Vision foundation models (VFMs) are pre-trained on extensive image datasets to learn general representations for diverse types of data. These models can subsequently be fine-tuned for specific downstream tasks, significantly boosting performance across a broad range of applications. However, existing vision foundation models that claim to be applicable to various clinical tasks are mostly pre-trained on 3D computed tomography (CT), which benefits from the availability of extensive 3D CT databases. Significant differences between CT and magnetic resonance imaging (MRI) in imaging principles, signal characteristics, and data distribution may hinder their practical performance and versatility in MRI-specific applications. Here, we propose Triad, a vision foundation model for 3D MRI. Triad adopts a widely used autoencoder architecture to learn robust representations from 131,170 3D MRI volumes and uses organ-independent imaging descriptions to constrain the semantic distribution of the visual modality. The above pre-training dataset is called Triad-131K, which is currently the largest 3D MRI pre-training dataset. We evaluate Triad across three tasks, namely, organ/tumor segmentation, organ/cancer classification, and medical image registration, in two data modalities (within-domain and out-of-domain) settings using 25 downstream datasets. By initializing models with Triad's pre-trained weights, nnUNet-Triad improves segmentation performance by 2.51% compared to nnUNet-Scratch across 17 datasets. Swin-B-Triad achieves a 3.97% improvement over Swin-B-Scratch in classification tasks across five datasets. SwinUNETR-Triad improves by 4.00% compared to SwinUNETR-Scratch in registration tasks across two datasets. Our study demonstrates that pre-training can improve performance when the data modalities and organs of upstream and downstream tasks are consistent.

To deploy machine learning models in the real world, researchers have proposed many OOD detection algorithms to help models identify unknown samples during the inference phase and prevent them from making untrustworthy predictions. Unlike methods that rely on extra data for outlier exposure training, post hoc methods detect Out-of-Distribution (OOD) samples by developing scoring functions, which are model agnostic and do not require additional training. However, previous post hoc methods may fail to capture the geometric cues embedded in network representations. Thus, in this study, we propose a novel score function based on the optimal transport theory, named OTOD, for OOD detection. We utilize information from features, logits, and the softmax probability space to calculate the OOD score for each test sample. Our experiments show that combining this information can boost the performance of OTOD with a certain margin. Experiments on the CIFAR-10 and CIFAR-100 benchmarks demonstrate the superior performance of our method. Notably, OTOD outperforms the state-of-the-art method GEN by 7.19% in the mean FPR@95 on the CIFAR-10 benchmark using ResNet-18 as the backbone, and by 12.51% in the mean FPR@95 using WideResNet-28 as the backbone. In addition, we provide theoretical guarantees for OTOD. The code is available in https://github.com/HengGao12/OTOD.

Non-small cell lung cancer (NSCLC) remains a major global health challenge, with high post-surgical recurrence rates underscoring the need for accurate pathological response predictions to guide personalized treatments. Although artificial intelligence models show promise in this domain, their clinical adoption is limited by the lack of medically grounded guidance during training, often resulting in non-explainable intrinsic predictions. To address this, we propose Doctor-in-the-Loop, a novel framework that integrates expert-driven domain knowledge with explainable artificial intelligence techniques, directing the model toward clinically relevant anatomical regions and improving both interpretability and trustworthiness. Our approach employs a gradual multi-view strategy, progressively refining the model's focus from broad contextual features to finer, lesion-specific details. By incorporating domain insights at every stage, we enhance predictive accuracy while ensuring that the model's decision-making process aligns more closely with clinical reasoning. Evaluated on a dataset of NSCLC patients, Doctor-in-the-Loop delivers promising predictive performance and provides transparent, justifiable outputs, representing a significant step toward clinically explainable artificial intelligence in oncology.

Detecting out-of-distribution (OOD) nodes in the graph-based machine-learning field is challenging, particularly when in-distribution (ID) node multi-category labels are unavailable. Thus, we focus on feature space rather than label space and find that, ideally, during the optimization of known ID samples, unknown ID samples undergo more significant representation changes than OOD samples, even if the model is trained to fit random targets, which we called the Feature Resonance phenomenon. The rationale behind it is that even without gold labels, the local manifold may still exhibit smooth resonance. Based on this, we further develop a novel graph OOD framework, dubbed Resonance-based Separation and Learning (RSL), which comprises two core modules: (i) a more practical micro-level proxy of feature resonance that measures the movement of feature vectors in one training step. (ii) integrate with synthetic OOD nodes strategy to train an effective OOD classifier. Theoretically, we derive an error bound showing the superior separability of OOD nodes during the resonance period. Empirically, RSL achieves state-of-the-art performance, reducing the FPR95 metric by an average of 18.51% across five real-world datasets.

Deep Neural Networks (DNNs) have demonstrated remarkable success across a wide range of tasks, particularly in fields such as image classification. However, DNNs are highly susceptible to adversarial attacks, where subtle perturbations are introduced to input images, leading to erroneous model outputs. In today's digital era, ensuring the security and integrity of images processed by DNNs is of critical importance. One of the most prominent adversarial attack methods is the Fast Gradient Sign Method (FGSM), which perturbs images in the direction of the loss gradient to deceive the model. This paper presents a novel approach for detecting and filtering FGSM adversarial attacks in image processing tasks. Our proposed method evaluates 10,000 images, each subjected to five different levels of perturbation, characterized by $\epsilon$ values of 0.01, 0.02, 0.05, 0.1, and 0.2. These perturbations are applied in the direction of the loss gradient. We demonstrate that our approach effectively filters adversarially perturbed images, mitigating the impact of FGSM attacks. The method is implemented in Python, and the source code is publicly available on GitHub for reproducibility and further research.

