Abstract-- Extremely preterm infants commonly require intubation and invasive mechanical ventilation after birth. While the duration of mechanical ventilation should be minimized in order to avoid complications, extubation failure is associated with increases in morbidities and mortality. As part of a prospective observational study aimed at developing an accurate predictor of extubation readiness, Markov and semi-Markov chain models were applied to gain insight into the respiratory patterns of these infants, with more robust timeseries modeling using semi-Markov models. This model revealed interesting similarities and differences between newborns who succeeded extubation and those who failed. The parameters of the model were further applied to predict extubation readiness via generative (joint likelihood) and discriminative (support vector machine) approaches. Results showed that up to 84% of infants who failed extubation could have been accurately identified prior to extubation.

Abstract-- Extremely preterm infants often require endotracheal intubation and mechanical ventilation during the first days of life. Due to the detrimental effects of prolonged invasive mechanical ventilation (IMV), clinicians aim to extubate infants as soon as they deem them ready. Unfortunately, existing strategies for prediction of extubation readiness vary across clinicians and institutions, and lead to high reintubation rates. We present an approach using Random Forest classifiers for the analysis of cardiorespiratory variability to predict extubation readiness. We address the issue of data imbalance by employing random undersampling of examples from the majority class before training each Decision Tree in a bag. By incorporating clinical domain knowledge, we further demonstrate that our classifier could have identified 71% of infants who failed extubation, while maintaining a success detection rate of 78%.

Recently, the introduction of the generative adversarial network (GAN) and its variants has enabled the generation of realistic synthetic samples, which has been used for enlarging training sets. Previous work primarily focused on data augmentation for semi-supervised and supervised tasks. In this paper, we instead focus on unsupervised anomaly detection and propose a novel generative data augmentation framework optimized for this task. In particular, we propose to oversample infrequent normal samples - normal samples that occur with small probability, e.g., rare normal events. We show that these samples are responsible for false positives in anomaly detection. However, oversampling of infrequent normal samples is challenging for real-world high-dimensional data with multimodal distributions. To address this challenge, we propose to use a GAN variant known as the adversarial autoencoder (AAE) to transform the high-dimensional multimodal data distributions into low-dimensional unimodal latent distributions with well-defined tail probability. Then, we systematically oversample at the `edge' of the latent distributions to increase the density of infrequent normal samples. We show that our oversampling pipeline is a unified one: it is generally applicable to datasets with different complex data distributions. To the best of our knowledge, our method is the first data augmentation technique focused on improving performance in unsupervised anomaly detection. We validate our method by demonstrating consistent improvements across several real-world datasets.

The accuracy and reliability of machine learning algorithms are an important concern for suppliers of artificial intelligence (AI) services, but considerations beyond accuracy, such as safety, security, and provenance, are also critical elements to engender consumers' trust in a service. In this paper, we propose a supplier's declaration of conformity (SDoC) for AI services to help increase trust in AI services. An SDoC is a transparent, standardized, but often not legally required, document used in many industries and sectors to describe the lineage of a product along with the safety and performance testing it has undergone. We envision an SDoC for AI services to contain purpose, performance, safety, security, and provenance information to be completed and voluntarily released by AI service providers for examination by consumers. Importantly, it conveys product-level rather than component-level functional testing. We suggest a set of declaration items tailored to AI and provide examples for two fictitious AI services.

After doing the usual Feature Engineering, Selection, and of course, implementing a model and getting some output in forms of a probability or a class, the next step is to find out how effective is the model based on some metric using test datasets. Different performance metrics are used to evaluate different Machine Learning Algorithms. For now, we will be focusing on the ones used for Classification problems. We can use classification performance metrics such as Log-Loss, Accuracy, AUC(Area under Curve) etc. Another example of metric for evaluation of machine learning algorithms is precision, recall, which can be used for sorting algorithms primarily used by search engines. The metrics that you choose to evaluate your machine learning model is very important.

