Large Language Model
Large language models provide unsafe answers to patient-posed medical questions
Draelos, Rachel L., Afreen, Samina, Blasko, Barbara, Brazile, Tiffany L., Chase, Natasha, Desai, Dimple Patel, Evert, Jessica, Gardner, Heather L., Herrmann, Lauren, House, Aswathy Vaikom, Kass, Stephanie, Kavan, Marianne, Khemani, Kirshma, Koire, Amanda, McDonald, Lauren M., Rabeeah, Zahraa, Shah, Amy
Millions of patients are already using large language model (LLM) chatbots for medical advice on a regular basis, raising patient safety concerns. This physician-led red-teaming study compares the safety of four publicly available chatbots--Claude by Anthropic, Gemini by Google, GPT-4o by OpenAI, and Llama3-70B by Meta--on a new dataset, HealthAdvice, using an evaluation framework that enables quantitative and qualitative analysis. In total, 888 chatbot responses are evaluated for 222 patient-posed advice-seeking medical questions on primary care topics spanning internal medicine, women's health, and pediatrics. We find statistically significant differences between chatbots. The rate of problematic responses varies from 21.6 percent (Claude) to 43.2 percent (Llama), with unsafe responses varying from 5 percent (Claude) to 13 percent (GPT-4o, Llama). Qualitative results reveal chatbot responses with the potential to lead to serious patient harm. This study suggests that millions of patients could be receiving unsafe medical advice from publicly available chatbots, and further work is needed to improve the clinical safety of these powerful tools.
Document Haystack: A Long Context Multimodal Image/Document Understanding Vision LLM Benchmark
Huybrechts, Goeric, Ronanki, Srikanth, Jayanthi, Sai Muralidhar, Fitzgerald, Jack, Veeravanallur, Srinivasan
The proliferation of multimodal Large Language Models has significantly advanced the ability to analyze and understand complex data inputs from different modalities. However, the processing of long documents remains under-explored, largely due to a lack of suitable benchmarks. To address this, we introduce Document Haystack, a comprehensive benchmark designed to evaluate the performance of Vision Language Models (VLMs) on long, visually complex documents. Document Haystack features documents ranging from 5 to 200 pages and strategically inserts pure text or multimodal text+image "needles" at various depths within the documents to challenge VLMs' retrieval capabilities. Comprising 400 document variants and a total of 8,250 questions, it is supported by an objective, automated evaluation framework. We detail the construction and characteristics of the Document Haystack dataset, present results from prominent VLMs and discuss potential research avenues in this area.
A Wireless Foundation Model for Multi-Task Prediction
Sheng, Yucheng, Wang, Jiacheng, Zhou, Xingyu, Liang, Le, Ye, Hao, Jin, Shi, Li, Geoffrey Ye
--With the growing complexity and dynamics of the mobile communication networks, accurately predicting key system parameters, such as channel state information (CSI), user location, and network traffic, has become essential for a wide range of physical (PHY)-layer and medium access control (MAC)-layer tasks. Although traditional deep learning (DL)- based methods have been widely applied to such prediction tasks, they often struggle to generalize across different scenarios and tasks. In response, we propose a unified foundation model for multi-task prediction in wireless networks that supports diverse prediction intervals. The proposed model enforces univariate decomposition to unify heterogeneous tasks, encodes granularity for interval awareness, and uses a causal Transformer backbone for accurate predictions. Additionally, we introduce a patch masking strategy during training to support arbitrary input lengths. After trained on large-scale datasets, the proposed foundation model demonstrates strong generalization to unseen scenarios and achieves zero-shot performance on new tasks that surpass traditional full-shot baselines. HE advent of 6G communications [1] has made wireless systems more intricate, featuring ultra-dense deployments, diverse service demands, and highly dynamic environments. Efficient execution of physical (PHY) and medium access control (MAC)-layer tasks require accurate and timely knowledge of the surrounding communication environment. Key parameters of interest include channel state information (CSI) [2], user locations [3], mobile traffic at the base station (BS) [4], etc. However, these parameters fluctuate rapidly over time, making real-time estimation and feedback particularly challenging. As a result, accurately predicting these variables has become essential for enabling a wide range of downstream communication tasks.
