The lack of non-parametric statistical tests for confounding bias significantly hampers the development of robust, valid and generalizable predictive models in many fields of research. Here I propose the partial and full confounder tests, which, for a given confounder variable, probe the null hypotheses of unconfounded and fully confounded models, respectively. The tests provide a strict control for Type I errors and high statistical power, even for non-normally and non-linearly dependent predictions, often seen in machine learning. Applying the proposed tests on models trained on functional brain connectivity data from the Human Connectome Project and the Autism Brain Imaging Data Exchange dataset reveals confounders that were previously unreported or found to be hard to correct for with state-of-the-art confound mitigation approaches. The tests, implemented in the package mlconfound (https://mlconfound.readthedocs.io), can aid the assessment and improvement of the generalizability and neurobiological validity of predictive models and, thereby, foster the development of clinically useful machine learning biomarkers.

Acyclic model, often depicted as a directed acyclic graph (DAG), has been widely employed to represent directional causal relations among collected nodes. In this article, we propose an efficient method to learn linear non-Gaussian DAG in high dimensional cases, where the noises can be of any continuous non-Gaussian distribution. This is in sharp contrast to most existing DAG learning methods assuming Gaussian noise with additional variance assumptions to attain exact DAG recovery. The proposed method leverages a novel concept of topological layer to facilitate the DAG learning. Particularly, we show that the topological layers can be exactly reconstructed in a bottom-up fashion, and the parent-child relations among nodes in each layer can also be consistently established. More importantly, the proposed method does not require the faithfulness or parental faithfulness assumption which has been widely assumed in the literature of DAG learning. Its advantage is also supported by the numerical comparison against some popular competitors in various simulated examples as well as a real application on the global spread of COVID-19.

In this extended abstract, we will present and discuss opportunities and challenges brought about by a new deep learning method by AUC maximization (aka \underline{\bf D}eep \underline{\bf A}UC \underline{\bf M}aximization or {\bf DAM}) for medical image classification. Since AUC (aka area under ROC curve) is a standard performance measure for medical image classification, hence directly optimizing AUC could achieve a better performance for learning a deep neural network than minimizing a traditional loss function (e.g., cross-entropy loss). Recently, there emerges a trend of using deep AUC maximization for large-scale medical image classification. In this paper, we will discuss these recent results by highlighting (i) the advancements brought by stochastic non-convex optimization algorithms for DAM; (ii) the promising results on various medical image classification problems. Then, we will discuss challenges and opportunities of DAM for medical image classification from three perspectives, feature learning, large-scale optimization, and learning trustworthy AI models.

In the current era of digitization, online payment systems are attracting considerable interest. Improving the efficiency of a payment system is important since it has a substantial impact on revenues for businesses. A gateway is an integral component of a payment system through which every transaction is routed. In an online payment system, payment processors integrate with these gateways by means of various configurations such as pricing, methods, risk checks, etc. These configurations are called terminals. Each gateway can have multiple terminals associated with it. Routing a payment transaction through the best terminal is crucial to increase the probability of a payment transaction being successful. Machine learning (ML) and artificial intelligence (AI) techniques can be used to accurately predict the best terminals based on their previous performance and various payment-related attributes. We have devised a pipeline consisting of static and dynamic modules. The static module does the initial filtering of the terminals using static rules and a logistic regression model that predicts gateway downtimes. Subsequently, the dynamic module computes a lot of novel features based on success rate, payment attributes, time lag, etc. to model the terminal behaviour accurately. These features are updated using an adaptive time decay rate algorithm in real-time using a feedback loop and passed to a random forest classifier to predict the success probabilities for every terminal. This pipeline is currently in production at Razorpay routing millions of transactions through it in real-time and has given a 4-6\% improvement in success rate across all payment methods (credit card, debit card, UPI, net banking). This has made our payment system more resilient to performance drops, which has improved the user experience, instilled more trust in the merchants, and boosted the revenue of the business.

While Out-of-distribution (OOD) detection has been well explored in computer vision, there have been relatively few prior attempts in OOD detection for NLP classification. In this paper we argue that these prior attempts do not fully address the OOD problem and may suffer from data leakage and poor calibration of the resulting models. We present PnPOOD, a data augmentation technique to perform OOD detection via out-of-domain sample generation using the recently proposed Plug and Play Language Model (Dathathri et al., 2020). Our method generates high quality discriminative samples close to the class boundaries, resulting in accurate OOD detection at test time. We demonstrate that our model outperforms prior models on OOD sample detection, and exhibits lower calibration error on the 20 newsgroup text and Stanford Sentiment Treebank dataset (Lang, 1995; Socheret al., 2013). We further highlight an important data leakage issue with datasets used in prior attempts at OOD detection, and share results on a new dataset for OOD detection that does not suffer from the same problem.

