Prostate cancer, the second most prevalent male malignancy, requires advanced diagnostic tools. We propose an explainable AI system combining BERT (for textual clinical notes) and Random Forest (for numerical lab data) through a novel multimodal fusion strategy, achieving superior classification performance on PLCO-NIH dataset (98% accuracy, 99% AUC). While multimodal fusion is established, our work demonstrates that a simple yet interpretable BERT+RF pipeline delivers clinically significant improvements - particularly for intermediate cancer stages (Class 2/3 recall: 0.900 combined vs 0.824 numerical/0.725 textual). SHAP analysis provides transparent feature importance rankings, while ablation studies prove textual features' complementary value. This accessible approach offers hospitals a balance of high performance (F1=89%), computational efficiency, and clinical interpretability - addressing critical needs in prostate cancer diagnostics.

In this work, we address the challenge of binary lung nodule classification (benign vs malignant) using CT images by proposing a multi-level attention stacked ensemble of deep neural networks. Three pretrained backbones -- EfficientNet V2 S, MobileViT XXS, and DenseNet201 -- are each adapted with a custom classification head tailored to 96 x 96 pixel inputs. A two-stage attention mechanism learns both model-wise and class-wise importance scores from concatenated logits, and a lightweight meta-learner refines the final prediction. To mitigate class imbalance and improve generalization, we employ dynamic focal loss with empirically calculated class weights, MixUp augmentation during training, and test-time augmentation at inference. Experiments on the LIDC-IDRI dataset demonstrate exceptional performance, achieving 98.09 accuracy and 0.9961 AUC, representing a 35 percent reduction in error rate compared to state-of-the-art methods. The model exhibits balanced performance across sensitivity (98.73) and specificity (98.96), with particularly strong results on challenging cases where radiologist disagreement was high. Statistical significance testing confirms the robustness of these improvements across multiple experimental runs. Our approach can serve as a robust, automated aid for radiologists in lung cancer screening.

Existing threat modeling frameworks related to transportation cyber-physical systems (CPS) are often narrow in scope, labor-intensive, and require substantial cybersecurity expertise. To this end, we introduce the Transportation Cybersecurity and Resiliency Threat Modeling Framework (TraCR-TMF), a large language model (LLM)-based threat modeling framework for transportation CPS that requires limited cybersecurity expert intervention. TraCR-TMF identifies threats, potential attack techniques, and relevant countermeasures for transportation CPS. Three LLM-based approaches support these identifications: (i) a retrieval-augmented generation approach requiring no cybersecurity expert intervention, (ii) an in-context learning approach with low expert intervention, and (iii) a supervised fine-tuning approach with moderate expert intervention. TraCR-TMF offers LLM-based attack path identification for critical assets based on vulnerabilities across transportation CPS entities. Additionally, it incorporates the Common Vulnerability Scoring System (CVSS) scores of known exploited vulnerabilities to prioritize threat mitigations. The framework was evaluated through two cases. First, the framework identified relevant attack techniques for various transportation CPS applications, 73% of which were validated by cybersecurity experts as correct. Second, the framework was used to identify attack paths for a target asset in a real-world cyberattack incident. TraCR-TMF successfully predicted exploitations, like lateral movement of adversaries, data exfiltration, and data encryption for ransomware, as reported in the incident. These findings show the efficacy of TraCR-TMF in transportation CPS threat modeling, while reducing the need for extensive involvement of cybersecurity experts. To facilitate real-world adoptions, all our codes are shared via an open-source repository.