Planning paths that maximize information gain for robotic platforms has wide-ranging applications and significant potential impact. To effectively adapt to real-time data collection, informative path planning must be computed online and be responsive to new observations. In this work, we present IA-TIGRIS, an incremental and adaptive sampling-based informative path planner that can be run efficiently with onboard computation. Our approach leverages past planning efforts through incremental refinement while continuously adapting to updated world beliefs. We additionally present detailed implementation and optimization insights to facilitate real-world deployment, along with an array of reward functions tailored to specific missions and behaviors. Extensive simulation results demonstrate IA-TIGRIS generates higher-quality paths compared to baseline methods. We validate our planner on two distinct hardware platforms: a hexarotor UAV and a fixed-wing UAV, each having unique motion models and configuration spaces. Our results show up to a 41% improvement in information gain compared to baseline methods, suggesting significant potential for deployment in real-world applications.

With the rapid development of artificial intelligence (AI), especially in the medical field, the need for its explainability has grown. In medical image analysis, a high degree of transparency and model interpretability can help clinicians better understand and trust the decision-making process of AI models. In this study, we propose a Knowledge Distillation (KD)-based approach that aims to enhance the transparency of the AI model in medical image analysis. The initial step is to use traditional CNN to obtain a teacher model and then use KD to simplify the CNN architecture, retain most of the features of the data set, and reduce the number of network layers. It also uses the feature map of the student model to perform hierarchical analysis to identify key features and decision-making processes. This leads to intuitive visual explanations. We selected three public medical data sets (brain tumor, eye disease, and Alzheimer's disease) to test our method. It shows that even when the number of layers is reduced, our model provides a remarkable result in the test set and reduces the time required for the interpretability analysis.

Large Language Models (LLMs) have attained human-level fluency in text generation, which complicates the distinguishing between human-written and LLM-generated texts. This increases the risk of misuse and highlights the need for reliable detectors. Yet, existing detectors exhibit poor robustness on out-of-distribution (OOD) data and attacked data, which is critical for real-world scenarios. Also, they struggle to provide explainable evidence to support their decisions, thus undermining the reliability. In light of these challenges, we propose IPAD (Inverse Prompt for AI Detection), a novel framework consisting of a Prompt Inverter that identifies predicted prompts that could have generated the input text, and a Distinguisher that examines how well the input texts align with the predicted prompts. We develop and examine two versions of Distinguishers. Empirical evaluations demonstrate that both Distinguishers perform significantly better than the baseline methods, with version2 outperforming baselines by 9.73% on in-distribution data (F1-score) and 12.65% on OOD data (AUROC). Furthermore, a user study is conducted to illustrate that IPAD enhances the AI detection trustworthiness by allowing users to directly examine the decision-making evidence, which provides interpretable support for its state-of-the-art detection results.

Medicare fraud poses a substantial challenge to healthcare systems, resulting in significant financial losses and undermining the quality of care provided to legitimate beneficiaries. This study investigates the use of machine learning (ML) to enhance Medicare fraud detection, addressing key challenges such as class imbalance, high-dimensional data, and evolving fraud patterns. A dataset comprising inpatient claims, outpatient claims, and beneficiary details was used to train and evaluate five ML models: Random Forest, KNN, LDA, Decision Tree, and AdaBoost. Data preprocessing techniques included resampling SMOTE method to address the class imbalance, feature selection for dimensionality reduction, and aggregation of diagnostic and procedural codes. Random Forest emerged as the best-performing model, achieving a training accuracy of 99.2% and validation accuracy of 98.8%, and F1-score (98.4%). The Decision Tree also performed well, achieving a validation accuracy of 96.3%. KNN and AdaBoost demonstrated moderate performance, with validation accuracies of 79.2% and 81.1%, respectively, while LDA struggled with a validation accuracy of 63.3% and a low recall of 16.6%. The results highlight the importance of advanced resampling techniques, feature engineering, and adaptive learning in detecting Medicare fraud effectively. This study underscores the potential of machine learning in addressing the complexities of fraud detection. Future work should explore explainable AI and hybrid models to improve interpretability and performance, ensuring scalable and reliable fraud detection systems that protect healthcare resources and beneficiaries.

The growing use of large language models (LLMs) for text generation has led to widespread concerns about AI-generated content detection. However, an overlooked challenge is AI-polished text, where human-written content undergoes subtle refinements using AI tools. This raises a critical question: should minimally polished text be classified as AI-generated? Misclassification can lead to false plagiarism accusations and misleading claims about AI prevalence in online content. In this study, we systematically evaluate eleven state-of-the-art AI-text detectors using our AI-Polished-Text Evaluation (APT-Eval) dataset, which contains $11.7K$ samples refined at varying AI-involvement levels. Our findings reveal that detectors frequently misclassify even minimally polished text as AI-generated, struggle to differentiate between degrees of AI involvement, and exhibit biases against older and smaller models. These limitations highlight the urgent need for more nuanced detection methodologies.