Large language models (LLMs) have demonstrated robust capabilities across various natural language tasks. However, producing outputs that are consistently honest and helpful remains an open challenge. To overcome this challenge, this paper tackles the problem through two complementary directions. It conducts a comprehensive benchmark evaluation of ten widely used large language models, including both proprietary and open-weight models from OpenAI, Meta, and Google. In parallel, it proposes a novel prompting strategy, self-critique-guided curiosity refinement prompting. The key idea behind this strategy is enabling models to self-critique and refine their responses without additional training. The proposed method extends the curiosity-driven prompting strategy by incorporating two lightweight in-context steps including self-critique step and refinement step. The experiment results on the HONESET dataset evaluated using the framework $\mathrm{H}^2$ (honesty and helpfulness), which was executed with GPT-4o as a judge of honesty and helpfulness, show consistent improvements across all models. The approach reduces the number of poor-quality responses, increases high-quality responses, and achieves relative gains in $\mathrm{H}^2$ scores ranging from 1.4% to 4.3% compared to curiosity-driven prompting across evaluated models. These results highlight the effectiveness of structured self-refinement as a scalable and training-free strategy to improve the trustworthiness of LLMs outputs.

With recent advancements in AI and computational tools, intelligent paradigms have emerged to enhance fields like shared autonomy and human-machine teaming in healthcare. Advanced AI algorithms (e.g., reinforcement learning) can autonomously make decisions to achieve planning and motion goals. However, in healthcare, where human intent is crucial, fully independent machine decisions may not be ideal. This chapter presents a comprehensive review of human-centered shared autonomy AI frameworks, focusing on upper limb biosignal-based machine interfaces and associated motor control systems, including computer cursors, robotic arms, and planar platforms. We examine motor planning, learning (rehabilitation), and control, covering conceptual foundations of human-machine teaming in reach-and-grasp tasks and analyzing both theoretical and practical implementations. Each section explores how human and machine inputs can be blended for shared autonomy in healthcare applications. Topics include human factors, biosignal processing for intent detection, shared autonomy in brain-computer interfaces (BCI), rehabilitation, assistive robotics, and Large Language Models (LLMs) as the next frontier. We propose adaptive shared autonomy AI as a high-performance paradigm for collaborative human-AI systems, identify key implementation challenges, and outline future directions, particularly regarding AI reasoning agents. This analysis aims to bridge neuroscientific insights with robotics to create more intuitive, effective, and ethical human-machine teaming frameworks.

--This paper presents a novel Retrieval-Augmented Generation (RAG) framework tailored for complex question answering tasks, addressing challenges in multi-hop reasoning and contextual understanding across lengthy documents. Built upon LLaMA 3, the framework integrates a dense retrieval module with advanced context fusion and multi-hop reasoning mechanisms, enabling more accurate and coherent response generation. A joint optimization strategy combining retrieval likelihood and generation cross-entropy improves the model's robustness and adaptability. Experimental results show that the proposed system outperforms existing retrieval-augmented and generative baselines, confirming its effectiveness in delivering precise, contextually grounded answers. Understanding complex question answering (QA) tasks requires deep comprehension of documents containing numbers, legal texts, and intricate language.

Current research on long-form context in Large Language Models (LLMs) primarily focuses on the understanding of long-contexts, the Open-ended Long Text Generation (Open-LTG) remains insufficiently explored. Training a long-context generation model requires curation of gold standard reference data, which is typically nonexistent for informative Open-LTG tasks. However, previous methods only utilize general assessments as reward signals, which limits accuracy. To bridge this gap, we introduce ProxyReward, an innovative reinforcement learning (RL) based framework, which includes a dataset and a reward signal computation method. Firstly, ProxyReward Dataset generation is accomplished through simple prompts that enables the model to create automatically, obviating extensive labeled data or significant manual effort. Secondly, ProxyReward Signal offers a targeted evaluation of information comprehensiveness and accuracy for specific questions. The experimental results indicate that our method ProxyReward surpasses even GPT-4-Turbo. It can significantly enhance performance by 20% on the Open-LTG task when training widely used open-source models, while also surpassing the LLM-as-a-Judge approach. Our work presents effective methods to enhance the ability of LLMs to address complex open-ended questions posed by human.

Foundation models (FMs), powered by self-supervised learning (SSL), have redefined the capabilities of artificial intelligence, demonstrating exceptional performance in domains like natural language processing and computer vision. These advances present a transformative opportunity for brain signal analysis. Unlike traditional supervised learning, which is limited by the scarcity of labeled neural data, SSL offers a promising solution by enabling models to learn meaningful representations from unlabeled data. This is particularly valuable in addressing the unique challenges of brain signals, including high noise levels, inter-subject variability, and low signal-to-noise ratios. This survey systematically reviews the emerging field of bridging brain signals with foundation models through the innovative application of SSL. It explores key SSL techniques, the development of brain-specific foundation models, their adaptation to downstream tasks, and the integration of brain signals with other modalities in multimodal SSL frameworks. The review also covers commonly used evaluation metrics and benchmark datasets that support comparative analysis. Finally, it highlights key challenges and outlines future research directions. This work aims to provide researchers with a structured understanding of this rapidly evolving field and a roadmap for developing generalizable brain foundation models powered by self-supervision.

