An automatic image segmentation procedure is an inevitable part of many image analyses and computer vision which deeply affect the rest of the system; therefore, a set of interactive segmentation evaluation methods can substantially simplify the system development process. This entry presents the state of the art of quantitative evaluation metrics for color image segmentation methods by performing an analytical and comparative review of the measures. The decision-making process in selecting a suitable evaluation metric is still very serious because each metric tends to favor a different segmentation method for each benchmark dataset. Furthermore, a conceptual comparison of these metrics is provided at a high level of abstraction and is discussed for understanding the quantitative changes in different image segmentation results.

This paper describes a methodology to detect sepsis ahead of time by analyzing hourly patient records. The Physionet 2019 challenge consists of medical records of over 40,000 patients. Using imputation and weak ensembler technique to analyze these medical records and 3-fold validation, a model is created and validated internally. The model achieved an accuracy of 93.45% and a utility score of 0.271. The utility score as defined by the organizers takes into account true positives, negatives and false alarms.

In many contemporary applications, large amounts of unlabeled data are readily available while labeled examples are limited. There has been substantial interest in semi-supervised learning (SSL) which aims to leverage unlabeled data to improve estimation or prediction. However, current SSL literature focuses primarily on settings where labeled data is selected randomly from the population of interest. Non-random sampling, while posing additional analytical challenges, is highly applicable to many real world problems. Moreover, no SSL methods currently exist for estimating the prediction performance of a fitted model under non-random sampling. In this paper, we propose a two-step SSL procedure for evaluating a prediction rule derived from a working binary regression model based on the Brier score and overall misclassification rate under stratified sampling. In step I, we impute the missing labels via weighted regression with nonlinear basis functions to account for nonrandom sampling and to improve efficiency. In step II, we augment the initial imputations to ensure the consistency of the resulting estimators regardless of the specification of the prediction model or the imputation model. The final estimator is then obtained with the augmented imputations. We provide asymptotic theory and numerical studies illustrating that our proposals outperform their supervised counterparts in terms of efficiency gain. Our methods are motivated by electronic health records (EHR) research and validated with a real data analysis of an EHR-based study of diabetic neuropathy.

Data distributions in streaming environments are usually not stationary. In order to maintain a high predictive quality at all times, online learning models need to adapt to distributional changes, which are known as concept drift. The timely and robust identification of concept drift can be difficult, as we never have access to the true distribution of streaming data. In this work, we propose a novel framework for the detection of real concept drift, called ERICS. By treating the parameters of a predictive model as random variables, we show that concept drift corresponds to a change in the distribution of optimal parameters. To this end, we adopt common measures from information theory. The proposed framework is completely model-agnostic. By choosing an appropriate base model, ERICS is also capable to detect concept drift at the input level, which is a significant advantage over existing approaches. An evaluation on several synthetic and real-world data sets suggests that the proposed framework identifies concept drift more effectively and precisely than various existing works.

Modern large-scale kernel-based tests such as maximum mean discrepancy (MMD) and kernelized Stein discrepancy (KSD) optimize kernel hyperparameters on a held-out sample via data splitting to obtain the most powerful test statistics. While data splitting results in a tractable null distribution, it suffers from a reduction in test power due to smaller test sample size. Inspired by the selective inference framework, we propose an approach that enables learning the hyperparameters and testing on the full sample without data splitting. Our approach can correctly calibrate the test in the presence of such dependency, and yield a test threshold in closed form. At the same significance level, our approach's test power is empirically larger than that of the data-splitting approach, regardless of its split proportion.

Estimation of uncertainty in deep learning models is of vital importance, especially in medical imaging, where reliance on inference without taking into account uncertainty could lead to misdiagnosis. Recently, the probabilistic Variational AutoEncoder (VAE) has become a popular model for anomaly detection in applications such as lesion detection in medical images. The VAE is a generative graphical model that is used to learn the data distribution from samples and then generate new samples from this distribution. By training on normal samples, the VAE can be used to detect inputs that deviate from this learned distribution. The VAE models the output as a conditionally independent Gaussian characterized by means and variances for each output dimension. VAEs can therefore use reconstruction probability instead of reconstruction error for anomaly detection. Unfortunately, joint optimization of both mean and variance in the VAE leads to the well-known problem of shrinkage or underestimation of variance. We describe an alternative approach that avoids this variance shrinkage problem by using quantile regression. Using estimated quantiles to compute mean and variance under the Gaussian assumption, we compute reconstruction probability as a principled approach to outlier or anomaly detection. Results on simulated and Fashion MNIST data demonstrate the effectiveness of our approach. We also show how our approach can be used for principled heterogeneous thresholding for lesion detection in brain images.

