BC Cancer Agency 601 West 10th Ave, Epidemiology 601 West 10th Ave, Epidemiology Vancouver BC Canada V5Z 1L3 Vancouver BC Canada V5Z 1L3 tap@comp.vuw.ac.nz Abstract Epidemiological data is traditionally analyzed with very simple techniques. Flexible models, such as neural networks, have the potential to discover unanticipated features in the data. However, to be useful, flexible models must have effective control on overfitting. This paper reports on a comparative study of the predictive quality of neural networks and other flexible models applied to real and artificial epidemiological data. The results suggest that there are no major unanticipated complex features in the real data, and also demonstrate that MacKay's [1995] Bayesian neural network methodology provides effective control on overfitting while retaining the ability to discover complex features in the artificial data. 1 Introduction Traditionally, very simple statistical techniques are used in the analysis of epidemiological studies.

The perturbation method which we have presented overcomes the limitations of standard approaches, which are only appropriate for models with a single layer of adjustable weights, albeit at considerable computational expense. It has the added bonus of automatically taking into account the effect of regularisation techniques such as weight decay. The experimental results illustrate the application of the technique to two simple problems. As expected the number of degrees of freedom in the models is found to be related to the amount of weight decay used during training. The equivalent kernels are found to vary significantly in different regions of input space and the functions reconstructed from the estimated smoother matrices closely match the origna!

A new regression technique based on Vapnik's concept of support vectors is introduced. We compare support vector regression (SVR) with a committee regression technique (bagging) based on regression trees and ridge regression done in feature space. On the basis of these experiments, it is expected that SVR will have advantages in high dimensionality space because SVR optimization does not depend on the dimensionality of the input space.

BC Cancer Agency 601 West 10th Ave, Epidemiology 601 West 10th Ave, Epidemiology Vancouver BC Canada V5Z 1L3 Vancouver BC Canada V5Z 1L3 tap@comp.vuw.ac.nz Abstract Epidemiological data is traditionally analyzed with very simple techniques. Flexible models, such as neural networks, have the potential to discover unanticipated features in the data. However, to be useful, flexible models must have effective control on overfitting. This paper reports on a comparative study of the predictive quality of neural networks and other flexible models applied to real and artificial epidemiological data. The results suggest that there are no major unanticipated complex features in the real data, and also demonstrate that MacKay's [1995] Bayesian neural network methodology provides effective control on overfitting while retaining the ability to discover complex features in the artificial data. 1 Introduction Traditionally, very simple statistical techniques are used in the analysis of epidemiological studies.

The perturbation method which we have presented overcomes the limitations of standard approaches, which are only appropriate for models with a single layer of adjustable weights, albeit at considerable computational expense. It has the added bonus of automatically taking into account the effect of regularisation techniques such as weight decay. The experimental results illustrate the application of the technique to two simple problems. As expected the number of degrees of freedom in the models is found to be related to the amount of weight decay used during training. The equivalent kernels are found to vary significantly in different regions of input space and the functions reconstructed from the estimated smoother matrices closely match the origna!

A new regression technique based on Vapnik's concept of support vectors is introduced. We compare support vector regression (SVR) with a committee regression technique (bagging) based on regression trees and ridge regression done in feature space. On the basis of these experiments, it is expected that SVR will have advantages in high dimensionality space because SVR optimization does not depend on the dimensionality of the input space.

The perturbation method which we have presented overcomes the limitations of standard approaches, which are only appropriate for models with a single layer of adjustable weights, albeit at considerable computational expense. It has the added bonus of automatically taking into account the effect of regularisation techniques such as weight decay. The experimental results illustrate the application of the technique to two simple problems. As expected the number of degrees of freedom in the models is found to be related to the amount of weight decay used during training. The equivalent kernels are found to vary significantly in different regions of input space and the functions reconstructed from the estimated smoother matrices closely match the origna!

Model learning combined with dynamic programming has been shown to be effective for learning control of continuous state dynamic systems. The simplest method assumes the learned model is correct and applies dynamic programming to it, but many approximators provide uncertainty estimates on the fit. How can they be exploited? This paper addresses the case where the system must be prevented from having catastrophic failures during learning.We propose a new algorithm adapted from the dual control literature and use Bayesian locally weighted regression models with dynamic programming.A common reinforcement learning assumption is that aggressive exploration should be encouraged. This paper addresses the converse casein which the system has to reign in exploration.

Tony Plate BC Cancer Agency 601 West 10th Ave, Epidemiology Vancouver BC Canada V5Z 1L3 tap@comp.vuw.ac.nz PierreBand BC Cancer Agency 601 West 10th Ave, Epidemiology Vancouver BC Canada V5Z 1L3 Joel Bert Dept of Chemical Engineering University of British Columbia 2216 Main Mall Vancouver BC Canada V6T 1Z4 JohnGrace Dept of Chemical Engineering University of British Columbia 2216 Main Mall Vancouver BC Canada V6T 1Z4 Abstract Epidemiological data is traditionally analyzed with very simple techniques. Flexible models, such as neural networks, have the potential to discover unanticipated features in the data. However, to be useful, flexible models must have effective control on overfitting. Thispaper reports on a comparative study of the predictive quality of neural networks and other flexible models applied to real and artificial epidemiological data.

A new regression technique based on Vapnik's concept of support vectors is introduced. We compare support vector regression (SVR) with a committee regression technique (bagging) based on regression trees and ridge regression done in feature space. On the basis of these experiments, it is expected that SVR will have advantages in high dimensionality space because SVR optimization does not depend on the dimensionality of the input space.