Users often take notes for instructional videos to access key knowledge later without revisiting long videos. Automated note generation tools enable users to obtain informative notes efficiently. However, notes generated by existing research or off-the-shelf tools fail to preserve the information conveyed in the original videos comprehensively, nor can they satisfy users' expectations for diverse presentation formats and interactive features when using notes digitally. In this work, we present NoteIt, a system, which automatically converts instructional videos to interactable notes using a novel pipeline that faithfully extracts hierarchical structure and multimodal key information from videos. With NoteIt's interface, users can interact with the system to further customize the content and presentation formats of the notes according to their preferences. We conducted both a technical evaluation and a comparison user study (N=36). The solid performance in objective metrics and the positive user feedback demonstrated the effectiveness of the pipeline and the overall usability of NoteIt. Project website: https://zhaorunning.github.io/NoteIt/

Recent advances in large language models (LLMs) have enabled new possibilities in simulating complex physiological systems. We introduce Organ-Agents, a multi-agent framework that simulates human physiology via LLM-driven agents. Each Simulator models a specific system (e.g., cardiovascular, renal, immune). Training consists of supervised fine-tuning on system-specific time-series data, followed by reinforcement-guided coordination using dynamic reference selection and error correction. We curated data from 7,134 sepsis patients and 7,895 controls, generating high-resolution trajectories across 9 systems and 125 variables. Organ-Agents achieved high simulation accuracy on 4,509 held-out patients, with per-system MSEs <0.16 and robustness across SOFA-based severity strata. External validation on 22,689 ICU patients from two hospitals showed moderate degradation under distribution shifts with stable simulation. Organ-Agents faithfully reproduces critical multi-system events (e.g., hypotension, hyperlactatemia, hypoxemia) with coherent timing and phase progression. Evaluation by 15 critical care physicians confirmed realism and physiological plausibility (mean Likert ratings 3.9 and 3.7). Organ-Agents also enables counterfactual simulations under alternative sepsis treatment strategies, generating trajectories and APACHE II scores aligned with matched real-world patients. In downstream early warning tasks, classifiers trained on synthetic data showed minimal AUROC drops (<0.04), indicating preserved decision-relevant patterns. These results position Organ-Agents as a credible, interpretable, and generalizable digital twin for precision diagnosis, treatment simulation, and hypothesis testing in critical care.

Traditional protocol fuzzing techniques, such as those employed by AFL-based systems, often lack effectiveness due to a limited semantic understanding of complex protocol grammars and rigid seed mutation strategies. Recent works, such as ChatAFL, have integrated Large Language Models (LLMs) to guide protocol fuzzing and address these limitations, pushing protocol fuzzers to wider exploration of the protocol state space. But ChatAFL still faces issues like unreliable output, LLM hallucinations, and assumptions of LLM knowledge about protocol specifications. This paper introduces MultiFuzz, a novel dense retrieval-based multi-agent system designed to overcome these limitations by integrating semantic-aware context retrieval, specialized agents, and structured tool-assisted reasoning. MultiFuzz utilizes agentic chunks of protocol documentation (RFC Documents) to build embeddings in a vector database for a retrieval-augmented generation (RAG) pipeline, enabling agents to generate more reliable and structured outputs, enhancing the fuzzer in mutating protocol messages with enhanced state coverage and adherence to syntactic constraints. The framework decomposes the fuzzing process into modular groups of agents that collaborate through chain-of-thought reasoning to dynamically adapt fuzzing strategies based on the retrieved contextual knowledge. Experimental evaluations on the Real-Time Streaming Protocol (RTSP) demonstrate that MultiFuzz significantly improves branch coverage and explores deeper protocol states and transitions over state-of-the-art (SOTA) fuzzers such as NSFuzz, AFLNet, and ChatAFL. By combining dense retrieval, agentic coordination, and language model reasoning, MultiFuzz establishes a new paradigm in autonomous protocol fuzzing, offering a scalable and extensible foundation for future research in intelligent agentic-based fuzzing systems.

