Learning from electronic medical records (EMR) is challenging due to their relational nature and the uncertain dependence between a patient's past and future health status. Statistical relational learning is a natural fit for analyzing EMRs but is less adept at handling their inherent latent structure, such as connections between related medications or diseases. One way to capture the latent structure is via a relational clustering of objects. We propose a novel approach that, instead of pre-clustering the objects, performs a demand-driven clustering during learning. We evaluate our algorithm on three real-world tasks where the goal is to use EMRs to predict whether a patient will have an adverse reaction to a medication. We find that our approach is more accurate than performing no clustering, pre-clustering, and using expert-constructed medical heterarchies.

In this paper we consider the problem of Gaussian process classifier (GPC) model selection with different Leave-One-Out (LOO) Cross Validation (CV) based optimization criteria and provide a practical algorithm using LOO predictive distributions with such criteria to select hyperparameters. Apart from the standard average negative logarithm of predictive probability (NLP), we also consider smoothed versions of criteria such as F-measure and Weighted Error Rate (WER), which are useful for handling imbalanced data. Unlike the regression case, LOO predictive distributions for the classifier case are intractable. We use approximate LOO predictive distributions arrived from Expectation Propagation (EP) approximation. We conduct experiments on several real world benchmark datasets. When the NLP criterion is used for optimizing the hyperparameters, the predictive approaches show better or comparable NLP generalization performance with existing GPC approaches. On the other hand, when the F-measure criterion is used, the F-measure generalization performance improves significantly on several datasets. Overall, the EP-based predictive algorithm comes out as an excellent choice for GP classifier model selection with different optimization criteria.

Ranking objects is a simple and natural procedure for organizing data. It is often performed by assigning a quality score to each object according to its relevance to the problem at hand. Ranking is widely used for object selection, when resources are limited and it is necessary to select a subset of most relevant objects for further processing. In real world situations, the object's scores are often calculated from noisy measurements, casting doubt on the ranking reliability. We introduce an analytical method for assessing the influence of noise levels on the ranking reliability. We use two similarity measures for reliability evaluation, Top-K-List overlap and Kendall's tau measure, and show that the former is much more sensitive to noise than the latter. We apply our method to gene selection in a series of microarray experiments of several cancer types. The results indicate that the reliability of the lists obtained from these experiments is very poor, and that experiment sizes which are necessary for attaining reasonably stable Top-K-Lists are much larger than those currently available. Simulations support our analytical results.

In real-world classification problems, the class balance in the training dataset does not necessarily reflect that of the test dataset, which can cause significant estimation bias. If the class ratio of the test dataset is known, instance re-weighting or resampling allows systematical bias correction. However, learning the class ratio of the test dataset is challenging when no labeled data is available from the test domain. In this paper, we propose to estimate the class ratio in the test dataset by matching probability distributions of training and test input data. We demonstrate the utility of the proposed approach through experiments.

This paper addresses the problem of inferring a regular expression from a given set of strings that resembles, as closely as possible, the regular expression that a human expert would have written to identify the language. This is motivated by our goal of automating the task of postmasters of an email service who use regular expressions to describe and blacklist email spam campaigns. Training data contains batches of messages and corresponding regular expressions that an expert postmaster feels confident to blacklist. We model this task as a learning problem with structured output spaces and an appropriate loss function, derive a decoder and the resulting optimization problem, and a report on a case study conducted with an email service.

Much of current machine learning (ML) research has lost its connection to problems of import to the larger world of science and society. From this perspective, there exist glaring limitations in the data sets we investigate, the metrics we employ for evaluation, and the degree to which results are communicated back to their originating domains. What changes are needed to how we conduct research to increase the impact that ML has? We present six Impact Challenges to explicitly focus the field?s energy and attention, and we discuss existing obstacles that must be addressed. We aim to inspire ongoing discussion and focus on ML that matters.

Positive definite operator-valued kernels generalize the well-known notion of reproducing kernels, and are naturally adapted to multi-output learning situations. This paper addresses the problem of learning a finite linear combination of infinite-dimensional operator-valued kernels which are suitable for extending functional data analysis methods to nonlinear contexts. We study this problem in the case of kernel ridge regression for functional responses with an lr-norm constraint on the combination coefficients. The resulting optimization problem is more involved than those of multiple scalar-valued kernel learning since operator-valued kernels pose more technical and theoretical issues. We propose a multiple operator-valued kernel learning algorithm based on solving a system of linear operator equations by using a block coordinatedescent procedure. We experimentally validate our approach on a functional regression task in the context of finger movement prediction in brain-computer interfaces.

Traditional multi-view learning approaches suffer in the presence of view disagreement,i.e., when samples in each view do not belong to the same class due to view corruption, occlusion or other noise processes. In this paper we present a multi-view learning approach that uses a conditional entropy criterion to detect view disagreement. Once detected, samples with view disagreement are filtered and standard multi-view learning methods can be successfully applied to the remaining samples. Experimental evaluation on synthetic and audio-visual databases demonstrates that the detection and filtering of view disagreement considerably increases the performance of traditional multi-view learning approaches.

Confidence measures for the generalization error are crucial when small training samples are used to construct classifiers. A common approach is to estimate the generalization error by resampling and then assume the resampled estimator follows a known distribution to form a confidence set [Kohavi 1995, Martin 1996,Yang 2006]. Alternatively, one might bootstrap the resampled estimator of the generalization error to form a confidence set. Unfortunately, these methods do not reliably provide sets of the desired confidence. The poor performance appears to be due to the lack of smoothness of the generalization error as a function of the learned classifier. This results in a non-normal distribution of the estimated generalization error. We construct a confidence set for the generalization error by use of a smooth upper bound on the deviation between the resampled estimate and generalization error. The confidence set is formed by bootstrapping this upper bound. In cases in which the approximation class for the classifier can be represented as a parametric additive model, we provide a computationally efficient algorithm. This method exhibits superior performance across a series of test and simulated data sets.

We derive a novel norm that corresponds to the tightest convex relaxation of sparsity combined with an $\ell_2$ penalty. We show that this new {\em $k$-support norm} provides a tighter relaxation than the elastic net and is thus a good replacement for the Lasso or the elastic net in sparse prediction problems. Through the study of the $k$-support norm, we also bound the looseness of the elastic net, thus shedding new light on it and providing justification for its use.