Computing Center, Anshan Normal University, Anshan 114007, China Abstract--Graph anomaly detection is a popular and vital task in various real-world scenarios, which has been studied for several decades. Recently, many studies extending deep learning-based methods have shown preferable performance on graph anomaly detection. However, existing methods are lack of efficiency that is definitely necessary for embedded devices. Towards this end, we propose an Efficient Anomaly detection model on heterogeneous Graphs via contrastive LEarning (EAGLE) by contrasting abnormal nodes with normal ones in terms of their distances to the local context. The proposed method first samples instance pairs on meta path-level for contrastive learning. Then, a graph autoencoder-based model is applied to learn informative node embeddings in an unsupervised way, which will be further combined with the discriminator to predict the anomaly scores of nodes. Experimental results show that EAGLE outperforms the state-of-the-art methods on three heterogeneous network datasets. Typical examples include social networks, bibliographic networks, and transportation networks. Recent years have witnessed increasing attention on graph data mining and analysis tasks, such as node/graph classification, recommendation systems, and anomaly detection [2].

From the original abstract: This thesis initially aims to study the pain assessment process from a clinical-theoretical perspective while exploring and examining existing automatic approaches. Building on this foundation, the primary objective of this Ph.D. project is to develop innovative computational methods for automatic pain assessment that achieve high performance and are applicable in real clinical settings. A primary goal is to thoroughly investigate and assess significant factors, including demographic elements that impact pain perception, as recognized in pain research, through a computational standpoint. Within the limits of the available data in this research area, our goal was to design, develop, propose, and offer automatic pain assessment pipelines for unimodal and multimodal configurations that are applicable to the specific requirements of different scenarios. The studies published in this Ph.D. thesis showcased the effectiveness of the proposed methods, achieving state-of-the-art results. Additionally, they paved the way for exploring new approaches in artificial intelligence, foundation models, and generative artificial intelligence.

User authentication is essential to ensure secure access to computer systems, yet traditional methods face limitations in usability, cost, and security. Mouse dynamics authentication, based on the analysis of users' natural interaction behaviors with mouse devices, offers a cost-effective, non-intrusive, and adaptable solution. However, challenges remain in determining the optimal data volume, balancing accuracy and practicality, and effectively capturing temporal behavioral patterns. In this study, we propose a statistical method using Gaussian kernel density estimate (KDE) and Kullback-Leibler (KL) divergence to estimate the sufficient data volume for training authentication models. We introduce the Mouse Authentication Unit (MAU), leveraging Approximate Entropy (ApEn) to optimize segment length for efficient and accurate behavioral representation. Furthermore, we design the Local-Time Mouse Authentication (LT-AMouse) framework, integrating 1D-ResNet for local feature extraction and GRU for modeling long-term temporal dependencies. Taking the Balabit and DFL datasets as examples, we significantly reduced the data scale, particularly by a factor of 10 for the DFL dataset, greatly alleviating the training burden. Additionally, we determined the optimal input recognition unit length for the user authentication system on different datasets based on the slope of Approximate Entropy. Training with imbalanced samples, our model achieved a successful defense AUC 98.52% for blind attack on the DFL dataset and 94.65% on the Balabit dataset, surpassing the current sota performance.

Assessing consistency in Pairwise Comparison Matrices (PCMs) within the Analytical Hierarchy Process (AHP) poses significant challenges when using the traditional Consistency Ratio (CR) method. This study introduces a novel alternative that leverages triadic preference reversals (PR) to provide a more robust and interpretable assessment of consistency. Triadic preference reversals capture inconsistencies between a pair of elements by comparing the direction of preference derived from the global eigenvector with that from a 3x3 submatrix (triad) containing the same pair, highlighting local-global preference conflicts. This method detects a reversal when one eigen ratio exceeds one while another falls below one, signaling inconsistency. We identify two key features: the proportion of preference reversals and the maximum reversal, which mediate the impact of a PCM's order on its consistency. Using these features simulated PCMs are clustered into consistent and inconsistent classes through k-means clustering, followed by training a logistic classifier for consistency evaluation. The PR method achieves 97\% accuracy, significantly surpassing the Consistency Ratio (CR) method's 50%, with a false negative rate of only 2.6\% compared to 5.5\%. These findings demonstrate the PR method's superior accuracy in assessing AHP consistency, thereby enabling more reliable decision-making. The proposed triadic preference reversal (PR) approach is implemented in the R package AHPtools publicly available on the Comprehensive R Archive Network (CRAN).

We revisit the problem of ensuring strong test-set performance via cross-validation. Motivated by the generalization theory literature, we propose a nested k-fold cross-validation scheme that selects hyperparameters by minimizing a weighted sum of the usual cross-validation metric and an empirical model-stability measure. The weight on the stability term is itself chosen via a nested cross-validation procedure. This reduces the risk of strong validation set performance and poor test set performance due to instability. We benchmark our procedure on a suite of 13 real-world UCI datasets, and find that, compared to k-fold cross-validation over the same hyperparameters, it improves the out-of-sample MSE for sparse ridge regression and CART by 4% on average, but has no impact on XGBoost. This suggests that for interpretable and unstable models, such as sparse regression and CART, our approach is a viable and computationally affordable method for improving test-set performance.

