Large language models are often assumed to acquire increasingly structured, generalizable internal representations simply by scaling data and parameters. We interrogate this assumption by introducing a Clinical Trial Natural Language Inference benchmark comprising four reasoning families, Causal Attribution, Compositional Grounding, Epistemic Verification, and Risk State Abstraction. Each item is paired with a targeted Ground Knowledge and Meta-Level Reasoning Verification (GKMRV) probe, allowing us to dissociate failures of factual access from failures of inference. We evaluate six contemporary LLMs under both direct and chain of thought prompting. Models achieve near-ceiling GKMRV accuracy (mean accuracy 0.918) yet perform poorly on the main reasoning tasks (mean accuracy 0.25). Despite low accuracy, output inferences are highly consistent across samples (mean 0.87), indicating a systematic application of underlying heuristics and shortcuts. These results reveal fundamental structural and representational limitations: current LLMs often possess the relevant clinical knowledge but lack the structured, composable internal representations needed to deploy it reliably (e.g., integrating constraints, weighing evidence, or simulating counterfactuals). Decoupling knowledge from reasoning with GKMRV makes this dissociation explicit and measurable, providing an effective framework for probing the reliability of LLMs in high-stakes domains.

Recent advances in AI-generated content have fueled the rise of highly realistic synthetic videos, posing severe risks to societal trust and digital integrity. Existing benchmarks for video authenticity detection typically suffer from limited realism, insufficient scale, and inadequate complexity, failing to effectively evaluate modern vision-language models against sophisticated forgeries. To address this critical gap, we introduce AEGIS, a novel large-scale benchmark explicitly targeting the detection of hyper-realistic and semantically nuanced AI-generated videos. AEGIS comprises over 10,000 rigorously curated real and synthetic videos generated by diverse, state-of-the-art generative models, including Stable Video Diffusion, CogVideoX-5B, KLing, and Sora, encompassing open-source and proprietary architectures. In particular, AEGIS features specially constructed challenging subsets enhanced with robustness evaluation. Furthermore, we provide multimodal annotations spanning Semantic-Authenticity Descriptions, Motion Features, and Low-level Visual Features, facilitating authenticity detection and supporting downstream tasks such as multimodal fusion and forgery localization. Extensive experiments using advanced vision-language models demonstrate limited detection capabilities on the most challenging subsets of AEGIS, highlighting the dataset's unique complexity and realism beyond the current generalization capabilities of existing models. In essence, AEGIS establishes an indispensable evaluation benchmark, fundamentally advancing research toward developing genuinely robust, reliable, broadly generalizable video authenticity detection methodologies capable of addressing real-world forgery threats. Our dataset is available on https://huggingface.co/datasets/Clarifiedfish/AEGIS.

As AI-generated content becomes widespread, so does the risk of misinformation. While prior research has primarily focused on identifying whether content is authentic, much less is known about how such content influences human perception and behavior. In domains like trading or the stock market, predicting how people react (e.g., whether a news post will go viral), can be more critical than verifying its factual accuracy. To address this, we take a human-centered approach and introduce the MhAIM Dataset, which contains 154,552 online posts (111,153 of them AI-generated), enabling large-scale analysis of how people respond to AI-generated content. Our human study reveals that people are better at identifying AI content when posts include both text and visuals, particularly when inconsistencies exist between the two. We propose three new metrics: trustworthiness, impact, and openness, to quantify how users judge and engage with online content. We present T-Lens, an LLM-based agent system designed to answer user queries by incorporating predicted human responses to multimodal information. At its core is HR-MCP (Human Response Model Context Protocol), built on the standardized Model Context Protocol (MCP), enabling seamless integration with any LLM. This integration allows T-Lens to better align with human reactions, enhancing both interpretability and interaction capabilities. Our work provides empirical insights and practical tools to equip LLMs with human-awareness capabilities. By highlighting the complex interplay among AI, human cognition, and information reception, our findings suggest actionable strategies for mitigating the risks of AI-driven misinformation.

