The mortality related to cervical cancer can be substantially reduced throughearly detection and treatment. However, current detection techniques, such as Pap smear and colposcopy, fail to achieve a concurrently high sensitivity and specificity. In vivo fluorescence spectroscopy is a technique which quickly, noninvasively andquantitatively probes the biochemical and morphological changes that occur in precancerous tissue. RBF ensemble algorithms based on such spectra provide automated, and near realtime implementationof pre-cancer detection in the hands of nonexperts. Theresults are more reliable, direct and accurate than those achieved by either human experts or multivariate statistical algorithms. 1 Introduction Cervical carcinoma is the second most common cancer in women worldwide, exceeded onlyby breast cancer (Ramanujam et al., 1996). The mortality related to cervical cancer can be reduced if this disease is detected at the precancerous state, known as squamous intraepitheliallesion (SIL).

Predictions oflifetimes of dynamically allocated objects can be used to improve time and space efficiency of dynamic memory management incomputer programs. Barrett and Zorn [1993] used a simple lifetime predictor and demonstrated this improvement on a variety of computer programs. In this paper, we use decision trees to do lifetime prediction on the same programs and show significantly better prediction. Our method also has the advantage that during training we can use a large number of features and let the decision tree automatically choose the relevant subset.

This paper describes a new technique for object recognition based on learning appearance models. The image is decomposed into local regions which are described by a new texture representation called "Generalized Second Moments" thatare derived from the output of multiscale, multiorientation filter banks. Class-characteristic local texture features and their global composition is learned by a hierarchical mixture of experts architecture (Jordan & Jacobs). The technique is applied to a vehicle database consisting of 5 general car categories (Sedan, Van with backdoors, Van without backdoors, old Sedan, and Volkswagen Bug). This is a difficult problem with considerable in-class variation. The new technique has a 6.5% misclassification rate, compared to eigen-images which give 17.4% misclassification rate, and nearest neighbors which give 15 .7%

Machine-learning research has been making great progress in many directions. This article summarizes four of these directions and discusses some current open problems. The four directions are (1) the improvement of classification accuracy by learning ensembles of classifiers, (2) methods for scaling up supervised learning algorithms, (3) reinforcement learning, and (4) the learning of complex stochastic models.

Instance-based learning techniques typically handle continuous and linear input values well, but often do not handle nominal input attributes appropriately. The Value Difference Metric (VDM) was designed to find reasonable distance values between nominal attribute values, but it largely ignores continuous attributes, requiring discretization to map continuous values into nominal values. This paper proposes three new heterogeneous distance functions, called the Heterogeneous Value Difference Metric (HVDM), the Interpolated Value Difference Metric (IVDM), and the Windowed Value Difference Metric (WVDM). These new distance functions are designed to handle applications with nominal attributes, continuous attributes, or both. In experiments on 48 applications the new distance metrics achieve higher classification accuracy on average than three previous distance functions on those datasets that have both nominal and continuous attributes.

Most current methods for prediction of protein secondary structure use a small window of the protein sequence to predict the structure of the central amino acid. We describe a new method for prediction of the non-local structure called,8-sheet, which consists of two or more,8-strands that are connected by hydrogen bonds. Since,8-strands are often widely separated in the protein chain, a network with two windows is introduced. After training on a set of proteins the network predicts the sheets well, but there are many false positives. By using a global energy function the,8-sheet prediction is combined with a local prediction of the three secondary structures a-helix,,8-strand and coil.

Central to the performance improvement of a committee relative to individual networks is the error correlation between networks in the committee. We investigated methods of achieving error independence between the networks by training the networks with different resampling sets from the original training set. The methods were tested on the sinwave artificial task and the real-world problems of hepatoma (liver cancer) and breast cancer diagnoses.

We present a neural network-based face detection system. A retinally connected neural network examines small windows of an image, and decides whether each window contains a face. The system arbitrates between multiple networks to improve performance over a single network. We use a bootstrap algorithm for training, which adds false detections into the training set as training progresses. This eliminates the difficult task of manually selecting non-face training examples, which must be chosen to span the entire space of non-face images.

We define a Gamma multi-layer perceptron (MLP) as an MLP with the usual synaptic weights replaced by gamma filters (as proposed by de Vries and Principe (de Vries and Principe, 1992)) and associated gain terms throughout all layers. We derive gradient descent update equations and apply the model to the recognition of speech phonemes. We find that both the inclusion of gamma filters in all layers, and the inclusion of synaptic gains, improves the performance of the Gamma MLP. We compare the Gamma MLP with TDNN, Back-Tsoi FIR MLP, and Back-Tsoi I1R MLP architectures, and a local approximation scheme. We find that the Gamma MLP results in an substantial reduction in error rates.

We work in a setting in which we must choose the right number of parameters for a hypothesis function in response to a finite training sample, with the goal of minimizing the resulting generalization error. There is a large and interesting literature on cross validation methods, which often emphasizes asymptotic statistical properties, or the exact calculation of the generalization error for simple models. Our approach here is somewhat different, and is pri mari I y inspired by two sources. The first is the work of Barron and Cover [2], who introduced the idea of bounding the error of a model selection method (in their case, the Minimum Description Length Principle) in terms of a quantity known as the index of resolvability. The second is the work of Vapnik [5], who provided extremely powerful and general tools for uniformly bounding the deviations between training and generalization errors. We combine these methods to give a new and general analysis of cross validation performance. In the first and more formal part of the paper, we give a rigorous bound on the error of cross validation in terms of two parameters of the underlying model selection problem: the approximation rate and the estimation rate. In the second and more experimental part of the paper, we investigate the implications of our bound for choosing'Y, the fraction of data withheld for testing in cross validation. The most interesting aspect of this analysis is the identification of several qualitative properties of the optimal'Y that appear to be invariant over a wide class of model selection problems: - When the target function complexity is small compared to the sample size, the performance of cross validation is relatively insensitive to the choice of'Y.