Brain tumors are an abnormal growth of cells in the brain. They can be classified into distinct grades based on their growth. Often grading is performed based on a histological image and is one of the most significant predictors of a patients prognosis, the higher the grade, the more aggressive the tumor. Correct diagnosis of a tumor grade remains challenging. Though histopathological grading has been shown to be prognostic, results are subject to interobserver variability, even among experienced pathologists. Recently, the World Health Organization reported that advances in molecular genetics have led to improvements in tumor classification. This paper seeks to integrate histological images and genetic data for improved computer-aided diagnosis. We propose a novel Multi-modal Outer Arithmetic Block (MOAB) based on arithmetic operations to combine latent representations of the different modalities for predicting the tumor grade (Grade \rom{2}, \rom{3} and \rom{4}). Extensive experiments evaluate the effectiveness of our approach. By applying MOAB to The Cancer Genome Atlas (TCGA) glioma dataset, we show that it can improve separation between similar classes (Grade \rom{2} and \rom{3}) and outperform prior state-of-the-art grade classification techniques.

Edge perturbation is a basic method to modify graph structures. It can be categorized into two veins based on their effects on the performance of graph neural networks (GNNs), i.e., graph data augmentation and attack. Surprisingly, both veins of edge perturbation methods employ the same operations, yet yield opposite effects on GNNs' accuracy. A distinct boundary between these methods in using edge perturbation has never been clearly defined. Consequently, inappropriate perturbations may lead to undesirable outcomes, necessitating precise adjustments to achieve desired effects. Therefore, questions of ``why edge perturbation has a two-faced effect?'' and ``what makes edge perturbation flexible and effective?'' still remain unanswered. In this paper, we will answer these questions by proposing a unified formulation and establishing a clear boundary between two categories of edge perturbation methods. Specifically, we conduct experiments to elucidate the differences and similarities between these methods and theoretically unify the workflow of these methods by casting it to one optimization problem. Then, we devise Edge Priority Detector (EPD) to generate a novel priority metric, bridging these methods up in the workflow. Experiments show that EPD can make augmentation or attack flexibly and achieve comparable or superior performance to other counterparts with less time overhead.

This work showcases our team's (The BEEGees) contributions to the 2023 George B. Moody PhysioNet Challenge. The aim was to predict neurological recovery from coma following cardiac arrest using clinical data and time-series such as multi-channel EEG and ECG signals. Our modelling approach is multimodal, based on two-dimensional spectrogram representations derived from numerous EEG channels, alongside the integration of clinical data and features extracted directly from EEG recordings. Our submitted model achieved a Challenge score of $0.53$ on the hidden test set for predictions made $72$ hours after return of spontaneous circulation. Our study shows the efficacy and limitations of employing transfer learning in medical classification. With regard to prospective implementation, our analysis reveals that the performance of the model is strongly linked to the selection of a decision threshold and exhibits strong variability across data splits.

Machine learning requires defining one's target variable for predictions or decisions, a process that can have profound implications on fairness: biases are often encoded in target variable definition itself, before any data collection or training. We present an interactive simulator, FairTargetSim (FTS), that illustrates how target variable definition impacts fairness. FTS is a valuable tool for algorithm developers, researchers, and non-technical stakeholders. FTS uses a case study of algorithmic hiring, using real-world data and user-defined target variables. FTS is open-source and available at: http://tinyurl.com/ftsinterface. The video accompanying this paper is here: http://tinyurl.com/ijcaifts.

In this paper, we propose a new framework for improving Content Based Image Retrieval (CBIR) for texture images. This is achieved by using a new image representation based on the RCT-Plus transform which is a novel variant of the Redundant Contourlet transform that extracts a richer directional information in the image. Moreover, the process of image search is improved through a learning-based approach where the images of the database are classified using an adapted similarity metric to the statistical modeling of the RCT-Plus transform. A query is then first classified to select the best texture class after which the retained class images are ranked to select top ones. By this, we have achieved significant improvements in the retrieval rates compared to previous CBIR schemes.

