In this work, we propose and evaluate the feasibility of a two-stage pipeline to evaluate literary machine translation, in a fine-grained manner, from English to Korean. The results show that our framework provides fine-grained, interpretable metrics suited for literary translation and obtains a higher correlation with human judgment than traditional machine translation metrics. Nonetheless, it still fails to match interhuman agreement, especially in metrics like Korean Honorifics. We also observe that LLMs tend to favor translations generated by other LLMs, and we highlight the necessity of developing more sophisticated evaluation methods to ensure accurate and culturally sensitive machine translation of literary works. Figure 1: The overview of our proposed framework: we evaluate translation of literary works in two stages.

Identifying druggable genes is essential for developing effective pharmaceuticals. With the availability of extensive, high-quality data, computational methods have become a significant asset. Protein Interaction Network (PIN) is valuable but challenging to implement due to its high dimensionality and sparsity. Previous methods relied on indirect integration, leading to resolution loss. This study proposes GAN-TAT, a framework utilizing an advanced graph embedding technology, ImGAGN, to directly integrate PIN for druggable gene inference work. Tested on three Pharos datasets, GAN-TAT achieved the highest AUC-ROC score of 0.951 on Tclin. Further evaluation shows that GAN-TAT's predictions are supported by clinical evidence, highlighting its potential practical applications in pharmacogenomics. This research represents a methodological attempt with the direct utilization of PIN, expanding potential new solutions for developing drug targets.

Despite the progress made in deepfake detection research, recent studies have shown that biases in the training data for these detectors can result in varying levels of performance across different demographic groups, such as race and gender. These disparities can lead to certain groups being unfairly targeted or excluded. Traditional methods often rely on fair loss functions to address these issues, but they under-perform when applied to unseen datasets, hence, fairness generalization remains a challenge. In this work, we propose a data-driven framework for tackling the fairness generalization problem in deepfake detection by leveraging synthetic datasets and model optimization. Our approach focuses on generating and utilizing synthetic data to enhance fairness across diverse demographic groups. By creating a diverse set of synthetic samples that represent various demographic groups, we ensure that our model is trained on a balanced and representative dataset. This approach allows us to generalize fairness more effectively across different domains. We employ a comprehensive strategy that leverages synthetic data, a loss sharpness-aware optimization pipeline, and a multi-task learning framework to create a more equitable training environment, which helps maintain fairness across both intra-dataset and cross-dataset evaluations. Extensive experiments on benchmark deepfake detection datasets demonstrate the efficacy of our approach, surpassing state-of-the-art approaches in preserving fairness during cross-dataset evaluation. Our results highlight the potential of synthetic datasets in achieving fairness generalization, providing a robust solution for the challenges faced in deepfake detection.

This article considers the impact of different thresholding methods to the Nearest Shrunken Centroid algorithm, which is popularly referred as the Prediction Analysis of Microarrays (PAM) for high-dimensional classification. PAM uses soft thresholding to achieve high computational efficiency and high classification accuracy but in the price of retaining too many features. When applied to microarray human cancers, PAM selected 2611 features on average from 10 multi-class datasets. Such a large number of features make it difficult to perform follow up study. One reason behind this problem is the soft thresholding, which is known to produce biased parameter estimate in regression analysis. In this article, we extend the PAM algorithm with two other thresholding methods, hard and order thresholding, and a deep search algorithm to achieve better thresholding parameter estimate. The modified algorithms are extensively tested and compared to the original one based on real data and Monte Carlo studies. In general, the modification not only gave better cancer status prediction accuracy, but also resulted in more parsimonious models with significantly smaller number of features.

Machine learning (ML) and deep learning (DL) techniques have been widely applied to analyze electroencephalography (EEG) signals for disease diagnosis and brain-computer interfaces (BCI). The integration of multimodal data has been shown to enhance the accuracy of ML and DL models. Combining EEG with other modalities can improve clinical decision-making by addressing complex tasks in clinical populations. This systematic literature review explores the use of multimodal EEG data in ML and DL models for clinical applications. A comprehensive search was conducted across PubMed, Web of Science, and Google Scholar, yielding 16 relevant studies after three rounds of filtering. These studies demonstrate the application of multimodal EEG data in addressing clinical challenges, including neuropsychiatric disorders, neurological conditions (e.g., seizure detection), neurodevelopmental disorders (e.g., autism spectrum disorder), and sleep stage classification. Data fusion occurred at three levels: signal, feature, and decision levels. The most commonly used ML models were support vector machines (SVM) and decision trees. Notably, 11 out of the 16 studies reported improvements in model accuracy with multimodal EEG data. This review highlights the potential of multimodal EEG-based ML models in enhancing clinical diagnostics and problem-solving.