Jailbreak attacks pose a serious challenge to the safe deployment of large language models (LLMs). We introduce CCFC (Core & Core-Full-Core), a dual-track, prompt-level defense framework designed to mitigate LLMs' vulnerabilities from prompt injection and structure-aware jailbreak attacks. CCFC operates by first isolating the semantic core of a user query via few-shot prompting, and then evaluating the query using two complementary tracks: a core-only track to ignore adversarial distractions (e.g., toxic suffixes or prefix injections), and a core-full-core (CFC) track to disrupt the structural patterns exploited by gradient-based or edit-based attacks. The final response is selected based on a safety consistency check across both tracks, ensuring robustness without compromising on response quality. We demonstrate that CCFC cuts attack success rates by 50-75% versus state-of-the-art defenses against strong adversaries (e.g., DeepInception, GCG), without sacrificing fidelity on benign queries. Our method consistently outperforms state-of-the-art prompt-level defenses, offering a practical and effective solution for safer LLM deployment.

Specifications for code writing tasks are usually expressed in natural language and may be ambiguous. Programmers must therefore develop the ability to recognize ambiguities in task specifications and resolve them by asking clarifying questions. We present and evaluate a prototype system, based on a novel technique (ARHF: Ambiguity Resolution with Human Feedback), that (1) suggests specific inputs on which a given task specification may be ambiguous, (2) seeks limited human feedback about the code's desired behavior on those inputs, and (3) uses this feedback to generate code that resolves these ambiguities. We evaluate the efficacy of our prototype, and we discuss the implications of such assistive systems on Computer Science education.

Engineering education has historically been constrained by rigid, standardized frameworks, often neglecting students' diverse learning needs and interests. While significant advancements have been made in online and personalized education within K-12 and foundational sciences, engineering education at both undergraduate and graduate levels continues to lag in adopting similar innovations. Traditional evaluation methods, such as exams and homework assignments, frequently overlook individual student requirements, impeding personalized educational experiences. To address these limitations, this paper introduces the Personalized AI-Powered Progressive Learning (PAPPL) platform, an advanced Intelligent Tutoring System (ITS) designed specifically for engineering education. It highlights the development of a scalable, data-driven tutoring environment leveraging cutting-edge AI technology to enhance personalized learning across diverse academic disciplines, particularly in STEM fields. PAPPL integrates core ITS components including the expert module, student module, tutor module, and user interface, and utilizes GPT-4o, a sophisticated large language model (LLM), to deliver context-sensitive and pedagogically sound hints based on students' interactions. The system uniquely records student attempts, detects recurring misconceptions, and generates progressively targeted feedback, providing personalized assistance that adapts dynamically to each student's learning profile. Additionally, PAPPL offers instructors detailed analytics, empowering evidence-based adjustments to teaching strategies. This study provides a fundamental framework for the progression of Generative ITSs scalable to all education levels, delivering important perspectives on personalized progressive learning and the wider possibilities of Generative AI in the field of education.

In this paper we explore where information is collected and how it is propagated throughout layers in large language models (LLMs). We begin by examining the surprising computational importance of punctuation tokens which previous work has identified as attention sinks and memory aids. Using intervention-based techniques, we evaluate the necessity and sufficiency (for preserving model performance) of punctuation tokens across layers in GPT-2, DeepSeek, and Gemma. Our results show stark model-specific differences: for GPT-2, punctuation is both necessary and sufficient in multiple layers, while this holds far less in DeepSeek and not at all in Gemma. Extending beyond punctuation, we ask whether LLMs process different components of input (e.g., subjects, adjectives, punctuation, full sentences) by forming early static summaries reused across the network, or if the model remains sensitive to changes in these components across layers. Extending beyond punctuation, we investigate whether different reasoning rules are processed differently by LLMs. In particular, through interchange intervention and layer-swapping experiments, we find that conditional statements (if, then), and universal quantification (for all) are processed very differently. Our findings offer new insight into the internal mechanisms of punctuation usage and reasoning in LLMs and have implications for interpretability.

