Brain network analysis plays a crucial role in diagnosing and monitoring neurodegenerative disorders such as Alzheimer's disease (AD). Existing approaches for constructing structural brain networks from diffusion tensor imaging (DTI) often rely on specialized toolkits that suffer from inherent limitations: operator subjectivity, labor-intensive workflows, and restricted capacity to capture complex topological features and disease-specific biomarkers. To overcome these challenges and advance computational neuroimaging instrumentation, ConnectomeDiffuser is proposed as a novel diffusion-based framework for automated end-to-end brain network construction from DTI. The proposed model combines three key components: (1) a Template Network that extracts topological features from 3D DTI scans using Riemannian geometric principles, (2) a diffusion model that generates comprehensive brain networks with enhanced topological fidelity, and (3) a Graph Convolutional Network classifier that incorporates disease-specific markers to improve diagnostic accuracy. ConnectomeDiffuser demonstrates superior performance by capturing a broader range of structural connectivity and pathology-related information, enabling more sensitive analysis of individual variations in brain networks. Experimental validation on datasets representing two distinct neurodegenerative conditions demonstrates significant performance improvements over other brain network methods. This work contributes to the advancement of instrumentation in the context of neurological disorders, providing clinicians and researchers with a robust, generalizable measurement framework that facilitates more accurate diagnosis, deeper mechanistic understanding, and improved therapeutic monitoring of neurodegenerative diseases such as AD.

In connected and autonomous vehicles, machine learning for safety message classification has become critical for detecting malicious or anomalous behavior. However, conventional approaches that rely on centralized data collection or purely local training face limitations due to the large scale, high mobility, and heterogeneous data distributions inherent in inter-vehicle networks. To overcome these challenges, this paper explores Distributed Federated Learning (DFL), whereby vehicles collaboratively train deep learning models by exchanging model updates among one-hop neighbors and propagating models over multiple hops. Using the Vehicular Reference Misbehavior (VeReMi) Extension Dataset, we show that DFL can significantly improve classification accuracy across all vehicles compared to learning strictly with local data. Notably, vehicles with low individual accuracy see substantial accuracy gains through DFL, illustrating the benefit of knowledge sharing across the network. We further show that local training data size and time-varying network connectivity correlate strongly with the model's overall accuracy. We investigate DFL's resilience and vulnerabilities under attacks in multiple domains, namely wireless jamming and training data poisoning attacks. Our results reveal important insights into the vulnerabilities of DFL when confronted with multi-domain attacks, underlining the need for more robust strategies to secure DFL in vehicular networks.

Integrating structured information has long improved the quality of abstractive summarization, particularly in retaining salient content. In this work, we focus on a specific form of structure: argument roles, which are crucial for summarizing documents in high-stakes domains such as law. We investigate whether instruction-tuned large language models (LLMs) adequately preserve this information. To this end, we introduce Argument Representation Coverage (ARC), a framework for measuring how well LLM-generated summaries capture salient arguments. Using ARC, we analyze summaries produced by three open-weight LLMs in two domains where argument roles are central: long legal opinions and scientific articles. Our results show that while LLMs cover salient argument roles to some extent, critical information is often omitted in generated summaries, particularly when arguments are sparsely distributed throughout the input. Further, we use ARC to uncover behavioral patterns -- specifically, how the positional bias of LLM context windows and role-specific preferences impact the coverage of key arguments in generated summaries, emphasizing the need for more argument-aware summarization strategies.

Multi-Modal Learning (MML) integrates information from diverse modalities to improve predictive accuracy. However, existing methods mainly aggregate gradients with fixed weights and treat all dimensions equally, overlooking the intrinsic gradient uncertainty of each modality. This may lead to (i) excessive updates in sensitive dimensions, degrading performance, and (ii) insufficient updates in less sensitive dimensions, hindering learning. To address this issue, we propose BOGC-MML, a Bayesian-Oriented Gradient Calibration method for MML to explicitly model the gradient uncertainty and guide the model optimization towards the optimal direction. Specifically, we first model each modality's gradient as a random variable and derive its probability distribution, capturing the full uncertainty in the gradient space. Then, we propose an effective method that converts the precision (inverse variance) of each gradient distribution into a scalar evidence. This evidence quantifies the confidence of each modality in every gradient dimension. Using these evidences, we explicitly quantify per-dimension uncertainties and fuse them via a reduced Dempster-Shafer rule. The resulting uncertainty-weighted aggregation produces a calibrated update direction that balances sensitivity and conservatism across dimensions. Extensive experiments on multiple benchmark datasets demonstrate the effectiveness and advantages of the proposed method.

Background Sepsis is a life - threatening condition affecting over 48.9 million people globally and causing 11 million deaths annually. Despite medical advancements, predicting sepsis remains a challenge due to non - specific symptoms and complex pathophysiology. The SXI++ LNM model is a machine learning - based scoring system that refines sepsis prediction by leveraging multiple algorithms and deep neural networks. The COMPOSER model, a de ep learning framework utilizing conformal prediction, aims to improve robustness in clinical applications. This study compares the predictive performance of SXI++ LNM and COMPOSER for sepsis prediction. Methods A dataset containing 1,552,210 rows with 43 columns was cleaned and refined to 964,355 rows and 14 key features for sepsis prediction. Data were sourced from ICU patients across three separate hospital systems, including two publicly available datasets fro m Kaggle and the Early Prediction of Sepsis from Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019.

