For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep convolutional neural networks can extract structural features of complex tissues directly from these massive size images in a patched way. In order to face the challenge arise from morphological diversity in histopathological slides, we built a multicenter database of 2241 digital whole-slide images from 1321 patients from 2008 to 2018. We trained both ResNet50 and Vgg19 using over 9.95 million patches by transferring learning, and test performance with two kinds of critical classifications: malignant melanomas versus benign nevi in separate and mixed magnification; and distinguish among nevi in maximum magnification. The CNNs achieves superior performance across both tasks, demonstrating an AI capable of classifying skin cancer in the analysis from histopathological images. For making the classifications reasonable, the visualization of CNN representations is furthermore used to identify cells between melanoma and nevi. Regions of interest (ROI) are also located which are significantly helpful, giving pathologists more support of correctly diagnosis.

With the wide deployment of machine learning (ML) based systems for a variety of applications including medical, military, automotive, genomic, as well as multimedia and social networking, there is great potential for damage from adversarial learning (AL) attacks. In this paper, we provide a contemporary survey of AL, focused particularly on defenses against attacks on statistical classifiers. After introducing relevant terminology and the goals and range of possible knowledge of both attackers and defenders, we survey recent work on test-time evasion (TTE), data poisoning (DP), and reverse engineering (RE) attacks and particularly defenses against same. In so doing, we distinguish robust classification from anomaly detection (AD), unsupervised from supervised, and statistical hypothesis-based defenses from ones that do not have an explicit null (no attack) hypothesis; we identify the hyperparameters a particular method requires, its computational complexity, as well as the performance measures on which it was evaluated and the obtained quality. We then dig deeper, providing novel insights that challenge conventional AL wisdom and that target unresolved issues, including: 1) robust classification versus AD as a defense strategy; 2) the belief that attack success increases with attack strength, which ignores susceptibility to AD; 3) small perturbations for test-time evasion attacks: a fallacy or a requirement?; 4) validity of the universal assumption that a TTE attacker knows the ground-truth class for the example to be attacked; 5) black, grey, or white box attacks as the standard for defense evaluation; 6) susceptibility of query-based RE to an AD defense. We then present benchmark comparisons of several defenses against TTE, RE, and backdoor DP attacks on images. The paper concludes with a discussion of future work.

We propose a supervised anomaly detection method based on neural density estimators, where the negative log likelihood is used for the anomaly score. Density estimators have been widely used for unsupervised anomaly detection. By the recent advance of deep learning, the density estimation performance has been greatly improved. However, the neural density estimators cannot exploit anomaly label information, which would be valuable for improving the anomaly detection performance. The proposed method effectively utilizes the anomaly label information by training the neural density estimator so that the likelihood of normal instances is maximized and the likelihood of anomalous instances is lower than that of the normal instances. We employ an autoregressive model for the neural density estimator, which enables us to calculate the likelihood exactly. With the experiments using 16 datasets, we demonstrate that the proposed method improves the anomaly detection performance with a few labeled anomalous instances, and achieves better performance than existing unsupervised and supervised anomaly detection methods.

Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein structure hinders the direct association of the signaling activity with the molecular structure. Therefore, the proposed solution involves the use of protein star graphs for the peptide sequence information encoding into specific topological indices calculated with S2SNet tool. The Quantitative Structure - Activity Relationship classification model obtained with Machine Learning techniques is able to predict new signaling peptides. The best classification model is the first signaling prediction model, which is based on eleven descriptors and it was obtained using the Support Vector Machines - Recursive Feature Elimination (SVM-RFE) technique with the Laplacian kernel (RFE-LAP) and an AUROC of 0.961. Testing a set of 3114 proteins of unknown function from the PDB database assessed the prediction performance of the model. Important signaling pathways are presented for three UniprotIDs (34 PDBs) with a signaling prediction greater than 98.0%.

Although First Person Vision systems can sense the environment from the user's perspective, they are generally unable to predict his intentions and goals. Since human activities can be decomposed in terms of atomic actions and interactions with objects, intelligent wearable systems would benefit from the ability to anticipate user-object interactions. Even if this task is not trivial, the First Person Vision paradigm can provide important cues to address this challenge. We propose to exploit the dynamics of the scene to recognize next-active-objects before an object interaction begins. We train a classifier to discriminate trajectories leading to an object activation from all others and forecast next-active-objects by analyzing fixed-length trajectory segments within a temporal sliding window. The proposed method compares favorably with respect to several baselines on the Activity of Daily Living (ADL) egocentric dataset comprising 10 hours of videos acquired by 20 subjects while performing unconstrained interactions with several objects.

