Department of Multidisciplinary Engineering (AI & DS) Vishwakarma Institute of Technology, Pune, 411037, Maharashtra, India Abstract - Sepsis is a potentially fatal medical disorder that needs to be identified and treated right away to avoid fatalities. It must be quickly identified and treated in order to stop it from developing into severe sepsis, septic shock, and multi-organ failure. Sepsis remains a significant problem for doctors despite advancements in medical technology and treatment methods. The beginning of the disease has been successfully predicted by machine learning models in recent years, but due to their black-box character, it is challenging to interpret these predictions and comprehend the underlying illness mechanisms. In this research, we propose a comprehensible AI method for sepsis analysis that combines machine learning with clinical knowledge and expertise in the domain. Our method allows clinicians to understand and verify the model's predictions based on clinical expertise and preexisting beliefs, in addition to providing precise predictions of the onset of sepsis. Keywords - Sepsis, Artificial Intelligence, Machine Learning, Explainable AI, Sensitivity Analysis I. INTRODUCTION As the world continues to advance in technology, the potential of artificial intelligence (AI) in healthcare is becoming more apparent.

Drug-target interaction (DTI) prediction is of great significance for drug discovery and drug repurposing. With the accumulation of a large volume of valuable data, data-driven methods have been increasingly harnessed to predict DTIs, reducing costs across various dimensions. Therefore, this paper proposes a $\textbf{L}$arge $\textbf{L}$anguage $\textbf{M}$odel and $\textbf{M}$ulti-$\textbf{M}$odel data co-powered $\textbf{D}$rug $\textbf{T}$arget $\textbf{I}$nteraction prediction framework, named LLM$^3$-DTI. LLM$^3$-DTI constructs multi-modal data embedding to enhance DTI prediction performance. In this framework, the text semantic embeddings of drugs and targets are encoded by a domain-specific LLM. To effectively align and fuse multi-modal embedding. We propose the dual cross-attention mechanism and the TSFusion module. Finally, these multi-modal data are utilized for the DTI task through an output network. The experimental results indicate that LLM$^3$-DTI can proficiently identify validated DTIs, surpassing the performance of the models employed for comparison across diverse scenarios. Consequently, LLM$^3$-DTI is adept at fulfilling the task of DTI prediction with excellence. The data and code are available at https://github.com/chaser-gua/LLM3DTI.

Accurate accident anticipation is essential for enhancing the safety of autonomous vehicles (A Vs). However, existing methods often assume ideal conditions, overlooking challenges such as sensor failures, environmental disturbances, and data imperfections, which can significantly degrade prediction accuracy. Additionally, previous models have not adequately addressed the considerable variability in driver behavior and accident rates across different vehicle types. To overcome these limitations, this study introduces ROAR, a novel approach for accident detection and prediction. ROAR combines Discrete Wavelet Transform (DWT), a self-adaptive object-aware module, and dynamic focal loss to tackle these challenges. The DWT effectively extracts features from noisy and incomplete data, while the object-aware module improves accident prediction by focusing on high-risk vehicles and modeling the spatial-temporal relationships among traffic agents. Evaluated on three widely used datasets--Dashcam Accident Dataset (DAD), Car Crash Dataset (CCD), and AnAn Accident Detection (A3D)--our model consistently outperforms existing baselines in key metrics such as Average Precision (AP) and mean Time-to-Accident (mTT A). These results demonstrate the model's robustness in real-world conditions, particularly in handling sensor degradation, environmental noise, and imbalanced data distributions. This work offers a promising solution for reliable and accurate accident anticipation in complex traffic environments. INTRODUCTION Traffic accidents are a persistent global issue, causing significant harm to both individuals and society. With the rise of autonomous driving, the need to proactively address this challenge has never been more pressing [1].