Evaluating LLMs on Real-World Forecasting Against Expert Forecasters
Large language models (LLMs) have demonstrated remarkable capabilities across diverse tasks, but their ability to forecast future events remains understudied. A year ago, large language models struggle to come close to the accuracy of a human crowd. I evaluate state-of-the-art LLMs on 464 forecasting questions from Metaculus, comparing their performance against top forecasters. Frontier models achieve Brier scores that ostensibly surpass the human crowd but still significantly underperform a group of experts.
STRUCTSENSE: A Task-Agnostic Agentic Framework for Structured Information Extraction with Human-In-The-Loop Evaluation and Benchmarking
Chhetri, Tek Raj, Chen, Yibei, Trivedi, Puja, Jarecka, Dorota, Haobsh, Saif, Ray, Patrick, Ng, Lydia, Ghosh, Satrajit S.
The ability to extract structured information from unstructured sources-such as free-text documents and scientific literature-is critical for accelerating scientific discovery and knowledge synthesis. Large Language Models (LLMs) have demonstrated remarkable capabilities in various natural language processing tasks, including structured information extraction. However, their effectiveness often diminishes in specialized, domain-specific contexts that require nuanced understanding and expert-level domain knowledge. In addition, existing LLM-based approaches frequently exhibit poor transferability across tasks and domains, limiting their scalability and adaptability. To address these challenges, we introduce StructSense, a modular, task-agnostic, open-source framework for structured information extraction built on LLMs. StructSense is guided by domain-specific symbolic knowledge encoded in ontologies, enabling it to navigate complex domain content more effectively. It further incorporates agentic capabilities through self-evaluative judges that form a feedback loop for iterative refinement, and includes human-in-the-loop mechanisms to ensure quality and validation. We demonstrate that StructSense can overcome both the limitations of domain sensitivity and the lack of cross-task generalizability, as shown through its application to diverse neuroscience information extraction tasks.
AI4Research: A Survey of Artificial Intelligence for Scientific Research
Chen, Qiguang, Yang, Mingda, Qin, Libo, Liu, Jinhao, Yan, Zheng, Guan, Jiannan, Peng, Dengyun, Ji, Yiyan, Li, Hanjing, Hu, Mengkang, Zhang, Yimeng, Liang, Yihao, Zhou, Yuhang, Wang, Jiaqi, Chen, Zhi, Che, Wanxiang
Recent advancements in artificial intelligence (AI), particularly in large language models (LLMs) such as OpenAI-o1 and DeepSeek-R1, have demonstrated remarkable capabilities in complex domains such as logical reasoning and experimental coding. Motivated by these advancements, numerous studies have explored the application of AI in the innovation process, particularly in the context of scientific research. These AI technologies primarily aim to develop systems that can autonomously conduct research processes across a wide range of scientific disciplines. Despite these significant strides, a comprehensive survey on AI for Research (AI4Research) remains absent, which hampers our understanding and impedes further development in this field. To address this gap, we present a comprehensive survey and offer a unified perspective on AI4Research. Specifically, the main contributions of our work are as follows: (1) Systematic taxonomy: We first introduce a systematic taxonomy to classify five mainstream tasks in AI4Research. (2) New frontiers: Then, we identify key research gaps and highlight promising future directions, focusing on the rigor and scalability of automated experiments, as well as the societal impact. (3) Abundant applications and resources: Finally, we compile a wealth of resources, including relevant multidisciplinary applications, data corpora, and tools. We hope our work will provide the research community with quick access to these resources and stimulate innovative breakthroughs in AI4Research.
Evaluating Structured Output Robustness of Small Language Models for Open Attribute-Value Extraction from Clinical Notes
Neveditsin, Nikita, Lingras, Pawan, Mago, Vijay
We present a comparative analysis of the parseability of structured outputs generated by small language models for open attribute-value extraction from clinical notes. We evaluate three widely used serialization formats: JSON, YAML, and XML, and find that JSON consistently yields the highest parseability. Structural robustness improves with targeted prompting and larger models, but declines for longer documents and certain note types. Our error analysis identifies recurring format-specific failure patterns. These findings offer practical guidance for selecting serialization formats and designing prompts when deploying language models in privacy-sensitive clinical settings.
