We propose a novel framework for integrating fragmented multi-modal data in Alzheimer's disease (AD) research using large language models (LLMs) and knowledge graphs. While traditional multimodal analysis requires matched patient IDs across datasets, our approach demonstrates population-level integration of MRI, gene expression, biomarkers, EEG, and clinical indicators from independent cohorts. Statistical analysis identified significant features in each modality, which were connected as nodes in a knowledge graph. LLMs then analyzed the graph to extract potential correlations and generate hypotheses in natural language. This approach revealed several novel relationships, including a potential pathway linking metabolic risk factors to tau protein abnormalities via neuroinflammation (r>0.6, p<0.001), and unexpected correlations between frontal EEG channels and specific gene expression profiles (r=0.42-0.58, p<0.01). Cross-validation with independent datasets confirmed the robustness of major findings, with consistent effect sizes across cohorts (variance <15%). The reproducibility of these findings was further supported by expert review (Cohen's k=0.82) and computational validation. Our framework enables cross modal integration at a conceptual level without requiring patient ID matching, offering new possibilities for understanding AD pathology through fragmented data reuse and generating testable hypotheses for future research.

--This paper presents JARVIS, a novel multi-agent framework that leverages Large Language Models (LLMs) and domain expertise to generate high-quality scripts for specialized Electronic Design Automation (EDA) tasks. By combining a domain-specific LLM trained with synthetically generated data, a custom compiler for structural verification, rule enforcement, code fixing capabilities, and advanced retrieval mechanisms, our approach achieves significant improvements over state-of-the-art domain-specific models. Our framework addresses the challenges of data scarcity and hallucination errors in LLMs, demonstrating the potential of LLMs in specialized engineering domains. We evaluate our framework on multiple benchmarks and show that it outperforms existing models in terms of accuracy and reliability. Our work sets a new precedent for the application of LLMs in EDA and paves the way for future innovations in this field. Large Language Models (LLMs) have revolutionized software development by automating various coding tasks, streamlining repetitive processes, and enhancing developer productivity. Tools like Microsoft's Copilot and Meta's CodeLlama have demonstrated the potential of LLMs in generating boilerplate code, automating common patterns, and embedding best practices within generated outputs [3], [17], [21]. However, when applied to specialized fields like V ery-Large-Scale Integration (VLSI) design within Electronic Design Automation (EDA), LLM performance is hindered by the scarcity of relevant training data, leading to unreliable and inaccurate outputs. These models often misinterpret and hallucinate due to a lack of contextual depth, highlighting the need for domain-specific fine-tuning. Recent efforts have focused on enhancing the reasoning capabilities of LLM models using CoT [23] and agent-based frameworks [24] for general tasks.

Scientific retrieval is essential for advancing scientific knowledge discovery. Within this process, document reranking plays a critical role in refining first-stage retrieval results. However, standard LLM listwise reranking faces challenges in the scientific domain. First-stage retrieval is often suboptimal in the scientific domain, so relevant documents are ranked lower. Meanwhile, conventional listwise reranking places the full text of candidates into the context window, limiting the number of candidates that can be considered. As a result, many relevant documents are excluded before reranking, constraining overall retrieval performance. To address these challenges, we explore semantic-feature-based compact document representations (e.g., categories, sections, and keywords) and propose CoRank, a training-free, model-agnostic reranking framework for scientific retrieval. It presents a three-stage solution: (i) offline extraction of document features, (ii) coarse-grained reranking using these compact representations, and (iii) fine-grained reranking on full texts of the top candidates from (ii). This integrated process addresses suboptimal first-stage retrieval: Compact representations allow more documents to fit within the context window, improving candidate set coverage, while the final fine-grained ranking ensures a more accurate ordering. Experiments on 5 academic retrieval datasets show that CoRank significantly improves reranking performance across different LLM backbones (average nDCG@10 from 50.6 to 55.5). Overall, these results underscore the synergistic interaction between information extraction and information retrieval, demonstrating how structured semantic features can enhance reranking in the scientific domain.