Feature selection plays a crucial role in improving predictive accuracy by identifying relevant features while filtering out irrelevant ones. This study investigates the importance of effective feature selection in enhancing the performance of classification models. By employing reinforcement learning (RL) algorithms, specifically Q-learning (QL) and SARSA learning, this paper addresses the feature selection challenge. Using the Breast Cancer Coimbra dataset (BCCDS) and three normalization methods (Min-Max, l1, and l2), the study evaluates the performance of these algorithms. Results show that QL@Min-Max and SARSA@l2 achieve the highest classification accuracies, reaching 87% and 88%, respectively. This highlights the effectiveness of RL-based feature selection methods in optimizing classification tasks, contributing to improved model accuracy and efficiency.

The escalating integration of machine learning in high-stakes fields such as healthcare raises substantial concerns about model fairness. We propose an interpretable framework - Fairness-Aware Interpretable Modeling (FAIM), to improve model fairness without compromising performance, featuring an interactive interface to identify a "fairer" model from a set of high-performing models and promoting the integration of data-driven evidence and clinical expertise to enhance contextualized fairness. We demonstrated FAIM's value in reducing sex and race biases by predicting hospital admission with two real-world databases, MIMIC-IV-ED and SGH-ED. We show that for both datasets, FAIM models not only exhibited satisfactory discriminatory performance but also significantly mitigated biases as measured by well-established fairness metrics, outperforming commonly used bias-mitigation methods. Our approach demonstrates the feasibility of improving fairness without sacrificing performance and provides an a modeling mode that invites domain experts to engage, fostering a multidisciplinary effort toward tailored AI fairness.

Collecting well-matched multimedia datasets is crucial for training cross-modal retrieval models. However, in real-world scenarios, massive multimodal data are harvested from the Internet, which inevitably contains Partially Mismatched Pairs (PMPs). Undoubtedly, such semantical irrelevant data will remarkably harm the cross-modal retrieval performance. Previous efforts tend to mitigate this problem by estimating a soft correspondence to down-weight the contribution of PMPs. In this paper, we aim to address this challenge from a new perspective: the potential semantic similarity among unpaired samples makes it possible to excavate useful knowledge from mismatched pairs. To achieve this, we propose L2RM, a general framework based on Optimal Transport (OT) that learns to rematch mismatched pairs. In detail, L2RM aims to generate refined alignments by seeking a minimal-cost transport plan across different modalities. To formalize the rematching idea in OT, first, we propose a self-supervised cost function that automatically learns from explicit similarity-cost mapping relation. Second, we present to model a partial OT problem while restricting the transport among false positives to further boost refined alignments. Extensive experiments on three benchmarks demonstrate our L2RM significantly improves the robustness against PMPs for existing models. The code is available at https://github.com/hhc1997/L2RM.

Intent classifiers must be able to distinguish when a user's utterance does not belong to any supported intent to avoid producing incorrect and unrelated system responses. Although out-of-scope (OOS) detection for intent classifiers has been studied, previous work has not yet studied changes in classifier performance against hard-negative out-of-scope utterances (i.e., inputs that share common features with in-scope data, but are actually out-of-scope). We present an automated technique to generate hard-negative OOS data using ChatGPT. We use our technique to build five new hard-negative OOS datasets, and evaluate each against three benchmark intent classifiers. We show that classifiers struggle to correctly identify hard-negative OOS utterances more than general OOS utterances. Finally, we show that incorporating hard-negative OOS data for training improves model robustness when detecting hard-negative OOS data and general OOS data. Our technique, datasets, and evaluation address an important void in the field, offering a straightforward and inexpensive way to collect hard-negative OOS data and improve intent classifiers' robustness.

Machine learning techniques are utilized to estimate the electronic band gap energy and forecast the band gap category of materials based on experimentally quantifiable properties. The determination of band gap energy is critical for discerning various material properties, such as its metallic nature, and potential applications in electronic and optoelectronic devices. While numerical methods exist for computing band gap energy, they often entail high computational costs and have limitations in accuracy and scalability. A machine learning-driven model capable of swiftly predicting material band gap energy using easily obtainable experimental properties would offer a superior alternative to conventional density functional theory (DFT) methods. Our model does not require any preliminary DFT-based calculation or knowledge of the structure of the material. We present a scheme for improving the performance of simple regression and classification models by partitioning the dataset into multiple clusters. A new evaluation scheme for comparing the performance of ML-based models in material sciences involving both regression and classification tasks is introduced based on traditional evaluation metrics. It is shown that on this new evaluation metric, our method of clustering the dataset results in better performance.