Uncertainty quantification is becoming increasingly important in image segmentation, especially for high-stakes applications like medical imaging. While conformal risk control generalizes conformal prediction beyond standard miscoverage to handle various loss functions such as false negative rate, its application to segmentation often yields inadequate conditional risk control: some images experience very high false negative rates while others have negligibly small ones. We develop Conformal Risk Adaptation (CRA), which introduces a new score function for creating adaptive prediction sets that significantly improve conditional risk control for segmentation tasks. We establish a novel theoretical framework that demonstrates a fundamental connection between conformal risk control and conformal prediction through a weighted quantile approach, applicable to any score function. To address the challenge of poorly calibrated probabilities in segmentation models, we introduce a specialized probability calibration framework that enhances the reliability of pixel-wise inclusion estimates. Using these calibrated probabilities, we propose Calibrated Conformal Risk Adaptation (CCRA) and a stratified variant (CCRA-S) that partitions images based on their characteristics and applies group-specific thresholds to further enhance conditional risk control. Our experiments on polyp segmentation demonstrate that all three methods (CRA, CCRA, and CCRA-S) provide valid marginal risk control and deliver more consistent conditional risk control across diverse images compared to standard approaches, offering a principled approach to uncertainty quantification that is particularly valuable for high-stakes and personalized segmentation applications.

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any cur rent or future media. Caroline Panggabean Departement of CSE (AI) JAIN (Deemed - to - be University) Bangalore, Karnataka carolinepgabean@gmail.com Sincy John Departement of CSE (AIM) JAIN (Deemed - to - be University) Bangalore, Karnataka sincyjohn@jainuniversity.ac.in Chandrasekar Venkatachalam Departement of CSE (AI) JAIN (Deemed - to - be University) Bangalore, Karnataka chandrasekar.v@jainuniversity.ac.in Renuka Devi P Departement of CSE (AIML) JAIN (Deemed - to - be University) Bangalore, Karnataka renukadevi.p@jainuniversity.ac.in Priyanka Shah Departement of CSE (AI) JAIN (Deemed - to - be University) Bangalore, Karnataka priyankashah8324@gmail.com Shanmugavalli Venkatachalam Department of CSE KSR College of Engineering Namakkal, Tamil N adu drvshanmugavalli@gmail.com Abstract -- Detecting Denial of Service (DoS) and Distributed Denial of Service (DDoS) attacks remains a critical challenge in cybersecurity. This research introduces a hybrid deep learning model combining Gated Recurrent Units (GRUs) and a Neural Turing Machine (NTM) for enhanced intrusion detection. Trained on UNSW - NB15 and BoT - IoT datasets, the model employs GRU layers for sequential data processing and an NTM for long - term pattern recognition.

This study reveals the important role of prevention care and medication adherence in reducing hospitalizations. By using a structured dataset of 1,171 patients, four machine learning models Logistic Regression, Gradient Boosting, Random Forest, and Artificial Neural Networks are applied to predict five-year hospitalization risk, with the Gradient Boosting model achieving the highest accuracy of 81.2%. The result demonstrated that patients with high medication adherence and consistent preventive care can reduce 38.3% and 37.7% in hospitalization risk. The finding also suggests that targeted preventive care can have positive Return on Investment (ROI), and therefore ML models can effectively direct personalized interventions and contribute to long-term medical savings.

Climate science studies the structure and dynamics of Earth's climate system and seeks to understand how climate changes over time, where the data is usually stored in the format of time series, recording the climate features, geolocation, time attributes, etc. Recently, much research attention has been paid to the climate benchmarks. In addition to the most common task of weather forecasting, several pioneering benchmark works are proposed for extending the modality, such as domain-specific applications like tropical cyclone intensity prediction and flash flood damage estimation, or climate statement and confidence level in the format of natural language. To further motivate the artificial general intelligence development for climate science, in this paper, we first contribute a multi-modal climate benchmark, i.e., ClimateBench-M, which aligns (1) the time series climate data from ERA5, (2) extreme weather events data from NOAA, and (3) satellite image data from NASA HLS based on a unified spatial-temporal granularity. Second, under each data modality, we also propose a simple but strong generative method that could produce competitive performance in weather forecasting, thunderstorm alerts, and crop segmentation tasks in the proposed ClimateBench-M. The data and code of ClimateBench-M are publicly available at https://github.com/iDEA-iSAIL-Lab-UIUC/ClimateBench-M.

Blood cultures are often over ordered without clear justification, straining healthcare resources and contributing to inappropriate antibiotic use pressures worsened by the global shortage. In study of 135483 emergency department (ED) blood culture orders, we developed machine learning (ML) models to predict the risk of bacteremia using structured electronic health record (EHR) data and provider notes via a large language model (LLM). The structured models AUC improved from 0.76 to 0.79 with note embeddings and reached 0.81 with added diagnosis codes. Compared to an expert recommendation framework applied by human reviewers and an LLM-based pipeline, our ML approach offered higher specificity without compromising sensitivity. The recommendation framework achieved sensitivity 86%, specificity 57%, while the LLM maintained high sensitivity (96%) but over classified negatives, reducing specificity (16%). These findings demonstrate that ML models integrating structured and unstructured data can outperform consensus recommendations, enhancing diagnostic stewardship beyond existing standards of care.

