Operationalizing the EU AI Act requires clear technical documentation to ensure AI systems are transparent, traceable, and accountable. Existing documentation templates for AI systems do not fully cover the entire AI lifecycle while meeting the technical documentation requirements of the AI Act. This paper addresses those shortcomings by introducing open-source templates and examples for documenting data, models, and applications to provide sufficient documentation for certifying compliance with the AI Act. These templates track the system's status over the entire AI lifecycle, ensuring traceability, reproducibility, and compliance with the AI Act. They also promote discoverability and collaboration, reduce risks, and align with best practices in AI documentation and governance. The templates are evaluated and refined based on user feedback to enable insights into their usability and implementabil-ity. We then validate the approach on real-world scenarios, providing examples that further guide their implementation: the data template is followed to document a skin tones dataset created to support fairness evaluations of downstream computer vision models and human-centric applications; the model template is followed to document a neural network for segmenting human silhouettes in photos. The application template is tested on a system deployed for construction site safety using real-time video analytics and sensor data. Our results show that TechOps can serve as a practical tool to enable oversight for regulatory compliance and responsible AI development.

In digital substations, security events pose significant challenges to the sustained operation of power systems. To mitigate these challenges, the implementation of robust defense strategies is critically important. A thorough process of anomaly identification and detection in information and communication technology (ICT) frameworks is crucial to ensure secure and reliable communication and coordination between interconnected devices within digital substations. Hence, this paper addresses the critical cybersecurity challenges confronting IEC61850-based digital substations within modern smart grids, where the integration of advanced communication protocols, e.g., generic object-oriented substation event (GOOSE), has enhanced energy management and introduced significant vulnerabilities to cyberattacks. Focusing on the limitations of traditional anomaly detection systems (ADSs) in detecting threats, this research proposes a transformative approach by leveraging generative AI (GenAI) to develop robust ADSs. The primary contributions include the suggested advanced adversarial traffic mutation (AATM) technique to generate synthesized and balanced datasets for GOOSE messages, ensuring protocol compliance and enabling realistic zero-day attack pattern creation to address data scarcity. Then, the implementation of GenAI-based ADSs incorporating the task-oriented dialogue (ToD) processes has been explored for improved detection of attack patterns. Finally, a comparison of the GenAI-based ADS with machine learning (ML)-based ADSs has been implemented to showcase the outperformance of the GenAI-based frameworks considering the AATM-generated GOOSE datasets and standard/advanced performance evaluation metrics.

Advances in large language models (LLMs) have enabled a wide range of applications. However, depression prediction is hindered by the lack of large-scale, high-quality, and rigorously annotated datasets. This study introduces DepressLLM, trained and evaluated on a novel corpus of 3,699 autobiographical narratives reflecting both happiness and distress. DepressLLM provides interpretable depression predictions and, via its Score-guided Token Probability Summation (SToPS) module, delivers both improved classification performance and reliable confidence estimates, achieving an AUC of 0.789, which rises to 0.904 on samples with confidence $\geq$ 0.95. To validate its robustness to heterogeneous data, we evaluated DepressLLM on in-house datasets, including an Ecological Momentary Assessment (EMA) corpus of daily stress and mood recordings, and on public clinical interview data. Finally, a psychiatric review of high-confidence misclassifications highlighted key model and data limitations that suggest directions for future refinements. These findings demonstrate that interpretable AI can enable earlier diagnosis of depression and underscore the promise of medical AI in psychiatry.

