The development of vaccines and immunotherapies against infectious diseases and cancers has been one of the major achievements of medical science in the last century. Subunit vaccines offer key advantages over whole-inactivated or attenuated-pathogen-based vaccines, as they elicit more specific Band T-cell responses with improved safety. However, developing subunit vaccines is often cost and timeconsuming and may not predict fast, strong, and long-lasting immunity, limiting their ability to rapidly counter apparent growing emerging pandemics and cancers. In the past, the development of vaccines and immunotherapeutics relied heavily on trial-and-error experimentation and extensive in vivo testing, often requiring years of pre-clinical and clinical trials. Today, artificial intelligence (AI) and deep learning (DL) are actively transforming vaccine and immunotherapeutic design, by (i) offering predictive frameworks that support rapid, data-driven decision-making; (ii) increasingly being implemented as time-and resourceefficient strategies that integrate computational models; systems vaccinology and multi-omics data to better phenotype, differentiate, and classify patients diseases and cancers; predict patients' immune responses and identify the factors contributing to optimal vaccine and immunotherapeutic protective efficacy; (iii) refining the selection of Band T-cell antigen/epitope targets to enhance efficacy and durability of immune protection; and (iv) enabling a deeper understanding of immune regulation, immune evasion, immune checkpoints, and regulatory pathways. The future of AI and DL points toward (i) replacing animal preclinical testing of drugs, vaccines, and immunotherapeutics with computational-based models, as recently proposed by the United States FDA; and (ii) enabling real-time in vivo modeling for immunobridging and prediction of protection in clinical trials. This may result in a fast and transformative shift for the development of personal vaccines and immunotherapeutics against infectious pathogens and cancers.

The EUNIS habitat classification is crucial for categorising European habitats, supporting European policy on nature conservation and implementing the Nature Restoration Law. To meet the growing demand for detailed and accurate habitat information, we provide spatial predictions for 260 EUNIS habitat types at hierarchical level 3, together with independent validation and uncertainty analyses. Using ensemble machine learning models, together with high-resolution satellite imagery and ecologically meaningful climatic, topographic and edaphic variables, we produced a European habitat map indicating the most probable EUNIS habitat at 100-m resolution across Europe. Additionally, we provide information on prediction uncertainty and the most probable habitats at level 3 within each EUNIS level 1 formation. This product is particularly useful for both conservation and restoration purposes. Predictions were cross-validated at European scale using a spatial block cross-validation and evaluated against independent data from France (forests only), the Netherlands and Austria. The habitat maps obtained strong predictive performances on the validation datasets with distinct trade-offs in terms of recall and precision across habitat formations.

Chest radiography is widely used in diagnostic imaging. However, perceptual errors -- especially overlooked but visible abnormalities -- remain common and clinically significant. Current workflows and AI systems provide limited support for detecting such errors after interpretation and often lack meaningful human--AI collaboration. We introduce RADAR (Radiologist--AI Diagnostic Assistance and Review), a post-interpretation companion system. RADAR ingests finalized radiologist annotations and CXR images, then performs regional-level analysis to detect and refer potentially missed abnormal regions. The system supports a "second-look" workflow and offers suggested regions of interest (ROIs) rather than fixed labels to accommodate inter-observer variation. We evaluated RADAR on a simulated perceptual-error dataset derived from de-identified CXR cases, using F1 score and Intersection over Union (IoU) as primary metrics. RADAR achieved a recall of 0.78, precision of 0.44, and an F1 score of 0.56 in detecting missed abnormalities in the simulated perceptual-error dataset. Although precision is moderate, this reduces over-reliance on AI by encouraging radiologist oversight in human--AI collaboration. The median IoU was 0.78, with more than 90% of referrals exceeding 0.5 IoU, indicating accurate regional localization. RADAR effectively complements radiologist judgment, providing valuable post-read support for perceptual-error detection in CXR interpretation. Its flexible ROI suggestions and non-intrusive integration position it as a promising tool in real-world radiology workflows. To facilitate reproducibility and further evaluation, we release a fully open-source web implementation alongside a simulated error dataset. All code, data, demonstration videos, and the application are publicly available at https://github.com/avutukuri01/RADAR.