One of the most common problems when working with classification tasks is imbalanced data where one class is dominating over the other. For example, in the Credit Card fraud detection task, there will be very few fraud transactions (positive class) when compared with non-fraud transactions (negative class). Sometimes, it is even possible that 99.99% of transactions will be non-fraud and only 0.01% of transactions will be fraud transactions. You can have a class imbalance problem on binary classification tasks as well as multi-class classification tasks. However, the techniques we are going to learn here can be applied to both.

Imbalanced learning (IL), i.e., learning unbiased models from class-imbalanced data, is a challenging problem. Typical IL methods including resampling and reweighting were designed based on some heuristic assumptions. They often suffer from unstable performance, poor applicability, and high computational cost in complex tasks where their assumptions do not hold. In this paper, we introduce a novel ensemble IL framework named MESA. It adaptively resamples the training set in iterations to get multiple classifiers and forms a cascade ensemble model. MESA directly learns the sampling strategy from data to optimize the final metric beyond following random heuristics. Moreover, unlike prevailing meta-learning-based IL solutions, we decouple the model-training and meta-training in MESA by independently train the meta-sampler over task-agnostic meta-data. This makes MESA generally applicable to most of the existing learning models and the meta-sampler can be efficiently applied to new tasks. Extensive experiments on both synthetic and real-world tasks demonstrate the effectiveness, robustness, and transferability of MESA. Our code is available at https://github.com/ZhiningLiu1998/mesa.

The thesis explores the role machine learning methods play in creating intuitive computational models of neural processing. Combined with interpretability techniques, machine learning could replace human modeler and shift the focus of human effort to extracting the knowledge from the ready-made models and articulating that knowledge into intuitive descroptions of reality. This perspective makes the case in favor of the larger role that exploratory and data-driven approach to computational neuroscience could play while coexisting alongside the traditional hypothesis-driven approach. We exemplify the proposed approach in the context of the knowledge representation taxonomy with three research projects that employ interpretability techniques on top of machine learning methods at three different levels of neural organization. The first study (Chapter 3) explores feature importance analysis of a random forest decoder trained on intracerebral recordings from 100 human subjects to identify spectrotemporal signatures that characterize local neural activity during the task of visual categorization. The second study (Chapter 4) employs representation similarity analysis to compare the neural responses of the areas along the ventral stream with the activations of the layers of a deep convolutional neural network. The third study (Chapter 5) proposes a method that allows test subjects to visually explore the state representation of their neural signal in real time. This is achieved by using a topology-preserving dimensionality reduction technique that allows to transform the neural data from the multidimensional representation used by the computer into a two-dimensional representation a human can grasp. The approach, the taxonomy, and the examples, present a strong case for the applicability of machine learning methods to automatic knowledge discovery in neuroscience.

Making predictions that are fair with regard to protected group membership (race, gender, age, etc.) has become an important requirement for classification algorithms. Existing techniques derive a fair model from sampled labeled data relying on the assumption that training and testing data are identically and independently drawn (iid) from the same distribution.In practice, distribution shift can and does occur between training and testing datasets as the characteristics of individuals interacting with the machine learning system -- and which individuals interact with the system -- change. We investigate fairness under covariate shift, a relaxation of the iid assumption in which the inputs or covariates change while the conditional label distribution remains the same. We seek fair decisions under these assumptions on target data with unknown labels.We propose an approach that obtains the predictor that is robust to the worst-case in terms of target performance while satisfying target fairness requirements and matching statistical properties of the source data. We demonstrate the benefits of our approach on benchmark prediction tasks.