Powerful AI tools for drug discovery reside in isolated web apps, desktop programs, and code libraries. Such fragmentation forces scientists to manage incompatible interfaces and specialized scripts, which can be a cumbersome and repetitive process. To address this issue, a Full-pROcess druG dEsign ageNT, named FROGENT, has been proposed. Specifically, FROGENT utilizes a Large Language Model and the Model Context Protocol to integrate multiple dynamic biochemical databases, extensible tool libraries, and task-specific AI models. This agentic framework allows FROGENT to execute complicated drug discovery workflows dynamically, including component tasks such as target identification, molecule generation and retrosynthetic planning. FROGENT has been evaluated on eight benchmarks that cover various aspects of drug discovery, such as knowledge retrieval, property prediction, virtual screening, mechanistic analysis, molecular design, and synthesis. It was compared against six increasingly advanced ReAct-style agents that support code execution and literature searches. Empirical results demonstrated that FROGENT triples the best baseline performance in hit-finding and doubles it in interaction profiling, significantly outperforming both the open-source model Qwen3-32B and the commercial model GPT-4o. In addition, real-world cases have been utilized to validate the practicability and generalization of FROGENT. This development suggests that streamlining the agentic drug discovery pipeline can significantly enhance researcher productivity.

Recent advances in Multimodal Large Language Models (MLLMs) have significantly pushed the frontier of egocentric video question answering (EgocentricQA). However, existing benchmarks and studies are mainly limited to common daily activities such as cooking and cleaning. In contrast, real-world deployment inevitably encounters domain shifts, where target domains differ substantially in both visual style and semantic content. To bridge this gap, we introduce \textbf{EgoCross}, a comprehensive benchmark designed to evaluate the cross-domain generalization of MLLMs in EgocentricQA. EgoCross covers four diverse and challenging domains, including surgery, industry, extreme sports, and animal perspective, representing realistic and high-impact application scenarios. It comprises approximately 1,000 QA pairs across 798 video clips, spanning four key QA tasks: prediction, recognition, localization, and counting. Each QA pair provides both OpenQA and CloseQA formats to support fine-grained evaluation. Extensive experiments show that most existing MLLMs, whether general-purpose or egocentric-specialized, struggle to generalize to domains beyond daily life, highlighting the limitations of current models. Furthermore, we conduct several pilot studies, \eg, fine-tuning and reinforcement learning, to explore potential improvements. We hope EgoCross and our accompanying analysis will serve as a foundation for advancing domain-adaptive, robust egocentric video understanding. Data and codes will be released at: \href{https://github.com/MyUniverse0726/EgoCross}{https://github.com/MyUniverse0726/EgoCross.}

The exploitation of 1 day or n day vulnerabilities poses severe threats to networked devices due to massive deployment scales and delayed patching (average Mean Time To Patch exceeds 60 days). Existing defenses, including host based patching and network based filtering, are inadequate due to limited scalability across diverse devices, compatibility issues especially with embedded or legacy systems, and error prone deployment process (manual patch validation). To address these issues, we introduce REFN (Reinforcement Learning From Network), a novel framework that trains Large Language Models (LLMs) to autonomously generate network filters to prevent 1 day or n day exploitations. REFN ensures scalability by uniquely employs Reinforcement Learning (RL) driven by online network rewards instead of traditional Human Feedback (RLHF). REFN guarantees compatibility via unified deployment on edge security gateways (Amazon Eero). REFN provides robustness via online validation using real network traffic. Crucially, REFN addresses three core challenges in training LLMs for exploit prevention: 1) expanding current LLMs limited vulnerability fixing expertise via Agentic RAG based Knowledge Distillation, 2) bridging current LLMs language to network gaps through an RL From VNF Pipeline that translates language context (vulnerability description) into network enforcement, 3) addressing the LLM hallucination and non determinism via the Online Agentic Validation that penalizes erroneous outputs. Evaluated across 22 families of 1 day or n day exploits, REFN demonstrates effectiveness (21.1 percent higher accuracy than alternatives), efficiency (Mean Time To Patch of 3.65 hours) and scalability (easily scale to 10K devices). REFN serves as an initial step toward training LLMs to rapidly prevent massive scale 1 day or n day exploitations.

