We study the relationship between catastrophic forgetting and properties of task sequences. In particular, given a sequence of tasks, we would like to understand which properties of this sequence influence the error rates of continual learning algorithms trained on the sequence. To this end, we propose a new procedure that makes use of recent developments in task space modeling as well as correlation analysis to specify and analyze the properties we are interested in. As an application, we apply our procedure to study two properties of a task sequence: (1) total complexity and (2) sequential heterogeneity. We show that error rates are strongly and positively correlated to a task sequence's total complexity for some state-of-the-art algorithms. We also show that, surprisingly, the error rates have no or even negative correlations in some cases to sequential heterogeneity. Our findings suggest directions for improving continual learning benchmarks and methods.

After admission to emergency department (ED), patients with critical illnesses are transferred to intensive care unit (ICU) due to unexpected clinical deterioration occurrence. Identifying such unplanned ICU transfers is urgently needed for medical physicians to achieve two-fold goals: improving critical care quality and preventing mortality. A priority task is to understand the crucial rationale behind diagnosis results of individual patients during stay in ED, which helps prepare for an early transfer to ICU. Most existing prediction studies were based on univariate analysis or multiple logistic regression to provide one-size-fit-all results. However, patient condition varying from case to case may not be accurately examined by the only judgment. In this study, we present a new decision tool using a mathematical optimization approach aiming to automatically discover rules associating diagnostic features with high-risk outcome (i.e., unplanned transfers) in different deterioration scenarios. We consider four mutually exclusive patient subgroups based on the principal reasons of ED visits: infections, cardiovascular/respiratory diseases, gastrointestinal diseases, and neurological/other diseases at a suburban teaching hospital. The analysis results demonstrate significant rules associated with unplanned transfer outcome for each subgroups and also show comparable prediction accuracy, compared to state-of-the-art machine learning methods while providing easy-to-interpret symptom-outcome information.

Understanding the connectivity in the brain is an important prerequisite for understanding how the brain processes information. In the Brain/MINDS project, a connectivity study on marmoset brains uses two-photon microscopy fluorescence images of axonal projections to collect the neuron connectivity from defined brain regions at the mesoscopic scale. The processing of the images requires the detection and segmentation of the axonal tracer signal. The objective is to detect as much tracer signal as possible while not misclassifying other background structures as the signal. This can be challenging because of imaging noise, a cluttered image background, distortions or varying image contrast cause problems. We are developing MarmoNet, a pipeline that processes and analyzes tracer image data of the common marmoset brain. The pipeline incorporates state-of-the-art machine learning techniques based on artificial convolutional neural networks (CNN) and image registration techniques to extract and map all relevant information in a robust manner. The pipeline processes new images in a fully automated way. This report introduces the current state of the tracer signal analysis part of the pipeline.

We trained and evaluated a localization-based deep CNN for breast cancer screening exam classification on over 200,000 exams (over 1,000,000 images). Our model achieves an AUC of 0.919 in predicting malignancy in patients undergoing breast cancer screening, reducing the error rate of the baseline (Wu et al., 2019a) by 23%. In addition, the models generates bounding boxes for benign and malignant findings, providing interpretable predictions.

Various domain users are increasingly leveraging real-time social media data to gain rapid situational awareness. However, due to the high noise in the deluge of data, effectively determining semantically relevant information can be difficult, further complicated by the changing definition of relevancy by each end user for different events. The majority of existing methods for short text relevance classification fail to incorporate users' knowledge into the classification process. Existing methods that incorporate interactive user feedback focus on historical datasets. Therefore, classifiers cannot be interactively retrained for specific events or user-dependent needs in real-time. This limits real-time situational awareness, as streaming data that is incorrectly classified cannot be corrected immediately, permitting the possibility for important incoming data to be incorrectly classified as well. We present a novel interactive learning framework to improve the classification process in which the user iteratively corrects the relevancy of tweets in real-time to train the classification model on-the-fly for immediate predictive improvements. We computationally evaluate our classification model adapted to learn at interactive rates. Our results show that our approach outperforms state-of-the-art machine learning models. In addition, we integrate our framework with the extended Social Media Analytics and Reporting Toolkit (SMART) 2.0 system, allowing the use of our interactive learning framework within a visual analytics system tailored for real-time situational awareness. To demonstrate our framework's effectiveness, we provide domain expert feedback from first responders who used the extended SMART 2.0 system.

First, we analyze the variance of the Cross Validation (CV)-based estimators used for estimating the performance of classification rules. Second, we propose a novel estimator to estimate this variance using the Influence Function (IF) approach that had been used previously very successfully to estimate the variance of the bootstrap-based estimators. The motivation for this research is that, as the best of our knowledge, the literature lacks a rigorous method for estimating the variance of the CV-based estimators. What is available is a set of ad-hoc procedures that have no mathematical foundation since they ignore the covariance structure among dependent random variables. The conducted experiments show that the IF proposed method has small RMS error with some bias. However, surprisingly, the ad-hoc methods still work better than the IF-based method. Unfortunately, this is due to the lack of enough smoothness if compared to the bootstrap estimator. This opens the research for three points: (1) more comprehensive simulation study to clarify when the IF method win or loose; (2) more mathematical analysis to figure out why the ad-hoc methods work well; and (3) more mathematical treatment to figure out the connection between the appropriate amount of "smoothness" and decreasing the bias of the IF method.

