Static feature exclusion strategies often fail to prevent bias when hidden dependencies influence the model predictions. To address this issue, we explore a reinforcement learning (RL) framework that integrates bias mitigation and automated feature selection within a single learning process. Unlike traditional heuristic-driven filter or wrapper approaches, our RL agent adaptively selects features using a reward signal that explicitly integrates predictive performance with fairness considerations. This dynamic formulation allows the model to balance generalization, accuracy, and equity throughout the training process, rather than rely exclusively on pre-processing adjustments or post hoc correction mechanisms. In this paper, we describe the construction of a multi-component reward function, the specification of the agents action space over feature subsets, and the integration of this system with ensemble learning. We aim to provide a flexible and generalizable way to select features in environments where predictors are correlated and biases can inadvertently re-emerge.

Outlier detection in tabular data is crucial for safeguarding data integrity in high-stakes domains such as cybersecurity, financial fraud detection, and healthcare, where anomalies can cause serious operational and economic impacts. Despite advances in both data mining and deep learning, many existing methods struggle with mixed-type tabular data, often relying on encoding schemes that lose important semantic information. Moreover, they frequently lack interpretability, offering little insight into which specific values cause anomalies. To overcome these challenges, we introduce \textsf{\textbf{RFOD}}, a novel \textsf{\textbf{R}}andom \textsf{\textbf{F}}orest-based \textsf{\textbf{O}}utlier \textsf{\textbf{D}}etection framework tailored for tabular data. Rather than modeling a global joint distribution, \textsf{RFOD} reframes anomaly detection as a feature-wise conditional reconstruction problem, training dedicated random forests for each feature conditioned on the others. This design robustly handles heterogeneous data types while preserving the semantic integrity of categorical features. To further enable precise and interpretable detection, \textsf{RFOD} combines Adjusted Gower's Distance (AGD) for cell-level scoring, which adapts to skewed numerical data and accounts for categorical confidence, with Uncertainty-Weighted Averaging (UWA) to aggregate cell-level scores into robust row-level anomaly scores. Extensive experiments on 15 real-world datasets demonstrate that \textsf{RFOD} consistently outperforms state-of-the-art baselines in detection accuracy while offering superior robustness, scalability, and interpretability for mixed-type tabular data.

Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting 35% of extremely low birth weight infants. Defined by oxygen dependence at 36 weeks postmenstrual age, it causes lifelong respiratory complications. However, preventive interventions carry severe risks, including neurodevelopmental impairment, ventilator-induced lung injury, and systemic complications. Therefore, early BPD prognosis and prediction of BPD outcome is crucial to avoid unnecessary toxicity in low risk infants. Admission radiographs of extremely preterm infants are routinely acquired within 24h of life and could serve as a non-invasive prognostic tool. In this work, we developed and investigated a deep learning approach using chest X-rays from 163 extremely low-birth-weight infants ($\leq$32 weeks gestation, 401-999g) obtained within 24 hours of birth. We fine-tuned a ResNet-50 pretrained specifically on adult chest radiographs, employing progressive layer freezing with discriminative learning rates to prevent overfitting and evaluated a CutMix augmentation and linear probing. For moderate/severe BPD outcome prediction, our best performing model with progressive freezing, linear probing and CutMix achieved an AUROC of 0.78 $\pm$ 0.10, balanced accuracy of 0.69 $\pm$ 0.10, and an F1-score of 0.67 $\pm$ 0.11. In-domain pre-training significantly outperformed ImageNet initialization (p = 0.031) which confirms domain-specific pretraining to be important for BPD outcome prediction. Routine IRDS grades showed limited prognostic value (AUROC 0.57 $\pm$ 0.11), confirming the need of learned markers. Our approach demonstrates that domain-specific pretraining enables accurate BPD prediction from routine day-1 radiographs. Through progressive freezing and linear probing, the method remains computationally feasible for site-level implementation and future federated learning deployments.

