The introduction of Large Language Models (LLMs) has advanced data representation and analysis, bringing significant progress in their use for medical questions and answering. Despite these advancements, integrating tabular data, especially numerical data pivotal in clinical contexts, into LLM paradigms has not been thoroughly explored. In this study, we examine the effectiveness of vector representations from last hidden states of LLMs for medical diagnostics and prognostics using electronic health record (EHR) data. We compare the performance of these embeddings with that of raw numerical EHR data when used as feature inputs to traditional machine learning (ML) algorithms that excel at tabular data learning, such as eXtreme Gradient Boosting. We focus on instruction-tuned LLMs in a zero-shot setting to represent abnormal physiological data and evaluating their utilities as feature extractors to enhance ML classifiers for predicting diagnoses, length of stay, and mortality. Furthermore, we examine prompt engineering techniques on zero-shot and few-shot LLM embeddings to measure their impact comprehensively. Although findings suggest the raw data features still prevails in medical ML tasks, zero-shot LLM embeddings demonstrate competitive results, suggesting a promising avenue for future research in medical applications.

We study the task of agnostic tomography: given copies of an unknown $n$-qubit state $\rho$ which has fidelity $\tau$ with some state in a given class $C$, find a state which has fidelity $\ge \tau - \epsilon$ with $\rho$. We give a new framework, stabilizer bootstrapping, for designing computationally efficient protocols for this task, and use this to get new agnostic tomography protocols for the following classes: Stabilizer states: We give a protocol that runs in time $\mathrm{poly}(n,1/\epsilon)\cdot (1/\tau)^{O(\log(1/\tau))}$, answering an open question posed by Grewal, Iyer, Kretschmer, Liang [40] and Anshu and Arunachalam [6]. Previous protocols ran in time $\mathrm{exp}(\Theta(n))$ or required $\tau>\cos^2(\pi/8)$. States with stabilizer dimension $n - t$: We give a protocol that runs in time $n^3\cdot(2^t/\tau)^{O(\log(1/\epsilon))}$, extending recent work on learning quantum states prepared by circuits with few non-Clifford gates, which only applied in the realizable setting where $\tau = 1$ [30, 37, 46, 61]. Discrete product states: If $C = K^{\otimes n}$ for some $\mu$-separated discrete set $K$ of single-qubit states, we give a protocol that runs in time $(n/\mu)^{O((1 + \log (1/\tau))/\mu)}/\epsilon^2$. This strictly generalizes a prior guarantee which applied to stabilizer product states [39]. For stabilizer product states, we give a further improved protocol that runs in time $(n^2/\epsilon^2)\cdot (1/\tau)^{O(\log(1/\tau))}$. As a corollary, we give the first protocol for estimating stabilizer fidelity, a standard measure of magic for quantum states, to error $\epsilon$ in $n^3 \mathrm{quasipoly}(1/\epsilon)$ time.

Foundational Models (FMs) are gaining increasing attention in the biomedical AI ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool for a variety of tasks, including biomedical reasoning, hypothesis generation, and interpreting complex imaging data. In this review paper, we address the unique challenges associated with establishing an ethical and trustworthy biomedical AI ecosystem, with a particular focus on the development of FMs and their downstream applications. We explore strategies that can be implemented throughout the biomedical AI pipeline to effectively tackle these challenges, ensuring that these FMs are translated responsibly into clinical and translational settings. Additionally, we emphasize the importance of key stewardship and co-design principles that not only ensure robust regulation but also guarantee that the interests of all stakeholders, especially those involved in or affected by these clinical and translational applications are adequately represented. We aim to empower the biomedical AI community to harness these models responsibly and effectively. As we navigate this exciting frontier, our collective commitment to ethical stewardship, co-design, and responsible translation will be instrumental in ensuring that the evolution of FMs truly enhances patient care and medical decision making, ultimately leading to a more equitable and trustworthy biomedical AI ecosystem.

Web-based Large Language Model (LLM) services have been widely adopted and have become an integral part of our Internet experience. Third-party plugins enhance the functionalities of LLM by enabling access to real-world data and services. However, the privacy consequences associated with these services and their third-party plugins are not well understood. Sensitive prompt data are stored, processed, and shared by cloud-based LLM providers and third-party plugins. In this paper, we propose Casper, a prompt sanitization technique that aims to protect user privacy by detecting and removing sensitive information from user inputs before sending them to LLM services. Casper runs entirely on the user's device as a browser extension and does not require any changes to the online LLM services. At the core of Casper is a three-layered sanitization mechanism consisting of a rule-based filter, a Machine Learning (ML)-based named entity recognizer, and a browser-based local LLM topic identifier. We evaluate Casper on a dataset of 4000 synthesized prompts and show that it can effectively filter out Personal Identifiable Information (PII) and privacy-sensitive topics with high accuracy, at 98.5% and 89.9%, respectively.

