Four other squad members, who were close contacts, also missed the game and that followed Aaron Connolly and Adam Idah sitting out Thursday's Euro 2020 play-off as being close contacts of the member of the backroom staff, who it was later discovered had a false positive test.

Fairness in machine learning is crucial when individuals are subject to automated decisions made by models in high-stake domains. Organizations that employ these models may also need to satisfy regulations that promote responsible and ethical A.I. While fairness metrics relying on comparing model error rates across subpopulations have been widely investigated for the detection and mitigation of bias, fairness in terms of the equalized ability to achieve recourse for different protected attribute groups has been relatively unexplored. We present a novel formulation for training neural networks that considers the distance of data points to the decision boundary such that the new objective: (1) reduces the average distance to the decision boundary between two groups for individuals subject to a negative outcome in each group, i.e. the network is more fair with respect to the ability to obtain recourse, and (2) increases the average distance of data points to the boundary to promote adversarial robustness. We demonstrate that training with this loss yields more fair and robust neural networks with similar accuracies to models trained without it. Moreover, we qualitatively motivate and empirically show that reducing recourse disparity across groups also improves fairness measures that rely on error rates. To the best of our knowledge, this is the first time that recourse capabilities across groups are considered to train fairer neural networks, and a relation between error rates based fairness and recourse based fairness is investigated.

Federated Learning enables a population of clients, working with a trusted server, to collaboratively learn a shared machine learning model while keeping each client's data within its own local systems. This reduces the risk of exposing sensitive data, but it is still possible to reverse engineer information about a client's private data set from communicated model parameters. Most federated learning systems therefore use differential privacy to introduce noise to the parameters. This adds uncertainty to any attempt to reveal private client data, but also reduces the accuracy of the shared model, limiting the useful scale of privacy-preserving noise. A system can further reduce the coordinating server's ability to recover private client information, without additional accuracy loss, by also including secure multiparty computation. An approach combining both techniques is especially relevant to financial firms as it allows new possibilities for collaborative learning without exposing sensitive client data. This could produce more accurate models for important tasks like optimal trade execution, credit origination, or fraud detection. The key contributions of this paper are: We present a privacy-preserving federated learning protocol to a non-specialist audience, demonstrate it using logistic regression on a real-world credit card fraud data set, and evaluate it using an open-source simulation platform which we have adapted for the development of federated learning systems.

Diagnosis of Parkinson's disease (PD) is commonly based on medical observations and assessment of clinical signs, including the characterization of a variety of motor symptoms. However, traditional diagnostic approaches may suffer from subjectivity as they rely on the evaluation of movements that are sometimes subtle to human eyes and therefore difficult to classify, leading to possible misclassification. In the meantime, early non-motor symptoms of PD may be mild and can be caused by many other conditions. Therefore, these symptoms are often overlooked, making diagnosis of PD at an early stage challenging. To address these difficulties and to refine the diagnosis and assessment procedures of PD, machine learning methods have been implemented for the classification of PD and healthy controls or patients with similar clinical presentations (e.g., movement disorders or other Parkinsonian syndromes). To provide a comprehensive overview of data modalities and machine learning methods that have been used in the diagnosis and differential diagnosis of PD, in this study, we conducted a systematic literature review of studies published until February 14, 2020, using the PubMed and IEEE Xplore databases. A total of 209 studies were included, extracted for relevant information and presented in this systematic review, with an investigation of their aims, sources of data, types of data, machine learning methods and associated outcomes. These studies demonstrate a high potential for adaptation of machine learning methods and novel biomarkers in clinical decision making, leading to increasingly systematic, informed diagnosis of PD.

Inspired by mixture-of-experts models and the analysis of the hidden activations of neural networks, we introduce a novel unsupervised anomaly detection method called ARGUE. Multiple expert networks, which specialise on parts of the data deemed as normal, contribute to the overall anomaly score. For its final decision, ARGUE weights the distributed knowledge across the expert systems using a gated mixture-of-experts architecture. ARGUE achieves superior detection performance across several domains in a purely data-driven fashion and is more robust to noisy data sets than other state-of-the-art anomaly detection methods.

Detecting anomalous inputs, such as adversarial and out-of-distribution (OOD) inputs, is critical for classifiers deployed in real-world applications, especially deep neural network (DNN) classifiers that are known to be brittle on such inputs. We propose an unsupervised statistical testing framework for detecting such anomalous inputs to a trained DNN classifier based on its internal layer representations. By calculating test statistics at the input and intermediate-layer representations of the DNN, conditioned individually on the predicted class and on the true class of labeled training data, the method characterizes their class-conditional distributions on natural inputs. Given a test input, its extent of nonconformity with respect to the training distribution is captured using p-values of the class-conditional test statistics across the layers, which are then combined using a scoring function designed to score high on anomalous inputs. We focus on adversarial inputs, which are an important class of anomalous inputs, and also demonstrate the effectiveness of our method on general OOD inputs. The proposed framework also provides an alternative class prediction that can be used to correct the DNN's prediction on (detected) adversarial inputs. Experiments on well-known image classification datasets with strong adversarial attacks, including a custom attack method that uses the internal layer representations of the DNN, demonstrate that our method outperforms or performs comparably with five recently-proposed, competing detection methods.