Host-response-based diagnostics can improve the accuracy of diagnosing bacterial and viral infections, thereby reducing inappropriate antibiotic prescriptions. However, the existing cohorts with limited sample size and coarse infections types are unable to support the exploration of an accurate and generalizable diagnostic model. Here, we curate the largest infection host-response transcriptome data, including 11,247 samples across 89 blood transcriptome datasets from 13 countries and 21 platforms. We build a diagnostic model for pathogen prediction starting from a pan-infection model as foundation (AUC = 0.97) based on the pan-infection dataset. Then, we utilize knowledge distillation to efficiently transfer the insights from this "teacher" model to four lightweight pathogen "student" models, i.e., staphylococcal infection (AUC = 0.99), streptococcal infection (AUC = 0.94), HIV infection (AUC = 0.93), and RSV infection (AUC = 0.94), as well as a sepsis "student" model (AUC = 0.99). The proposed knowledge distillation framework not only facilitates the diagnosis of pathogens using pan-infection data, but also enables an across-disease study from pan-infection to sepsis. Moreover, the framework enables high-degree lightweight design of diagnostic models, which is expected to be adaptively deployed in clinical settings.

In machine learning, metric elicitation refers to the selection of performance metrics that best reflect an individual's implicit preferences for a given application. Currently, metric elicitation methods only consider metrics that depend on the accuracy values encoded within a given model's confusion matrix. However, focusing solely on confusion matrices does not account for other model feasibility considerations such as varied monetary costs or latencies. In our work, we build upon the multiclass metric elicitation framework of Hiranandani et al., extrapolating their proposed Diagonal Linear Performance Metric Elicitation (DLPME) algorithm to account for additional bounded costs and rewards. Our experimental results with synthetic data demonstrate our approach's ability to quickly converge to the true metric.

This study presents a machine learning approach to predict the number of barges transported by vessels on inland waterways using tracking data from the Automatic Identification System (AIS). While AIS tracks the location of tug and tow vessels, it does not monitor the presence or number of barges transported by those vessels. Understanding the number and types of barges conveyed along river segments, between ports, and at ports is crucial for estimating the quantities of freight transported on the nation's waterways. This insight is also valuable for waterway management and infrastructure operations impacting areas such as targeted dredging operations, and data-driven resource allocation. Labeled sample data was generated using observations from traffic cameras located along key river segments and matched to AIS data records. A sample of 164 vessels representing up to 42 barge convoys per vessel was used for model development. The methodology involved first predicting barge presence and then predicting barge quantity. Features derived from the AIS data included speed measures, vessel characteristics, turning measures, and interaction terms. For predicting barge presence, the AdaBoost model achieved an F1 score of 0.932. For predicting barge quantity, the Random Forest combined with an AdaBoost ensemble model achieved an F1 score of 0.886. Bayesian optimization was used for hyperparameter tuning. By advancing predictive modeling for inland waterways, this study offers valuable insights for transportation planners and organizations, which require detailed knowledge of traffic volumes, including the flow of commodities, their destinations, and the tonnage moving in and out of ports.

The unpredictable nature of outdoor settings introduces numerous safety concerns, making hazard detection crucial for safe navigation. This paper introduces a novel system for sidewalk safety navigation utilizing a hybrid approach that combines a Variational Autoencoder (VAE) with a One-Class Support Vector Machine (OCSVM). The system is designed to detect anomalies on sidewalks that could potentially pose walking hazards. A dataset comprising over 15,000 training frames and 5,000 testing frames was collected using video recordings, capturing various sidewalk scenarios, including normal and hazardous conditions. During deployment, the VAE utilizes its reconstruction mechanism to detect anomalies within a frame. Poor reconstruction by the VAE implies the presence of an anomaly, after which the OCSVM is used to confirm whether the anomaly is hazardous or non-hazardous. The proposed VAE model demonstrated strong performance, with a high Area Under the Curve (AUC) of 0.94, effectively distinguishing anomalies that could be potential hazards. The OCSVM is employed to reduce the detection of false hazard anomalies, such as manhole or water valve covers. This approach achieves an accuracy of 91.4%, providing a highly reliable system for distinguishing between hazardous and non-hazardous scenarios. These results suggest that the proposed system offers a robust solution for hazard detection in uncertain environments.

This paper presents a comprehensive study on the classification and detection of Silicosis-related lung inflammation. Our main contributions include 1) the creation of a newly curated chest X-ray (CXR) image dataset named SVBCX that is tailored to the nuances of lung inflammation caused by distinct agents, providing a valuable resource for silicosis and pneumonia research community; and 2) we propose a novel deep-learning architecture that integrates graph transformer networks alongside a traditional deep neural network module for the effective classification of silicosis and pneumonia. Additionally, we employ the Balanced Cross-Entropy (BalCE) as a loss function to ensure more uniform learning across different classes, enhancing the model's ability to discern subtle differences in lung conditions. The proposed model architecture and loss function selection aim to improve the accuracy and reliability of inflammation detection, particularly in the context of Silicosis. Furthermore, our research explores the efficacy of an ensemble approach that combines the strengths of diverse model architectures. Experimental results on the constructed dataset demonstrate promising outcomes, showcasing substantial enhancements compared to baseline models. The ensemble of models achieves a macro-F1 score of 0.9749 and AUC ROC scores exceeding 0.99 for each class, underscoring the effectiveness of our approach in accurate and robust lung inflammation classification.