We propose a compressive classification framework for settings where the data dimensionality is significantly higher than the sample size. The proposed method, referred to as compressive regularized discriminant analysis (CRDA) is based on linear discriminant analysis and has the ability to select significant features by using joint-sparsity promoting hard thresholding in the discriminant rule. Since the number of features is larger than the sample size, the method also uses state-of-the-art regularized sample covariance matrix estimators. Several analysis examples on real data sets, including image, speech signal and gene expression data illustrate the promising improvements offered by the proposed CRDA classifier in practise. Overall, the proposed method gives fewer misclassification errors than its competitors, while at the same time achieving accurate feature selection results. The open-source R package and MA TLAB toolbox of the proposed method (named compressiveRDA) is freely available. High-dimensional (HD) classification is at the core of numerous contemporary statistical studies. An increasingly common occurrence is the collection of large amounts of information on each individual sample point, even though the number of sample points themselves may remain relatively small. Typical examples are gene expression and protein mass spectrometry data, and other areas of computational biology. Regularization and shrinkage are commonly used tools in many applications such as regression or classification to overcome significant statistical challenges posed particularly due to the huge-dimension, low-sample-size (HDLSS) data settings in which the number of features, p, is often several magnitudes larger than the sample size, n (i.e., p null n).

The last decade saw the emergence of systematic large-scale replication projects in the social and behavioral sciences, (Camerer et al., 2016, 2018; Ebersole et al., 2016; Klein et al., 2014, 2018; Collaboration, 2015). These projects were driven by theoretical and conceptual concerns about a high fraction of "false positives" in the scientific publications (Ioannidis, 2005) (and a high prevalence of "questionable research practices" (Simmons, Nelson, and Simonsohn, 2011). Concerns about the credibility of research findings are not unique to the behavioral and social sciences; within Computer Science, Artificial Intelligence (AI) and Machine Learning (ML) are areas of particular concern (Lucic et al., 2018; Freire, Bonnet, and Shasha, 2012; Gundersen and Kjensmo, 2018; Henderson et al., 2018). Given the pioneering role of the behavioral and social sciences in the promotion of novel methodologies to improve the credibility of research, it is a promising approach to analyze the lessons learned from this field and adjust strategies for Computer Science, AI and ML In this paper, we review approaches used in the behavioral and social sciences and in the DARPA SCORE project. We particularly focus on the role of human forecasting of replication outcomes, and how forecasting can leverage the information gained from relatively labor and resource-intensive replications. We will discuss opportunities and challenges of using these approaches to monitor and improve the credibility of research areas in Computer Science, AI, and ML.

As the advancement of deep learning (DL), the Internet of Things and cloud computing techniques for biomedical and healthcare problems, mobile healthcare systems have received unprecedented attention. Since DL techniques usually require enormous amount of computation, most of them cannot be directly deployed on the resource-constrained mobile and IoT devices. Hence, most of the mobile healthcare systems leverage the cloud computing infrastructure, where the data collected by the mobile and IoT devices would be transmitted to the cloud computing platforms for analysis. However, in the contested environments, relying on the cloud might not be practical at all times. For instance, the satellite communication might be denied or disrupted. We propose SAIA, a Split Artificial Intelligence Architecture for mobile healthcare systems. Unlike traditional approaches for artificial intelligence (AI) which solely exploits the computational power of the cloud server, SAIA could not only relies on the cloud computing infrastructure while the wireless communication is available, but also utilizes the lightweight AI solutions that work locally on the client side, hence, it can work even when the communication is impeded. In SAIA, we propose a meta-information based decision unit, that could tune whether a sample captured by the client should be operated by the embedded AI (i.e., keeping on the client) or the networked AI (i.e., sending to the server), under different conditions. In our experimental evaluation, extensive experiments have been conducted on two popular healthcare datasets. Our results show that SAIA consistently outperforms its baselines in terms of both effectiveness and efficiency.

Republican senators are saying out loud the extent of mass testing for COVID-19 in the United States isn't where it should be -- not by a long shot -- and contradict president Donald Trump's oft repeated claims the U.S. has so much testing available. "We have so much testing," claimed Trump Thursday. Mass testing is one of the only few known ways to end the COVID-19 pandemic in this country. The U.S. has conducted only 8.1 million tests since February. The White House says its goal is two million tests per week per state by the end of May.

In recent years, academics and investigative journalists have criticized certain commercial risk assessments for their black-box nature and failure to satisfy competing notions of fairness. Since then, the field of interpretable machine learning has created simple yet effective algorithms, while the field of fair machine learning has proposed various mathematical definitions of fairness. However, studies from these fields are largely independent, despite the fact that many applications of machine learning to social issues require both fairness and interpretability. We explore the intersection by revisiting the recidivism prediction problem using state-of-the-art tools from interpretable machine learning, and assessing the models for performance, interpretability, and fairness. Unlike previous works, we compare against two existing risk assessments (COMPAS and the Arnold Public Safety Assessment) and train models that output probabilities rather than binary predictions. We present multiple models that beat these risk assessments in performance, and provide a fairness analysis of these models. Our results imply that machine learning models should be trained separately for separate locations, and updated over time.

