Reasoning models improve their problem-solving ability through inference-time scaling, allocating more compute via longer token budgets. Identifying which reasoning traces are likely to succeed remains a key opportunity: reliably predicting productive paths can substantially reduce wasted computation and improve overall efficiency. We introduce Latent-Trajectory signals that characterize the temporal evolution of a model's internal representations during the generation of intermediate reasoning tokens. By measuring the overall change in latent representations between the start and end of reasoning, the change accumulated across intermediate steps, and the extent to which these changes advance toward the final state, we show that these signals predict solution accuracy more reliably than both cross-layer metrics and output-based confidence measures. When used to guide answer selection across multiple sampled generations, Latent-Trajectory signals make test-time scaling more effective and efficient than majority voting, reducing token usage by up to 70% while preserving and even improving accuracy by 2.6% on average. Moreover, these predictive signals often emerge early in the reasoning trace, enabling early selection and allocation of compute to the most promising candidates. Our findings contribute not only practical strategies for inference-time efficiency, but also a deeper interpretability perspective on how reasoning processes are represented and differentiated in latent space. Recent advances in large language models (LLMs) have shown that complex reasoning tasks can be solved more effectively by scaling compute at inference time to generate longer and multiple chains-of-thought (reasoning traces) and aggregating them into a final solution (Guo et al., 2025; Abdin et al., 2025; OpenAI, 2024; Y ang et al., 2025a). However, not all reasoning traces are equal: while some contain productive steps that lead to correct answers, others may deviate into unproductive paths such as overthinking, failing to converge on a valid solution strategy, or exhibiting inconsistent reasoning (Shojaee et al., 2025; Chen et al., 2024; Sun et al., 2025). Identifying the quality of a reasoning trace (the likelihood of it leading to a correct solution) is critical. It not only enables more reliable prediction of correct answers, but it can also improve computational efficiency by potentially avoiding wasted effort on unproductive paths, and can provide feedback signals that can enhance model training.

Vision-Language Models (VLMs) integrate visual knowledge with the analytical capabilities of Large Language Models (LLMs) through supervised visual instruction tuning, using image-question-answer triplets. However, the potential of VLMs trained without supervised instruction remains largely unexplored. This study validates that VLMs possess inherent self-refinement capabilities, enabling them to generate high-quality supervised data without external inputs and thereby learn autonomously. Specifically, to stimulate the self-refinement ability of VLMs, we propose a self-refinement framework based on a Triangular Consistency principle: within the image-query-answer triangle, any masked elements should be consistently and accurately reconstructed. The framework involves three steps: (1) We enable the instruction generation ability of VLMs by adding multi-task instruction tuning like image$\rightarrow$question-answer or image-answer$\rightarrow$question. (2) We generate image-query-answer triplets from unlabeled images and use the Triangular Consistency principle for filtering. (3) The model is further updated using the filtered synthetic data. To investigate the underlying mechanisms behind this self-refinement capability, we conduct a theoretical analysis from a causal perspective. Using the widely recognized LLaVA-1.5 as our baseline, our experiments reveal that the model can autonomously achieve consistent, though deliberately modest, improvements across multiple benchmarks without any external supervision, such as human annotations or environmental feedback. We expect that the insights of this study on the self-refinement ability of VLMs can inspire future research on the learning mechanism of VLMs. Code is available at https://github.com/dengyl20/SRF-LLaVA-1.5.