The management of chronic Heart Failure (HF) presents significant challenges in modern healthcare, requiring continuous monitoring, early detection of exacerbations, and personalized treatment strategies. In this paper, we present a predictive model founded on Machine Learning (ML) techniques to identify patients at HF risk. This model is an ensemble learning approach, a modified stacking technique, that uses two specialized models leveraging clinical and echocardiographic features and then a meta-model to combine the predictions of these two models. We initially assess the model on a real dataset and the obtained results suggest that it performs well in the stratification of patients at HR risk. Specifically, we obtained high sensitivity (95\%), ensuring that nearly all high-risk patients are identified. As for accuracy, we obtained 84\%, which can be considered moderate in some ML contexts. However, it is acceptable given our priority of identifying patients at risk of HF because they will be asked to participate in the telemonitoring program of the PrediHealth research project on which some of the authors of this paper are working. The initial findings also suggest that ML-based risk stratification models can serve as valuable decision-support tools not only in the PrediHealth project but also for healthcare professionals, aiding in early intervention and personalized patient management. To have a better understanding of the value and of potentiality of our predictive model, we also contrasted its results with those obtained by using three baseline models. The preliminary results indicate that our predictive model outperforms these baselines that flatly consider features, \ie not grouping them in clinical and echocardiographic features.

The widespread availability of video recording through smartphones and digital devices has made video-based evidence more accessible than ever. Surveillance footage plays a crucial role in security, law enforcement, and judicial processes. However, with the rise of advanced video editing tools, tampering with digital recordings has become increasingly easy, raising concerns about their authenticity. Ensuring the integrity of surveillance videos is essential, as manipulated footage can lead to misinformation and undermine judicial decisions. This paper provides a comprehensive review of existing forensic techniques used to detect video forgery, focusing on their effectiveness in verifying the authenticity of surveillance recordings. Various methods, including compression-based analysis, frame duplication detection, and machine learning-based approaches, are explored. The findings highlight the growing necessity for more robust forensic techniques to counteract evolving forgery methods. Strengthening video forensic capabilities will ensure that surveillance recordings remain credible and admissible as legal evidence.

Machine unlearning enables the removal of specific data from ML models to uphold the right to be forgotten . While approximate unlearning algorithms offer efficient alternatives to full retraining, this work reveals that they fail to adequately protect the privacy of unlearned data. In particular, these algorithms introduce implicit residuals which facilitate privacy attacks targeting at unlearned data. W e observe that these residuals persist regardless of model architectures, parameters, and unlearning algorithms, exposing a new attack surface beyond conventional output-based leakage. Based on this insight, we propose the Reminiscence Attack (ReA), which amplifies the correlation between residuals and membership privacy through targeted fine-tuning processes. ReA achieves up to 1. 90 and 1.12 higher accuracy than prior attacks when inferring class-wise and sample-wise membership, respectively. T o mitigate such residual-induced privacy risk, we develop a dual-phase approximate unlearning framework that first eliminates deep-layer unlearned data traces and then enforces convergence stability to prevent models from "pseudo-convergence", where their outputs are similar to retrained models but still preserve unlearned residuals. Our framework works for both classification and generation tasks. Experimental evaluations confirm that our approach maintains high unlearning efficacy, while reducing the adaptive privacy attack accuracy to nearly random guess, at the computational cost of 2 12% of full retraining from scratch.

Accurate prediction of traffic accident severity is critical for improving road safety, optimizing emergency response strategies, and informing the design of safer transportation infrastructure. However, existing approaches often struggle to effectively model the intricate interdependencies among spatial, temporal, and contextual variables that govern accident outcomes. In this study, we introduce STARN-GAT, a Multi-Modal Spatio-Temporal Graph Attention Network, which leverages adaptive graph construction and modality-aware attention mechanisms to capture these complex relationships. Unlike conventional methods, STARN-GAT integrates road network topology, temporal traffic patterns, and environmental context within a unified attention-based framework. The model is evaluated on the Fatality Analysis Reporting System (FARS) dataset, achieving a Macro F1-score of 85 percent, ROC-AUC of 0.91, and recall of 81 percent for severe incidents. To ensure generalizability within the South Asian context, STARN-GAT is further validated on the ARI-BUET traffic accident dataset, where it attains a Macro F1-score of 0.84, recall of 0.78, and ROC-AUC of 0.89. These results demonstrate the model's effectiveness in identifying high-risk cases and its potential for deployment in real-time, safety-critical traffic management systems. Furthermore, the attention-based architecture enhances interpretability, offering insights into contributing factors and supporting trust in AI-assisted decision-making. Overall, STARN-GAT bridges the gap between advanced graph neural network techniques and practical applications in road safety analytics.