The document contains the following terms with appropriate definitions: Medical dataset (reference data) is a collection of high-level attributes of reusable medical image datasets suitable to train, test, validate, verify, and regulate AI algorithms. Intellectual technologies are information technologies created based on "artificial intelligence" . " Artificial Intelligence" (AI) refers to systems that display intelligent behavior by analyzing their environment and taking actions - with some degree of autonomy - to achieve specific goals. AIbased systems can be purely software-based, acting in the virtual world (e.g., voice assistants, image analysis software, search engines, speech and face recognition systems) or AI can be embedded in hardware devices (e.g., advanced robots, autonomous cars, drones, or Internet of Things applications) [6]. Mathematical model is an abstract mathematical representation of a process, device or concept; it uses a number of variables to represent inputs, outputs and internal states, and sets of equations and inequalities to describe their interaction.

Deep learning (DL) has shown great potential in medical image enhancement problems, such as super-resolution or image synthesis. However, to date, little consideration has been given to uncertainty quantification over the output image. Here we introduce methods to characterise different components of uncertainty in such problems and demonstrate the ideas using diffusion MRI super-resolution. Specifically, we propose to account for $intrinsic$ uncertainty through a heteroscedastic noise model and for $parameter$ uncertainty through approximate Bayesian inference, and integrate the two to quantify $predictive$ uncertainty over the output image. Moreover, we introduce a method to propagate the predictive uncertainty on a multi-channelled image to derived scalar parameters, and separately quantify the effects of intrinsic and parameter uncertainty therein. The methods are evaluated for super-resolution of two different signal representations of diffusion MR images---DTIs and Mean Apparent Propagator MRI---and their derived quantities such as MD and FA, on multiple datasets of both healthy and pathological human brains. Results highlight three key benefits of uncertainty modelling for improving the safety of DL-based image enhancement systems. Firstly, incorporating uncertainty improves the predictive performance even when test data departs from training data. Secondly, the predictive uncertainty highly correlates with errors, and is therefore capable of detecting predictive "failures". Results demonstrate that such an uncertainty measure enables subject-specific and voxel-wise risk assessment of the output images. Thirdly, we show that the method for decomposing predictive uncertainty into its independent sources provides high-level "explanations" for the performance by quantifying how much uncertainty arises from the inherent difficulty of the task or the limited training examples.

N-grams have been a common tool for information retrieval and machine learning applications for decades. In nearly all previous works, only a few values of $n$ are tested, with $n > 6$ being exceedingly rare. Larger values of $n$ are not tested due to computational burden or the fear of overfitting. In this work, we present a method to find the top-$k$ most frequent $n$-grams that is 60$\times$ faster for small $n$, and can tackle large $n\geq1024$. Despite the unprecedented size of $n$ considered, we show how these features still have predictive ability for malware classification tasks. More important, large $n$-grams provide benefits in producing features that are interpretable by malware analysis, and can be used to create general purpose signatures compatible with industry standard tools like Yara. Furthermore, the counts of common $n$-grams in a file may be added as features to publicly available human-engineered features that rival efficacy of professionally-developed features when used to train gradient-boosted decision tree models on the EMBER dataset.

Many versions of cross-validation (CV) exist in the literature; and each version though has different variants. All are used interchangeably by many practitioners; yet, without explanation to the connection or difference among them. This article has three contributions. First, it starts by mathematical formalization of these different versions and variants that estimate the error rate and the Area Under the ROC Curve (AUC) of a classification rule, to show the connection and difference among them. Second, we prove some of their properties and prove that many variants are either redundant or "not smooth". Hence, we suggest to abandon all redundant versions and variants and only keep the leave-one-out, the $K$-fold, and the repeated $K$-fold. We show that the latter is the only among the three versions that is "smooth" and hence looks mathematically like estimating the mean performance of the classification rules. However, empirically, for the known phenomenon of "weak correlation", which we explain mathematically and experimentally, it estimates both conditional and mean performance almost with the same accuracy. Third, we conclude the article with suggesting two research points that may answer the remaining question of whether we can come up with a finalist among the three estimators: (1) a comparative study, that is much more comprehensive than those available in literature and conclude no overall winner, is needed to consider a wide range of distributions, datasets, and classifiers including complex ones obtained via the recent deep learning approach. (2) we sketch the path of deriving a rigorous method for estimating the variance of the only "smooth" version, repeated $K$-fold CV, rather than those ad-hoc methods available in the literature that ignore the covariance structure among the folds of CV.