Background: Pleural Mesothelioma (PM) is an unusual, belligerent tumor that rapidly develops into cancer in the pleura of the lungs. Pleural Mesothelioma is a common type of Mesothelioma that accounts for about 75% of all Mesothelioma diagnosed yearly in the U.S. Diagnosis of Mesothelioma takes several months and is expensive. Given the risk and constraints associated with PM diagnosis, early identification of this ailment is essential for patient health. Objective: In this study, we use artificial intelligence algorithms recommending the best fit model for early diagnosis and prognosis of MPM. Methods: We retrospectively retrieved patients clinical data collected by Dicle University, Turkey, and applied multilayered perceptron (MLP), voted perceptron (VP), Clojure classifier (CC), kernel logistic regression (KLR), stochastic gradient decent SGD), adaptive boosting (AdaBoost), Hoeffding tree (VFDT), and primal estimated sub-gradient solver for support vector machine (s-Pegasos). We evaluated the models, compared and tested using paired T-test (corrected) at 0.05 significance based on their respective classification accuracy, f-measure, precision, recall, root mean squared error, receivers characteristic curve (ROC), and precision-recall curve (PRC). Results: In phase-1, SGD, AdaBoost. M1, KLR, MLP, VFDT generate optimal results with the highest possible performance measures. In phase 2, AdaBoost, with a classification accuracy of 71.29%, outperformed all other algorithms. C-reactive protein, platelet count, duration of symptoms, gender, and pleural protein were found to be the most relevant predictors that can prognosticate Mesothelioma. Conclusion: This study confirms that data obtained from Biopsy and imagining tests are strong predictors of Mesothelioma but are associated with a high cost; however, they can identify Mesothelioma with optimal accuracy.

TorchXRayVision is an open source software library for working with chest X-ray datasets and deep learning models. It provides a common interface and common pre-processing chain for a wide set of publicly available chest X-ray datasets. In addition, a number of classification and representation learning models with different architectures, trained on different data combinations, are available through the library to serve as baselines or feature extractors.

Have we identified the perfect metrics to measure the efficacy of our machine learning models? A perfect metric - does that even exist. A recent feed from LinkedIn on measuring metrics caught my attention, It is a bit opinionated claim from the author with substantial shreds of evidence and arguments. His post drew attention from many and made it a valuable repository of information and views from diverse people. I thank Nikhil and the LinkedIn community who participated in the discussion for inspiring me to write this post.

For autonomous vehicles to viably replace human drivers they must contend with inclement weather. Falling rain and snow introduce noise in LiDAR returns resulting in both false positive and false negative object detections. In this article we introduce the Winter Adverse Driving dataSet (WADS) collected in the snow belt region of Michigan's Upper Peninsula. WADS is the first multi-modal dataset featuring dense point-wise labeled sequential LiDAR scans collected in severe winter weather; weather that would cause an experienced driver to alter their driving behavior. We have labelled and will make available over 7 GB or 3.6 billion labelled LiDAR points out of over 26 TB of total LiDAR and camera data collected. We also present the Dynamic Statistical Outlier Removal (DSOR) filter, a statistical PCL-based filter capable or removing snow with a higher recall than the state of the art snow de-noising filter while being 28\% faster. Further, the DSOR filter is shown to have a lower time complexity compared to the state of the art resulting in an improved scalability. Our labeled dataset and DSOR filter will be made available at https://bitbucket.org/autonomymtu/dsor_filter

Objectives-Geriatric clinical care is a multidisciplinary assessment designed to evaluate older patients (age 65 years and above) functional ability, physical health, and cognitive wellbeing. The majority of these patients suffer from multiple chronic conditions and require special attention. Recently, hospitals utilize various artificial intelligence (AI) systems to improve care for elderly patients. The purpose of this systematic literature review is to understand the current use of AI systems, particularly machine learning (ML), in geriatric clinical care for chronic diseases. Materials and Methods-We restricted our search to eight databases, namely PubMed, WorldCat, MEDLINE, ProQuest, ScienceDirect, SpringerLink, Wiley, and ERIC, to analyze research articles published in English between January 2010 and June 2019. We focused on studies that used ML algorithms in the care of geriatrics patients with chronic conditions. Results-We identified 35 eligible studies and classified in three groups-psychological disorder (n=22), eye diseases (n=6), and others (n=7). This review identified the lack of standardized ML evaluation metrics and the need for data governance specific to health care applications. Conclusion- More studies and ML standardization tailored to health care applications are required to confirm whether ML could aid in improving geriatric clinical care.