Open-source large language models (LLMs) have demonstrated considerable dominance over proprietary LLMs in resolving neural processing tasks, thanks to the collaborative and sharing nature. Although full access to source codes, model parameters, and training data lays the groundwork for transparency, we argue that such a full-access manner is vulnerable to stego attacks, and their ill-effects are not fully understood. In this paper, we conduct a systematic formalization for stego attacks on open-source LLMs by enumerating all possible threat models associated with adversary objectives, knowledge, and capabilities. Therein, the threat posed by adversaries with internal knowledge, who inject payloads and triggers during the model sharing phase, is of practical interest. We go even further and propose the first stego attack on open-source LLMs, dubbed SASER, which wields impacts through identifying targeted parameters, embedding payloads, injecting triggers, and executing payloads sequentially. Particularly, SASER enhances the attack robustness against quantization-based local deployment by de-quantizing the embedded payloads. In addition, to achieve stealthiness, SASER devises the performance-aware importance metric to identify targeted parameters with the least degradation of model performance. Extensive experiments on LlaMA2-7B and ChatGLM3-6B, without quantization, show that the stealth rate of SASER outperforms existing stego attacks (for general DNNs) by up to 98.1%, while achieving the same attack success rate (ASR) of 100%. More importantly, SASER improves ASR on quantized models from 0 to 100% in all settings. We appeal for investigations on countermeasures against SASER in view of the significant attack effectiveness.

Diffusion LLMs have attracted growing interest, with plenty of recent work emphasizing their great potential in various downstream tasks; yet the long-context behavior of diffusion LLMs remains largely uncharted. We present a case study of post-training techniques for extending the context window of diffusion LLMs (i.e., LLaDA) without retraining from scratch. We show that a simple modification to the standard Rotary Positional Embeddings (RoPE) extension effectively accommodates the probabilistic modeling inherent in the diffusion process, enabling stable scaling to longer context ranges. We further compare masking strategies used during post-training and analyze their impact on optimization stability and long-range recall. Instantiating these insights, we introduce UltraLLaDA, a diffusion LLM with a 128K-token context window that, in our empirical evaluation on long-context tasks, significantly outperforms training-free baselines. Our experimental results highlight the special positional extension as a key lever for scaling diffusion LLMs to extended contexts and offer practical guidance for practitioners seeking 128K-scale context via efficient post-training.

Medical order extraction is essential for structuring actionable clinical information, supporting decision-making, and enabling downstream applications such as documentation and workflow automation. Orders may be embedded in diverse sources, including electronic health records, discharge summaries, and multi-turn doctor-patient dialogues, and can span categories such as medications, laboratory tests, imaging studies, and follow-up actions. The MEDIQA-OE 2025 shared task focuses on extracting structured medical orders from extended conversational transcripts, requiring the identification of order type, description, reason, and provenance. We present the MasonNLP submission, which ranked 5th among 17 participating teams with 105 total submissions. Our approach uses a general-purpose, instruction-tuned LLaMA-4 17B model without domain-specific fine-tuning, guided by a single in-context example. This few-shot configuration achieved an average F1 score of 37.76, with notable improvements in reason and provenance accuracy. These results demonstrate that large, non-domain-specific LLMs, when paired with effective prompt engineering, can serve as strong, scalable baselines for specialized clinical NLP tasks.

The deployment of large language models (LLMs) is increasingly constrained by memory and latency bottlenecks, motivating the need for quantization techniques that flexibly balance accuracy and efficiency. Recent work has introduced multi-precision models, which enable inference at multiple precisions within a single model depending on runtime constraints. To support such flexibility, quantized weights are often stored as bit-planes, where hardware efficiency improves when the compute operates directly at the bit-plane level and activates only the precision required by each request. In this work, we present AnyBCQ, a hardware-friendly multi-precision extension of Binary-Coded Quantization (BCQ) that supports direct bit-plane operations. By representing weights as binary bit-planes with corresponding scale factors, AnyBCQ enables bit-plane-level computation and maps naturally to accelerator-friendly, bit-parallel arithmetic. Our progressive precision expansion mechanism incrementally refines scaling factors while reusing previously assigned binary codes, yielding monotonic improvements in accuracy as additional bits are enabled. We further co-design a specialized kernel that exploits the BCQ structure to support dynamic per-request precision selection with negligible overhead. Experiments on recent LLMs demonstrate that AnyBCQ significantly narrows the accuracy drop in the low-bit regime (e.g. 2-bit), remains competitive at higher precision, and achieves throughput gains of up to 3.0x over half precision and 1.2x over state-of-the-art multi-precision methods. By aligning algorithmic flexibility with hardware efficiency, AnyBCQ provides a practical foundation for multi-precision LLM deployment across diverse service-level objectives.