Detecting AI-generated text is a difficult problem to begin with; detecting AI-generated text on social media is made even more difficult due to the short text length and informal, idiosyncratic language of the internet. It is nonetheless important to tackle this problem, as social media represents a significant attack vector in online influence campaigns, which may be bolstered through the use of mass-produced AI-generated posts supporting (or opposing) particular policies, decisions, or events. We approach this problem with the mindset and resources of a reasonably sophisticated threat actor, and create a dataset of 505,159 AI-generated social media posts from a combination of open-source, closed-source, and fine-tuned LLMs, covering 11 different controversial topics. We show that while the posts can be detected under typical research assumptions about knowledge of and access to the generating models, under the more realistic assumption that an attacker will not release their fine-tuned model to the public, detectability drops dramatically. This result is confirmed with a human study. Ablation experiments highlight the vulnerability of various detection algorithms to fine-tuned LLMs. This result has implications across all detection domains, since fine-tuning is a generally applicable and realistic LLM use case.

We present Distill CLIP (DCLIP), a fine-tuned variant of the CLIP model that enhances multimodal image-text retrieval while preserving the original model's strong zero-shot classification capabilities. CLIP models are typically constrained by fixed image resolutions and limited context, which can hinder their effectiveness in retrieval tasks that require fine-grained cross-modal understanding. DCLIP addresses these challenges through a meta teacher-student distillation framework, where a cross-modal transformer teacher is fine-tuned to produce enriched embeddings via bidirectional cross-attention between YOLO-extracted image regions and corresponding textual spans. These semantically and spatially aligned global representations guide the training of a lightweight student model using a hybrid loss that combines contrastive learning and cosine similarity objectives. Despite being trained on only ~67,500 samples curated from MSCOCO, Flickr30k, and Conceptual Captions-just a fraction of CLIP's original dataset-DCLIP significantly improves image-text retrieval metrics (Recall@K, MAP), while retaining approximately 94% of CLIP's zero-shot classification performance. These results demonstrate that DCLIP effectively mitigates the trade-off between task specialization and generalization, offering a resource-efficient, domain-adaptive, and detail-sensitive solution for advanced vision-language tasks. Code available at https://anonymous.4open.science/r/DCLIP-B772/README.md.

Advancements in digitization have enabled two sided manufacturing-as-a-service (MaaS) marketplaces which has significantly reduced product development time for designers. These platforms provide designers with access to manufacturing resources through a network of suppliers and have instant order placement capabilities. Two key decision making levers are typically used to optimize the operations of these marketplaces: pricing and matching. The existing marketplaces operate in a centralized structure where they have complete control over decision making. However, a decentralized organization of the platform enables transparency of information across clients and suppliers. This dissertation focuses on developing tools for decision making enabling decentralization in MaaS marketplaces. In pricing mechanisms, a data driven method is introduced which enables small service providers to price services based on specific attributes of the services offered. A data mining method recommends a network based price to a supplier based on its attributes and the attributes of other suppliers on the platform. Three different approaches are considered for matching mechanisms. First, a reverse auction mechanism is introduced where designers bid for manufacturing services and the mechanism chooses a supplier which can match the bid requirements and stated price. The second approach uses mechanism design and mathematical programming to develop a stable matching mechanism for matching orders to suppliers based on their preferences. Empirical simulations are used to test the mechanisms in a simulated 3D printing marketplace and to evaluate the impact of stability on its performance. The third approach considers the matching problem in a dynamic and stochastic environment where demand (orders) and supply (supplier capacities) arrive over time and matching is performed online.

The game-theoretic notion of the semivalue offers a popular framework for credit attribution and data valuation in machine learning. Semivalues have been proposed for a variety of high-stakes decisions involving data, such as determining contributor compensation, acquiring data from external sources, or filtering out low-value datapoints. In these applications, semivalues depend on the specification of a utility function that maps subsets of data to a scalar score. While it is broadly agreed that this utility function arises from a composition of a learning algorithm and a performance metric, its actual instantiation involves numerous subtle modeling choices. We argue that this underspecification leads to varying degrees of arbitrariness in semivalue-based valuations. Small, but arguably reasonable changes to the utility function can induce substantial shifts in valuations across datapoints. Moreover, these valuation methodologies are also often gameable: low-cost adversarial strategies exist to exploit this ambiguity and systematically redistribute value among datapoints. Through theoretical constructions and empirical examples, we demonstrate that a bad-faith valuator can manipulate utility specifications to favor preferred datapoints, and that a good-faith valuator is left without principled guidance to justify any particular specification. These vulnerabilities raise ethical and epistemic concerns about the use of semivalues in several applications. We conclude by highlighting the burden of justification that semivalue-based approaches place on modelers and discuss important considerations for identifying appropriate uses.

