We consider the task of robust non-linear regression in the presence of both inlier noise and outliers. Assuming that the unknown non-linear function belongs to a Reproducing Kernel Hilbert Space (RKHS), our goal is to estimate the set of the associated unknown parameters. Due to the presence of outliers, common techniques such as the Kernel Ridge Regression (KRR) or the Support Vector Regression (SVR) turn out to be inadequate. Instead, we employ sparse modeling arguments to explicitly model and estimate the outliers, adopting a greedy approach. The proposed robust scheme, i.e., Kernel Greedy Algorithm for Robust Denoising (KGARD), is inspired by the classical Orthogonal Matching Pursuit (OMP) algorithm. Specifically, the proposed method alternates between a KRR task and an OMP-like selection step. Theoretical results concerning the identification of the outliers are provided. Moreover, KGARD is compared against other cutting edge methods, where its performance is evaluated via a set of experiments with various types of noise. Finally, the proposed robust estimation framework is applied to the task of image denoising, and its enhanced performance in the presence of outliers is demonstrated.

The bootstrap [15] is a ubiquitous tool in applied statistics, allowing for inference when very little is known about the properties of the data-generating distribution. The bootstrap is a powerful tool in applied settings because it does not make the strong assumptions common to classical statistical theory regarding this data-generating distribution. Instead, the bootstrap resamples the observed data to create an estimate, ˆF, of the unknown data-generating distribution, F. ˆF then forms the basis of further inference. Since its introduction, a large amount of research has explored the theoretical properties of the bootstrap, improvements for estimating F under different scenarios, and how to most effectively estimate different quantities from ˆF (see the pioneering [6] for instance and many many more references in the book-length review of [8], as well as [61] for a short summary of the modern point of view on these questions). Other resampling techniques exist of course, such as subsampling, m-out-of-n bootstrap, and jackknifing, and have been studied and much discussed (see [16], [31], [53], [5], and [18] for a practical introduction). An important limitation for the bootstrap is the quality of ˆF. The standard bootstrap estimate of F based on the empirical distribution of the data may be a poor estimate when the data has a nontrivial dependency structure, when the quantity being estimated, such as a quantile, is sensitive to the discreteness of ˆF, or when the functionals of interest are not smooth (see e.g [6] for a classic reference, as well as [3] or [14] in the context of multivariate statistics).

In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer. DNA methylation is a gene-regulatory pattern, and hence provides a means by which to assess genomic regulatory interactions. Network models are a natural way to represent and analyse groups of such interactions. The utility of network models also increases as the quantity of data and number of variables increase, making them increasingly relevant to large-scale genomic studies. We propose methodology to infer prognostic genomic networks from a DNA methylation-based measure of genomic interaction and association. We then show how to identify prognostic biomarkers from such networks, which we term `network community oncomarkers'. We illustrate the power of our proposed methodology in the context of a large publicly available breast cancer dataset.

In this article the package High-dimensional Metrics (\texttt{hdm}) is introduced. It is a collection of statistical methods for estimation and quantification of uncertainty in high-dimensional approximately sparse models. It focuses on providing confidence intervals and significance testing for (possibly many) low-dimensional subcomponents of the high-dimensional parameter vector. Efficient estimators and uniformly valid confidence intervals for regression coefficients on target variables (e.g., treatment or policy variable) in a high-dimensional approximately sparse regression model, for average treatment effect (ATE) and average treatment effect for the treated (ATET), as well for extensions of these parameters to the endogenous setting are provided. Theory grounded, data-driven methods for selecting the penalization parameter in Lasso regressions under heteroscedastic and non-Gaussian errors are implemented. Moreover, joint/ simultaneous confidence intervals for regression coefficients of a high-dimensional sparse regression are implemented. Data sets which have been used in the literature and might be useful for classroom demonstration and for testing new estimators are included.

The package High-dimensional Metrics (\Rpackage{hdm}) is an evolving collection of statistical methods for estimation and quantification of uncertainty in high-dimensional approximately sparse models. It focuses on providing confidence intervals and significance testing for (possibly many) low-dimensional subcomponents of the high-dimensional parameter vector. Efficient estimators and uniformly valid confidence intervals for regression coefficients on target variables (e.g., treatment or policy variable) in a high-dimensional approximately sparse regression model, for average treatment effect (ATE) and average treatment effect for the treated (ATET), as well for extensions of these parameters to the endogenous setting are provided. Theory grounded, data-driven methods for selecting the penalization parameter in Lasso regressions under heteroscedastic and non-Gaussian errors are implemented. Moreover, joint/ simultaneous confidence intervals for regression coefficients of a high-dimensional sparse regression are implemented, including a joint significance test for Lasso regression. Data sets which have been used in the literature and might be useful for classroom demonstration and for testing new estimators are included. \R and the package \Rpackage{hdm} are open-source software projects and can be freely downloaded from CRAN: \texttt{http://cran.r-project.org}.

