Despite coronary artery calcium scoring being considered a largely solved problem within the realm of medical artificial intelligence, this paper argues that significant improvements can still be made. By shifting the focus from pathology detection to a deeper understanding of anatomy, the novel algorithm proposed in the paper both achieves high accuracy in coronary artery calcium scoring and offers enhanced interpretability of the results. This approach not only aids in the precise quantification of calcifications in coronary arteries, but also provides valuable insights into the underlying anatomical structures. Through this anatomically-informed methodology, the paper shows how a nuanced understanding of the heart's anatomy can lead to more accurate and interpretable results in the field of cardiovascular health. We demonstrate the superior accuracy of the proposed method by evaluating it on an open-source multi-vendor dataset, where we obtain results at the inter-observer level, surpassing the current state of the art. Finally, the qualitative analyses show the practical value of the algorithm in such tasks as labeling coronary artery calcifications, identifying aortic calcifications, and filtering out false positive detections due to noise.

Previous works have demonstrated the effectiveness of Chain-of-Thought (COT) prompts and verifiers in guiding Large Language Models (LLMs) through the space of reasoning. However, most such studies either use a fine-tuned verifier or rely on manually handcrafted few-shot examples. In contrast, in this paper, we focus on LLM-based self-verification of self-generated reasoning steps via COT prompts in a completely zero-shot regime. To explore this setting, we design a new zero-shot prompt, which we call COT STEP, to aid zero-shot decomposition of reasoning steps and design two new zero-shot prompts for LLM-based verifiers. We evaluate the verifiers' ability to classify the correctness of reasoning chains and explore different ways to use verifier scores in guiding reasoning for various mathematical and commonsense reasoning tasks with different LLMs.

Trojan backdoors can be injected into large language models at various stages, including pretraining, fine-tuning, and in-context learning, posing a significant threat to the model's alignment. Due to the nature of causal language modeling, detecting these triggers is challenging given the vast search space. In this study, we propose a multistage framework for detecting Trojan triggers in large language models consisting of token filtration, trigger identification, and trigger verification. We discuss existing trigger identification methods and propose two variants of a black-box trigger inversion method that rely on output logits, utilizing beam search and greedy decoding respectively. We show that the verification stage is critical in the process and propose semantic-preserving prompts and special perturbations to differentiate between actual Trojan triggers and other adversarial strings that display similar characteristics. The evaluation of our approach on the TrojAI and RLHF poisoned model datasets demonstrates promising results.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with lung metastases being the most common site of distant spread and significantly worsening prognosis. Despite the growing availability of clinical and demographic data, predictive models for lung metastasis in HCC remain limited in scope and clinical applicability. In this study, we develop and validate an end-to-end machine learning pipeline using data from the Surveillance, Epidemiology, and End Results (SEER) database. We evaluated three machine learning models (Random Forest, XGBoost, and Logistic Regression) alongside a multilayer perceptron (MLP) neural network. Our models achieved high AUROC values and recall, with the Random Forest and MLP models demonstrating the best overall performance (AUROC = 0.82). However, the low precision across models highlights the challenges of accurately predicting positive cases. To address these limitations, we developed a custom loss function incorporating recall optimization, enabling the MLP model to achieve the highest sensitivity. An ensemble approach further improved overall recall by leveraging the strengths of individual models. Feature importance analysis revealed key predictors such as surgery status, tumor staging, and follow up duration, emphasizing the relevance of clinical interventions and disease progression in metastasis prediction. While this study demonstrates the potential of machine learning for identifying high-risk patients, limitations include reliance on imbalanced datasets, incomplete feature annotations, and the low precision of predictions. Future work should leverage the expanding SEER dataset, improve data imputation techniques, and explore advanced pre-trained models to enhance predictive accuracy and clinical utility.

The right to privacy, enshrined in various human rights declarations, faces new challenges in the age of artificial intelligence (AI). This paper explores the concept of the Right to be Forgotten (RTBF) within AI systems, contrasting it with traditional data erasure methods. We introduce Forgotten by Design, a proactive approach to privacy preservation that integrates instance-specific obfuscation techniques during the AI model training process. Unlike machine unlearning, which modifies models post-training, our method prevents sensitive data from being embedded in the first place. Using the LIRA membership inference attack, we identify vulnerable data points and propose defenses that combine additive gradient noise and weighting schemes. Our experiments on the CIFAR-10 dataset demonstrate that our techniques reduce privacy risks by at least an order of magnitude while maintaining model accuracy (at 95% significance). Additionally, we present visualization methods for the privacy-utility trade-off, providing a clear framework for balancing privacy risk and model accuracy. This work contributes to the development of privacy-preserving AI systems that align with human cognitive processes of motivated forgetting, offering a robust framework for safeguarding sensitive information and ensuring compliance with privacy regulations.