--Access to real-world medical data is often restricted due to privacy regulations, posing a significant barrier to the advancement of healthcare research. Synthetic data offers a promising alternative; however, generating realistic, clinically valid, and privacy-conscious records remains a major challenge. Recent advancements in Large Language Models (LLMs) offer new opportunities for structured data generation; however, existing approaches frequently lack systematic prompting strategies and comprehensive, multi-dimensional evaluation frameworks. In this paper, we present SynLLM, a modular framework for generating high-quality synthetic medical tabular data using 20 state-of-the-art open-source LLMs, including LLaMA, Mistral, and GPT variants, guided by structured prompts. We propose four distinct prompt types, ranging from example-driven to rule-based constraints, that encode schema, metadata, and domain knowledge to control generation without model fine-tuning. Our framework features a comprehensive evaluation pipeline that rigorously assesses generated data across statistical fidelity, clinical consistency, and privacy preservation. We evaluate SynLLM across three public medical datasets, including Diabetes, Cirrhosis, and Stroke, using 20 open-source LLMs. Our results show that prompt engineering significantly impacts data quality and privacy risk, with rule-based prompts achieving the best privacy-quality balance. SynLLM establishes that, when guided by well-designed prompts and evaluated with robust, multi-metric criteria, LLMs can generate synthetic medical data that is both clinically plausible and privacy-aware, paving the way for safer and more effective data sharing in healthcare research. Access to real-world medical data is frequently restricted due to privacy regulations, ethical constraints, and institutional barriers, posing a significant challenge for the development of AI-driven healthcare solutions. While data protection laws such as the Health Insurance Portability and Accountability Act (HIP AA) [11] and the General Data Protection Regulation (GDPR) [37] are essential for safeguarding patient confidentiality, they often hinder the availability of data for clinical model development and research.

Liver cancer is one of the most prevalent and lethal forms of cancer, making early detection crucial for effective treatment. This paper introduces a novel approach for automated liver tumor segmentation in computed tomography (CT) images by integrating a 3D U-Net architecture with the Bat Algorithm for hyperparameter optimization. The method enhances segmentation accuracy and robustness by intelligently optimizing key parameters like the learning rate and batch size. Evaluated on a publicly available dataset, our model demonstrates a strong ability to balance precision and recall, with a high F1-score at lower prediction thresholds. This is particularly valuable for clinical diagnostics, where ensuring no potential tumors are missed is paramount. Our work contributes to the field of medical image analysis by demonstrating that the synergy between a robust deep learning architecture and a metaheuristic optimization algorithm can yield a highly effective solution for complex segmentation tasks.

Robot-assisted neurological surgery is receiving growing interest due to the improved dexterity, precision, and control of surgical tools, which results in better patient outcomes. However, such systems often limit surgeons' natural sensory feedback, which is crucial in identifying tissues -- particularly in oncological procedures where distinguishing between healthy and tumorous tissue is vital. While imaging and force sensing have addressed the lack of sensory feedback, limited research has explored multimodal sensing options for accurate tissue boundary delineation. We present a user-friendly, modular test bench designed to evaluate and integrate complementary multimodal sensors for tissue identification. Our proposed system first uses vision-based guidance to estimate boundary locations with visual cues, which are then refined using data acquired by contact microphones and a force sensor. Real-time data acquisition and visualization are supported via an interactive graphical interface. Experimental results demonstrate that multimodal fusion significantly improves material classification accuracy. The platform provides a scalable hardware-software solution for exploring sensor fusion in surgical applications and demonstrates the potential of multimodal approaches in real-time tissue boundary delineation.

Developers insert logging statements in source code to capture relevant runtime information essential for maintenance and debugging activities. Log level choice is an integral, yet tricky part of the logging activity as it controls log verbosity and therefore influences systems' observability and performance. Recent advances in ML-based log level prediction have leveraged large language models (LLMs) to propose log level predictors (LLPs) that demonstrated promising performance improvements (AUC between 0.64 and 0.8). Nevertheless, current LLM-based LLPs rely on randomly selected in-context examples, overlooking the structure and the diverse logging practices within modern software projects. In this paper, we propose OmniLLP, a novel LLP enhancement framework that clusters source files based on (1) semantic similarity reflecting the code's functional purpose, and (2) developer ownership cohesion. By retrieving in-context learning examples exclusively from these semantic and ownership aware clusters, we aim to provide more coherent prompts to LLPs leveraging LLMs, thereby improving their predictive accuracy. Our results show that both semantic and ownership-aware clusterings statistically significantly improve the accuracy (by up to 8\% AUC) of the evaluated LLM-based LLPs compared to random predictors (i.e., leveraging randomly selected in-context examples from the whole project). Additionally, our approach that combines the semantic and ownership signal for in-context prediction achieves an impressive 0.88 to 0.96 AUC across our evaluated projects. Our findings highlight the value of integrating software engineering-specific context, such as code semantic and developer ownership signals into LLM-LLPs, offering developers a more accurate, contextually-aware approach to logging and therefore, enhancing system maintainability and observability.

