Objective: Medical relations are the core components of medical knowledge graphs that are needed for healthcare artificial intelligence. However, the requirement of expert annotation by conventional algorithm development processes creates a major bottleneck for mining new relations. In this paper, we present Hi-RES, a framework for high-throughput relation extraction algorithm development. We also show that combining knowledge articles with electronic health records (EHRs) significantly increases the classification accuracy. Methods: We use relation triplets obtained from structured databases and semistructured webpages to label sentences from target corpora as positive training samples. Two methods are also provided for creating improved negative samples by combining positive samples with na\"ive negative samples. We propose a common model that summarizes sentence information using large-scale pretrained language models and multi-instance attention, which then joins with the concept embeddings trained from the EHRs for relation prediction. Results: We apply the Hi-RES framework to develop classification algorithms for disorder-disorder relations and disorder-location relations. Millions of sentences are created as training data. Using pretrained language models and EHR-based embeddings individually provides considerable accuracy increases over those of previous models. Joining them together further tremendously increases the accuracy to 0.947 and 0.998 for the two sets of relations, respectively, which are 10-17 percentage points higher than those of previous models. Conclusion: Hi-RES is an efficient framework for achieving high-throughput and accurate relation extraction algorithm development.

Let me start with a very simple example. Robin and Sam both started preparing for an entrance exam for engineering college. They both shared a room and put an equal amount of hard work while solving numerical problems. They both studied almost the same hours for the entire year and appeared in the final exam. Surprisingly, Robin cleared, but Sam did not.

Question classification (QC) is a prime constituent of automated question answering system. The work presented here demonstrates that the combination of multiple models achieve better classification performance than those obtained with existing individual models for the question classification task in Bengali. We have exploited state-of-the-art multiple model combination techniques, i.e., ensemble, stacking and voting, to increase QC accuracy. Lexical, syntactic and semantic features of Bengali questions are used for four well-known classifiers, namely Naïve Bayes, kernel Naïve Bayes, Rule Induction, and Decision Tree, which serve as our base learners. Single-layer question-class taxonomy with 8 coarse-grained classes is extended to two-layer taxonomy by adding 69 fine-grained classes. We carried out the experiments both on single-layer and two-layer taxonomies. Experimental results confirmed that classifier combination approaches outperform single classifier classification approaches by 4.02% for coarse-grained question classes. Overall, the stacking approach produces the best results for fine-grained classification and achieves 87.79% of accuracy. The approach presented here could be used in other Indo-Aryan or Indic languages to develop a question answering system. Both theoretical [22, 23] and empirical [24-26] studies confirm that the classifier combination approach is generally more accurate than any of the individual classifiers making up the ensemble. Furthermore, a number of studies [27, 30] were successfully carried out on classifier combination methods for the QC task which outperformed the individual classifiers.

Decision making in crucial applications such as lending, hiring, and college admissions has witnessed increasing use of algorithmic models and techniques as a result of a confluence of factors such as ubiquitous connectivity, ability to collect, aggregate, and process large amounts of fine-grained data using cloud computing, and ease of access to applying sophisticated machine learning models. Quite often, such applications are powered by search and recommendation systems, which in turn make use of personalized ranking algorithms. At the same time, there is increasing awareness about the ethical and legal challenges posed by the use of such data-driven systems. Researchers and practitioners from different disciplines have recently highlighted the potential for such systems to discriminate against certain population groups, due to biases in the datasets utilized for learning their underlying recommendation models. We present a study of fairness in online personalization settings involving the ranking of individuals. Starting from a fair warm-start machine-learned model, we first demonstrate that online personalization can cause the model to learn to act in an unfair manner if the user is biased in his/her responses. For this purpose, we construct a stylized model for generating training data with potentially biased features as well as potentially biased labels and quantify the extent of bias that is learned by the model when the user responds in a biased manner as in many real-world scenarios. We then formulate the problem of learning personalized models under fairness constraints and present a regularization based approach for mitigating biases in machine learning. We demonstrate the efficacy of our approach through extensive simulations with different parameter settings. Code: https://github.com/groshanlal/Fairness-Aware-Online-Personalization

This thesis develops a conceptual framework considering social data as representing the surface layer of a hierarchy of human social behaviours, needs and cognition which is employed to transform social data into representations that preserve social behaviours and their causalities. Based on this framework two platforms were built to capture insights from fast-paced and slow-paced social data. For fast-paced, a self-structuring and incremental learning technique was developed to automatically capture salient topics and corresponding dynamics over time. An event detection technique was developed to automatically monitor those identified topic pathways for significant fluctuations in social behaviours using multiple indicators such as volume and sentiment. This platform is demonstrated using two large datasets with over 1 million tweets. The separated topic pathways were representative of the key topics of each entity and coherent against topic coherence measures. Identified events were validated against contemporary events reported in news. Secondly for the slow-paced social data, a suite of new machine learning and natural language processing techniques were developed to automatically capture self-disclosed information of the individuals such as demographics, emotions and timeline of personal events. This platform was trialled on a large text corpus of over 4 million posts collected from online support groups. This was further extended to transform prostate cancer related online support group discussions into a multidimensional representation and investigated the self-disclosed quality of life of patients (and partners) against time, demographics and clinical factors. The capabilities of this extended platform have been demonstrated using a text corpus collected from 10 prostate cancer online support groups comprising of 609,960 prostate cancer discussions and 22,233 patients.

