We trained and evaluated a localization-based deep CNN for breast cancer screening exam classification on over 200,000 exams (over 1,000,000 images). Our model achieves an AUC of 0.919 in predicting malignancy in patients undergoing breast cancer screening, reducing the error rate of the baseline (Wu et al., 2019a) by 23%. In addition, the models generates bounding boxes for benign and malignant findings, providing interpretable predictions.

Various domain users are increasingly leveraging real-time social media data to gain rapid situational awareness. However, due to the high noise in the deluge of data, effectively determining semantically relevant information can be difficult, further complicated by the changing definition of relevancy by each end user for different events. The majority of existing methods for short text relevance classification fail to incorporate users' knowledge into the classification process. Existing methods that incorporate interactive user feedback focus on historical datasets. Therefore, classifiers cannot be interactively retrained for specific events or user-dependent needs in real-time. This limits real-time situational awareness, as streaming data that is incorrectly classified cannot be corrected immediately, permitting the possibility for important incoming data to be incorrectly classified as well. We present a novel interactive learning framework to improve the classification process in which the user iteratively corrects the relevancy of tweets in real-time to train the classification model on-the-fly for immediate predictive improvements. We computationally evaluate our classification model adapted to learn at interactive rates. Our results show that our approach outperforms state-of-the-art machine learning models. In addition, we integrate our framework with the extended Social Media Analytics and Reporting Toolkit (SMART) 2.0 system, allowing the use of our interactive learning framework within a visual analytics system tailored for real-time situational awareness. To demonstrate our framework's effectiveness, we provide domain expert feedback from first responders who used the extended SMART 2.0 system.

First, we analyze the variance of the Cross Validation (CV)-based estimators used for estimating the performance of classification rules. Second, we propose a novel estimator to estimate this variance using the Influence Function (IF) approach that had been used previously very successfully to estimate the variance of the bootstrap-based estimators. The motivation for this research is that, as the best of our knowledge, the literature lacks a rigorous method for estimating the variance of the CV-based estimators. What is available is a set of ad-hoc procedures that have no mathematical foundation since they ignore the covariance structure among dependent random variables. The conducted experiments show that the IF proposed method has small RMS error with some bias. However, surprisingly, the ad-hoc methods still work better than the IF-based method. Unfortunately, this is due to the lack of enough smoothness if compared to the bootstrap estimator. This opens the research for three points: (1) more comprehensive simulation study to clarify when the IF method win or loose; (2) more mathematical analysis to figure out why the ad-hoc methods work well; and (3) more mathematical treatment to figure out the connection between the appropriate amount of "smoothness" and decreasing the bias of the IF method.

The document contains the following terms with appropriate definitions: Medical dataset (reference data) is a collection of high-level attributes of reusable medical image datasets suitable to train, test, validate, verify, and regulate AI algorithms. Intellectual technologies are information technologies created based on "artificial intelligence" . " Artificial Intelligence" (AI) refers to systems that display intelligent behavior by analyzing their environment and taking actions - with some degree of autonomy - to achieve specific goals. AIbased systems can be purely software-based, acting in the virtual world (e.g., voice assistants, image analysis software, search engines, speech and face recognition systems) or AI can be embedded in hardware devices (e.g., advanced robots, autonomous cars, drones, or Internet of Things applications) [6]. Mathematical model is an abstract mathematical representation of a process, device or concept; it uses a number of variables to represent inputs, outputs and internal states, and sets of equations and inequalities to describe their interaction.

Deep learning (DL) has shown great potential in medical image enhancement problems, such as super-resolution or image synthesis. However, to date, little consideration has been given to uncertainty quantification over the output image. Here we introduce methods to characterise different components of uncertainty in such problems and demonstrate the ideas using diffusion MRI super-resolution. Specifically, we propose to account for $intrinsic$ uncertainty through a heteroscedastic noise model and for $parameter$ uncertainty through approximate Bayesian inference, and integrate the two to quantify $predictive$ uncertainty over the output image. Moreover, we introduce a method to propagate the predictive uncertainty on a multi-channelled image to derived scalar parameters, and separately quantify the effects of intrinsic and parameter uncertainty therein. The methods are evaluated for super-resolution of two different signal representations of diffusion MR images---DTIs and Mean Apparent Propagator MRI---and their derived quantities such as MD and FA, on multiple datasets of both healthy and pathological human brains. Results highlight three key benefits of uncertainty modelling for improving the safety of DL-based image enhancement systems. Firstly, incorporating uncertainty improves the predictive performance even when test data departs from training data. Secondly, the predictive uncertainty highly correlates with errors, and is therefore capable of detecting predictive "failures". Results demonstrate that such an uncertainty measure enables subject-specific and voxel-wise risk assessment of the output images. Thirdly, we show that the method for decomposing predictive uncertainty into its independent sources provides high-level "explanations" for the performance by quantifying how much uncertainty arises from the inherent difficulty of the task or the limited training examples.

