We present TRACE (Transformer-based Risk Assessment for Clinical Evaluation), a novel method for clinical risk assessment based on clinical data, leveraging the self-attention mechanism for enhanced feature interaction and result interpretation. Our approach is able to handle different data modalities, including continuous, categorical and multiple-choice (checkbox) attributes. The proposed architecture features a shared representation of the clinical data obtained by integrating specialized embeddings of each data modality, enabling the detection of high-risk individuals using Transformer encoder layers. To assess the effectiveness of the proposed method, a strong baseline based on non-negative multi-layer perceptrons (MLPs) is introduced. The proposed method outperforms various baselines widely used in the domain of clinical risk assessment, while effectively handling missing values. In terms of explainability, our Transformer-based method offers easily interpretable results via attention weights, further enhancing the clinicians' decision-making process.

Society is increasingly relying on predictive models in fields like criminal justice, credit risk management, or hiring. To prevent such automated systems from discriminating against people belonging to certain groups, fairness measures have become a crucial component in socially relevant applications of machine learning. However, existing fairness measures have been designed to assess the bias between predictions for protected groups without considering the imbalance in the classes of the target variable. Current research on the potential effect of class imbalance on fairness focuses on practical applications rather than dataset-independent measure properties. In this paper, we study the general properties of fairness measures for changing class and protected group proportions. For this purpose, we analyze the probability mass functions of six of the most popular group fairness measures. We also measure how the probability of achieving perfect fairness changes for varying class imbalance ratios. Moreover, we relate the dataset-independent properties of fairness measures described in this paper to classifier fairness in real-life tasks. Our results show that measures such as Equal Opportunity and Positive Predictive Parity are more sensitive to changes in class imbalance than Accuracy Equality. These findings can help guide researchers and practitioners in choosing the most appropriate fairness measures for their classification problems.

Brain connectivity alternations associated with brain disorders have been widely reported in resting-state functional imaging (rs-fMRI) and diffusion tensor imaging (DTI). While many dual-modal fusion methods based on graph neural networks (GNNs) have been proposed, they generally follow homogenous fusion ways ignoring rich heterogeneity of dual-modal information. To address this issue, we propose a novel method that integrates functional and structural connectivity based on heterogeneous graph neural networks (HGNNs) to better leverage the rich heterogeneity in dual-modal images. We firstly use blood oxygen level dependency and whiter matter structure information provided by rs-fMRI and DTI to establish homo-meta-path, capturing node relationships within the same modality. At the same time, we propose to establish hetero-meta-path based on structure-function coupling and brain community searching to capture relations among cross-modal nodes. Secondly, we further introduce a heterogeneous graph pooling strategy that automatically balances homo- and hetero-meta-path, effectively leveraging heterogeneous information and preventing feature confusion after pooling. Thirdly, based on the flexibility of heterogeneous graphs, we propose a heterogeneous graph data augmentation approach that can conveniently address the sample imbalance issue commonly seen in clinical diagnosis. We evaluate our method on ADNI-3 dataset for mild cognitive impairment (MCI) diagnosis. Experimental results indicate the proposed method is effective and superior to other algorithms, with a mean classification accuracy of 93.3%.

The distributed representations currently used are dense and uninterpretable, leading to interpretations that themselves are relative, overcomplete, and hard to interpret. We propose a method that transforms these word vectors into reduced syntactic representations. The resulting representations are compact and interpretable allowing better visualization and comparison of the word vectors and we successively demonstrate that the drawn interpretations are in line with human judgment. The syntactic representations are then used to create hierarchical word vectors using an incremental learning approach similar to the hierarchical aspect of human learning. As these representations are drawn from pre-trained vectors, the generation process and learning approach are computationally efficient. Most importantly, we find out that syntactic representations provide a plausible interpretation of the vectors and subsequent hierarchical vectors outperform the original vectors in benchmark tests. Distributed representation of words present words as dense vectors in a continuous vector space.

Shifts in data distribution can substantially harm the performance of clinical AI models. Hence, various methods have been developed to detect the presence of such shifts at deployment time. However, root causes of dataset shifts are varied, and the choice of shift mitigation strategies is highly dependent on the precise type of shift encountered at test time. As such, detecting test-time dataset shift is not sufficient: precisely identifying which type of shift has occurred is critical. In this work, we propose the first unsupervised dataset shift identification framework, effectively distinguishing between prevalence shift (caused by a change in the label distribution), covariate shift (caused by a change in input characteristics) and mixed shifts (simultaneous prevalence and covariate shifts). We discuss the importance of self-supervised encoders for detecting subtle covariate shifts and propose a novel shift detector leveraging both self-supervised encoders and task model outputs for improved shift detection. We report promising results for the proposed shift identification framework across three different imaging modalities (chest radiography, digital mammography, and retinal fundus images) on five types of real-world dataset shifts, using four large publicly available datasets.

