Multiple Sclerosis (MS) is a chronic autoimmune and inflammatory neurological disorder characterised by episodes of symptom exacerbation, known as relapses. In this study, we investigate the role of environmental factors in relapse occurrence among MS patients, using data from the H2020 BRAINTEASER project. We employed predictive models, including Random Forest (RF) and Logistic Regression (LR), with varying sets of input features to predict the occurrence of relapses based on clinical and pollutant data collected over a week. The RF yielded the best result, with an AUC-ROC score of 0.713. Environmental variables, such as precipitation, NO2, PM2.5, humidity, and temperature, were found to be relevant to the prediction.

This study investigates machine learning algorithms to identify objective features for diagnosing food addiction (FA) and assessing confirmed symptoms (SC). Data were collected from 81 participants (mean age: 21.5 years, range: 18-61 years, women: 77.8%) whose FA and SC were measured using the Yale Food Addiction Scale (YFAS). Participants provided demographic and anthropometric data, completed the YFAS, the Zung Self-Rating Depression Scale, and the Dutch Eating Behavior Questionnaire, and wore an actimeter on the non-dominant wrist for a week to record motor activity. Analysis of the actimetric data identified significant statistical and entropy-based features that accurately predicted FA and SC using ML. The Matthews correlation coefficient (MCC) was the primary metric. Activity-related features were more effective for FA prediction (MCC=0.88) than rest-related features (MCC=0.68). For SC, activity segments yielded MCC=0.47, rest segments MCC=0.38, and their combination MCC=0.51. Significant correlations were also found between actimetric features related to FA, emotional, and restrained eating behaviors, supporting the model's validity. Our results support the concept of a human bionic suite composed of IoT devices and ML sensors, which implements health digital assistance with real-time monitoring and analysis of physiological indicators related to FA and SC.

Esophageal cancer is a major cause of cancer-related mortality internationally, with high recurrence rates and poor survival even among patients treated with curative-intent surgery. Investigating relevant prognostic factors and predicting prognosis can enhance post-operative clinical decision-making and potentially improve patients' outcomes. In this work, we assessed prognostic factor identification and discriminative performances of three models for Disease-Free Survival (DFS) and Overall Survival (OS) using a large multicenter international dataset from ENSURE study. We first employed Cox Proportional Hazards (CoxPH) model to assess the impact of each feature on outcomes. Subsequently, we utilised CoxPH and two deep neural network (DNN)-based models, DeepSurv and DeepHit, to predict DFS and OS. The significant prognostic factors identified by our models were consistent with clinical literature, with post-operative pathologic features showing higher significance than clinical stage features. DeepSurv and DeepHit demonstrated comparable discriminative accuracy to CoxPH, with DeepSurv slightly outperforming in both DFS and OS prediction tasks, achieving C-index of 0.735 and 0.74, respectively. While these results suggested the potential of DNNs as prognostic tools for improving predictive accuracy and providing personalised guidance with respect to risk stratification, CoxPH still remains an adequately good prediction model, with the data used in this study.

The explosion of large-scale data in fields such as finance, e-commerce, and social media has outstripped the processing capabilities of single-machine systems, driving the need for distributed statistical inference methods. Traditional approaches to distributed inference often struggle with achieving true sparsity in high-dimensional datasets and involve high computational costs. We propose a novel, two-stage, distributed best subset selection algorithm to address these issues. Our approach starts by efficiently estimating the active set while adhering to the $\ell_0$ norm-constrained surrogate likelihood function, effectively reducing dimensionality and isolating key variables. A refined estimation within the active set follows, ensuring sparse estimates and matching the minimax $\ell_2$ error bound. We introduce a new splicing technique for adaptive parameter selection to tackle subproblems under $\ell_0$ constraints and a Generalized Information Criterion (GIC). Our theoretical and numerical studies show that the proposed algorithm correctly finds the true sparsity pattern, has the oracle property, and greatly lowers communication costs. This is a big step forward in distributed sparse estimation.

Recently, there has been an increasing interest in the construction of general-domain and domain-specific causal knowledge graphs. Such knowledge graphs enable reasoning for causal analysis and event prediction, and so have a range of applications across different domains. While great progress has been made toward automated construction of causal knowledge graphs, the evaluation of such solutions has either focused on low-level tasks (e.g., cause-effect phrase extraction) or on ad hoc evaluation data and small manual evaluations. In this Resource Track paper, we present a corpus, task, and evaluation framework for causal knowledge graph construction. Our corpus consists of Wikipedia articles for a collection of event-related concepts in Wikidata. The task is to extract causal relations between event concepts from the corpus. The evaluation is performed in part using existing causal relations in Wikidata to measure recall, and in part using Large Language Models to avoid the need for manual or crowd-sourced evaluation. We evaluate a pipeline for causal knowledge graph construction that relies on neural models for question answering and concept linking, and show how the corpus and the evaluation framework allow us to effectively find the right model for each task. The corpus and the evaluation framework are publicly available.

