Early diagnosis of Alzheimer's disease is a challenge because the existing methodologies do not identify the patients in their preclinical stage, which can last up to a decade prior to the onset of clinical symptoms. Several research studies demonstrate the potential of cerebrospinal fluid biomarkers, amyloid beta 1-42, T-tau, and P-tau, in early diagnosis of Alzheimer's disease stages. In this work, we used machine learning models to classify different stages of Alzheimer's disease based on the cerebrospinal fluid biomarker levels alone. An electronic health record of patients from the National Alzheimer's Coordinating Centre database was analyzed and the patients were subdivided based on mini-mental state scores and clinical dementia ratings. Statistical and correlation analyses were performed to identify significant differences between the Alzheimer's stages. Afterward, machine learning classifiers including K-Nearest Neighbors, Ensemble Boosted Tree, Ensemble Bagged Tree, Support Vector Machine, Logistic Regression, and Naïve Bayes classifiers were employed to classify the Alzheimer's disease stages. The results demonstrate that Ensemble Boosted Tree (84.4%) and Logistic Regression (73.4%) provide the highest accuracy for binary classification, while Ensemble Bagged Tree (75.4%) demonstrates better accuracy for multiclassification. The findings from this research are expected to help clinicians in making an informed decision regarding the early diagnosis of Alzheimer's from the cerebrospinal fluid biomarkers alone, monitoring of the disease progression, and implementation of appropriate intervention measures.

Devising procedures for downstream task-oriented generative model selections is an unresolved problem of practical importance. Existing studies focused on the utility of a single family of generative models. They provided limited insights on how synthetic data practitioners select the best family generative models for synthetic training tasks given a specific combination of machine learning model class and performance metric. In this paper, we approach the downstream task-oriented generative model selections problem in the case of training fraud detection models and investigate the best practice given different combinations of model interpretability and model performance constraints. Our investigation supports that, while both Neural Network(NN)-based and Bayesian Network(BN)-based generative models are both good to complete synthetic training task under loose model interpretability constrain, the BN-based generative models is better than NN-based when synthetic training fraud detection model under strict model interpretability constrain. Our results provides practical guidance for machine learning practitioner who is interested in replacing their training dataset from real to synthetic, and shed lights on more general downstream task-oriented generative model selection problems.

Objective: Blood transfusions, crucial in managing anemia and coagulopathy in ICU settings, require accurate prediction for effective resource allocation and patient risk assessment. However, existing clinical decision support systems have primarily targeted a particular patient demographic with unique medical conditions and focused on a single type of blood transfusion. This study aims to develop an advanced machine learning-based model to predict the probability of transfusion necessity over the next 24 hours for a diverse range of non-traumatic ICU patients. Methods: We conducted a retrospective cohort study on 72,072 adult non-traumatic ICU patients admitted to a high-volume US metropolitan academic hospital between 2016 and 2020. We developed a meta-learner and various machine learning models to serve as predictors, training them annually with four-year data and evaluating on the fifth, unseen year, iteratively over five years. Results: The experimental results revealed that the meta-model surpasses the other models in different development scenarios. It achieved notable performance metrics, including an Area Under the Receiver Operating Characteristic (AUROC) curve of 0.97, an accuracy rate of 0.93, and an F1-score of 0.89 in the best scenario. Conclusion: This study pioneers the use of machine learning models for predicting blood transfusion needs in a diverse cohort of critically ill patients. The findings of this evaluation confirm that our model not only predicts transfusion requirements effectively but also identifies key biomarkers for making transfusion decisions.

Exploring generative model training for synthetic tabular data, specifically in sequential contexts such as credit card transaction data, presents significant challenges. This paper addresses these challenges, focusing on attaining both high fidelity to actual data and optimal utility for machine learning tasks. We introduce five pre-processing schemas to enhance the training of the Conditional Probabilistic Auto-Regressive Model (CPAR), demonstrating incremental improvements in the synthetic data's fidelity and utility. Upon achieving satisfactory fidelity levels, our attention shifts to training fraud detection models tailored for time-series data, evaluating the utility of the synthetic data. Our findings offer valuable insights and practical guidelines for synthetic data practitioners in the finance sector, transitioning from real to synthetic datasets for training purposes, and illuminating broader methodologies for synthesizing credit card transaction time series.

Identifying relevant machine-learning features for multi-sensing platforms is both an applicative limitation to recognize environments and a necessity to interpret the physical relevance of transducers' complementarity in their information processing. Particularly for long acquisitions, feature extraction must be fully automatized without human intervention and resilient to perturbations without increasing significantly the computational cost of a classifier. In this study, we investigate on the relative resistance and current modulation of a 24-dimensional conductimetric electronic nose, which uses the exponential moving average as a floating reference in a low-cost information descriptor for environment recognition. In particular, we identified that depending on the structure of a linear classifier, the 'modema' descriptor is optimized for different material sensing elements' contributions to classify information patterns. The low-pass filtering optimization leads to opposite behaviors between unsupervised and supervised learning: the latter one favors longer integration of the reference, allowing to recognize five different classes over 90%, while the first one prefers using the latest events as its reference to clusterize patterns by environment nature. Its electronic implementation shall greatly diminish the computational requirements of conductimetric electronic noses for on-board environment recognition without human supervision.