Personalization is crucial for enhancing both the effectiveness and user satisfaction of language technologies, particularly in information-seeking tasks like question answering. Current approaches for personalizing large language models (LLMs) often rely on retrieval-augmented generation (RAG), followed by reinforcement learning with scalar reward signals to teach models how to use retrieved personal context. We believe that these scalar rewards sometimes provide weak, non-instructive feedback, limiting learning efficiency and personalization quality. We introduce VAC, a novel framework for personalized response generation that replaces scalar rewards with natural language feedback (NLF) that are generated conditioned on the user profiles and the question narratives. NLF serves as a rich and actionable supervision signal, allowing the policy model to iteratively refine its outputs and internalize effective personalization strategies. Training alternates between optimizing the feedback model and fine-tuning the policy model on the improved responses, resulting in a policy model that no longer requires feedback at inference. Evaluation on the LaMP-QA benchmark that consists of three diverse domains demonstrates consistent and significant improvements over the state-of-the-art results. Human evaluations further confirm the superior quality of the generated responses. These results demonstrate that NLF provides more effective signals for optimizing personalized question answering.

Effective incident response (IR) is critical for mitigating cyber threats, yet security teams are overwhelmed by alert fatigue, high false-positive rates, and the vast volume of unstructured Cyber Threat Intelligence (CTI) documents. While CTI holds immense potential for enriching security operations, its extensive and fragmented nature makes manual analysis time-consuming and resource-intensive. To bridge this gap, we introduce a novel Retrieval-Augmented Generation (RAG)-based framework that leverages Large Language Models (LLMs) to automate and enhance IR by integrating dynamically retrieved CTI. Our approach introduces a hybrid retrieval mechanism that combines NLP-based similarity searches within a CTI vector database with standardized queries to external CTI platforms, facilitating context-aware enrichment of security alerts. The augmented intelligence is then leveraged by an LLM-powered response generation module, which formulates precise, actionable, and contextually relevant incident mitigation strategies. We propose a dual evaluation paradigm, wherein automated assessment using an auxiliary LLM is systematically cross-validated by cybersecurity experts. Empirical validation on real-world and simulated alerts demonstrates that our approach enhances the accuracy, contextualization, and efficiency of IR, alleviating analyst workload and reducing response latency. This work underscores the potential of LLM-driven CTI fusion in advancing autonomous security operations and establishing a foundation for intelligent, adaptive cybersecurity frameworks.

Large visual language models (LVLMs) have demonstrated impressive performance in coarse-grained geo-localization at the country or city level, but they struggle with fine-grained street-level localization within urban areas. In this paper, we explore integrating city-wide address localization capabilities into LVLMs, facilitating flexible address-related question answering using street-view images. A key challenge is that the street-view visual question-and-answer (VQA) data provides only microscopic visual cues, leading to subpar performance in fine-tuned models. To tackle this issue, we incorporate perspective-invariant satellite images as macro cues and propose cross-view alignment tuning including a satellite-view and street-view image grafting mechanism, along with an automatic label generation mechanism. Then LVLM's global understanding of street distribution is enhanced through cross-view matching. Our proposed model, named AddressVLM, consists of two-stage training protocols: cross-view alignment tuning and address localization tuning. Furthermore, we have constructed two street-view VQA datasets based on image address localization datasets from Pittsburgh and San Francisco. Qualitative and quantitative evaluations demonstrate that AddressVLM outperforms counterpart LVLMs by over 9% and 12% in average address localization accuracy on these two datasets, respectively.

Estimating treatment effects (TE) from observational data is a critical yet complex task in many fields, from healthcare and economics to public policy. While recent advances in machine learning and causal inference have produced powerful estimation techniques, their adoption remains limited due to the need for deep expertise in causal assumptions, adjustment strategies, and model selection. In this paper, we introduce CATE-B, an open-source co-pilot system that uses large language models (LLMs) within an agentic framework to guide users through the end-to-end process of treatment effect estimation. CATE-B assists in (i) constructing a structural causal model via causal discovery and LLM-based edge orientation, (ii) identifying robust adjustment sets through a novel Minimal Uncertainty Adjustment Set criterion, and (iii) selecting appropriate regression methods tailored to the causal structure and dataset characteristics. To encourage reproducibility and evaluation, we release a suite of benchmark tasks spanning diverse domains and causal complexities. By combining causal inference with intelligent, interactive assistance, CATE-B lowers the barrier to rigorous causal analysis and lays the foundation for a new class of benchmarks in automated treatment effect estimation.