Language is a valuable source of clinical information in Alzheimer's Disease, as it declines concurrently with neurodegeneration. Consequently, speech and language data have been extensively studied in connection with its diagnosis. This paper summarises current findings on the use of artificial intelligence, speech and language processing to predict cognitive decline in the context of Alzheimer's Disease, detailing current research procedures, highlighting their limitations and suggesting strategies to address them. We conducted a systematic review of original research between 2000 and 2019, registered in PROSPERO (reference CRD42018116606). An interdisciplinary search covered six databases on engineering (ACM and IEEE), psychology (PsycINFO), medicine (PubMed and Embase) and Web of Science. Bibliographies of relevant papers were screened until December 2019. From 3,654 search results 51 articles were selected against the eligibility criteria. Four tables summarise their findings: study details (aim, population, interventions, comparisons, methods and outcomes), data details (size, type, modalities, annotation, balance, availability and language of study), methodology (pre-processing, feature generation, machine learning, evaluation and results) and clinical applicability (research implications, clinical potential, risk of bias and strengths/limitations). While promising results are reported across nearly all 51 studies, very few have been implemented in clinical research or practice. We concluded that the main limitations of the field are poor standardisation, limited comparability of results, and a degree of disconnect between study aims and clinical applications. Attempts to close these gaps should support translation of future research into clinical practice.

Class distribution skews in imbalanced datasets may lead to models with prediction bias towards majority classes, making fair assessment of classifiers a challenging task. Balanced Accuracy is a popular metric used to evaluate a classifier's prediction performance under such scenarios. However, this metric falls short when classes vary in importance, especially when class importance is skewed differently from class cardinality distributions. In this paper, we propose a simple and general-purpose evaluation framework for imbalanced data classification that is sensitive to arbitrary skews in class cardinalities and importances. Experiments with several state-of-the-art classifiers tested on real-world datasets and benchmarks from two different domains show that our new framework is more effective than Balanced Accuracy - not only in evaluating and ranking model predictions, but also in training the models themselves. For a broad range of machine learning (ML) tasks, predictive modeling in the presence of imbalanced datasets - those with severe distribution skews - has been a longstanding problem (He & Garcia, 2009; Sun et al., 2009; He & Ma, 2013; Branco et al., 2016; Hilario et al., 2018; Johnson & Khoshgoftaar, 2019). Imbalanced training datasets lead to models with prediction bias towards majority classes, which in turn results in misclassification of the underrepresented ones.

Anginal symptoms can connote increased cardiac risk and a need for change in cardiovascular management. This study evaluated the potential to extract these symptoms from physician notes using the Bidirectional Encoder from Transformers language model fine-tuned on a domain-specific corpus. The history of present illness section of 459 expert annotated primary care physician notes from consecutive patients referred for cardiac testing without known atherosclerotic cardiovascular disease were included. Notes were annotated for positive and negative mentions of chest pain and shortness of breath characterization. The results demonstrate high sensitivity and specificity for the detection of chest pain or discomfort, substernal chest pain, shortness of breath, and dyspnea on exertion. Small sample size limited extracting factors related to provocation and palliation of chest pain. This study provides a promising starting point for the natural language processing of physician notes to characterize clinically actionable anginal symptoms. Introduction Angina pectoris is a constellation of symptoms that portends inadequate oxygenation of cardiac muscle due to either a decrease in coronary blood supply, an increase in myocardial oxygen demand, or both.

Detection of semantic similarity plays a vital role in sentence matching. It requires to learn discriminative representations of natural language. Recently, owing to more and more sophisticated model architecture, impressive progress has been made, along with a time-consuming training process and not-interpretable inference. To alleviate this problem, we explore a metric learning approach, named FILM (Fast, Interpretable, and Low-rank Metric learning) to efficiently find a high discriminative projection of the high-dimensional data. We construct this metric learning problem as a manifold optimization problem and solve it with the Cayley transformation method with the Barzilai-Borwein step size. In experiments, we apply FILM with triplet loss minimization objective to the Quora Challenge and Semantic Textual Similarity (STS) Task. The results demonstrate that the FILM method achieves superior performance as well as the fastest computation speed, which is consistent with our theoretical analysis of time complexity.