In this thesis, we introduce Bayesian filtering as a principled framework for tackling diverse sequential machine learning problems, including online (continual) learning, pre-quential (one-step-ahead) forecasting, and contextual bandits. To this end, this thesis addresses key challenges in applying Bayesian filtering to these problems: adaptivity to non-stationary environments, robustness to model misspecification and outliers, and scalability to the high-dimensional parameter space of deep neural networks. We develop novel tools within the Bayesian filtering framework to address each of these challenges, including: (i) a modular framework that enables the development adaptive approaches for online learning; (ii) a novel, provably robust filter with similar computational cost to standard filters, that employs Generalised Bayes; and (iii) a set of tools for sequentially updating model parameters using approximate second-order optimisation methods that exploit the overparametrisation of high-dimensional parametric models such as neural networks. Theoretical analysis and empirical results demonstrate the improved performance of our methods in dynamic, high-dimensional, and misspecified models.

Causal machine learning (CML) enables individualized estimation of treatment effects, offering critical advantages over traditional correlation-based methods. However, existing approaches for medical survival data with censoring such as causal survival forests estimate effects at fixed time points, limiting their ability to capture dynamic changes over time. We introduce Causal Analysis for Survival Trajectories (CAST), a novel framework that models treatment effects as continuous functions of time following treatment. By combining parametric and non-parametric methods, CAST overcomes the limitations of discrete time-point analysis to estimate continuous effect trajectories. Using the RADCURE dataset [1] of 2,651 patients with head and neck squamous cell carcinoma (HNSCC) as a clinically relevant example, CAST models how chemotherapy and radiotherapy effects evolve over time at the population and individual levels. By capturing the temporal dynamics of treatment response, CAST reveals how treatment effects rise, peak, and decline over the follow-up period, helping clinicians determine when and for whom treatment benefits are maximized. This framework advances the application of CML to personalized care in HNSCC and other life-threatening medical conditions. Source code/data available at: https://github.com/CAST-FW/HNSCC

Many classification performance metrics exist, each suited to a specific application. However, these metrics often differ in scale and can exhibit varying sensitivity to class imbalance rates in the test set. As a result, it is difficult to use the nominal values of these metrics to interpret and evaluate classification performances, especially when imbalance rates vary. To address this problem, we introduce the outperformance score function, a universal standardization method for confusion-matrix-based classification performance (CMBCP) metrics. It maps any given metric to a common scale of $[0,1]$, while providing a clear and consistent interpretation. Specifically, the outperformance score represents the percentile rank of the observed classification performance within a reference distribution of possible performances. This unified framework enables meaningful comparison and monitoring of classification performance across test sets with differing imbalance rates. We illustrate how the outperformance scores can be applied to a variety of commonly used classification performance metrics and demonstrate the robustness of our method through experiments on real-world datasets spanning multiple classification applications.

Small nucleolar RNAs (snoRNAs) are increasingly recognized for their critical role in the pathogenesis and characterization of various human diseases. Consequently, the precise identification of snoRNA-disease associations (SDAs) is essential for the progression of diseases and the advancement of treatment strategies. However, conventional biological experimental approaches are costly, time-consuming, and resource-intensive; therefore, machine learning-based computational methods offer a promising solution to mitigate these limitations. This paper proposes a model called 'GBDTSVM', representing a novel and efficient machine learning approach for predicting snoRNA-disease associations by leveraging a Gradient Boosting Decision Tree (GBDT) and Support Vector Machine (SVM). 'GBDTSVM' effectively extracts integrated snoRNA-disease feature representations utilizing GBDT and SVM is subsequently utilized to classify and identify potential associations. Furthermore, the method enhances the accuracy of these predictions by incorporating Gaussian kernel profile similarity for both snoRNAs and diseases. Experimental evaluation of the GBDTSVM model demonstrated superior performance compared to state-of-the-art methods in the field, achieving an area under the receiver operating characteristic (AUROC) of 0.96 and an area under the precision-recall curve (AUPRC) of 0.95 on MDRF dataset. Moreover, our model shows superior performance on two more datasets named LSGT and PsnoD. Additionally, a case study on the predicted snoRNA-disease associations verified the top 10 predicted snoRNAs across nine prevalent diseases, further validating the efficacy of the GBDTSVM approach. These results underscore the model's potential as a robust tool for advancing snoRNA-related disease research. Source codes and datasets our proposed framework can be obtained from: https://github.com/mariamuna04/gbdtsvm

This paper presents a novel methodology for enhancing Automated Program Repair (APR) through synthetic data generation utilizing Large Language Models (LLMs). Current APR systems are constrained by the limited availability of high-quality training data encompassing diverse bug types across multiple programming languages. The proposed approach addresses this limitation through a two-phase process: a synthetic sample generation followed by a rigorous quality assessment. Multiple state-of-the-art LLMs were employed to generate approximately 30,000 paired examples of buggy and fixed code across 12 programming languages and 13 bug categories. Subsequently, these samples underwent cross-model evaluation against five criteria: correctness, code quality, security, performance, and completeness. Experimental evaluation on the VulRepair test set dataset showed statistically significant improvements in Perfect Prediction rates, with the quality-filtered synthetic dataset outperforming both baseline and real-world commit data configurations in certain scenarios. The methodology was validated through rigorous statistical testing, including ANOVA and post-hoc Tukey's Honest Significant Difference analysis. Furthermore, the best-performing configurations surpassed existing systems despite using a less computationally intensive decoding strategy. This research establishes a self-bootstrapping paradigm in which LLMs generate and evaluate their own training data, potentially transforming approaches to data scarcity across software engineering tasks and advancing the development of robust, adaptable tools for automated code maintenance.