Vietnamese, the 20th most spoken language with over 102 million native speakers, lacks robust resources for key natural language processing tasks such as text segmentation and machine reading comprehension (MRC). To address this gap, we present VSMRC, the Vietnamese Text Segmentation and Multiple-Choice Reading Comprehension Dataset. Sourced from Vietnamese Wikipedia, our dataset includes 15,942 documents for text segmentation and 16,347 synthetic multiple-choice question-answer pairs generated with human quality assurance, ensuring a reliable and diverse resource. Experiments show that mBERT consistently outperforms monolingual models on both tasks, achieving an accuracy of 88.01% on MRC test set and an F1 score of 63.15\% on text segmentation test set. Our analysis reveals that multilingual models excel in NLP tasks for Vietnamese, suggesting potential applications to other under-resourced languages. VSMRC is available at HuggingFace

Generating unbiased summaries in real-world settings such as political perspective summarization remains a crucial application of Large Language Models (LLMs). Yet, existing evaluation frameworks rely on traditional metrics for measuring key attributes such as coverage and faithfulness without verifying their applicability, and efforts to develop improved summarizers are still nascent. We address these gaps by (1) identifying reliable metrics for measuring perspective summary quality, and (2) investigating the efficacy of LLM-based methods beyond zero-shot inference. Namely, we build a test set for benchmarking metric reliability using human annotations and show that traditional metrics underperform compared to language model-based metrics, which prove to be strong evaluators. Using these metrics, we show that reranking-based methods yield strong results, and preference tuning with synthetically generated and reranking-labeled data further boosts performance. Our findings aim to contribute to the reliable evaluation and development of perspective summarization methods.

Transformer-based neural speech processing has achieved state-of-the-art performance. Since speech audio signals are known to be highly compressible, here we seek to accelerate neural speech transcription by time-domain signal sparsification early in the neural encoding stage, taking advantage of the interpretability of the self-attention mechanism in transformer audio encoders. With the Whisper family of models, we perform a systematic architecture search over the joint space of sparsification stage (a certain encoder layer) and compression ratio (sparsity). We found that the best resulting solutions under 1% accuracy degradation choose to sparsify the hidden state to 40-60% sparsity at an early encoding stage, and thereby achieve up to 1.6x runtime acceleration in English speech transcription tasks on Nvidia GPUs without any fine-tuning.

Retrieval-augmented Generation (RAG) is powerful, but its effectiveness hinges on which retrievers we use and how. Different retrievers offer distinct, often complementary signals: BM25 captures lexical matches; dense retrievers, semantic similarity. Yet in practice, we typically fix a single retriever based on heuristics, which fails to generalize across diverse information needs. Can we dynamically select and integrate multiple retrievers for each individual query, without the need for manual selection? In our work, we validate this intuition with quantitative analysis and introduce mixture of retrievers: a zero-shot, weighted combination of heterogeneous retrievers. Extensive experiments show that such mixtures are effective and efficient: Despite totaling just 0.8B parameters, this mixture outperforms every individual retriever and even larger 7B models by +10.8% and +3.9% on average, respectively. Further analysis also shows that this mixture framework can help incorporate specialized non-oracle human information sources as retrievers to achieve good collaboration, with a 58.9% relative performance improvement over simulated humans alone.

Hematoxylin and Eosin (H&E) staining is a cornerstone of pathological analysis, offering reliable visualization of cellular morphology and tissue architecture for cancer diagnosis, subtyping, and grading. Immunohistochemistry (IHC) staining provides molecular insights by detecting specific proteins within tissues, enhancing diagnostic accuracy, and improving treatment planning. However, IHC staining is costly, time-consuming, and resource-intensive, requiring specialized expertise. To address these limitations, this study proposes HistoStainAlign, a novel deep learning framework that predicts IHC staining patterns directly from H&E whole-slide images (WSIs) by learning joint representations of morphological and molecular features. The framework integrates paired H&E and IHC embeddings through a contrastive training strategy, capturing complementary features across staining modalities without patch-level annotations or tissue registration. The model was evaluated on gastrointestinal and lung tissue WSIs with three commonly used IHC stains: P53, PD-L1, and Ki-67. HistoStainAlign achieved weighted F1 scores of 0.735 [95% Confidence Interval (CI): 0.670-0.799], 0.830 [95% CI: 0.772-0.886], and 0.723 [95% CI: 0.607-0.836], respectively for these three IHC stains. Embedding analyses demonstrated the robustness of the contrastive alignment in capturing meaningful cross-stain relationships. Comparisons with a baseline model further highlight the advantage of incorporating contrastive learning for improved stain pattern prediction. This study demonstrates the potential of computational approaches to serve as a pre-screening tool, helping prioritize cases for IHC staining and improving workflow efficiency.