--Reliable anomaly detection is essential for ensuring the safety of autonomous robots, particularly when conventional detection systems based on vision or LiDAR become unreliable in adverse or unpredictable conditions. In such scenarios, alternative sensing modalities are needed to provide timely and robust feedback. T o this end, we explore the use of audio and inertial measurement unit (IMU) sensors to detect underlying anomalies in autonomous mobile robots, such as collisions and internal mechanical faults. Furthermore, to address the challenge of limited labeled anomaly data, we propose an unsupervised anomaly detection framework based on Mahalanobis Support V ector Data Description (M-SVDD). In contrast to conventional SVDD methods that rely on Euclidean distance and assume isotropic feature distributions, our approach employs the Mahalanobis distance to adaptively scale feature dimensions and capture inter-feature correlations, enabling more expressive decision boundaries. In addition, a reconstruction-based auxiliary branch is introduced to preserve feature diversity and prevent representation collapse, further enhancing the robustness of anomaly detection. Extensive experiments on a collected mobile robot dataset and four public datasets demonstrate the effectiveness of the proposed method, as shown in the video https://youtu.be/yh1tn6DDD4A. NOMAL Y detection is essential for ensuring the safety and reliability of many safety-critical systems, including industrial automation [1], aerospace [2] and robotic systems [3], [4]. In the context of autonomous mobile robots, the ability to detect anomalies, such as mechanical faults or unexpected collisions, is important for maintaining safe operations and preventing potential hazards. With the increasing deployment of robots in dynamic and unstructured environments, robust anomaly detection has become an indispensable component of autonomous operation.

The integration of AI into daily life has generated considerable attention and excitement, while also raising concerns about automating algorithmic harms and re-entrenching existing social inequities. While the responsible deployment of trustworthy AI systems is a worthy goal, there are many possible ways to realize it, from policy and regulation to improved algorithm design and evaluation. In fact, since AI trains on social data, there is even a possibility for everyday users, citizens, or workers to directly steer its behavior through Algorithmic Collective Action, by deliberately modifying the data they share with a platform to drive its learning process in their favor. This paper considers how these grassroots efforts to influence AI interact with methods already used by AI firms and governments to improve model trustworthiness. In particular, we focus on the setting where the AI firm deploys a differentially private model, motivated by the growing regulatory focus on privacy and data protection. We investigate how the use of Differentially Private Stochastic Gradient Descent (DPSGD) affects the collective's ability to influence the learning process. Our findings show that while differential privacy contributes to the protection of individual data, it introduces challenges for effective algorithmic collective action. We characterize lower bounds on the success of algorithmic collective action under differential privacy as a function of the collective's size and the firm's privacy parameters, and verify these trends experimentally by simulating collective action during the training of deep neural network classifiers across several datasets.

Drug resistance presents a major challenge in cancer therapy. Single cell profiling offers insights into cellular heterogeneity, yet the application of large-scale foundation models for predicting drug response in single cell data remains underexplored. To address this, we developed scDrugMap, an integrated framework featuring both a Python command-line interface and a web server for drug response prediction. scDrugMap evaluates a wide range of foundation models, including eight single-cell models and two large language models, using a curated dataset of over 326,000 cells in the primary collection and 18,800 cells in the validation set, spanning 36 datasets and diverse tissue and cancer types. We benchmarked model performance under pooled-data and cross-data evaluation settings, employing both layer freezing and Low-Rank Adaptation (LoRA) fine-tuning strategies. In the pooled-data scenario, scFoundation achieved the best performance, with mean F1 scores of 0.971 (layer freezing) and 0.947 (fine-tuning), outperforming the lowest-performing model by over 50%. In the cross-data setting, UCE excelled post fine-tuning (mean F1: 0.774), while scGPT led in zero-shot learning (mean F1: 0.858). Overall, scDrugMap provides the first large-scale benchmark of foundation models for drug response prediction in single-cell data and serves as a user-friendly, flexible platform for advancing drug discovery and translational research.

Gliomas are aggressive brain tumors that pose serious health risks. Deep learning aids in lesion segmentation, but CNN and Transformer-based models often lack context modeling or demand heavy computation, limiting real-time use on mobile medical devices. We propose GaMNet, integrating the NMamba module for global modeling and a multi-scale CNN for efficient local feature extraction. To improve interpretability and mimic the human visual system, we apply Gabor filters at multiple scales. Our method achieves high segmentation accuracy with fewer parameters and faster computation. Extensive experiments show GaMNet outperforms existing methods, notably reducing false positives and negatives, which enhances the reliability of clinical diagnosis.

The design of AI systems to assist human decision-making typically requires the availability of labels to train and evaluate supervised models. Frequently, however, these labels are unknown, and different ways of estimating them involve unverifiable assumptions or arbitrary choices. In this work, we introduce the concept of label indeterminacy and derive important implications in high-stakes AI-assisted decision-making. We present an empirical study in a healthcare context, focusing specifically on predicting the recovery of comatose patients after resuscitation from cardiac arrest. Our study shows that label indeterminacy can result in models that perform similarly when evaluated on patients with known labels, but vary drastically in their predictions for patients where labels are unknown. After demonstrating crucial ethical implications of label indeterminacy in this high-stakes context, we discuss takeaways for evaluation, reporting, and design.