Pre-training, which utilizes extensive and varied datasets, is a critical factor in the success of Large Language Models (LLMs) across numerous applications. However, the detailed makeup of these datasets is often not disclosed, leading to concerns about data security and potential misuse. This is particularly relevant when copyrighted material, still under legal protection, is used inappropriately, either intentionally or unintentionally, infringing on the rights of the authors. In this paper, we introduce a detailed framework designed to detect and assess the presence of content from potentially copyrighted books within the training datasets of LLMs. This framework also provides a confidence estimation for the likelihood of each content sample's inclusion. To validate our approach, we conduct a series of simulated experiments, the results of which affirm the framework's effectiveness in identifying and addressing instances of content misuse in LLM training processes. Furthermore, we investigate the presence of recognizable quotes from famous literary works within these datasets. The outcomes of our study have significant implications for ensuring the ethical use of copyrighted materials in the development of LLMs, highlighting the need for more transparent and responsible data management practices in this field.

This paper introduces Auto-modeling of Formal Verification with Real-world Prompting for 5G and NextG protocols (AVRE), a novel system designed for the formal verification of Next Generation (NextG) communication protocols, addressing the increasing complexity and scalability challenges in network protocol design and verification. Utilizing Large Language Models (LLMs), AVRE transforms protocol descriptions into dependency graphs and formal models, efficiently resolving ambiguities and capturing design intent. The system integrates a transformer model with LLMs to autonomously establish quantifiable dependency relationships through cross- and self-attention mechanisms. Enhanced by iterative feedback from the HyFuzz experimental platform, AVRE significantly advances the accuracy and relevance of formal verification in complex communication protocols, offering a groundbreaking approach to validating sophisticated communication systems. We compare CAL's performance with state-of-the-art LLM-based models and traditional time sequence models, demonstrating its superiority in accuracy and robustness, achieving an accuracy of 95.94\% and an AUC of 0.98. This NLP-based approach enables, for the first time, the creation of exploits directly from design documents, making remarkable progress in scalable system verification and validation.

Watermarking of language model outputs enables statistical detection of model-generated text, which has many applications in the responsible deployment of language models. Existing watermarking strategies operate by altering the decoder of an existing language model, and the ability for a language model to directly learn to generate the watermark would have significant implications for the real-world deployment of watermarks. First, learned watermarks could be used to build open models that naturally generate watermarked text, allowing for open models to benefit from watermarking. Second, if watermarking is used to determine the provenance of generated text, an adversary can hurt the reputation of a victim model by spoofing its watermark and generating damaging watermarked text. To investigate the learnability of watermarks, we propose watermark distillation, which trains a student model to behave like a teacher model that uses decoding-based watermarking. We test our approach on three distinct decoding-based watermarking strategies and various hyperparameter settings, finding that models can learn to generate watermarked text with high detectability. We also find limitations to learnability, including the loss of watermarking capabilities under fine-tuning on normal text and high sample complexity when learning low-distortion watermarks.

Significant progress has been made in automatic text evaluation with the introduction of large language models (LLMs) as evaluators. However, current sample-wise evaluation paradigm suffers from the following issues: (1) Sensitive to prompt design; (2) Poor resistance to noise; (3) Inferior ensemble performance with static reference. Inspired by the fact that humans treat both criterion definition and inter sample comparison as references for evaluation, we propose BatchEval, a paradigm that conducts batch-wise evaluation iteratively to alleviate the above problems. We explore variants under this paradigm and confirm the optimal settings are two stage procedure with heterogeneous batch composition strategy and decimal scoring format. Comprehensive experiments across 3 LLMs on 4 text evaluation tasks demonstrate that BatchEval outperforms state-of-the-art methods by 10.5% on Pearson correlations with only 64% API cost on average. Further analyses have been conducted to verify the robustness, generalization, and working mechanism of BatchEval.

The growing popularity of generative artificial intelligence (AI) chatbots such as ChatGPT is having transformative effects on social media. As the prevalence of AI-generated content grows, concerns have been raised regarding privacy and misinformation online. Among social media platforms, Discord enables AI integrations -- making their primarily "Generation Z" userbase particularly exposed to AI-generated content. We surveyed Generation Z aged individuals (n = 335) to evaluate their proficiency in discriminating between AI-generated and human-authored text on Discord. The investigation employed one-shot prompting of ChatGPT, disguised as a text message received on the Discord.com platform. We explore the influence of demographic factors on ability, as well as participants' familiarity with Discord and artificial intelligence technologies. We find that Generation Z individuals are unable to discern between AI and human-authored text (p = 0.011), and that those with lower self-reported familiarity with Discord demonstrated an improved ability in identifying human-authored compared to those with self-reported experience with AI (p << 0.0001). Our results suggest that there is a nuanced relationship between AI technology and popular modes of communication for Generation Z, contributing valuable insights into human-computer interactions, digital communication, and artificial intelligence literacy.