The growing capability and accessibility of machine learning has led to its application to many real-world domains and data about people. Despite the benefits algorithmic systems may bring, models can reflect, inject, or exacerbate implicit and explicit societal biases into their outputs, disadvantaging certain demographic subgroups. Discovering which biases a machine learning model has introduced is a great challenge, due to the numerous definitions of fairness and the large number of potentially impacted subgroups. We present FairVis, a mixed-initiative visual analytics system that integrates a novel subgroup discovery technique for users to audit the fairness of machine learning models. Through FairVis, users can apply domain knowledge to generate and investigate known subgroups, and explore suggested and similar subgroups. FairVis' coordinated views enable users to explore a high-level overview of subgroup performance and subsequently drill down into detailed investigation of specific subgroups. We show how FairVis helps to discover biases in two real datasets used in predicting income and recidivism. As a visual analytics system devoted to discovering bias in machine learning, FairVis demonstrates how interactive visualization may help data scientists and the general public in understanding and creating more equitable algorithmic systems.

There is a growing body of work that proposes methods for mitigating bias in machine learning systems. These methods typically rely on access to protected attributes such as race, gender, or age. However, this raises two significant challenges: (1) protected attributes may not be available or it may not be legal to use them, and (2) it is often desirable to simultaneously consider multiple protected attributes, as well as their intersections. In the context of mitigating bias in occupation classification, we propose a method for discouraging correlation between the predicted probability of an individual's true occupation and a word embedding of their name. This method leverages the societal biases that are encoded in word embeddings, eliminating the need for access to protected attributes. Crucially, it only requires access to individuals' names at training time and not at deployment time. We evaluate two variations of our proposed method using a large-scale dataset of online biographies. We find that both variations simultaneously reduce race and gender biases, with almost no reduction in the classifier's overall true positive rate.

In the semantic segmentation of street scenes the reliability of the prediction and therefore uncertainty measures are of highest interest. We present a method that generates for each input image a hierarchy of nested crops around the image center and presents these, all re-scaled to the same size, to a neural network for semantic segmentation. The resulting softmax outputs are then post processed such that we can investigate mean and variance over all image crops as well as mean and variance of uncertainty heat maps obtained from pixel-wise uncertainty measures, like the entropy, applied to each crop's softmax output. In our tests, we use the publicly available DeepLabv3+ MobilenetV2 network (trained on the Cityscapes dataset) and demonstrate that the incorporation of crops improves the quality of the prediction and that we obtain more reliable uncertainty measures. These are then aggregated over predicted segments for either classifying between IoU=0 and IoU>0 (meta classification) or predicting the IoU via linear regression (meta regression). The latter yields reliable performance estimates for segmentation networks, in particular useful in the absence of ground truth. For the task of meta classification we obtain a classification accuracy of $81.93\%$ and an AUROC of $89.89\%$. For meta regression we obtain an $R^2$ value of $84.77\%$. These results yield significant improvements compared to other approaches.

Deep learning (DL) algorithms have successfully solved real-world classification problems from a variety of fields, including recognizing handwritten digits and identifying the presence of key diagnostic features in medical images [18, 16]. A typical classification challenge for a DL algorithm consists of training the algorithm on an example data set, then using a separate set of test data to evaluate its performance. The aim is to provide answers that are as accurate as possible, as measured by the true positive rate (TPR) and the true negative rate (TNR). Many DL classifiers, particularly those using a softmax function in the very last layer, yield a continuous score, h; A step function is used to map this continuous score to each of the possible categories that are being classified. TPR and TNR scores are then generated for each separate variable that is being predicted by setting a threshold parameter that is applied when mapping h to the decision. Values above this threshold are mapped to positive predictions, while values below it are mapped to negative predictions. The ROC curve is then generated from these pairs of TPR/TPN scores.

K-fold Cross Validation is commonly used to evaluate classifiers and tune their hyperparameters. However, it assumes that data points are Independent and Identically Distributed (i.i.d.) so that samples used in the training and test sets can be selected randomly and uniformly. In Human Activity Recognition datasets, we note that the samples produced by the same subjects are likely to be correlated due to diverse factors. Hence, k-fold cross validation may overestimate the performance of activity recognizers, in particular when overlapping sliding windows are used. In this paper, we investigate the effect of Subject Cross Validation on the performance of Human Activity Recognition, both with non-overlapping and with overlapping sliding windows. Results show that k-fold cross validation artificially increases the performance of recognizers by about 10%, and even by 16% when overlapping windows are used. In addition, we do not observe any performance gain from the use of overlapping windows. We conclude that Human Activity Recognition systems should be evaluated by Subject Cross Validation, and that overlapping windows are not worth their extra computational cost.