Heart disease is the leading cause of death, and experts estimate that approximately half of all heart attacks and strokes occur in people who have not been flagged as "at risk." Thus, there is an urgent need to improve the accuracy of heart disease diagnosis. To this end, we investigate the potential of using data analysis, and in particular the design and use of deep neural networks (DNNs) for detecting heart disease based on routine clinical data. Our main contribution is the design, evaluation, and optimization of DNN architectures of increasing depth for heart disease diagnosis. This work led to the discovery of a novel five layer DNN architecture - named Heart Evaluation for Algorithmic Risk-reduction and Optimization Five (HEARO-5) -- that yields best prediction accuracy. HEARO-5's design employs regularization optimization and automatically deals with missing data and/or data outliers. To evaluate and tune the architectures we use k-way cross-validation as well as Matthews correlation coefficient (MCC) to measure the quality of our classifications. The study is performed on the publicly available Cleveland dataset of medical information, and we are making our developments open source, to further facilitate openness and research on the use of DNNs in medicine. The HEARO-5 architecture, yielding 99% accuracy and 0.98 MCC, significantly outperforms currently published research in the area.

Deep Neural Networks are powerful models that attained remarkable results on a variety of tasks. These models are shown to be extremely efficient when training and test data are drawn from the same distribution. However, it is not clear how a network will act when it is fed with an out-of-distribution example. In this work, we consider the problem of out-of-distribution detection in neural networks. We propose to use multiple semantic dense representations instead of sparse representation as the target label. Specifically, we propose to use several word representations obtained from different corpora or architectures as target labels. We evaluated the proposed model on computer vision, and speech commands detection tasks and compared it to previous methods. Results suggest that our method compares favorably with previous work. Besides, we present the efficiency of our approach for detecting wrongly classified and adversarial examples.

A large number of papers have introduced novel machine learning and feature extraction methods for automatic classification of AD. However, they are difficult to reproduce because key components of the validation are often not readily available. These components include selected participants and input data, image preprocessing and cross-validation procedures. The performance of the different approaches is also difficult to compare objectively. In particular, it is often difficult to assess which part of the method provides a real improvement, if any. We propose a framework for reproducible and objective classification experiments in AD using three publicly available datasets (ADNI, AIBL and OASIS). The framework comprises: i) automatic conversion of the three datasets into BIDS format, ii) a modular set of preprocessing pipelines, feature extraction and classification methods, together with an evaluation framework, that provide a baseline for benchmarking the different components. We demonstrate the use of the framework for a large-scale evaluation on 1960 participants using T1 MRI and FDG PET data. In this evaluation, we assess the influence of different modalities, preprocessing, feature types, classifiers, training set sizes and datasets. Performances were in line with the state-of-the-art. FDG PET outperformed T1 MRI for all classification tasks. No difference in performance was found for the use of different atlases, image smoothing, partial volume correction of FDG PET images, or feature type. Linear SVM and L2-logistic regression resulted in similar performance and both outperformed random forests. The classification performance increased along with the number of subjects used for training. Classifiers trained on ADNI generalized well to AIBL and OASIS. All the code of the framework and the experiments is publicly available at: https://gitlab.icm-institute.org/aramislab/AD-ML.

Survival analysis in the presence of multiple possible adverse events, i.e., competing risks, is a pervasive problem in many industries (healthcare, finance, etc.). Since only one event is typically observed, the incidence of an event of interest is often obscured by other related competing events. This nonidentifiability, or inability to estimate true cause-specific survival curves from empirical data, further complicates competing risk survival analysis. We introduce Siamese Survival Prognosis Network (SSPN), a novel deep learning architecture for estimating personalized risk scores in the presence of competing risks. SSPN circumvents the nonidentifiability problem by avoiding the estimation of cause-specific survival curves and instead determines pairwise concordant time-dependent risks, where longer event times are assigned lower risks. Furthermore, SSPN is able to directly optimize an approximation to the C-discrimination index, rather than relying on well-known metrics which are unable to capture the unique requirements of survival analysis with competing risks.

Machine learning has become one of the main components for task automation in many application domains. Despite the advancements and impressive achievements of machine learning, it has been shown that learning algorithms can be compromised by attackers both at training and test time. Machine learning systems are especially vulnerable to adversarial examples where small perturbations added to the original data points can produce incorrect or unexpected outputs in the learning algorithms at test time. Mitigation of these attacks is hard as adversarial examples are difficult to detect. Existing related work states that the security of machine learning systems against adversarial examples can be weakened when feature selection is applied to reduce the systems' complexity. In this paper, we empirically disprove this idea, showing that the relative distortion that the attacker has to introduce to succeed in the attack is greater when the target is using a reduced set of features. We also show that the minimal adversarial examples differ statistically more strongly from genuine examples with a lower number of features. However, reducing the feature count can negatively impact the system's performance. We illustrate the trade-off between security and accuracy with specific examples. We propose a design methodology to evaluate the security of machine learning classifiers with embedded feature selection against adversarial examples crafted using different attack strategies.