Large language models (LLMs) have shown promise in medical domains, but their ability to handle specialized neurological reasoning requires systematic evaluation. We developed a comprehensive benchmark using 305 questions from Israeli Board Certification Exams in Neurology, classified along three complexity dimensions: factual knowledge depth, clinical concept integration, and reasoning complexity. We evaluated ten LLMs using base models, retrieval-augmented generation (RAG), and a novel multi-agent system. Results showed significant performance variation. OpenAI-o1 achieved the highest base performance (90.9% accuracy), while specialized medical models performed poorly (52.9% for Meditron-70B). RAG provided modest benefits but limited effectiveness on complex reasoning questions. In contrast, our multi-agent framework, decomposing neurological reasoning into specialized cognitive functions including question analysis, knowledge retrieval, answer synthesis, and validation, achieved dramatic improvements, especially for mid-range models. The LLaMA 3.3-70B-based agentic system reached 89.2% accuracy versus 69.5% for its base model, with substantial gains on level 3 complexity questions. The multi-agent approach transformed inconsistent subspecialty performance into uniform excellence, addressing neurological reasoning challenges that persisted with RAG enhancement. We validated our approach using an independent dataset of 155 neurological cases from MedQA. Results confirm that structured multi-agent approaches designed to emulate specialized cognitive processes significantly enhance complex medical reasoning, offering promising directions for AI assistance in challenging clinical contexts.

Large Language Models (LLMs) are increasingly deployed across diverse applications that demand balancing multiple, often conflicting, objectives -- such as helpfulness, harmlessness, or humor. Aligning outputs to user-specific preferences in such multi-objective settings typically requires fine-tuning models for each objective or preference configuration, which is computationally expensive and inflexible. We introduce MAVIS -- Multi-Objective Alignment via Value-Guided Inference-Time Search -- a lightweight inference-time alignment framework that enables dynamic control over LLM behavior without modifying the base model's weights. MAVIS trains a set of small value models, each corresponding to a distinct objective. At inference time, these value models are combined using user-specified weights to produce a tilting function that adjusts the base model's output distribution toward desired trade-offs. The value models are trained using a simple iterative algorithm that ensures monotonic improvement of the KL-regularized policy. We show empirically that MAVIS outperforms baselines that fine-tune per-objective models and combine them post hoc, and even approaches the performance of the idealized setting where models are fine-tuned for a user's exact preferences.

Recent advances in large language model (LLM) pretraining have shown that simply scaling data quantity eventually leads to diminishing returns, hitting a data wall. In response, the use of synthetic data for pretraining has emerged as a promising paradigm for pushing the frontier of performance. Despite this, the factors affecting synthetic data quality remain poorly understood. In this work, we introduce BeyondWeb, a synthetic data generation framework that produces high-quality synthetic data for pretraining. BeyondWeb significantly extends the capabilities of traditional web-scale datasets, outperforming state-of-the-art synthetic pretraining datasets such as Cosmopedia and Nemotron-CC's high-quality synthetic subset (Nemotron-Synth) by up to 5.1 percentage points (pp) and 2.6pp, respectively, when averaged across a suite of 14 benchmark evaluations. It delivers up to 7.7x faster training than open web data and 2.7x faster than Nemotron-Synth. Remarkably, a 3B model trained for 180B tokens on BeyondWeb outperforms an 8B model trained for the same token budget on Cosmopedia. We also present several insights from BeyondWeb on synthetic data for pretraining: what drives its benefits, which data to rephrase and how, and the impact of model size and family on data quality. Overall, our work shows that there's no silver bullet for generating high-quality synthetic pretraining data. The best outcomes require jointly optimizing many factors, a challenging task that requires rigorous science and practical expertise. Naive approaches can yield modest improvements, potentially at great cost, while well-executed methods can yield transformative improvements, as exemplified by BeyondWeb.