Many computer aided diagnosis (CAD) problems can be best modelled as a multiple-instance learning (MIL) problem with unbalanced data: i.e., the training data typically consists of a few positive bags, and a very large number of negative instances. Existing MIL algorithms are much too computationally expensive for these datasets. We describe CH, a framework for learning a Convex Hull representation of multiple instances that is significantly faster than existing MIL algorithms. Our CH framework applies to any standard hyperplane-based learning algorithm, and for some algorithms, is guaranteed to find the global optimal solution. Experimental studies on two different CAD applications further demonstrate that the proposed algorithm significantly improves diagnostic accuracy when compared to both MIL and traditional classifiers. Although not designed for standard MIL problems (which have both positive and negative bags and relatively balanced datasets), comparisons against other MIL methods on benchmark problems also indicate that the proposed method is competitive with the state-of-the-art.

We consider single-class classification (SCC) as a two-person game between the learner and an adversary. In this game the target distribution is completely known to the learner and the learner's goal is to construct a classifier capable of guaranteeing a given tolerance for the false-positive error while minimizing the false negative error. We identify both "hard" and "soft" optimal classification strategies for different types of games and demonstrate that soft classification can provide a significant advantage. Our optimal strategies and bounds provide worst-case lower bounds for standard, finite-sample SCC and also motivate new approaches to solving SCC.

We consider the problem of learning classifiers for structurally incomplete data, where some objects have a subset of features inherently absent due to complex relationships between the features. The common approach for handling missing features is to begin with a preprocessing phase that completes the missing features, and then use a standard classification procedure. In this paper we show how incomplete data can be classified directly without any completion of the missing features using a max-margin learning framework. We formulate this task using a geometrically-inspired objective function, and discuss two optimization approaches: The linearly separable case is written as a set of convex feasibility problems, and the non-separable case has a non-convex objective that we optimize iteratively. By avoiding the pre-processing phase in which the data is completed, these approaches offer considerable computational savings. More importantly, we show that by elegantly handling complex patterns of missing values, our approach is both competitive with other methods when the values are missing at random and outperforms them when the missing values have nontrivial structure. We demonstrate our results on two real-world problems: edge prediction in metabolic pathways, and automobile detection in natural images.

We study a setting that is motivated by the problem of filtering spam messages for many users. Each user receives messages according to an individual, unknown distribution, reflected only in the unlabeled inbox. The spam filter for a user is required to perform well with respect to this distribution. Labeled messages from publicly available sources can be utilized, but they are governed by a distinct distribution, not adequately representing most inboxes. We devise a method that minimizes a loss function with respect to a user's personal distribution based on the available biased sample. A nonparametric hierarchical Bayesian model furthermore generalizes across users by learning a common prior which is imposed on new email accounts. Empirically, we observe that bias-corrected learning outperforms naive reliance on the assumption of independent and identically distributed data; Dirichlet-enhanced generalization across users outperforms a single ("one size fits all") filter as well as independent filters for all users.

We consider a general form of transductive learning on graphs with Laplacian regularization, and derive margin-based generalization bounds using appropriate geometric properties of the graph. We use this analysis to obtain a better understanding of the role of normalization of the graph Laplacian matrix as well as the effect of dimension reduction. The results suggest a limitation of the standard degree-based normalization. We propose a remedy from our analysis and demonstrate empirically that the remedy leads to improved classification performance.

Many computer aided diagnosis (CAD) problems can be best modelled as a multiple-instance learning (MIL) problem with unbalanced data: i.e., the training data typically consists of a few positive bags, and a very large number of negative instances.Existing MIL algorithms are much too computationally expensive for these datasets. We describe CH, a framework for learning a Convex Hull representation of multiple instances that is significantly faster than existing MIL algorithms. Our CH framework applies to any standard hyperplane-based learning algorithm, and for some algorithms, is guaranteed to find the global optimal solution. Experimentalstudies on two different CAD applications further demonstrate that the proposed algorithm significantly improves diagnostic accuracy when compared toboth MIL and traditional classifiers. Although not designed for standard MIL problems (which have both positive and negative bags and relatively balanced datasets),comparisons against other MIL methods on benchmark problems also indicate that the proposed method is competitive with the state-of-the-art.

We describe an unsupervised method for learning a probabilistic grammar of an object from a set of training examples. Our approach is invariant to the scale and rotation of the objects. We illustrate our approach using thirteen objects from the Caltech 101 database. In addition, we learn the model of a hybrid object class where we do not know the specific object or its position, scale or pose. This is illustrated bylearning a hybrid class consisting of faces, motorbikes, and airplanes. The individual objects can be recovered as different aspects of the grammar for the object class.

Such a problem can occur in many real-world tasks, e.g. an image usually

We describe a nonnegative variant of the "Sparse PCA" problem. The goal is to create a low dimensional representation from a collection of points which on the one hand maximizes the variance of the projected points and on the other uses only parts of the original coordinates, and thereby creating a sparse representation. Whatdistinguishes our problem from other Sparse PCA formulations is that the projection involves only nonnegative weights of the original coordinates -- a desired quality in various fields, including economics, bioinformatics and computer vision.Adding nonnegativity contributes to sparseness, where it enforces a partitioning of the original coordinates among the new axes. We describe a simple yetefficient iterative coordinate-descent type of scheme which converges to a local optimum of our optimization criteria, giving good results on large real world datasets.

We demonstrate how our framework encompasses problems from manufacturing to Vision processing.