Credit scores are critical for allocating consumer debt in the United States, yet little evidence is available on their performance. We benchmark a widely used credit score against a machine learning model of consumer default and find significant misclassification of borrowers, especially those with low scores. Our model improves predictive accuracy for young, low-income, and minority groups due to its superior performance with low quality data, resulting in a gain in standing for these populations. Our findings suggest that improving credit scoring performance could lead to more equitable access to credit.

Autism Spectrum Disorder (ASD) is a lifelong condition that significantly influencing an individual's communication abilities and their social interactions. Early diagnosis and intervention are critical due to the profound impact of ASD's characteristic behaviors on foundational developmental stages. However, limitations of standardized diagnostic tools necessitate the development of objective and precise diagnostic methodologies. This paper proposes an end-to-end framework for automatically predicting the social communication severity of children with ASD from raw speech data. This framework incorporates an automatic speech recognition model, fine-tuned with speech data from children with ASD, followed by the application of fine-tuned pre-trained language models to generate a final prediction score. Achieving a Pearson Correlation Coefficient of 0.6566 with human-rated scores, the proposed method showcases its potential as an accessible and objective tool for the assessment of ASD.

In the realm of cyber-security, detecting Advanced Persistent Threats (APTs) remains a formidable challenge due to their stealthy and sophisticated nature. This research paper presents an innovative approach that leverages Convolutional Neural Networks (CNNs) with a 2D baseline model, enhanced by the cutting-edge Cat Swarm Optimization (CSO) algorithm, to significantly improve APT detection accuracy. By seamlessly integrating the 2D-CNN baseline model with CSO, we unlock the potential for unprecedented accuracy and efficiency in APT detection. The results unveil an impressive accuracy score of $98.4\%$, marking a significant enhancement in APT detection across various attack stages, illuminating a path forward in combating these relentless and sophisticated threats.

Software security remains a critical concern, particularly as junior developers, often lacking comprehensive knowledge of security practices, contribute to codebases. While there are tools to help developers proactively write secure code, their actual effectiveness in helping developers fix their vulnerable code remains largely unmeasured. Moreover, these approaches typically focus on classifying and localizing vulnerabilities without highlighting the specific code segments that are the root cause of the issues, a crucial aspect for developers seeking to fix their vulnerable code. To address these challenges, we conducted a comprehensive study evaluating the efficacy of existing methods in helping junior developers secure their code. Our findings across five types of security vulnerabilities revealed that current tools enabled developers to secure only 36.2\% of vulnerable code. Questionnaire results from these participants further indicated that not knowing the code that was the root cause of the vulnerability was one of their primary challenges in repairing the vulnerable code. Informed by these insights, we developed an automated vulnerability root cause (RC) toolkit called T5-RCGCN, that combines T5 language model embeddings with a graph convolutional network (GCN) for vulnerability classification and localization. Additionally, we integrated DeepLiftSHAP to identify the code segments that were the root cause of the vulnerability. We tested T5-RCGCN with 56 junior developers across three datasets, showing a 28.9\% improvement in code security compared to previous methods. Developers using the tool also gained a deeper understanding of vulnerability root causes, resulting in a 17.0\% improvement in their ability to secure code independently. These results demonstrate the tool's potential for both immediate security enhancement and long-term developer skill growth.

The application of machine learning methods to analyze changes in gene expression patterns has recently emerged as a powerful approach in cancer research, enhancing our understanding of the molecular mechanisms underpinning cancer development and progression. Combining gene expression data with other types of omics data has been reported by numerous works to improve cancer classification outcomes. Despite these advances, effectively integrating high-dimensional multi-omics data and capturing the complex relationships across different biological layers remains challenging. This paper introduces LASSO-MOGAT (LASSO-Multi-Omics Gated ATtention), a novel graph-based deep learning framework that integrates messenger RNA, microRNA, and DNA methylation data to classify 31 cancer types. Utilizing differential expression analysis with LIMMA and LASSO regression for feature selection, and leveraging Graph Attention Networks (GATs) to incorporate protein-protein interaction (PPI) networks, LASSO-MOGAT effectively captures intricate relationships within multi-omics data. Experimental validation using five-fold cross-validation demonstrates the method's precision, reliability, and capacity for providing comprehensive insights into cancer molecular mechanisms. The computation of attention coefficients for the edges in the graph by the proposed graph-attention architecture based on protein-protein interactions proved beneficial for identifying synergies in multi-omics data for cancer classification.