Automatic Prompt Optimization for Knowledge Graph Construction: Insights from an Empirical Study
Mihindukulasooriya, Nandana, D'Souza, Niharika S., Chowdhury, Faisal, Samulowitz, Horst
A KG represents a network of entities and illustrates relationships between them. KGs are used for various applications, including semantic search and discovery, reasoning, decision-making, natural language processing, machine learning, and recommendation systems. Triple (subject-relation-object) extraction from text is the fundamental building block of KG construction and has been widely studied, for example, in early benchmarks such as ACE 2002 to more recent ones, such as WebNLG 2020, REBEL and SynthIE. While the use of LLMs is explored for KG construction, handcrafting reasonable task-specific prompts for LLMs is a labour-intensive exercise and can be brittle due to subtle changes in the LLM models employed. Recent work in NLP tasks (e.g. autonomy generation) uses automatic prompt optimization/engineering to address this challenge by generating optimal or near-optimal task-specific prompts given input-output examples. This empirical study explores the application of automatic prompt optimization for the triple extraction task using experimental benchmarking. We evaluate different settings by changing (a) the prompting strategy, (b) the LLM being used for prompt optimization and task execution, (c) the number of canonical relations in the schema (schema complexity), (d) the length and diversity of input text, (e) the metric used to drive the prompt optimization, and (f) the dataset being used for training and testing. We evaluate three different automatic prompt optimizers, namely, DSPy, APE, and TextGrad and use two different triple extraction datasets, SynthIE and REBEL. Through rigorous empirical evaluation, our main contribution highlights that automatic prompt optimization techniques can generate reasonable prompts similar to humans for triple extraction. In turn, these optimized prompts achieve improved results, particularly with increasing schema complexity and text size.
Reinforcing VLMs to Use Tools for Detailed Visual Reasoning Under Resource Constraints
Kumar, Sunil, Zhao, Bowen, Dirac, Leo, Varshavskaya, Paulina
Despite tremendous recent advances in large model reasoning ability, vision-language models (VLMs) still struggle with detailed visual reasoning, especially when compute resources are limited. To address this challenge, we draw inspiration from methods like DeepSeek-R1 for VLMs and train smaller-scale models with Group Relative Policy Optimization (GRPO) to use external tools such as zoom. The greatest benefit is obtained with a combination of GRPO learning, a simple reward structure, a simplified tool-calling interface, allocating additional tokens to the result of the tool call, and a training data mix that over-represents visually difficult examples. Compared to similarly-sized baseline models, our method achieves better performance on some visual question-answering (VQA) tasks, thanks to the detailed visual information gathered from the external tool.
Causally Steered Diffusion for Automated Video Counterfactual Generation
Spyrou, Nikos, Vlontzos, Athanasios, Pegios, Paraskevas, Melistas, Thomas, Gkouti, Nefeli, Panagakis, Yannis, Papanastasiou, Giorgos, Tsaftaris, Sotirios A.
Adapting text-to-image (T2I) latent diffusion models (LDMs) to video editing has shown strong visual fidelity and con-trollability, but challenges remain in maintaining causal relationships inherent to the video data generating process. Edits affecting causally dependent attributes often generate unrealistic or misleading outcomes if these relationships are ignored. In this work, we introduce a causally faithful framework for counterfactual video generation, formulated as an Out-of-Distribution (OOD) prediction problem. We embed prior causal knowledge by encoding the relationships specified in a causal graph into text prompts and guide the generation process by optimizing these prompts using a vision-language model (VLM)-based textual loss. This loss encourages the latent space of the LDMs to capture OOD variations in the form of counterfactuals, effectively steering generation toward causally meaningful alternatives. The proposed framework, dubbed CSVC, is agnostic to the underlying video editing system and does not require access to its internal mechanisms or fine-tuning. We evaluate our approach using standard video quality metrics and counterfactual-specific criteria, such as causal effectiveness and minimality. Experimental results show that CSVC generates causally faithful video counterfactuals within the LDM distribution via prompt-based causal steering, achieving state-of-the-art causal effectiveness without compromising temporal consistency or visual quality on real-world facial videos. Due to its compatibility with any black-box video editing system, our framework has significant potential to generate realistic'what if' hypothetical video scenarios in diverse areas such as digital media and healthcare.