Precise and efficient automated identification of Gastrointestinal (GI) tract diseases can help doctors treat more patients and improve the rate of disease detection and identification. Currently, automatic analysis of diseases in the GI tract is a hot topic in both computer science and medical-related journals. Nevertheless, the evaluation of such an automatic analysis is often incomplete or simply wrong. Algorithms are often only tested on small and biased datasets, and cross-dataset evaluations are rarely performed. A clear understanding of evaluation metrics and machine learning models with cross datasets is crucial to bring research in the field to a new quality level. Towards this goal, we present comprehensive evaluations of five distinct machine learning models using Global Features and Deep Neural Networks that can classify 16 different key types of GI tract conditions, including pathological findings, anatomical landmarks, polyp removal conditions, and normal findings from images captured by common GI tract examination instruments. In our evaluation, we introduce performance hexagons using six performance metrics such as recall, precision, specificity, accuracy, F1-score, and Matthews Correlation Coefficient to demonstrate how to determine the real capabilities of models rather than evaluating them shallowly. Furthermore, we perform cross-dataset evaluations using different datasets for training and testing. With these cross-dataset evaluations, we demonstrate the challenge of actually building a generalizable model that could be used across different hospitals. Our experiments clearly show that more sophisticated performance metrics and evaluation methods need to be applied to get reliable models rather than depending on evaluations of the splits of the same dataset, i.e., the performance metrics should always be interpreted together rather than relying on a single metric.

Recent advances in biological research have seen the emergence of high-throughput technologies with numerous applications that allow the study of biological mechanisms at an unprecedented depth and scale. A large amount of genomic data is now distributed through consortia like The Cancer Genome Atlas (TCGA), where specific types of biological information on specific type of tissue or cell are available. In cancer research, the challenge is now to perform integrative analyses of high-dimensional multi-omic data with the goal to better understand genomic processes that correlate with cancer outcomes, e.g. elucidate gene networks that discriminate a specific cancer subgroups (cancer sub-typing) or discovering gene networks that overlap across different cancer types (pan-cancer studies). In this paper, we propose a novel mixed graphical model approach to analyze multi-omic data of different types (continuous, discrete and count) and perform model selection by extending the Birth-Death MCMC (BDMCMC) algorithm initially proposed by \citet{stephens2000bayesian} and later developed by \cite{mohammadi2015bayesian}. We compare the performance of our method to the LASSO method and the standard BDMCMC method using simulations and find that our method is superior in terms of both computational efficiency and the accuracy of the model selection results. Finally, an application to the TCGA breast cancer data shows that integrating genomic information at different levels (mutation and expression data) leads to better subtyping of breast cancers.

Large-sample data became prevalent as data acquisition became cheaper and easier. While a large sample size has theoretical advantages for many statistical methods, it presents computational challenges. Sketching, or compression, is a well-studied approach to address these issues in regression settings, but considerably less is known about its performance in classification settings. Here we consider the computational issues due to large sample size within the discriminant analysis framework. We propose a new compression approach for reducing the number of training samples for linear and quadratic discriminant analysis, in contrast to existing compression methods which focus on reducing the number of features. We support our approach with a theoretical bound on the misclassification error rate compared to the Bayes classifier. Empirical studies confirm the significant computational gains of the proposed method and its superior predictive ability compared to random sub-sampling.

In this paper we present the impact of alternative data that originates from an app-based marketplace, in contrast to traditional bureau data, upon credit scoring models. These alternative data sources have shown themselves to be immensely powerful in predicting borrower behavior in segments traditionally underserved by banks and financial institutions. Our results, validated across two countries, show that these new sources of data are particularly useful for predicting financial behavior in low-wealth and young individuals, who are also the most likely to engage with alternative lenders. Furthermore, using the TreeSHAP method for Stochastic Gradient Boosting interpretation, our results also revealed interesting non-linear trends in the variables originating from the app, which would not normally be available to traditional banks. Our results represent an opportunity for technology companies to disrupt traditional banking by correctly identifying alternative data sources and handling this new information properly. At the same time alternative data must be carefully validated to overcome regulatory hurdles across diverse jurisdictions.

Amazon operates in 14 countries around the world, nine of which are eligible for its Prime yearly subscription service. It goes without saying that the company has a real desire to make available its shopping experience in any number of languages, particularly where customers who speak different dialects are searching for the same products. In pursuit of an efficient means of translating multiple languages, Amazon researchers devised a shopping model called a multitask model, in which the functions overlap across tasks and tend to reinforce each other. They say that their AI, which was trained on data from several different languages at once, delivered better results using any of those languages. As Amazon applied scientist Nikhil Rao explained in a blog post, the reason for the improvement is that a corpus in one language is able to fill gaps in that of another language.