The estimation of heterogeneous treatment effects (HTEs) has attracted considerable interest in many disciplines, most prominently in medicine and economics. Contemporary research has so far primarily focused on continuous and binary responses where HTEs are traditionally estimated by a linear model, which allows the estimation of constant or heterogeneous effects even under certain model misspecifications. More complex models for survival, count, or ordinal outcomes require stricter assumptions to reliably estimate the treatment effect. Most importantly, the noncollapsibility issue necessitates the joint estimation of treatment and prognostic effects. Model-based forests allow simultaneous estimation of covariate-dependent treatment and prognostic effects, but only for randomized trials. In this paper, we propose modifications to model-based forests to address the confounding issue in observational data. In particular, we evaluate an orthogonalization strategy originally proposed by Robinson (1988, Econometrica) in the context of model-based forests targeting HTE estimation in generalized linear models and transformation models. We found that this strategy reduces confounding effects in a simulated study with various outcome distributions. We demonstrate the practical aspects of HTE estimation for survival and ordinal outcomes by an assessment of the potentially heterogeneous effect of Riluzole on the progress of Amyotrophic Lateral Sclerosis.

Recent studies show that graph convolutional network (GCN) often performs worse for low-degree nodes, exhibiting the so-called structural unfairness for graphs with long-tailed degree distributions prevalent in the real world. Graph contrastive learning (GCL), which marries the power of GCN and contrastive learning, has emerged as a promising self-supervised approach for learning node representations. How does GCL behave in terms of structural fairness? Surprisingly, we find that representations obtained by GCL methods are already fairer to degree bias than those learned by GCN. We theoretically show that this fairness stems from intra-community concentration and inter-community scatter properties of GCL, resulting in a much clear community structure to drive low-degree nodes away from the community boundary. Based on our theoretical analysis, we further devise a novel graph augmentation method, called GRAph contrastive learning for DEgree bias (GRADE), which applies different strategies to low- and high-degree nodes. Extensive experiments on various benchmarks and evaluation protocols validate the effectiveness of the proposed method.

Embeddings, which compress information in raw text into semantics-preserving low-dimensional vectors, have been widely adopted for their efficacy. However, recent research has shown that embeddings can potentially leak private information about sensitive attributes of the text, and in some cases, can be inverted to recover the original input text. To address these growing privacy challenges, we propose a privatization mechanism for embeddings based on homomorphic encryption, to prevent potential leakage of any piece of information in the process of text classification. In particular, our method performs text classification on the encryption of embeddings from state-of-the-art models like BERT, supported by an efficient GPU implementation of CKKS encryption scheme. We show that our method offers encrypted protection of BERT embeddings, while largely preserving their utility on downstream text classification tasks.

The supervised machine learning algorithms you will learn here are some of the most powerful data science tools you need to solve regression and classification tasks. These are invaluable skills anyone who wants to work as a machine learning engineer and data scientist should have in their toolkit. In this course, you will learn the theory behind all 6 algorithms, and then apply your skills to practical case studies tailored to each one of them, using Python's sci-kit learn library. First, we cover naïve Bayes – a powerful technique based on Bayesian statistics. Its strong point is that it's great at performing tasks in real-time.

We develop a regression based primal-dual martingale approach for solving finite time horizon MDPs with general state and action space. As a result, our method allows for the construction of tight upper and lower biased approximations of the value functions, and, provides tight approximations to the optimal policy. In particular, we prove tight error bounds for the estimated duality gap featuring polynomial dependence on the time horizon, and sublinear dependence on the cardinality/dimension of the possibly infinite state and action space. From a computational point of view the proposed method is efficient since, in contrast to usual duality-based methods for optimal control problems in the literature, the Monte Carlo procedures here involved do not require nested simulations.

$k$-subset sampling is ubiquitous in machine learning, enabling regularization and interpretability through sparsity. The challenge lies in rendering $k$-subset sampling amenable to end-to-end learning. This has typically involved relaxing the reparameterized samples to allow for backpropagation, with the risk of introducing high bias and high variance. In this work, we fall back to discrete $k$-subset sampling on the forward pass. This is coupled with using the gradient with respect to the exact marginals, computed efficiently, as a proxy for the true gradient. We show that our gradient estimator, SIMPLE, exhibits lower bias and variance compared to state-of-the-art estimators, including the straight-through Gumbel estimator when $k = 1$. Empirical results show improved performance on learning to explain and sparse linear regression. We provide an algorithm for computing the exact ELBO for the $k$-subset distribution, obtaining significantly lower loss compared to SOTA.