Machine learning (ML) systems are increasingly deployed in high-stakes domains where reliability is paramount. This thesis investigates how uncertainty estimation can enhance the safety and trustworthiness of ML, focusing on selective prediction -- where models abstain when confidence is low. We first show that a model's training trajectory contains rich uncertainty signals that can be exploited without altering its architecture or loss. By ensembling predictions from intermediate checkpoints, we propose a lightweight, post-hoc abstention method that works across tasks, avoids the cost of deep ensembles, and achieves state-of-the-art selective prediction performance. Crucially, this approach is fully compatible with differential privacy (DP), allowing us to study how privacy noise affects uncertainty quality. We find that while many methods degrade under DP, our trajectory-based approach remains robust, and we introduce a framework for isolating the privacy-uncertainty trade-off. Next, we then develop a finite-sample decomposition of the selective classification gap -- the deviation from the oracle accuracy-coverage curve -- identifying five interpretable error sources and clarifying which interventions can close the gap. This explains why calibration alone cannot fix ranking errors, motivating methods that improve uncertainty ordering. Finally, we show that uncertainty signals can be adversarially manipulated to hide errors or deny service while maintaining high accuracy, and we design defenses combining calibration audits with verifiable inference. Together, these contributions advance reliable ML by improving, evaluating, and safeguarding uncertainty estimation, enabling models that not only make accurate predictions -- but also know when to say "I do not know".

Federated learning has emerged as an essential paradigm for distributed multi-source data analysis under privacy concerns. Most existing federated learning methods focus on the ``static" datasets. However, in many real-world applications, data arrive continuously over time, forming streaming datasets. This introduces additional challenges for data storage and algorithm design, particularly under high-dimensional settings. In this paper, we propose a federated online learning (FOL) method for distributed multi-source streaming data analysis. To account for heterogeneity, a personalized model is constructed for each data source, and a novel ``subgroup" assumption is employed to capture potential similarities, thereby enhancing model performance. We adopt the penalized renewable estimation method and the efficient proximal gradient descent for model training. The proposed method aligns with both federated and online learning frameworks: raw data are not exchanged among sources, ensuring data privacy, and only summary statistics of previous data batches are required for model updates, significantly reducing storage demands. Theoretically, we establish the consistency properties for model estimation, variable selection, and subgroup structure recovery, demonstrating optimal statistical efficiency. Simulations illustrate the effectiveness of the proposed method. Furthermore, when applied to the financial lending data and the web log data, the proposed method also exhibits advantageous prediction performance. Results of the analysis also provide some practical insights.

Integrating multi-omics data, such as DNA methylation, mRNA expression, and microRNA (miRNA) expression, offers a comprehensive view of the biological mechanisms underlying disease. However, the high dimensionality and complex interactions among omics layers present major challenges for predictive modeling. We propose Multi-Omics integration with Tree-generated Graph Neural Network (MOTGNN), a novel and interpretable framework for binary disease classification. MOTGNN employs eXtreme Gradient Boosting (XGBoost) to perform omics-specific supervised graph construction, followed by modality-specific Graph Neural Networks (GNNs) for hierarchical representation learning, and a deep feedforward network for cross-omics integration. On three real-world disease datasets, MOTGNN outperforms state-of-the-art baselines by 5-10% in accuracy, ROC-AUC, and F1-score, and remains robust to severe class imbalance (e.g., 87.2% vs. 33.4% F1 on imbalanced data). The model maintains computational efficiency through sparse graphs (2.1-2.8 edges per node) and provides built-in interpretability, revealing both top-ranked biomarkers and the relative contributions of each omics modality. These results highlight MOTGNN's potential to improve both predictive accuracy and interpretability in multi-omics disease modeling.