The rapid proliferation of Internet of Things (IoT) devices has transformed numerous industries by enabling seamless connectivity and data-driven automation. However, this expansion has also exposed IoT networks to increasingly sophisticated security threats, including adversarial attacks targeting artificial intelligence (AI) and machine learning (ML)-based intrusion detection systems (IDS) to deliberately evade detection, induce misclassification, and systematically undermine the reliability and integrity of security defenses. To address these challenges, we propose a novel adversarial detection model that enhances the robustness of IoT IDS against adversarial attacks through SHapley Additive exPlanations (SHAP)-based fingerprinting. Using SHAP's DeepExplainer, we extract attribution fingerprints from network traffic features, enabling the IDS to reliably distinguish between clean and adversarially perturbed inputs. By capturing subtle attribution patterns, the model becomes more resilient to evasion attempts and adversarial manipulations. We evaluated the model on a standard IoT benchmark dataset, where it significantly outperformed a state-of-the-art method in detecting adversarial attacks. In addition to enhanced robustness, this approach improves model transparency and interpretability, thereby increasing trust in the IDS through explainable AI.

Connectomics - the mapping of neural connections in an organism's brain - currently requires extraordinary human effort to proofread the data collected from imaging and machine-learning assisted segmentation. With the growing excitement around using AI agents to automate important scientific tasks, we explore whether current AI systems can perform multiple tasks necessary for data proofreading. We introduce ConnectomeBench, a multimodal benchmark evaluating large language model (LLM) capabilities in three critical proofreading tasks: segment type identification, split error correction, and merge error detection. Using expert annotated data from two large open-source datasets - a cubic millimeter of mouse visual cortex and the complete Drosophila brain - we evaluate proprietary multimodal LLMs including Claude 3.7/4 Sonnet, o4-mini, GPT-4.1, GPT-4o, as well as open source models like InternVL-3 and NVLM. Our results demonstrate that current models achieve surprisingly high performance in segment identification (52-82% balanced accuracy vs. 20-25% chance) and binary/multiple choice split error correction (75-85% accuracy vs. 50% chance) while generally struggling on merge error identification tasks. Overall, while the best models still lag behind expert performance, they demonstrate promising capabilities that could eventually enable them to augment and potentially replace human proofreading in connectomics. Project page: https://github.com/jffbrwn2/ConnectomeBench and Dataset https://huggingface.co/datasets/jeffbbrown2/ConnectomeBench/tree/main

The early detection of mental health disorders from social media text is critical for enabling timely support, risk assessment, and referral to appropriate resources. This work introduces multiMentalRoBERTa, a fine-tuned RoBERTa model designed for multiclass classification of common mental health conditions, including stress, anxiety, depression, post-traumatic stress disorder (PTSD), suicidal ideation, and neutral discourse. Drawing on multiple curated datasets, data exploration is conducted to analyze class overlaps, revealing strong correlations between depression and suicidal ideation as well as anxiety and PTSD, while stress emerges as a broad, overlapping category. Comparative experiments with traditional machine learning methods, domain-specific transformers, and prompting-based large language models demonstrate that multiMentalRoBERTa achieves superior performance, with macro F1-scores of 0.839 in the six-class setup and 0.870 in the five-class setup (excluding stress), outperforming both fine-tuned MentalBERT and baseline classifiers. Beyond predictive accuracy, explainability methods, including Layer Integrated Gradients and KeyBERT, are applied to identify lexical cues that drive classification, with a particular focus on distinguishing depression from suicidal ideation. The findings emphasize the effectiveness of fine-tuned transformers for reliable and interpretable detection in sensitive contexts, while also underscoring the importance of fairness, bias mitigation, and human-in-the-loop safety protocols. Overall, multiMentalRoBERTa is presented as a lightweight, robust, and deployable solution for enhancing support in mental health platforms.