The medical device industry has significantly advanced by integrating sophisticated electronics like microchips and field-programmable gate arrays (FPGAs) to enhance the safety and usability of life-saving devices. These complex electro-mechanical systems, however, introduce challenging failure modes that are not easily detectable with conventional methods. Effective fault detection and mitigation become vital as reliance on such electronics grows. This paper explores three generative machine learning-based approaches for fault detection in medical devices, leveraging sensor data from surgical staplers,a class 2 medical device. Historically considered low-risk, these devices have recently been linked to an increasing number of injuries and fatalities. The study evaluates the performance and data requirements of these machine-learning approaches, highlighting their potential to enhance device safety.

Prompt learning is one of the most effective paradigms for adapting pre-trained vision-language models (VLMs) to the biomedical image classification tasks in few shot scenarios. However, most of the current prompt learning methods only used the text prompts and ignored the particular structures (such as the complex anatomical structures and subtle pathological features) in the biomedical images. In this work, we propose Biomed-DPT, a knowledge-enhanced dual modality prompt tuning technique. In designing the text prompt, Biomed-DPT constructs a dual prompt including the template-driven clinical prompts and the large language model (LLM)-driven domain-adapted prompts, then extracts the clinical knowledge from the domain-adapted prompts through the knowledge distillation technique. In designing the vision prompt, Biomed-DPT introduces the zero vector as a soft prompt to leverage attention re-weighting so that the focus on non-diagnostic regions and the recognition of non-critical pathological features are avoided. Biomed-DPT achieves an average classification accuracy of 66.14\% across 11 biomedical image datasets covering 9 modalities and 10 organs, with performance reaching 78.06\% in base classes and 75.97\% in novel classes, surpassing the Context Optimization (CoOp) method by 6.20\%, 3.78\%, and 8.04\%, respectively. Our code are available at \underline{https://github.com/Kanyooo/Biomed-DPT}.

Conformal prediction is a powerful tool for constructing prediction intervals for black-box models, providing a finite sample coverage guarantee for exchangeable data. However, this exchangeability is compromised when some entries of the test feature are contaminated, such as in the case of cellwise outliers. To address this issue, this paper introduces a novel framework called detect-then-impute conformal prediction. This framework first employs an outlier detection procedure on the test feature and then utilizes an imputation method to fill in those cells identified as outliers. To quantify the uncertainty in the processed test feature, we adaptively apply the detection and imputation procedures to the calibration set, thereby constructing exchangeable features for the conformal prediction interval of the test label. We develop two practical algorithms, PDI-CP and JDI-CP, and provide a distribution-free coverage analysis under some commonly used detection and imputation procedures. Notably, JDI-CP achieves a finite sample $1-2α$ coverage guarantee. Numerical experiments on both synthetic and real datasets demonstrate that our proposed algorithms exhibit robust coverage properties and comparable efficiency to the oracle baseline.

Model monitoring is a critical component of the machine learning lifecycle, safeguarding against undetected drops in the model's performance after deployment. Traditionally, performance monitoring has required access to ground truth labels, which are not always readily available. This can result in unacceptable latency or render performance monitoring altogether impossible. Recently, methods designed to estimate the accuracy of classifier models without access to labels have shown promising results. However, there are various other metrics that might be more suitable for assessing model performance in many cases. Until now, none of these important metrics has received similar interest from the scientific community. In this work, we address this gap by presenting CBPE, a novel method that can estimate any binary classification metric defined using the confusion matrix. In particular, we choose four metrics from this large family: accuracy, precision, recall, and F$_1$, to demonstrate our method. CBPE treats the elements of the confusion matrix as random variables and leverages calibrated confidence scores of the model to estimate their distributions. The desired metric is then also treated as a random variable, whose full probability distribution can be derived from the estimated confusion matrix. CBPE is shown to produce estimates that come with strong theoretical guarantees and valid confidence intervals.

--With the high penetration of renewables, traditional model-based power system operation is challenged to deliver economic, stable, and robust decisions. Machine learning has emerged as a powerful modeling tool for capturing complex dynamics to address these challenges. However, its separate design often lacks systematic integration with existing methods. T o fill the gap, this paper proposes a holistic framework of Learning-Augmented Power System Operations (LAPSO, pronounced as Lap-So). Adopting a native optimization perspective, LAPSO is centered on the operation stage and aims to break the boundary between temporally siloed power system tasks, such as forecast, operation and control, while unifying the objectives of machine learning and model-based optimizations at both training and inference stages. Systematic analysis and simulations demonstrate the effectiveness of applying LAPSO in designing new integrated algorithms, such as stability-constrained optimization (SCO) and objective-based forecasting (OBF), while enabling end-to-end tracing of different sources of uncertainties. In addition, a dedicated Python package-lapso is introduced to automatically augment existing power system optimization models with learnable components. All code and data are available at https://github.com/xuwkk/lapso_exp. Index T erms --Power system operation, machine learning, objective-based forecasting, stability-constrained optimization. A. Background and Motivation Power system decision-making consists of sequentially connected tasks, including modeling/forecasting, operation, and control (See Figure 1(a).) With the decarbonization need, traditional model-based approaches face significant challenges. For example, the increasing uncertainty associated with renewable generation undermines the reliability of deterministic forecasting and power system operation (PSO) [2]. Meanwhile, the declining share of inertia from synchronous generators (SGs) can cause grid instability [3].