Fostered by novel analytical techniques, digitalization and automation, modern bioprocess development provides high amounts of heterogeneous experimental data, containing valuable process information. In this context, data-driven methods like machine learning (ML) approaches have a high potential to rationally explore large design spaces while exploiting experimental facilities most efficiently. The aim of this review is to demonstrate how ML methods have been applied so far in bioprocess development, especially in strain engineering and selection, bioprocess optimization, scale-up, monitoring and control of bioprocesses. For each topic, we will highlight successful application cases, current challenges and point out domains that can potentially benefit from technology transfer and further progress in the field of ML.

Due to the privacy protection or the difficulty of data collection, we cannot observe individual outputs for each instance, but we can observe aggregated outputs that are summed over multiple instances in a set in some real-world applications. To reduce the labeling cost for training regression models for such aggregated data, we propose an active learning method that sequentially selects sets to be labeled to improve the predictive performance with fewer labeled sets. For the selection measurement, the proposed method uses the mutual information, which quantifies the reduction of the uncertainty of the model parameters by observing the aggregated output. With Bayesian linear basis functions for modeling outputs given an input, which include approximated Gaussian processes and neural networks, we can efficiently calculate the mutual information in a closed form. With the experiments using various datasets, we demonstrate that the proposed method achieves better predictive performance with fewer labeled sets than existing methods.

The notion of smart cities is being adapted globally to provide a better quality of living. A smart city's smart mobility component focuses on providing smooth and safe commuting for its residents and promotes eco-friendly and sustainable alternatives such as public transit (bus). Among several smart applications, a system that provides up-to-the-minute information like bus arrival, travel duration, schedule, etc., improves the reliability of public transit services. Still, this application needs live information on traffic flow, accidents, events, and the location of the buses. Most cities lack the infrastructure to provide these data. In this context, a bus arrival prediction model is proposed for forecasting the arrival time using limited data sets. The location data of public transit buses and spatial characteristics are used for the study. One of the routes of Tumakuru city service, Tumakuru, India, is selected and divided into two spatial patterns: sections with intersections and sections without intersections. The machine learning model XGBoost is modeled for both spatial patterns individually. A model to dynamically predict bus arrival time is developed using the preceding trip information and the machine learning model to estimate the arrival time at a downstream bus stop. The performance of models is compared based on the R-squared values of the predictions made, and the proposed model established superior results. It is suggested to predict bus arrival in the study area. The proposed model can also be extended to other similar cities with limited traffic-related infrastructure.

As a prevalent distributed learning paradigm, Federated Learning (FL) trains a global model on a massive amount of devices with infrequent communication. This paper investigates a class of composite optimization and statistical recovery problems in the FL setting, whose loss function consists of a data-dependent smooth loss and a non-smooth regularizer. Examples include sparse linear regression using Lasso, low-rank matrix recovery using nuclear norm regularization, etc. In the existing literature, federated composite optimization algorithms are designed only from an optimization perspective without any statistical guarantees. In addition, they do not consider commonly used (restricted) strong convexity in statistical recovery problems. We advance the frontiers of this problem from both optimization and statistical perspectives. From optimization upfront, we propose a new algorithm named \textit{Fast Federated Dual Averaging} for strongly convex and smooth loss and establish state-of-the-art iteration and communication complexity in the composite setting. In particular, we prove that it enjoys a fast rate, linear speedup, and reduced communication rounds. From statistical upfront, for restricted strongly convex and smooth loss, we design another algorithm, namely \textit{Multi-stage Federated Dual Averaging}, and prove a high probability complexity bound with linear speedup up to optimal statistical precision. Experiments in both synthetic and real data demonstrate that our methods perform better than other baselines. To the best of our knowledge, this is the first work providing fast optimization algorithms and statistical recovery guarantees for composite problems in FL.