Ensuring the safety and robustness of autonomous driving systems necessitates a comprehensive evaluation in safety-critical scenarios. However, these safety-critical scenarios are rare and difficult to collect from real-world driving data, posing significant challenges to effectively assessing the performance of autonomous vehicles. Typical existing methods often suffer from limited controllability and lack user-friendliness, as extensive expert knowledge is essentially required. To address these challenges, we propose LD-Scene, a novel framework that integrates Large Language Models (LLMs) with Latent Diffusion Models (LDMs) for user-controllable adversarial scenario generation through natural language. Our approach comprises an LDM that captures realistic driving trajectory distributions and an LLM-based guidance module that translates user queries into adversarial loss functions, facilitating the generation of scenarios aligned with user queries. The guidance module integrates an LLM-based Chain-of-Thought (CoT) code generator and an LLM-based code debugger, enhancing the controllability and robustness in generating guidance functions. Extensive experiments conducted on the nuScenes dataset demonstrate that LD-Scene achieves state-of-the-art performance in generating realistic, diverse, and effective adversarial scenarios. Furthermore, our framework provides fine-grained control over adversarial behaviors, thereby facilitating more effective testing tailored to specific driving scenarios.

Scaling inference-time computation has substantially improved the reasoning capabilities of language models. However, existing methods have significant limitations: serialized chain-of-thought approaches generate overly long outputs, leading to increased latency and exhausted context windows, while parallel methods such as self-consistency suffer from insufficient coordination, resulting in redundant computations and limited performance gains. To address these shortcomings, we propose Adaptive Parallel Reasoning (APR), a novel reasoning framework that enables language models to orchestrate both serialized and parallel computations end-to-end. APR generalizes existing reasoning methods by enabling adaptive multi-threaded inference using spawn() and join() operations. A key innovation is our end-to-end reinforcement learning strategy, optimizing both parent and child inference threads to enhance task success rate without requiring predefined reasoning structures. Experiments on the Countdown reasoning task demonstrate significant benefits of APR: (1) higher performance within the same context window (83.4% vs. 60.0% at 4k context); (2) superior scalability with increased computation (80.1% vs. 66.6% at 20k total tokens); (3) improved accuracy at equivalent latency (75.2% vs. 57.3% at approximately 5,000ms). APR represents a step towards enabling language models to autonomously optimize their reasoning processes through adaptive allocation of computation.

Evaluation of language model outputs on structured writing tasks is typically conducted with a number of desirable criteria presented to human evaluators or large language models (LLMs). For instance, on a prompt like "Help me draft an academic talk on coffee intake vs research productivity", a model response may be evaluated for criteria like accuracy and coherence. However, high-quality responses should do more than just satisfy basic task requirements. An effective response to this query should include quintessential features of an academic talk, such as a compelling opening, clear research questions, and a takeaway. To help identify these implicit criteria, we introduce EvalAgent, a novel framework designed to automatically uncover nuanced and task-specific criteria. EvalAgent first mines expert-authored online guidance. It then uses this evidence to propose diverse, long-tail evaluation criteria that are grounded in reliable external sources. Our experiments demonstrate that the grounded criteria produced by EvalAgent are often implicit (not directly stated in the user's prompt), yet specific (high degree of lexical precision). Further, EvalAgent criteria are often not satisfied by initial responses but they are actionable, such that responses can be refined to satisfy them. Finally, we show that combining LLM-generated and EvalAgent criteria uncovers more human-valued criteria than using LLMs alone.

We introduce SECQUE, a comprehensive benchmark for evaluating large language models (LLMs) in financial analysis tasks. SECQUE comprises 565 expert-written questions covering SEC filings analysis across four key categories: comparison analysis, ratio calculation, risk assessment, and financial insight generation. To assess model performance, we develop SECQUE-Judge, an evaluation mechanism leveraging multiple LLM-based judges, which demonstrates strong alignment with human evaluations. Additionally, we provide an extensive analysis of various models' performance on our benchmark. By making SECQUE publicly available, we aim to facilitate further research and advancements in financial AI.

Training large, general-purpose language models poses significant challenges. The growing availability of specialized expert models, fine-tuned from pretrained models for specific tasks or domains, offers a promising alternative. Leveraging the potential of these existing expert models in real-world applications requires effective methods to select or merge the models best suited for a given task. This paper introduces SPECTR, an approach for dynamically composing expert models at each time step during inference. Notably, our method requires no additional training and enables flexible, token- and layer-wise model combinations. Our experimental results demonstrate that SPECTR improves routing accuracy over alternative training-free methods, increasing task performance across expert domains.