With the advancements in graph neural network, there has been increasing interest in applying this network to ECG signal analysis. In this study, we generated an adjacency matrix using correlation matrix of extracted features and applied a graph neural network to classify arrhythmias. The proposed model was compared with existing approaches from the literature. The results demonstrated that precision and recall for all arrhythmia classes exceeded 50%, suggesting that this method can be considered an approach for arrhythmia classification.

This study investigates the impact of quantity and diversity of data on the performance of various machine-learning models for detecting general EEG pathology. We utilized an EEG dataset of 2,993 recordings from Temple University Hospital and a dataset of 55,787 recordings from Elmiko Biosignals sp. z o.o. The latter contains data from 39 hospitals and a diverse patient set with varied conditions. Thus, we introduce the Elmiko dataset - the largest publicly available EEG corpus. Our findings show that small and consistent datasets enable a wide range of models to achieve high accuracy; however, variations in pathological conditions, recording protocols, and labeling standards lead to significant performance degradation. Nonetheless, increasing the number of available recordings improves predictive accuracy and may even compensate for data diversity, particularly in neural networks based on attention mechanism or transformer architecture. A meta-model that combined these networks with a gradient-boosting approach using handcrafted features demonstrated superior performance across varied datasets.

Federated learning (FL) has become one of the key methods for privacy-preserving collaborative learning, as it enables the transfer of models without requiring local data exchange. Within the FL framework, an aggregation algorithm is recognized as one of the most crucial components for ensuring the efficacy and security of the system. Existing average aggregation algorithms typically assume that all client-trained data holds equal value or that weights are based solely on the quantity of data contributed by each client. In contrast, alternative approaches involve training the model locally after aggregation to enhance adaptability. However, these approaches fundamentally ignore the inherent heterogeneity between different clients' data and the complexity of variations in data at the aggregation stage, which may lead to a suboptimal global model. To address these issues, this study proposes a novel dual-criterion weighted aggregation algorithm involving the quantity and quality of data from the client node. Specifically, we quantify the data used for training and perform multiple rounds of local model inference accuracy evaluation on a specialized dataset to assess the data quality of each client. These two factors are utilized as weights within the aggregation process, applied through a dynamically weighted summation of these two factors. This approach allows the algorithm to adaptively adjust the weights, ensuring that every client can contribute to the global model, regardless of their data's size or initial quality. Our experiments show that the proposed algorithm outperforms several existing state-of-the-art aggregation approaches on both a general-purpose open-source dataset, CIFAR-10, and a dataset specific to visual obstacle avoidance.

Text toxicity detection systems exhibit significant biases, producing disproportionate rates of false positives on samples mentioning demographic groups. But what about toxicity detection in speech? To investigate the extent to which text-based biases are mitigated by speech-based systems, we produce a set of high-quality group annotations for the multilingual MuTox dataset, and then leverage these annotations to systematically compare speech- and text-based toxicity classifiers. Our findings indicate that access to speech data during inference supports reduced bias against group mentions, particularly for ambiguous and disagreement-inducing samples. Our results also suggest that improving classifiers, rather than transcription pipelines, is more helpful for reducing group bias. We publicly release our annotations and provide recommendations for future toxicity dataset construction.

Quality control of structures segmentation in volumetric medical images is important for identifying segmentation errors in clinical practice and for facilitating model development by enhancing network performance in semi-supervised and active learning setups. This paper introduces SegQC, a novel framework for segmentation quality estimation and segmentation error detection. SegQC computes an estimate measure of the quality of a segmentation in volumetric scans and in their individual slices and identifies possible segmentation error regions within a slice. The key components include: 1) SegQC-Net, a deep network that inputs a scan and its segmentation mask and outputs segmentation error probabilities for each voxel in the scan; 2) three new segmentation quality metrics, two overlap metrics and a structure size metric, computed from the segmentation error probabilities; 3) a new method for detecting possible segmentation errors in scan slices computed from the segmentation error probabilities. We introduce a new evaluation scheme to measure segmentation error discrepancies based on an expert radiologist corrections of automatically produced segmentations that yields smaller observer variability and is closer to actual segmentation errors. We demonstrate SegQC on three fetal structures in 198 fetal MRI scans - fetal brain, fetal body and the placenta. To assess the benefits of SegQC, we compare it to the unsupervised Test Time Augmentation (TTA)-based quality estimation. Our studies indicate that SegQC outperforms TTA-based quality estimation in terms of Pearson correlation and MAE for fetal body and fetal brain structures segmentation. Our segmentation error detection method achieved recall and precision rates of 0.77 and 0.48 for fetal body, and 0.74 and 0.55 for fetal brain segmentation error detection respectively. SegQC enhances segmentation metrics estimation for whole scans and individual slices, as well as provides error regions detection. Introduction The segmentation of structures in volumetric medical images is increasingly used in clinical practice for a variety of diagnostic and prognostic tasks. Since manual delineation of structures' contours is time-consuming and requires expertise, a variety of automatic segmentation methods have been developed.