Abstract--Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic reasoning and medication decisions. We identify a core limitation: existing medical AI systems process tasks in isolation without the cross-validation and knowledge integration found in clinical teams, reducing their effectiveness in real-world healthcare scenarios. T o transform the isolation paradigm into a collaborative approach, we propose MedCoAct, a confidence-aware multi-agent framework that simulates clinical collaboration by integrating specialized doctor and pharmacist agents, and present a benchmark, DrugCareQA, to evaluate medical AI capabilities in integrated diagnosis and treatment workflows. Our results demonstrate that MedCoAct achieves 67.58% diagnostic accuracy and 67.58% medication recommendation accuracy, outperforming single agent framework by 7.04% and 7.08% respectively. In healthcare, LLMs have demonstrated capabilities across diverse applications. Medical question-answering systems provide rapid access to comprehensive clinical knowledge and evidence-based recommendations [1]-[3]. LLMs assist also with medical imaging report generation, significantly reducing physician workload [4]. Moreover, LLMs help drug discovery research by accelerating molecular design and optimization processes [5].

Digital communication has become the cornerstone of modern interaction, enabling rapid, accessible, and interactive exchanges. However, individuals with lower academic literacy often face significant barriers, exacerbating the "digital divide". In this work, we introduce a novel, universal ideographic metalanguage designed as an innovative communication framework that transcends academic, linguistic, and cultural boundaries. Our approach leverages principles of Neuro-symbolic AI, combining neural-based large language models (LLMs) enriched with world knowledge and symbolic knowledge heuristics grounded in the linguistic theory of Natural Semantic Metalanguage (NSM). This enables the semantic decomposition of complex ideas into simpler, atomic concepts. Adopting a human-centric, collaborative methodology, we engaged over 200 semi-literate participants in defining the problem, selecting ideographs, and validating the system. With over 80\% semantic comprehensibility, an accessible learning curve, and universal adaptability, our system effectively serves underprivileged populations with limited formal education.

As the demand for comprehensive evaluations of diverse model capabilities steadily increases, benchmark suites have correspondingly grown significantly in scale. Despite notable advances in redundancy reduction and subset-level performance prediction, a systematic framework that effectively integrates these methods to ensure both prediction accuracy and ranking consistency is still largely elusive. In this paper, we first perform a sample-level analysis of benchmark redundancy and identify several highly similar samples that can be eliminated. Besides, we frame benchmark compression as an optimization problem with the aim of score reconstruction. Building on these, we then propose EssenceBench, a coarse-to-fine framework utilizing an iterative Genetic Algorithm (GA), which takes the advantages of fitness-based subset search and attribution-based sample search. Compared to previous methods, our approach yields superior compression results with lower reconstruction error and markedly higher efficiency. In particular, on the HellaSwag benchmark (10K samples), our method preserves the ranking of all models shifting within 5% using 25x fewer samples, and achieves 95% ranking preservation shifting within 5% using only 200x fewer samples.

Large language models (LLMs) offer a generalizable approach for modeling patient trajectories, but suffer from the long and noisy nature of electronic health records (EHR) data in temporal reasoning. To address these challenges, we introduce Traj-CoA, a multi-agent system involving chain-of-agents for patient trajectory modeling. Traj-CoA employs a chain of worker agents to process EHR data in manageable chunks sequentially, distilling critical events into a shared long-term memory module, EHRMem, to reduce noise and preserve a comprehensive timeline. A final manager agent synthesizes the worker agents' summary and the extracted timeline in EHRMem to make predictions. In a zero-shot one-year lung cancer risk prediction task based on five-year EHR data, Traj-CoA outperforms baselines of four categories. Analysis reveals that Traj-CoA exhibits clinically aligned temporal reasoning, establishing it as a promisingly robust and generalizable approach for modeling complex patient trajectories.