N-grams have been a common tool for information retrieval and machine learning applications for decades. In nearly all previous works, only a few values of $n$ are tested, with $n > 6$ being exceedingly rare. Larger values of $n$ are not tested due to computational burden or the fear of overfitting. In this work, we present a method to find the top-$k$ most frequent $n$-grams that is 60$\times$ faster for small $n$, and can tackle large $n\geq1024$. Despite the unprecedented size of $n$ considered, we show how these features still have predictive ability for malware classification tasks. More important, large $n$-grams provide benefits in producing features that are interpretable by malware analysis, and can be used to create general purpose signatures compatible with industry standard tools like Yara. Furthermore, the counts of common $n$-grams in a file may be added as features to publicly available human-engineered features that rival efficacy of professionally-developed features when used to train gradient-boosted decision tree models on the EMBER dataset.

Many versions of cross-validation (CV) exist in the literature; and each version though has different variants. All are used interchangeably by many practitioners; yet, without explanation to the connection or difference among them. This article has three contributions. First, it starts by mathematical formalization of these different versions and variants that estimate the error rate and the Area Under the ROC Curve (AUC) of a classification rule, to show the connection and difference among them. Second, we prove some of their properties and prove that many variants are either redundant or "not smooth". Hence, we suggest to abandon all redundant versions and variants and only keep the leave-one-out, the $K$-fold, and the repeated $K$-fold. We show that the latter is the only among the three versions that is "smooth" and hence looks mathematically like estimating the mean performance of the classification rules. However, empirically, for the known phenomenon of "weak correlation", which we explain mathematically and experimentally, it estimates both conditional and mean performance almost with the same accuracy. Third, we conclude the article with suggesting two research points that may answer the remaining question of whether we can come up with a finalist among the three estimators: (1) a comparative study, that is much more comprehensive than those available in literature and conclude no overall winner, is needed to consider a wide range of distributions, datasets, and classifiers including complex ones obtained via the recent deep learning approach. (2) we sketch the path of deriving a rigorous method for estimating the variance of the only "smooth" version, repeated $K$-fold CV, rather than those ad-hoc methods available in the literature that ignore the covariance structure among the folds of CV.

As machine learning becomes an important part of many real world applications affecting human lives, new requirements, besides high predictive accuracy, become important. One important requirement is transparency, which has been associated with model interpretability. Many machine learning algorithms induce models difficult to interpret, named black box. Moreover, people have difficulty to trust models that cannot be explained. In particular for machine learning, many groups are investigating new methods able to explain black box models. These methods usually look inside the black models to explain their inner work. By doing so, they allow the interpretation of the decision making process used by black box models. Among the recently proposed model interpretation methods, there is a group, named local estimators, which are designed to explain how the label of particular instance is predicted. For such, they induce interpretable models on the neighborhood of the instance to be explained. Local estimators have been successfully used to explain specific predictions. Although they provide some degree of model interpretability, it is still not clear what is the best way to implement and apply them. Open questions include: how to best define the neighborhood of an instance? How to control the trade-off between the accuracy of the interpretation method and its interpretability? How to make the obtained solution robust to small variations on the instance to be explained? To answer to these questions, we propose and investigate two strategies: (i) using data instance properties to provide improved explanations, and (ii) making sure that the neighborhood of an instance is properly defined by taking the geometry of the domain of the feature space into account. We evaluate these strategies in a regression task and present experimental results that show that they can improve local explanations.

In recent years, air traffic communication data has become easy to access, enabling novel research in many fields. Exploiting this new data source, a wide range of applications have emerged, from weather forecasting to stock market prediction, or the collection of intelligence about military and government movements. Typically these applications require knowledge about the metadata of the aircraft, specifically its operator and the aircraft category. armasuisse Science + Technology, the R&D agency for the Swiss Armed Forces, has been developing Classi-Fly, a novel approach to obtain metadata about aircraft based on their movement patterns. We validate Classi-Fly using several hundred thousand flights collected through open source means, in conjunction with ground truth from publicly available aircraft registries containing more than two million aircraft. We show that we can obtain the correct aircraft category with an accuracy of over 88%. In cases, where no metadata is available, this approach can be used to create the data necessary for applications working with air traffic communication. Finally, we show that it is feasible to automatically detect sensitive aircraft such as police and surveillance aircraft using this method.

Outlier detection is a fundamental task in data mining and has many applications including detecting errors in databases. While there has been extensive prior work on methods for outlier detection, modern datasets often have sizes that are beyond the ability of commonly used methods to process the data within a reasonable time. To overcome this issue, outlier detection methods can be trained over samples of the full-sized dataset. However, it is not clear how a model trained on a sample compares with one trained on the entire dataset. In this paper, we introduce the notion of resilience to sampling for outlier detection methods. Orthogonal to traditional performance metrics such as precision/recall, resilience represents the extent to which the outliers detected by a method applied to samples from a sampling scheme matches those when applied to the whole dataset. We propose a novel approach for estimating the resilience to sampling of both individual outlier methods and their ensembles. We performed an extensive experimental study on synthetic and real-world datasets where we study seven diverse and representative outlier detection methods, compare results obtained from samples versus those obtained from the whole datasets and evaluate the accuracy of our resilience estimates. We observed that the methods are not equally resilient to a given sampling scheme and it is often the case that careful joint selection of both the sampling scheme and the outlier detection method is necessary. It is our hope that the paper initiates research on designing outlier detection algorithms that are resilient to sampling.