Machine learning model genealogy enables practitioners to determine which architectural family a neural network belongs to. In this paper, we introduce ShadowGenes, a novel, signature-based method for identifying a given model's architecture, type, and family. Our method involves building a computational graph of the model that is agnostic of its serialization format, then analyzing its internal operations to identify unique patterns, and finally building and refining signatures based on these. We highlight important workings of the underlying engine and demonstrate the technique used to construct a signature and scan a given model. This approach to model genealogy can be applied to model files without the need for additional external information. We test ShadowGenes on a labeled dataset of over 1,400 models and achieve a mean true positive rate of 97.49% and a precision score of 99.51%; which validates the technique as a practical method for model genealogy. This enables practitioners to understand the use cases of a given model, the internal computational process, and identify possible security risks, such as the potential for model backdooring.

Transfer learning, successful in knowledge translation across related tasks, faces a substantial privacy threat from membership inference attacks (MIAs). These attacks, despite posing significant risk to ML model's training data, remain limited-explored in transfer learning. The interaction between teacher and student models in transfer learning has not been thoroughly explored in MIAs, potentially resulting in an under-examined aspect of privacy vulnerabilities within transfer learning. In this paper, we propose a new MIA vector against transfer learning, to determine whether a specific data point was used to train the teacher model while only accessing the student model in a white-box setting. Our method delves into the intricate relationship between teacher and student models, analyzing the discrepancies in hidden layer representations between the student model and its shadow counterpart. These identified differences are then adeptly utilized to refine the shadow model's training process and to inform membership inference decisions effectively. Our method, evaluated across four datasets in diverse transfer learning tasks, reveals that even when an attacker only has access to the student model, the teacher model's training data remains susceptible to MIAs. We believe our work unveils the unexplored risk of membership inference in transfer learning.

Current explainability methods often produce inconsistent results and struggle to highlight essential signals influencing model inferences. This paper introduces the Evolutionary Independent Deterministic Explanation (EVIDENCE) theory, a novel approach offering a deterministic, model-independent method for extracting significant signals from black-box models. EVIDENCE theory, grounded in robust mathematical formalization, is validated through empirical tests on diverse datasets, including COVID-19 audio diagnostics, Parkinson's disease voice recordings, and the George Tzanetakis music classification dataset (GTZAN). Practical applications of EVIDENCE include improving diagnostic accuracy in healthcare and enhancing audio signal analysis. For instance, in the COVID-19 use case, EVIDENCE-filtered spectrograms fed into a frozen Residual Network with 50 layers (ResNet50) improved precision by 32% for positive cases and increased the Area Under the Curve (AUC) by 16% compared to baseline models. For Parkinson's disease classification, EVIDENCE achieved near-perfect precision and sensitivity, with a macro average F1-Score of 0.997. In the GTZAN, EVIDENCE maintained a high AUC of 0.996, demonstrating its efficacy in filtering relevant features for accurate genre classification. EVIDENCE outperformed other Explainable Artificial Intelligence (XAI) methods such as Local Interpretable Model-agnostic Explanations (LIME), SHapley Additive exPlanations (SHAP), and Gradient-weighted Class-Activation Mapping (GradCAM) in almost all metrics. These findings indicate that EVIDENCE not only improves classification accuracy but also provides a transparent and reproducible explanation mechanism, crucial for advancing the trustworthiness and applicability of AI systems in real-world settings.

Hydrogen, the most abundant element in the universe, is crucial for understanding galaxy formation and evolution. The 21 cm neutral atomic hydrogen - HI spectral line maps the gas kinematics within galaxies, providing key insights into interactions, galactic structure, and star formation processes. With new radio instruments, the volume and complexity of data is increasing. To analyze and classify integrated HI spectral profiles in a efficient way, this work presents a framework that integrates Machine Learning techniques, combining unsupervised methods and CNNs. To this end, we apply our framework to a selected subsample of 318 spectral HI profiles of the CIG and 30.780 profiles from the Arecibo Legacy Fast ALFA Survey catalogue. Data pre-processing involved the Busyfit package and iterative fitting with polynomial, Gaussian, and double-Lorentzian models. Clustering methods, including K-means, spectral clustering, DBSCAN, and agglomerative clustering, were used for feature extraction and to bootstrap classification we applied K-NN, SVM, and Random Forest classifiers, optimizing accuracy with CNN. Additionally, we introduced a 2D model of the profiles to enhance classification by adding dimensionality to the data. Three 2D models were generated based on transformations and normalised versions to quantify the level of asymmetry. These methods were tested in a previous analytical classification study conducted by the Analysis of the Interstellar Medium in Isolated Galaxies group. This approach enhances classification accuracy and aims to establish a methodology that could be applied to data analysis in future surveys conducted with the Square Kilometre Array (SKA), currently under construction. All materials, code, and models have been made publicly available in an open-access repository, adhering to FAIR principles.

Hallucinations of deep neural models are amongst key challenges in automatic speech recognition (ASR). In this paper, we investigate hallucinations of the Whisper ASR model induced by non-speech audio segments present during inference. By inducting hallucinations with various types of sounds, we show that there exists a set of hallucinations that appear frequently. We then study hallucinations caused by the augmentation of speech with such sounds. Finally, we describe the creation of a bag of hallucinations (BoH) that allows to remove the effect of hallucinations through the post-processing of text transcriptions. The results of our experiments show that such post-processing is capable of reducing word error rate (WER) and acts as a good safeguard against problematic hallucinations.