Mental disorders including depression, anxiety, and other neurological disorders pose a significant global challenge, particularly among individuals exhibiting social avoidance tendencies. This study proposes a hybrid approach by leveraging smartphone sensor data measuring daily physical activities and analyzing their social media (Twitter) interactions for evaluating an individual's depression level. Using CNN-based deep learning models and Naive Bayes classification, we identify human physical activities accurately and also classify the user sentiments. A total of 33 participants were recruited for data acquisition, and nine relevant features were extracted from the physical activities and analyzed with their weekly depression scores, evaluated using the Geriatric Depression Scale (GDS) questionnaire. Of the nine features, six are derived from physical activities, achieving an activity recognition accuracy of 95%, while three features stem from sentiment analysis of Twitter activities, yielding a sentiment analysis accuracy of 95.6%. Notably, several physical activity features exhibited significant correlations with the severity of depression symptoms. For classifying the depression severity, a support vector machine (SVM)-based algorithm is employed that demonstrated a very high accuracy of 94%, outperforming alternative models, e.g., the multilayer perceptron (MLP) and k-nearest neighbor. It is a simple approach yet highly effective in the long run for monitoring depression without breaching personal privacy.

Deploying machine learning models in safety-critical domains poses a key challenge: ensuring reliable model performance on downstream user data without access to ground truth labels for direct validation. We propose the suitability filter, a novel framework designed to detect performance deterioration by utilizing suitability signals -- model output features that are sensitive to covariate shifts and indicative of potential prediction errors. The suitability filter evaluates whether classifier accuracy on unlabeled user data shows significant degradation compared to the accuracy measured on the labeled test dataset. Specifically, it ensures that this degradation does not exceed a pre-specified margin, which represents the maximum acceptable drop in accuracy. To achieve reliable performance evaluation, we aggregate suitability signals for both test and user data and compare these empirical distributions using statistical hypothesis testing, thus providing insights into decision uncertainty. Our modular method adapts to various models and domains. Empirical evaluations across different classification tasks demonstrate that the suitability filter reliably detects performance deviations due to covariate shift. This enables proactive mitigation of potential failures in high-stakes applications.

Whisper fails to correctly transcribe dementia speech because persons with dementia (PwDs) often exhibit irregular speech patterns and disfluencies such as pauses, repetitions, and fragmented sentences. It was trained on standard speech and may have had little or no exposure to dementia-affected speech. However, correct transcription is vital for dementia speech for cost-effective diagnosis and the development of assistive technology. In this work, we fine-tune Whisper with the open-source dementia speech dataset (DementiaBank) and our in-house dataset to improve its word error rate (WER). The fine-tuning also includes filler words to ascertain the filler inclusion rate (FIR) and F1 score. The fine-tuned models significantly outperformed the off-the-shelf models. The medium-sized model achieved a WER of 0.24, outperforming previous work. Similarly, there was a notable generalisability to unseen data and speech patterns.

Chain-of-Thought reasoning has emerged as a powerful approach for solving complex mathematical and logical problems. However, it can often veer off track through incorrect or unsubstantiated inferences. Formal mathematical reasoning, which can be checked with a formal verifier, is one approach to addressing this issue. However, currently LLMs are simply not good enough to solve complex problems in a formal way, and even just formalizing an informal problem statement can be challenging. Motivated by this fact, in this work we consider the problem of learning reliable verifiers for natural language Chain-of-Thought reasoning. That is, given a problem statement and step-by-step solution in natural language, the aim of the verifier is to output [Yes] if the reasoning steps in the solution are all valid, and [No] otherwise. In this work we give a formal PAC-learning framework for studying this problem. We propose and analyze several natural verification goals, at different levels of strength, in this framework. We provide sample complexity upper-bounds for learning verifiers satisfying these goals, as well as lower-bound and impossibility results for learning other natural verification objectives without additional assumptions.

Visual loop closure detection traditionally relies on place recognition methods to retrieve candidate loops that are validated using computationally expensive RANSAC-based geometric verification. As false positive loop closures significantly degrade downstream pose graph estimates, verifying a large number of candidates in online simultaneous localization and mapping scenarios is constrained by limited time and compute resources. While most deep loop closure detection approaches only operate on pairs of keyframes, we relax this constraint by considering neighborhoods of multiple keyframes when detecting loops. In this work, we introduce LoopGNN, a graph neural network architecture that estimates loop closure consensus by leveraging cliques of visually similar keyframes retrieved through place recognition. By propagating deep feature encodings among nodes of the clique, our method yields high-precision estimates while maintaining high recall. Extensive experimental evaluations on the TartanDrive 2.0 and NCLT datasets demonstrate that LoopGNN outperforms traditional baselines. Additionally, an ablation study across various keypoint extractors demonstrates that our method is robust, regardless of the type of deep feature encodings used, and exhibits higher computational efficiency compared to classical geometric verification baselines. We release our code, supplementary material, and keyframe data at https://loopgnn.cs.uni-freiburg.de.