Neural networks promise to bring robust, quantitative analysis to medical fields, but adoption is limited by the technicalities of training these networks. To address this translation gap between medical researchers and neural networks in the field of pathology, we have created an intuitive interface which utilizes the commonly used whole slide image (WSI) viewer, Aperio ImageScope (Leica Biosystems Imaging, Inc.), for the annotation and display of neural network predictions on WSIs. Leveraging this, we propose the use of a human-in-the-loop strategy to reduce the burden of WSI annotation. We track network performance improvements as a function of iteration and quantify the use of this pipeline for the segmentation of renal histologic findings on WSIs. More specifically, we present network performance when applied to segmentation of renal micro compartments, and demonstrate multi-class segmentation in human and mouse renal tissue slides. Finally, to show the adaptability of this technique to other medical imaging fields, we demonstrate its ability to iteratively segment human prostate glands from radiology imaging data. 1 Introduction In the current era of artificial intelligence, robust automated image analysis is attained using supervised machine learning algorithms. This approach is gaining considerable ground in virtually every domain of data analysis, mainly under the advent of neural networks [2-5]. Neural networks are a broad range of algorithms which can take many different forms, but all are considered graphical models, whose nodes can be variably activated by a nonlinear operation on the sum of their inputs [4, 6].

Abstract--We propose to apply deep transfer learning from computer vision to static malware classification. In the transfer learning scheme, we borrow knowledge from natural images or objects and apply to the target domain of static malware detection. As a result, training time of deep neural networks is accelerated while high classification performance is still maintained. We instrument an interpretation component to the algorithm and provide interpretable explanations to enhance security practitioners' trust to the model. We further discuss a convex combination scheme of transfer learning and training from scratch for enhanced malware detection, and provide insights of the algorithmic interpretation of vision-based malware classification techniques. I. INTRODUCTION Malware is a type of software that possesses malicious characteristics to cause damage to the user, computer or network. Categories of malware include virus, trojan horses, worms, spyware, ransomware and so on. Static analysis is a quick and straightforward way to detect malware without executing the application or monitoring the run time behavior. Onemain technique is the so-called signature matching, where the goal is to search whether the strings in the code actually match any identified malicious patterns in database. However when the code is obfuscated or morphed, signature matching cannot be applied and becomes less resilient to detect malicious patterns.

In this paper, we describe a deep neural network trained to predict FreeSurfer segmentations of structural MRI volumes, in seconds rather than hours. The network was trained and evaluated on an extremely large dataset (n = 11,148), obtained by combining data from more than a hundred sites. We also show that the prediction uncertainty of the network at each voxel is a good indicator of whether the network has made an error. The resulting uncertainty volume can be used in conjunction with the predicted segmentation to improve downstream uses, such as calculation of measures derived from segmentation regions of interest or the building of prediction models. Finally, we demonstrate that the average prediction uncertainty across voxels in the brain is an excellent indicator of manual quality control ratings, outperforming the best available automated solutions.

Binary classification rules based on covariates typically depend on simple loss functions such as zero-one misclassification. Some cases may require more complex loss functions. For example, individual-level monitoring of HIV-infected individuals on antiretroviral therapy (ART) requires periodic assessment of treatment failure, defined as having a viral load (VL) value above a certain threshold. In some resource limited settings, VL tests may be limited by cost or technology, and diagnoses are based on other clinical markers. Depending on scenario, higher premium may be placed on avoiding false-positives which brings greater cost and reduced treatment options. Here, the optimal rule is determined by minimizing a weighted misclassification loss/risk. We propose a method for finding and cross-validating optimal binary classification rules under weighted misclassification loss. We focus on rules comprising a prediction score and an associated threshold, where the score is derived using an ensemble learner. Simulations and examples show that our method, which derives the score and threshold jointly, more accurately estimates overall risk and has better operating characteristics compared with methods that derive the score first and the cutoff conditionally on the score especially for finite samples.