Yara rules are a ubiquitous tool among cybersecurity practitioners and analysts. Developing high-quality Yara rules to detect a malware family of interest can be labor- and time-intensive, even for expert users. Few tools exist and relatively little work has been done on how to automate the generation of Yara rules for specific families. In this paper, we leverage large n-grams ($n \geq 8$) combined with a new biclustering algorithm to construct simple Yara rules more effectively than currently available software. Our method, AutoYara, is fast, allowing for deployment on low-resource equipment for teams that deploy to remote networks. Our results demonstrate that AutoYara can help reduce analyst workload by producing rules with useful true-positive rates while maintaining low false-positive rates, sometimes matching or even outperforming human analysts. In addition, real-world testing by malware analysts indicates AutoYara could reduce analyst time spent constructing Yara rules by 44-86%, allowing them to spend their time on the more advanced malware that current tools can't handle. Code will be made available at https://github.com/NeuromorphicComputationResearchProgram .

Motivated by the pressing need for suicide prevention through improving behavioral healthcare, we use medical claims data to study the risk of subsequent suicide attempts for patients who were hospitalized due to suicide attempts and later discharged. Understanding the risk behaviors of such patients at elevated suicide risk is an important step towards the goal of "Zero Suicide". An immediate and unconventional challenge is that the identification of suicide attempts from medical claims contains substantial uncertainty: almost 20\% of "suspected" suicide attempts are identified from diagnostic codes indicating external causes of injury and poisoning with undermined intent. It is thus of great interest to learn which of these undetermined events are more likely actual suicide attempts and how to properly utilize them in survival analysis with severe censoring. To tackle these interrelated problems, we develop an integrative Cox cure model with regularization to perform survival regression with uncertain events and a latent cure fraction. We apply the proposed approach to study the risk of subsequent suicide attempt after suicide-related hospitalization for adolescent and young adult population, using medical claims data from Connecticut. The identified risk factors are highly interpretable; more intriguingly, our method distinguishes the risk factors that are most helpful in assessing either susceptibility or timing of subsequent attempt. The predicted statuses of the uncertain attempts are further investigated, leading to several new insights on suicide event identification.

The increased computerization in recent years has resulted in the production of a variety of different software, however measures need to be taken to ensure that the produced software isn't defective. Many researchers have worked in this area and have developed different Machine Learning-based approaches that predict whether the software is defective or not. This issue can't be resolved simply by using different conventional classifiers because the dataset is highly imbalanced i.e the number of defective samples detected is extremely less as compared to the number of non-defective samples. Therefore, to address this issue, certain sophisticated methods are required. The different methods developed by the researchers can be broadly classified into Resampling based methods, Cost-sensitive learning-based methods, and Ensemble Learning. Among these methods. This report analyses the performance of the Online Sequential Extreme Learning Machine (OS-ELM) proposed by Liang et.al. against several classifiers such as Logistic Regression, Support Vector Machine, Random Forest, and Na\"ive Bayes after oversampling the data. OS-ELM trains faster than conventional deep neural networks and it always converges to the globally optimal solution. A comparison is performed on the original dataset as well as the over-sampled data set. The oversampling technique used is Cluster-based Over-Sampling with Noise Filtering. This technique is better than several state-of-the-art techniques for oversampling. The analysis is carried out on 3 projects KC1, PC4 and PC3 carried out by the NASA group. The metrics used for measurement are recall and balanced accuracy. The results are higher for OS-ELM as compared to other classifiers in both scenarios.

Distributed computing is a standard way to scale up machine learning and data science algorithms to process large amounts of data. In such settings, avoiding communication amongst machines is paramount for achieving high performance. Rather than distribute the computation of existing algorithms, a common practice for avoiding communication is to compute local solutions or parameter estimates on each machine and then combine the results; in many convex optimization problems, even simple averaging of local solutions can work well. However, these schemes do not work when the local solutions are not unique. Spectral methods are a collection of such problems, where solutions are orthonormal bases of the leading invariant subspace of an associated data matrix, which are only unique up to rotation and reflections. Here, we develop a communication-efficient distributed algorithm for computing the leading invariant subspace of a data matrix. Our algorithm uses a novel alignment scheme that minimizes the Procrustean distance between local solutions and a reference solution, and only requires a single round of communication. For the important case of principal component analysis (PCA), we show that our algorithm achieves a similar error rate to that of a centralized estimator. We present numerical experiments demonstrating the efficacy of our proposed algorithm for distributed PCA, as well as other problems where solutions exhibit rotational symmetry, such as node embeddings for graph data and spectral initialization for quadratic sensing.

The Area Under the the Receiver Operating Characteristics (ROC) Curve, referred to as AUC, is a well-known performance measure in the supervised learning domain. Due to its compelling features, it has been employed in a number of studies to evaluate and compare the performance of different classifiers. In this work, we explore AUC as a performance measure in the unsupervised learning domain, more specifically, in the context of cluster analysis. In particular, we elaborate on the use of AUC as an internal/relative measure of clustering quality, which we refer to as Area Under the Curve for Clustering (AUCC). We show that the AUCC of a given candidate clustering solution has an expected value under a null model of random clustering solutions, regardless of the size of the dataset and, more importantly, regardless of the number or the (im)balance of clusters under evaluation. In addition, we demonstrate that, in the context of internal/relative clustering validation, AUCC is actually a linear transformation of the Gamma criterion from Baker and Hubert (1975), for which we also formally derive a theoretical expected value for chance clusterings. We also discuss the computational complexity of these criteria and show that, while an ordinary implementation of Gamma can be computationally prohibitive and impractical for most real applications of cluster analysis, its equivalence with AUCC actually unveils a computationally much more efficient and practical algorithmic procedure. Our theoretical findings are supported by experimental results.