Cyberattacks on e-commerce platforms have grown in sophistication, threatening consumer trust and operational continuity. This research presents a hybrid analytical framework that integrates statistical modelling and machine learning for detecting and forecasting cyberattack patterns in the e-commerce domain. Using the Verizon Community Data Breach (VCDB) dataset, the study applies Auto ARIMA for temporal forecasting and significance testing, including a Mann-Whitney U test (U = 2579981.5, p = 0.0121), which confirmed that holiday shopping events experienced significantly more severe cyberattacks than non-holiday periods. ANOVA was also used to examine seasonal variation in threat severity, while ensemble machine learning models (XGBoost, LightGBM, and CatBoost) were employed for predictive classification. Results reveal recurrent attack spikes during high-risk periods such as Black Friday and holiday seasons, with breaches involving Personally Identifiable Information (PII) exhibiting elevated threat indicators. Among the models, CatBoost achieved the highest performance (accuracy = 85.29%, F1 score = 0.2254, ROC AUC = 0.8247). The framework uniquely combines seasonal forecasting with interpretable ensemble learning, enabling temporal risk anticipation and breach-type classification. Ethical considerations, including responsible use of sensitive data and bias assessment, were incorporated. Despite class imbalance and reliance on historical data, the study provides insights for proactive cybersecurity resource allocation and outlines directions for future real-time threat detection research.

Scam detection remains a critical challenge in cybersecurity as adversaries craft messages that evade automated filters. We propose a Hierarchical Scam Detection System (HSDS) that combines a lightweight multi-model voting front end with a fine-tuned LLaMA 3.1 8B Instruct back end to improve accuracy and robustness against adversarial attacks. An ensemble of four classifiers provides preliminary predictions through majority vote, and ambiguous cases are escalated to the fine-tuned model, which is optimized with adversarial training to reduce misclassification. Experiments show that this hierarchical design both improves adversarial scam detection and shortens inference time by routing most cases away from the LLM, outperforming traditional machine-learning baselines and proprietary LLM baselines. The findings highlight the effectiveness of a hybrid voting mechanism and adversarial fine-tuning in fortifying LLMs against evolving scam tactics, enhancing the resilience of automated scam detection systems.

When we hear the word "house", we don't just process sound, we imagine walls, doors, memories. The brain builds meaning through layers, moving from raw acoustics to rich, multimodal associations. Inspired by this, we build on recent work from Meta that aligned EEG signals with averaged wav2vec2 speech embeddings, and ask a deeper question: which layers of pre-trained models best reflect this layered processing in the brain? We compare embeddings from two models: wav2vec2, which encodes sound into language, and CLIP, which maps words to images. Using EEG recorded during natural speech perception, we evaluate how these embeddings align with brain activity using ridge regression and contrastive decoding. We test three strategies: individual layers, progressive concatenation, and progressive summation. The findings suggest that combining multimodal, layer-aware representations may bring us closer to decoding how the brain understands language, not just as sound, but as experience.

Model inversion attacks pose an open challenge to privacy-sensitive applications that use machine learning (ML) models. For example, face authentication systems use modern ML models to compute embedding vectors from face images of the enrolled users and store them. If leaked, inversion attacks can accurately reconstruct user faces from the leaked vectors. There is no systematic characterization of properties needed in an ideal defense against model inversion, even for the canonical example application of a face authentication system susceptible to data breaches, despite a decade of best-effort solutions. In this paper, we formalize the desired properties of a provably strong defense against model inversion and connect it, for the first time, to the cryptographic concept of fuzzy extractors. We further show that existing fuzzy extractors are insecure for use in ML-based face authentication. We do so through a new model inversion attack called PIPE, which achieves a success rate of over 89% in most cases against prior schemes. We then propose L2FE-Hash, the first candidate fuzzy extractor which supports standard Euclidean distance comparators as needed in many ML-based applications, including face authentication. We formally characterize its computational security guarantees, even in the extreme threat model of full breach of stored secrets, and empirically show its usable accuracy in face authentication for practical face distributions. It offers attack-agnostic security without requiring any re-training of the ML model it protects. Empirically, it nullifies both prior state-of-the-art inversion attacks as well as our new PIPE attack.