An ability to map seizure-generating brain tissue, i.e., the seizure onset zone (SOZ), without recording actual seizures could reduce the duration of invasive EEG monitoring for patients with drug-resistant epilepsy. A widely-adopted practice in the literature is to compare the incidence (events/time) of putative pathological electrophysiological biomarkers associated with epileptic brain tissue with the SOZ determined from spontaneous seizures recorded with intracranial EEG, primarily using a single biomarker. Clinical translation of the previous efforts suffers from their inability to generalize across multiple patients because of (a) the inter-patient variability and (b) the temporal variability in the epileptogenic activity. Here, we report an artificial intelligence-based approach for combining multiple interictal electrophysiological biomarkers and their temporal characteristics as a way of accounting for the above barriers and show that it can reliably identify seizure onset zones in a study cohort of 82 patients who underwent evaluation for drug-resistant epilepsy. Our investigation provides evidence that utilizing the complementary information provided by multiple electrophysiological biomarkers and their temporal characteristics can significantly improve the localization potential compared to previously published single-biomarker incidence-based approaches, resulting in an average area under ROC curve (AUC) value of 0.73 in a cohort of 82 patients. Our results also suggest that recording durations between ninety minutes and two hours are sufficient to localize SOZs with accuracies that may prove clinically relevant. The successful validation of our approach on a large cohort of 82 patients warrants future investigation on the feasibility of utilizing intra-operative EEG monitoring and artificial intelligence to localize epileptogenic brain tissue.

Whereas previous post-processing approaches for increasing the fairness of predictions of biased classifiers address only group fairness, we propose a method for increasing both individual and group fairness. Our novel framework includes an individual bias detector used to prioritize data samples in a bias mitigation algorithm aiming to improve the group fairness measure of disparate impact. We show superior performance to previous work in the combination of classification accuracy, individual fairness and group fairness on several real-world datasets in applications such as credit, employment, and criminal justice.

In this paper, we propose an inverse reinforcement learning method for architecture search (IRLAS), which trains an agent to learn to search network structures that are topologically inspired by human-designed network. Most existing architecture search approaches totally neglect the topological characteristics of architectures, which results in complicated architecture with a high inference latency. Motivated by the fact that human-designed networks are elegant in topology with a fast inference speed, we propose a mirror stimuli function inspired by biological cognition theory to extract the abstract topological knowledge of an expert human-design network (ResNeXt). To avoid raising a too strong prior over the search space, we introduce inverse reinforcement learning to train the mirror stimuli function and exploit it as a heuristic guidance for architecture search, easily generalized to different architecture search algorithms. On CIFAR-10, the best architecture searched by our proposed IRLAS achieves 2.60% error rate. For ImageNet mobile setting, our model achieves a state-of-the-art top-1 accuracy 75.28%, while being 2~4x faster than most auto-generated architectures. A fast version of this model achieves 10% faster than MobileNetV2, while maintaining a higher accuracy.

Exploiting dependencies between labels is considered to be crucial for multi-label classification. Rules are able to expose label dependencies such as implications, subsumptions or exclusions in a human-comprehensible and interpretable manner. However, the induction of rules with multiple labels in the head is particularly challenging, as the number of label combinations which must be taken into account for each rule grows exponentially with the number of available labels. To overcome this limitation, algorithms for exhaustive rule mining typically use properties such as anti-monotonicity or decomposability in order to prune the search space. In the present paper, we examine whether commonly used multi-label evaluation metrics satisfy these properties and therefore are suited to prune the search space for multi-label heads.

Deep neural networks (DNN) have been shown to be useful in a wide range of applications. However, they are also known to be vulnerable to adversarial samples. By transforming a normal sample with some carefully crafted human non-perceptible perturbations, even highly accurate DNN makes wrong decisions. Multiple defense mechanisms have been proposed which aim to hinder the generation of such adversarial samples. However, a recent work show that most of them are ineffective. In this work, we propose an alternative approach to detect adversarial samples at runtime. Our main observation is that adversarial samples are much more sensitive than normal samples if we impose random mutations on the DNN. We thus first propose a measure of `sensitivity' and show empirically that normal samples and adversarial samples have distinguishable sensitivity. We then integrate statistical model checking and mutation testing to check whether an input sample is likely to be normal or adversarial at runtime by measuring its sensitivity. We evaluated our approach on the MNIST and CIFAR10 dataset. The results show that our approach detects adversarial samples generated by state-of-art attacking methods efficiently and accurately.

Many conversational agents in the market today follow a standard bot development framework which requires training intent classifiers to recognize user input. The need to create a proper set of training examples is often the bottleneck in the development process. In many occasions agent developers have access to historical chat logs that can provide a good quantity as well as coverage of training examples. However, the cost of labeling them with tens to hundreds of intents often prohibits taking full advantage of these chat logs. In this paper, we present a framework called \textit{search, label, and propagate} (SLP) for bootstrapping intents from existing chat logs using weak supervision. The framework reduces hours to days of labeling effort down to minutes of work by using a search engine to find examples, then relies on a data programming approach to automatically expand the labels. We report on a user study that shows positive user feedback for this new approach to build conversational agents, and demonstrates the effectiveness of using data programming for auto-labeling. While the system is developed for training conversational agents, the framework has broader application in significantly reducing labeling effort for training text classifiers.