The Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness. (WHO, 2020). While most persons with COVID-19 recover and return to normal health, some patients can have symptoms that can last for weeks or even months after recovery from acute illness.

Researchers at the University of Exeter, led by Professor David Lewellin, who published the study in the American medical journal JAMA Network Open, used data from 15.307 people with a mean age of 72 years and memory problems (of whom 1.568 diagnosed with Alzheimer's or another form of dementia within the next two years) tothe new machine learning algorithm, in order to recognize the precursor symptoms of dementia. The "smart" system has learned to detect hidden clues in the data, which the human eye, even a neurologist or other specialist, can not recognize. In addition, 130 diagnoses (8% of the total) turned out to be incorrect, as they were later overturned. Of these false positive cases of dementia, the algorithm was able to correctly diagnose that 84% actually had nothing to do with dementia. Therefore the system can not only distinguish who may develop neurodegeneration of the brain in the future, but also improve the accuracy of the diagnosis, so that someone who is not is not diagnosed as a patient.

The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors' institutions and Food and Drug Administration guidelines, including patient consent where appropriate.

This paper addresses and solves some challenges in the adoption of machine learning in insurance with the democratization of model deployment. The first challenge is reducing the labelling effort (hence focusing on the data quality) with the help of active learning, a feedback loop between the model inference and an oracle: as in insurance the unlabeled data is usually abundant, active learning can become a significant asset in reducing the labelling cost. For that purpose, this paper sketches out various classical active learning methodologies before studying their empirical impact on both synthetic and real datasets. Another key challenge in insurance is the fairness issue in model inferences. We will introduce and integrate a post-processing fairness for multi-class tasks in this active learning framework to solve these two issues. Finally numerical experiments on unfair datasets highlight that the proposed setup presents a good compromise between model precision and fairness.

We propose a simple and efficient image classification architecture based on deep multiple instance learning, and apply it to the challenging task of caries detection in dental radiographs. Technically, our approach contributes in two ways: First, it outputs a heatmap of local patch classification probabilities despite being trained with weak image-level labels. Second, it is amenable to learning from segmentation labels to guide training. In contrast to existing methods, the human user can faithfully interpret predictions and interact with the model to decide which regions to attend to. Experiments are conducted on a large clinical dataset of $\sim$38k bitewings ($\sim$316k teeth), where we achieve competitive performance compared to various baselines. When guided by an external caries segmentation model, a significant improvement in classification and localization performance is observed.

Deep learning (DL) has shown great potential in digital pathology applications. The robustness of a diagnostic DL-based solution is essential for safe clinical deployment. In this work we evaluate if adding uncertainty estimates for DL predictions in digital pathology could result in increased value for the clinical applications, by boosting the general predictive performance or by detecting mispredictions. We compare the effectiveness of model-integrated methods (MC dropout and Deep ensembles) with a model-agnostic approach (Test time augmentation, TTA). Moreover, four uncertainty metrics are compared. Our experiments focus on two domain shift scenarios: a shift to a different medical center and to an underrepresented subtype of cancer. Our results show that uncertainty estimates can add some reliability and reduce sensitivity to classification threshold selection. While advanced metrics and deep ensembles perform best in our comparison, the added value over simpler metrics and TTA is small. Importantly, the benefit of all evaluated uncertainty estimation methods is diminished by domain shift.

Building embodied intelligent agents that can interact with 3D indoor environments has received increasing research attention in recent years. While most works focus on single-object or agent-object visual functionality and affordances, our work proposes to study a new kind of visual relationship that is also important to perceive and model -- inter-object functional relationships (e.g., a switch on the wall turns on or off the light, a remote control operates the TV). Humans often spend little or no effort to infer these relationships, even when entering a new room, by using our strong prior knowledge (e.g., we know that buttons control electrical devices) or using only a few exploratory interactions in cases of uncertainty (e.g., multiple switches and lights in the same room). In this paper, we take the first step in building AI system learning inter-object functional relationships in 3D indoor environments with key technical contributions of modeling prior knowledge by training over large-scale scenes and designing interactive policies for effectively exploring the training scenes and quickly adapting to novel test scenes. We create a new benchmark based on the AI2Thor and PartNet datasets and perform extensive experiments that prove the effectiveness of our proposed method. Results show that our model successfully learns priors and fast-interactive-adaptation strategies for exploring inter-object functional relationships in complex 3D scenes. Several ablation studies further validate the usefulness of each proposed module.

Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hearing impairment. To this end, large-scale mouse phenotyping programs include auditory phenotyping of single-gene knockout mouse lines. Using the auditory brainstem response (ABR) procedure, the German Mouse Clinic and similar facilities worldwide have produced large, uniform data sets of averaged ABR raw data of mutant and wildtype mice. In the course of standard ABR analysis, hearing thresholds are assessed visually by trained staff from series of signal curves of increasing sound pressure level. This is time-consuming and prone to be biased by the reader as well as the graphical display quality and scale. In an attempt to reduce workload and improve quality and reproducibility, we developed and compared two methods for automated hearing threshold identification from averaged ABR raw data: a supervised approach involving two combined neural networks trained on human-generated labels and a self-supervised approach, which exploits the signal power spectrum and combines random forest sound level estimation with a piece-wise curve fitting algorithm for threshold finding. We show that both models work well, outperform human threshold detection, and are suitable for fast, reliable, and unbiased hearing threshold detection and quality control. In a high-throughput mouse phenotyping environment, both methods perform well as part of an automated end-to-end screening pipeline to detect candidate genes for hearing involvement. Code for both models as well as data used for this work are freely available.

Rolling bearings are one of the most widely used bearings in industrial machines. Deterioration in the condition of rolling bearings can result in the total failure of rotating machinery. AI-based methods are widely applied in the diagnosis of rolling bearings. Hybrid NN-based methods have been shown to achieve the best diagnosis results. Typically, raw data is generated from accelerometers mounted on the machine housing. However, the diagnostic utility of each signal is highly dependent on the location of the corresponding accelerometer. This paper proposes a novel hybrid CNN-MLP model-based diagnostic method which combines mixed input to perform rolling bearing diagnostics. The method successfully detects and localizes bearing defects using acceleration data from a shaft-mounted wireless acceleration sensor. The experimental results show that the hybrid model is superior to the CNN and MLP models operating separately, and can deliver a high detection accuracy of 99,6% for the bearing faults compared to 98% for CNN and 81% for MLP models.

When many labels are possible, choosing a single one can lead to low precision. A common alternative, referred to as top-$K$ classification, is to choose some number $K$ (commonly around 5) and to return the $K$ labels with the highest scores. Unfortunately, for unambiguous cases, $K>1$ is too many and, for very ambiguous cases, $K \leq 5$ (for example) can be too small. An alternative sensible strategy is to use an adaptive approach in which the number of labels returned varies as a function of the computed ambiguity, but must average to some particular $K$ over all the samples. We denote this alternative average-$K$ classification. This paper formally characterizes the ambiguity profile when average-$K$ classification can achieve a lower error rate than a fixed top-$K$ classification. Moreover, it provides natural estimation procedures for both the fixed-size and the adaptive classifier and proves their consistency. Finally, it reports experiments on real-world image data sets revealing the benefit of average-$K$ classification over top-$K$ in practice. Overall, when the ambiguity is known precisely, average-$K$ is never worse than top-$K$, and, in our experiments, when it is estimated, this also holds.