Searching for planets analogous to Earth in terms of mass and equilibrium temperature is currently the first step in the quest for habitable conditions outside our Solar System and, ultimately, the search for life in the universe. Future missions such as PLATO or LIFE will begin to detect and characterise these small, cold planets, dedicating significant observation time to them. The aim of this work is to predict which stars are most likely to host an Earth-like planet (ELP) to avoid blind searches, minimises detection times, and thus maximises the number of detections. Using a previous study on correlations between the presence of an ELP and the properties of its system, we trained a Random Forest to recognise and classify systems as 'hosting an ELP' or 'not hosting an ELP'. The Random Forest was trained and tested on populations of synthetic planetary systems derived from the Bern model, and then applied to real observed systems. The tests conducted on the machine learning (ML) model yield precision scores of up to 0.99, indicating that 99% of the systems identified by the model as having ELPs possess at least one. Among the few real observed systems that have been tested, 44 have been selected as having a high probability of hosting an ELP, and a quick study of the stability of these systems confirms that the presence of an Earth-like planet within them would leave them stable. The excellent results obtained from the tests conducted on the ML model demonstrate its ability to recognise the typical architectures of systems with or without ELPs within populations derived from the Bern model. If we assume that the Bern model adequately describes the architecture of real systems, then such a tool can prove indispensable in the search for Earth-like planets. A similar approach could be applied to other planetary system formation models to validate those predictions.

The ability to quickly and accurately identify microbial species in a sample, known as metagenomic profiling, is critical across various fields, from healthcare to environmental science. This paper introduces a novel method to profile signals coming from sequencing devices in parallel with determining their nucleotide sequences, a process known as basecalling, via a multi-objective deep neural network for simultaneous basecalling and multi-class genome classification. We introduce a new loss strategy where losses for basecalling and classification are back-propagated separately, with model weights combined for the shared layers, and a pre-configured ranking strategy allowing top-K species accuracy, giving users flexibility to choose between higher accuracy or higher speed at identifying the species. We achieve state-of-the-art basecalling accuracies, while classification accuracies meet and exceed the results of state-of-the-art binary classifiers, attaining an average of 92.5%/98.9% accuracy at identifying the top-1/3 species among a total of 17 genomes in the Wick bacterial dataset. The work presented here has implications for future studies in metagenomic profiling by accelerating the bottleneck step of matching the DNA sequence to the correct genome.

Using ML filters to help automated vulnerability repairs: when it helps and when it doesn't Authors: Maria Camporese, University of Trento (Italy) Fabio Massacci, University of Trento (Italy), Vrije Universiteit Amsterdam (The Netherlands)This work has been partly supported by the European Union (EU) under Horizon Europe grant n . This paper reflects only the author's view and the funders are not responsible for any use that may be made of the information contained therein. As artificial intelligence (AI) becomes omnipresent, even integrated within secure software development, the safety of digital infrastructures requires new technologies and new methodologies, as highlighted in the EU Strategic Plan 2021-2024. To achieve this goal, the EU-funded Sec4AI4Sec project will develop advanced security-by-design testing and assurance techniques tailored for AI-augmented systems. These systems can democratise security expertise, enabling intelligent, automated secure coding and testing while simultaneously lowering development costs and improving software quality. However, they also introduce unique security challenges, particularly concerning fairness and explainability. Sec4AI4Sec is at the forefront of the move to tackle these challenges with a comprehensive approach, embodying the vision of better security for AI and better AI for security. Hybrid Explainable Workflows for Security and Threat Intelligence (HEWSTI) In research into threats to safety and security, people and AI collaborate to obtain actionable intelligence.

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with early and accurate diagnosis playing a pivotal role in improving patient outcomes. Automated detection of pulmonary nodules in computed tomography (CT) scans is a challenging task due to variability in nodule size, shape, texture, and location. Traditional Convolutional Neural Networks (CNNs) have shown considerable promise in medical image analysis; however, their limited ability to capture fine-grained spatial-spectral variations restricts their performance in complex diagnostic scenarios. In this study, we propose a novel hybrid deep learning architecture that incorporates Chebyshev polynomial expansions into CNN layers to enhance expressive power and improve the representation of underlying anatomical structures. The proposed Chebyshev-CNN leverages the orthogonality and recursive properties of Chebyshev polynomials to extract high-frequency features and approximate complex nonlinear functions with greater fidelity. The model is trained and evaluated on benchmark lung cancer imaging datasets, including LUNA16 and LIDC-IDRI, achieving superior performance in classifying pulmonary nodules as benign or malignant. Quantitative results demonstrate significant improvements in accuracy, sensitivity, and specificity compared to traditional CNN-based approaches. This integration of polynomial-based spectral approximation within deep learning provides a robust framework for enhancing automated medical diagnostics and holds potential for broader applications in clinical decision support systems.

This study explores the intersection of continuous-variable quantum computing (CVQC) and classical machine learning, focusing on CVQC data encoding techniques, including Displacement encoding and squeezing encoding, alongside Instantaneous Quantum Polynomial (IQP) encoding from discrete quantum computing. We perform an extensive empirical analysis to assess the impact of these encoding methods on classical machine learning models, such as Logistic Regression, Support Vector Machines, K-Nearest Neighbors, and ensemble methods like Random Forest and LightGBM. Our findings indicate that CVQC-based encoding methods significantly enhance feature expressivity, resulting in improved classification accuracy and F1 scores, especially in high-dimensional and complex datasets. However, these improvements come with varying computational costs, which depend on the complexity of the encoding and the architecture of the machine learning models. Additionally, we examine the trade-off between quantum expressibility and classical learnability, offering valuable insights into the practical feasibility of incorporating these quantum encodings into real-world applications. This study contributes to the growing body of research on quantum-classical hybrid learning, emphasizing the role of CVQC in advancing quantum data representation and its integration into classical machine learning workflows.