Sparse linear regression, which entails finding a sparse solution to an underdetermined system of linear equations, can formally be expressed as an $l_0$-constrained least-squares problem. The Orthogonal Least-Squares (OLS) algorithm sequentially selects the features (i.e., columns of the coefficient matrix) to greedily find an approximate sparse solution. In this paper, a generalization of Orthogonal Least-Squares which relies on a recursive relation between the components of the optimal solution to select L features at each step and solve the resulting overdetermined system of equations is proposed. Simulation results demonstrate that the generalized OLS algorithm is computationally efficient and achieves performance superior to that of existing greedy algorithms broadly used in the literature.

We propose a calibrated multivariate regression method named CMR for fitting high dimensional multivariate regression models. Compared with existing methods, CMR calibrates regularization for each regression task with respect to its noise level so that it simultaneously attains improved finite-sample performance and tuning insensitiveness. Theoretically, we provide sufficient conditions under which CMR achieves the optimal rate of convergence in parameter estimation. Computationally, we propose an efficient smoothed proximal gradient algorithm with a worst-case numerical rate of convergence $\cO(1/\epsilon)$, where $\epsilon$ is a pre-specified accuracy of the objective function value. We conduct thorough numerical simulations to illustrate that CMR consistently outperforms other high dimensional multivariate regression methods. We also apply CMR to solve a brain activity prediction problem and find that it is as competitive as a handcrafted model created by human experts. The R package \texttt{camel} implementing the proposed method is available on the Comprehensive R Archive Network \url{http://cran.r-project.org/web/packages/camel/}.

Mixture models with Gamma and or inverse-Gamma distributed mixture components are useful for medical image tissue segmentation or as post-hoc models for regression coefficients obtained from linear regression within a Generalised Linear Modeling framework (GLM), used in this case to separate stochastic (Gaussian) noise from some kind of positive or negative "activation" (modeled as Gamma or inverse-Gamma distributed). To date, the most common choice in this context it is Gaussian/Gamma mixture models learned through a maximum likelihood (ML) approach; we recently extended such algorithm for mixture models with inverse-Gamma components. Here, we introduce a fully analytical Variational Bayes (VB) learning framework for both Gamma and/or inverse-Gamma components. We use synthetic and resting state fMRI data to compare the performance of the ML and VB algorithms in terms of area under the curve and computational cost. We observed that the ML Gaussian/Gamma model is very expensive specially when considering high resolution images; furthermore, these solutions are highly variable and they occasionally can overestimate the activations severely. The Bayesian Gauss-Gamma is in general the fastest algorithm but provides too dense solutions. The maximum likelihood Gaussian/inverse-Gamma is also very fast but provides in general very sparse solutions. The variational Gaussian/inverse-Gamma mixture model is the most robust and its cost is acceptable even for high resolution images. Further, the presented methodology represents an essential building block that can be directly used in more complex inference tasks, specially designed to analyse MRI-fMRI data; such models include for example analytical variational mixture models with adaptive spatial regularization or better source models for new spatial blind source separation approaches.

Least squares regression can cause impossible estimates such as probabilities that are less than zero and greater than 1.So, when the predicted value is measured as a probability, use Logistic Regression We use the log of the odds rather than the odds directly because an odds ratio cannot be a negative number--but its log can be negative. Notice that we have randomly initialized our coefficients for income and other predictors. These will be adjusted by Solver based on a likelihood function.We will cover them later Column H tells us the predicted probability of the borrower's actual behavior, whether that behavior is repayment or default--not simply, as in Column G, the predicted probability of defaulting on the loan. One property of logarithms is that their sum equals the logarithm of the product of the numbers on which they're based The logarithms of probabilities are always negative numbers, but the closer a probability is to 1.0, the closer its logarithm is to 0.0. I haven't covered cross-validation, which is commonly used to validate a logistic regression equation.If you don't always have a large number of cases to work with, a different approach is to use statistical inference.

Weka makes a large number of classification algorithms available. The large number of machine learning algorithms available is one of the benefits of using the Weka platform to work through your machine learning problems. In this post you will discover how to use 5 top machine learning algorithms in Weka. How To Use Classification Machine Learning Algorithms in Weka Photo by Don Graham, some rights reserved. We are going to take a tour of 5 top classification algorithms in Weka.