Dynamical systems in the life sciences are often composed of complex mixtures of overlapping behavioral regimes. Cellular subpopulations may shift from cycling to equilibrium dynamics or branch towards different developmental fates. The transitions between these regimes can appear noisy and irregular, posing a serious challenge to traditional, flow-based modeling techniques which assume locally smooth dynamics. To address this challenge, we propose MODE (Mixture Of Dynamical Experts), a graphical modeling framework whose neural gating mechanism decomposes complex dynamics into sparse, interpretable components, enabling both the unsupervised discovery of behavioral regimes and accurate long-term forecasting across regime transitions. Crucially, because agents in our framework can jump to different governing laws, MODE is especially tailored to the aforementioned noisy transitions. We evaluate our method on a battery of synthetic and real datasets from computational biology. First, we systematically benchmark MODE on an unsupervised classification task using synthetic dynamical snapshot data, including in noisy, few-sample settings. Next, we show how MODE succeeds on challenging forecasting tasks which simulate key cycling and branching processes in cell biology. Finally, we deploy our method on human, single-cell RNA sequencing data and show that it can not only distinguish proliferation from differentiation dynamics but also predict when cells will commit to their ultimate fate, a key outstanding challenge in computational biology.

Kidneys are the filter of the human body. About 10% of the global population is thought to be affected by Chronic Kidney Disease (CKD), which causes kidney function to decline. To protect in danger patients from additional kidney damage, effective risk evaluation of CKD and appropriate CKD monitoring are crucial. Due to quick and precise detection capabilities, Machine Learning models can help practitioners accomplish this goal efficiently; therefore, an enormous number of diagnosis systems and processes in the healthcare sector nowadays are relying on machine learning due to its disease prediction capability. In this study, we designed and suggested disease predictive computer-aided designs for the diagnosis of CKD. The dataset for CKD is attained from the repository of machine learning of UCL, with a few missing values; those are filled in using "mean-mode" and "Random sampling method" strategies. After successfully achieving the missing data, eight ML techniques (Random Forest, SVM, Naive Bayes, Logistic Regression, KNN, XGBoost, Decision Tree, and AdaBoost) were used to establish models, and the performance evaluation comparisons among the result accuracies are measured by the techniques to find the machine learning models with the highest accuracy. Among them, Random Forest as well as Logistic Regression showed an outstanding 99% accuracy, followed by the Ada Boost, XGBoost, Naive Bayes, Decision Tree, and SVM, whereas the KNN classifier model stands last with an accuracy of 73%.

We present CLARITY (Clinical Assistant for Routing, Inference and Triage), an AI-driven platform designed to facilitate patient-to-specialist routing, clinical consultations, and severity assessment of patient conditions. Its hybrid architecture combines a Finite State Machine (FSM) for structured dialogue flows with collaborative agents that employ Large Language Model (LLM) to analyze symptoms and prioritize referrals to appropriate specialists. Built on a modular microservices framework, CLARITY ensures safe, efficient, and robust performance, flexible and readily scalable to meet the demands of existing workflows and IT solutions in healthcare. We report integration of our clinical assistant into a large-scale national interhospital platform, with more than 55,000 content-rich user dialogues completed within the two months of deployment, 2,500 of which were expert-annotated for subsequent validation. The validation results show that CLARITY surpasses human-level performance in terms of the first-attempt routing precision, naturally requiring up to 3 times shorter duration of the consultation than with a human.

Causal discovery for dynamical systems poses a major challenge in fields where active interventions are infeasible. Most methods used to investigate these systems and their associated benchmarks are tailored to deterministic, low-dimensional and weakly nonlinear time-series data. To address these limitations, we present CausalDynamics, a large-scale benchmark and extensible data generation framework to advance the structural discovery of dynamical causal models. Our benchmark consists of true causal graphs derived from thousands of both linearly and nonlinearly coupled ordinary and stochastic differential equations as well as two idealized climate models. We perform a comprehensive evaluation of state-of-the-art causal discovery algorithms for graph reconstruction on systems with noisy, confounded, and lagged dynamics. CausalDynamics consists of a plug-and-play, build-your-own coupling workflow that enables the construction of a hierarchy of physical systems. We anticipate that our framework will facilitate the development of robust causal discovery algorithms that are broadly applicable across domains while addressing their unique challenges. We provide a user-friendly implementation and documentation on https://kausable.github.io/CausalDynamics.

