomes condensed into individual embeddings under the action of transformer layers. We use literary pieces to show that information about intangible, rather than factual, aspects of the prompt are contained in deep representations. We observe that short excerpts (10 - 100 tokens) from different novels separate in the latent space independently from what next-token prediction they converge towards. Ensembles from books from the same authors are much more entangled than across authors, suggesting that embeddings encode stylistic features. This geometry of style may have applications for authorship attribution and literary analysis, but most importantly reveals the sophistication of information processing and compression accomplished by language models.

Recent advances in artificial intelligence, particularly large language models LLMs, have shown promising capabilities in transforming rare disease research. This survey paper explores the integration of LLMs in the analysis of rare diseases, highlighting significant strides and pivotal studies that leverage textual data to uncover insights and patterns critical for diagnosis, treatment, and patient care. While current research predominantly employs textual data, the potential for multimodal data integration combining genetic, imaging, and electronic health records stands as a promising frontier. We review foundational papers that demonstrate the application of LLMs in identifying and extracting relevant medical information, simulating intelligent conversational agents for patient interaction, and enabling the formulation of accurate and timely diagnoses. Furthermore, this paper discusses the challenges and ethical considerations inherent in deploying LLMs, including data privacy, model transparency, and the need for robust, inclusive data sets. As part of this exploration, we present a section on experimentation that utilizes multiple LLMs alongside structured questionnaires, specifically designed for diagnostic purposes in the context of different diseases. We conclude with future perspectives on the evolution of LLMs towards truly multimodal platforms, which would integrate diverse data types to provide a more comprehensive understanding of rare diseases, ultimately fostering better outcomes in clinical settings.

Reinforcement learning (RL) is a powerful way to adapt foundation models to specialized tasks, but its reliance on large-scale human-labeled data limits broad adoption. We introduce Synthetic Data RL, a simple and general framework that reinforcement fine-tunes models using only synthetic data generated from a task definition. Our method first generates question and answer pairs from the task definition and retrieved documents, then adapts the difficulty of the question based on model solvability, and selects questions using the average pass rate of the model across samples for RL training. On Qwen-2.5-7B, our method achieves a 29.2% absolute improvement over the base model on GSM8K (+2.9 pp vs. instruction-tuned, +6.6 pp vs. Self-Instruct), 8.7% on MATH, 13.1% on GPQA (+7.0 pp vs. SynthLLM), 8.9% on MedQA, 17.7% on CQA (law) and 13.7% on CFA (finance). It surpasses supervised fine-tuning under the same data budget and nearly matches RL with full human data across datasets (e.g., +17.2 pp on GSM8K). Adding 100 human demonstrations improves the performance of GSM8K only by 0.4 pp, showing a limited added value. By reducing human data annotation, Synthetic Data RL enables scalable and efficient RL-based model adaptation. Code and demos are available at https://github.com/gydpku/Data_Synthesis_RL/.

In order to enable fluid and natural human-machine speech interaction, existing full-duplex conversational systems often adopt modular architectures with auxiliary components such as voice activity detectors, interrupters, conversation state predictors, or multiple LLMs. These systems, however, suffer from error accumulation across modules and struggle with key challenges such as context-dependent barge-in and echo cancellation. Recent approaches, most notably Moshi, simplify the pipeline by injecting audio codecs into the token space of a single LLM. However, such methods still incur significant performance degradation when operating on the speech rather than text modality. In this paper, we introduce SALMONN-omni, the first single, standalone full-duplex speech LLM that operates without audio codecs in its token space. It features a novel dynamic thinking mechanism within the LLM backbone, enabling the model to learn when to transition between speaking and listening states. Experiments on widely used benchmarks for spoken question answering and open-domain dialogue show that SALMONN-omni achieves at least 30\% relative performance improvement over existing open-source full-duplex models and performs highly competitively to half-duplex and turn-based systems, despite using substantially less training data. Moreover, SALMONN-omni demonstrates strong performance in complex conversational scenarios, including turn-taking, backchanneling, echo cancellation and context-dependent barge-in, with further improvements achieved through reinforcement learning. Some demo conversations between user and SALMONN-omni are provided in the following repository https://github.com/bytedance/SALMONN.

Understanding medical texts presents significant challenges due to complex terminology and context-specific language. This paper introduces Medalyze, an AI-powered application designed to enhance the comprehension of medical texts using three specialized FLAN-T5-Large models. These models are fine-tuned for (1) summarizing medical reports, (2) extracting health issues from patient-doctor conversations, and (3) identifying the key question in a passage. Medalyze is deployed across a web and mobile platform with real-time inference, leveraging scalable API and YugabyteDB. Experimental evaluations demonstrate the system's superior summarization performance over GPT-4 in domain-specific tasks, based on metrics like BLEU, ROUGE-L, BERTScore, and SpaCy Similarity. Medalyze provides a practical, privacy-preserving, and lightweight solution for improving information accessibility in healthcare.