Retinal fundus imaging plays an essential role in diagnosing various stages of diabetic retinopathy, where exudates are critical markers of early disease onset. Prompt detection of these exudates is pivotal for enabling optometrists to arrest or significantly decelerate the disease progression. This paper introduces a novel, lightweight convolutional neural network architecture tailored for automated exudate detection, designed to identify these markers efficiently and accurately. To address the challenge of limited training data, we have incorporated domain-specific data augmentations to enhance the model's generalizability. Furthermore, we applied a suite of regularization techniques within our custom architecture to boost diagnostic accuracy while optimizing computational efficiency. Remarkably, this streamlined model contains only 4.73 million parameters a reduction of nearly 60% compared to the standard ResNet-18 model, which has 11.69 million parameters. Despite its reduced complexity, our model achieves an impressive F1 score of 90%, demonstrating its efficacy in the early detection of diabetic retinopathy through fundus imaging.

Binary program vulnerability detection is critical for software security, yet existing deep learning approaches often rely on source code analysis, limiting their ability to detect unknown vulnerabilities. To address this, we propose VulCatch, a binary-level vulnerability detection framework. VulCatch introduces a Synergy Decompilation Module (SDM) and Kolmogorov-Arnold Networks (KAN) to transform raw binary code into pseudocode using CodeT5, preserving high-level semantics for deep analysis with tools like Ghidra and IDA. KAN further enhances feature transformation, enabling the detection of complex vulnerabilities. VulCatch employs word2vec, Inception Blocks, BiLSTM Attention, and Residual connections to achieve high detection accuracy (98.88%) and precision (97.92%), while minimizing false positives (1.56%) and false negatives (2.71%) across seven CVE datasets.

This work proposes a novel and efficient quadstream BiLSTM-Attention network, abbreviated as QSLA network, for robust automatic modulation classification (AMC) of wireless signals. The proposed model exploits multiple representations of the wireless signal as inputs to the network and the feature extraction process combines convolutional and BiLSTM layers for processing the spatial and temporal features of the signal, respectively. An attention layer is used after the BiLSTM layer to emphasize the important temporal features. The experimental results on the recent and realistic RML22 dataset demonstrate the superior performance of the proposed model with an accuracy up to around 99%. The model is compared with other benchmark models in the literature in terms of classification accuracy, computational complexity, memory usage, and training time to show the effectiveness of our proposed approach.

The appreciation and utilisation of risk and uncertainty can play a key role in helping to solve some of the many ethical issues that are posed by AI. Understanding the uncertainties can allow algorithms to make better decisions by providing interrogatable avenues to check the correctness of outputs. Allowing algorithms to deal with variability and ambiguity with their inputs means they do not need to force people into uncomfortable classifications. Provenance enables algorithms to know what they know preventing possible harms. Additionally, uncertainty about provenance highlights the trustworthiness of algorithms. It is essential to compute with what we know rather than make assumptions that may be unjustified or untenable. This paper provides a perspective on the need for the importance of risk and uncertainty in the development of ethical AI, especially in high-risk scenarios. It argues that the handling of uncertainty, especially epistemic uncertainty, is critical to ensuring that algorithms do not cause harm and are trustworthy and ensure that the decisions that they make are humane.

Multiview learning (MvL) is an advancing domain in machine learning, leveraging multiple data perspectives to enhance model performance through view-consistency and view-discrepancy. Despite numerous successful multiview-based SVM models, existing frameworks predominantly focus on the consensus principle, often overlooking the complementarity principle. Furthermore, they exhibit limited robustness against noisy, error-prone, and view-inconsistent samples, prevalent in multiview datasets. To tackle the aforementioned limitations, this paper introduces Wave-MvSVM, a novel multiview support vector machine framework leveraging the wave loss (W-loss) function, specifically designed to harness both consensus and complementarity principles. Unlike traditional approaches that often overlook the complementary information among different views, the proposed Wave-MvSVM ensures a more comprehensive and resilient learning process by integrating both principles effectively. The W-loss function, characterized by its smoothness, asymmetry, and bounded nature, is particularly effective in mitigating the adverse effects of noisy and outlier data, thereby enhancing model stability. Theoretically, the W-loss function also exhibits a crucial classification-calibrated property, further boosting its effectiveness. Wave-MvSVM employs a between-view co-regularization term to enforce view consistency and utilizes an adaptive combination weight strategy to maximize the discriminative power of each view. The optimization problem is efficiently solved using a combination of GD and the ADMM, ensuring reliable convergence to optimal solutions. Theoretical analyses, grounded in Rademacher complexity, validate the generalization capabilities of the Wave-MvSVM model. Extensive empirical evaluations across diverse datasets demonstrate the superior performance of Wave-MvSVM in comparison to existing benchmark models.

Hyperspectral sensing is a valuable tool for detecting anomalies and distinguishing between materials in a scene. Hyperspectral anomaly detection (HS-AD) helps characterize the captured scenes and separates them into anomaly and background classes. It is vital in agriculture, environment, and military applications such as RSTA (reconnaissance, surveillance, and target acquisition) missions. We previously designed an equal voting ensemble of hyperspectral unmixing and three unsupervised HS-AD algorithms. We later utilized a supervised classifier to determine the weights of a voting ensemble, creating a hybrid of heterogeneous unsupervised HS-AD algorithms with a supervised classifier in a model stacking, which improved detection accuracy. However, supervised classification methods usually fail to detect novel or unknown patterns that substantially deviate from those seen previously. In this work, we evaluate our technique and other supervised and unsupervised methods using general hyperspectral data to provide new insights.