Concerning machine learning, segmentation models can identify state changes within time series, facilitating the detection of transitions between normal and anomalous conditions. Specific techniques such as Change Point Detection (CPD), particularly algori thms like ChangeFinder, have been successfully applied to segment time series and improve anomaly detection by reducing temporal uncertainty, especially in multivariate environments. In this work, we explored how the integration of segmentation techniques, combined with a heterogeneous ensemble, can enhance anomaly detection in an industrial production context. The results show that applying segmentation as a pre - processing step before selecting heterogeneous ensemble algorithms provided a significant adva ntage in our case study, improving the AUC - ROC metric from 0.8599 (achieved with a PCA and LSTM ensemble) to 0.9760 (achieved with Random Forest and XGBoost). This improvement is imputable to the ability of segmentation to reduce temporal ambiguity and fac ilitate the learning process of supervised algorithms. In our future work, we intend to assess the benefit of introducing weighted features derived from the study of change points, combined with segmentation and the use of heterogeneous ensembles, to furt her optimize model performance in early anomaly detection. I n recent years, anomaly detection in time series has become a critical issue in the industrial context.

Peer review is the cornerstone of scientific publishing, yet it suffers from inconsistencies, reviewer subjectivity, and scalability challenges. We introduce ReviewerToo, a modular framework for studying and deploying AI-assisted peer review to complement human judgment with systematic and consistent assessments. ReviewerToo supports systematic experiments with specialized reviewer personas and structured evaluation criteria, and can be partially or fully integrated into real conference workflows. We validate ReviewerToo on a carefully curated dataset of 1,963 paper submissions from ICLR 2025, where our experiments with the gpt-oss-120b model achieves 81.8% accuracy for the task of categorizing a paper as accept/reject compared to 83.9% for the average human reviewer. Additionally, ReviewerToo-generated reviews are rated as higher quality than the human average by an LLM judge, though still trailing the strongest expert contributions. Our analysis highlights domains where AI reviewers excel (e.g., fact-checking, literature coverage) and where they struggle (e.g., assessing methodological novelty and theoretical contributions), underscoring the continued need for human expertise. Based on these findings, we propose guidelines for integrating AI into peer-review pipelines, showing how AI can enhance consistency, coverage, and fairness while leaving complex evaluative judgments to domain experts. Our work provides a foundation for systematic, hybrid peer-review systems that scale with the growth of scientific publishing.

The increasing adoption of LLM agents with access to numerous tools and sensitive data significantly widens the attack surface for indirect prompt injections. Due to the context-dependent nature of attacks, however, current defenses are often ill-calibrated as they cannot reliably differentiate malicious and benign instructions, leading to high false positive rates that prevent their real-world adoption. To address this, we present a novel approach inspired by the fundamental principle of computer security: data should not contain executable instructions. Instead of sample-level classification, we propose a token-level sanitization process, which surgically removes any instructions directed at AI systems from tool outputs, capturing malicious instructions as a byproduct. In contrast to existing safety classifiers, this approach is non-blocking, does not require calibration, and is agnostic to the context of tool outputs. Further, we can train such token-level predictors with readily available instruction-tuning data only, and don't have to rely on unrealistic prompt injection examples from challenges or of other synthetic origin. In our experiments, we find that this approach generalizes well across a wide range of attacks and benchmarks like AgentDojo, BIPIA, InjecAgent, ASB and SEP, achieving a 7-10x reduction of attack success rate (ASR) (34% to 3% on AgentDojo), without impairing agent utility in both benign and malicious settings.