Knowledge graphs (KGs) are useful for analyzing social structures, community dynamics, institutional memberships, and other complex relationships across domains from sociology to public health. While recent advances in large language models (LLMs) have improved the scalability and accessibility of automated KG extraction from large text corpora, the impacts of extraction errors on downstream analyses are poorly understood, especially for applied scientists who depend on accurate KGs for real-world insights. To address this gap, we conducted the first evaluation of KG extraction performance at two levels: (1) micro-level edge accuracy, which is consistent with standard NLP evaluations, and manual identification of common error sources; (2) macro-level graph metrics that assess structural properties such as community detection and connectivity, which are relevant to real-world applications. Focusing on affiliation graphs of person membership in organizations extracted from social register books, our study identifies a range of extraction performance where biases across most downstream graph analysis metrics are near zero. However, as extraction performance declines, we find that many metrics exhibit increasingly pronounced biases, with each metric tending toward a consistent direction of either over- or under-estimation. Through simulations, we further show that error models commonly used in the literature do not capture these bias patterns, indicating the need for more realistic error models for KG extraction. Our findings provide actionable insights for practitioners and underscores the importance of advancing extraction methods and error modeling to ensure reliable and meaningful downstream analyses.

Self-supervised pre-trained audio networks have seen widespread adoption in real-world systems, particularly in multi-modal large language models. These networks are often employed in a frozen state, under the assumption that the self-supervised pre-training has sufficiently equipped them to handle real-world audio. However, a critical question remains: how well do these models actually perform in real-world conditions, where audio is typically polyphonic and complex, involving multiple overlapping sound sources? Current audio self-supervised learning (SSL) methods are often benchmarked on datasets predominantly featuring monophonic audio, such as environmental sounds, and speech. As a result, the ability of SSL models to generalize to polyphonic audio, a common characteristic in natural scenarios, remains underexplored. This limitation raises concerns about the practical robustness of SSL models in more realistic audio settings. To address this gap, we introduce S elf-S upervised L earning from A udio M ixtures (SSLAM), a novel direction in audio SSL research, designed to improve the model's ability to learn from polyphonic data while maintaining strong performance on monophonic data. We thoroughly evaluate SSLAM on standard audio SSL benchmark datasets which are predominantly monophonic and conduct a comprehensive comparative analysis against state-of-the-art (SOT A) methods using a range of high-quality, publicly available polyphonic datasets. SS-LAM not only improves model performance on polyphonic audio, but also maintains or exceeds performance on standard audio SSL benchmarks. Notably, it achieves up to a 3.9% improvement on the AudioSet-2M(AS-2M), reaching a mean average precision (mAP) of 50.2. These results demonstrate SSLAM's effectiveness in both polyphonic and monophonic soundscapes, significantly enhancing the performance of audio SSL models. Code and pre-trained models are available at https://github.com/ta012/SSLAM .

An Advanced Persistent Threat (APT) is a multistage, highly sophisticated, and covert form of cyber threat that gains unauthorized access to networks to either steal valuable data or disrupt the targeted network. These threats often remain undetected for extended periods, emphasizing the critical need for early detection in networks to mitigate potential APT consequences. In this work, we propose a feature selection method for developing a lightweight intrusion detection system capable of effectively identifying APTs at the initial compromise stage. Our approach leverages the XGBoost algorithm and Explainable Artificial Intelligence (XAI), specifically utilizing the SHAP (SHapley Additive exPlanations) method for identifying the most relevant features of the initial compromise stage. The results of our proposed method showed the ability to reduce the selected features of the SCVIC-APT-2021 dataset from 77 to just four while maintaining consistent evaluation metrics for the suggested system. The estimated metrics values are 97% precision, 100% recall, and a 98% F1 score. The proposed method not only aids in preventing successful APT consequences but also enhances understanding of APT behavior at early stages.