DNA-binding proteins (DBPs) are integral to gene regulation and cellular processes, making their accurate identification essential for understanding biological functions and disease mechanisms. Experimental methods for DBP identification are time-consuming and costly, driving the need for efficient computational prediction techniques. In this study, we propose a novel deep learning framework, ResCap-DBP, that combines a residual learning-based encoder with a one-dimensional Capsule Network (1D-CapsNet) to predict DBPs directly from raw protein sequences. Our architecture incorporates dilated convolutions within residual blocks to mitigate vanishing gradient issues and extract rich sequence features, while capsule layers with dynamic routing capture hierarchical and spatial relationships within the learned feature space. We conducted comprehensive ablation studies comparing global and local embeddings from ProteinBERT and conventional one-hot encoding. Results show that ProteinBERT embeddings substantially outperform other representations on large datasets. Although one-hot encoding showed marginal advantages on smaller datasets, such as PDB186, it struggled to scale effectively. Extensive evaluations on four pairs of publicly available benchmark datasets demonstrate that our model consistently outperforms current state-of-the-art methods. It achieved AUC scores of 98.0% and 89.5% on PDB14189andPDB1075, respectively. On independent test sets PDB2272 and PDB186, the model attained top AUCs of 83.2% and 83.3%, while maintaining competitive performance on larger datasets such as PDB20000. Notably, the model maintains a well balanced sensitivity and specificity across datasets. These results demonstrate the efficacy and generalizability of integrating global protein representations with advanced deep learning architectures for reliable and scalable DBP prediction in diverse genomic contexts.

--How can we identify problematic upstream processes when a certain type of wafer defect starts appearing at a quality checkpoint? Given the complexity of modern semiconductor manufacturing, which involves thousands of process steps, cross-process root cause analysis for wafer defects has been considered highly challenging. This paper proposes a novel framework called Trajectory Shapley Attribution (TSA), an extension of Shapley values (SV), a widely used attribution algorithm in explainable artificial intelligence research. TSA overcomes key limitations of standard SV, including its disregard for the sequential nature of manufacturing processes and its reliance on an arbitrarily chosen reference point. We applied TSA to a good-bad wafer diagnosis task in experimental front-end-of-line processes at the NY CREA TES Albany NanoT ech fab, aiming to identify measurement items (serving as proxies for process parameters) most relevant to abnormal defect occurrence. Root cause analysis (RCA) of wafer defects is a key challenge throughout all stages of semiconductor manufacturing, from process integration to high-volume production.

Causal discovery from observational data is challenging, especially with large datasets and complex relationships. Traditional methods often struggle with scalability and capturing global structural information. To overcome these limitations, we introduce a novel graph neural network (GNN)-based probabilistic framework that learns a probability distribution over the entire space of causal graphs, unlike methods that output a single deterministic graph. Our framework leverages a GNN that encodes both node and edge attributes into a unified graph representation, enabling the model to learn complex causal structures directly from data. The GNN model is trained on a diverse set of synthetic datasets augmented with statistical and information-theoretic measures, such as mutual information and conditional entropy, capturing both local and global data properties. We frame causal discovery as a supervised learning problem, directly predicting the entire graph structure. Our approach demonstrates superior performance, outperforming both traditional and recent non-GNN-based methods, as well as a GNN-based approach, in terms of accuracy and scalability on synthetic and real-world datasets without further training. This probabilistic framework significantly improves causal structure learning, with broad implications for decision-making and scientific discovery across various fields.