Deep learning has seen tremendous interest in medical imaging, particularly in the use of convolutional neural networks (CNNs) for developing automated diagnostic tools. The facility of its non-invasive acquisition makes retinal fundus imaging amenable to such automated approaches. Recent work in analyzing fundus images using CNNs relies on access to massive data for training and validation - hundreds of thousands of images. However, data residency and data privacy restrictions stymie the applicability of this approach in medical settings where patient confidentiality is a mandate. Here, we showcase results for the performance of DL on small datasets to classify patient sex from fundus images - a trait thought not to be present or quantifiable in fundus images until recently. We fine-tune a Resnet-152 model whose last layer has been modified for binary classification. In several experiments, we assess performance in the small dataset context using one private (DOVS) and one public (ODIR) data source. Our models, developed using approximately 2500 fundus images, achieved test AUC scores of up to 0.72 (95% CI: [0.67, 0.77]). This corresponds to a mere 25% decrease in performance despite a nearly 1000-fold decrease in the dataset size compared to prior work in the literature. Even with a hard task like sex categorization from retinal images, we find that classification is possible with very small datasets. Additionally, we perform domain adaptation experiments between DOVS and ODIR; explore the effect of data curation on training and generalizability; and investigate model ensembling to maximize CNN classifier performance in the context of small development datasets.

Machine learning models are trained to minimize the mean loss for a single metric, and thus typically do not consider fairness and robustness. Neglecting such metrics in training can make these models prone to fairness violations when training data are imbalanced or test distributions differ. This work introduces Fairness Optimized Reweighting via Meta-Learning (FORML), a training algorithm that balances fairness and robustness with accuracy by jointly learning training sample weights and neural network parameters. The approach increases model fairness by learning to balance the contributions from both over- and under-represented sub-groups through dynamic reweighting of the data learned from a user-specified held-out set representative of the distribution under which fairness is desired. FORML improves equality of opportunity fairness criteria on image classification tasks, reduces bias of corrupted labels, and facilitates building more fair datasets via data condensation. These improvements are achieved without pre-processing data or post-processing model outputs, without learning an additional weighting function, without changing model architecture, and while maintaining accuracy on the original predictive metric.

Classification applications are typically associated with misclassification costs and benefits as a result of incorrect and correct classification, respectively. Many studies have focused on cost-sensitive classification approaches [7, 8, 9, 10, 11, 12] in an effort to reduce the costs of misclassification. We illustrate the concept of imbalanced misclassification costs using the current and real-world example of classifying COVID-19 patients. Incorrectly classifying an ill patient as healthy may put this patient's life at risk as well as others by allowing the ill person to circulate among healthy persons and infect them (an intangible cost, usually determined by the judicial system). Classifying a healthy individual as a COVID-19 patient, on the other hand, may lead to unnecessary treatment, misuse of medical resources and cause unnecessary financial hardship to the individual and the general economy. Many studies have applied cost-sensitive approaches to handling imbalanced classification problems [13, 14] where the decision maker is interested in detecting the positive cases. There are four main approaches for making a classifier cost-sensitive: (i) changing the distribution of classes using over-and under-sampling within the training data set (i.e., preprocessing of the training data) to reduce misclassification costs [7, 8], denoted hereafter approach A1; (ii) changing the data set according to the misclassified samples of the cost-insensitive classifiers and their error costs (post-processing the training data) using a boosting approach in ensemble learning methods [12, 15], denoted hereafter approach A2; (iii) incorporating meta-learning methods on outputs of cost-insensitive learners using threshold driven techniques in favor of utilizing the probability estimations for the classes [7, 8, 16, 17], hereafter denoted A3; (iv) directly incorporating cost-sensitive capabilities into a learning algorithm, i.e., an algorithm-level solution that adapts existing learning methods so they are biased towards classes with high misclassification costs, usually presented by minority classes [8, 18].

We propose a greedy algorithm to select $N$ important features among $P$ input features for a non-linear prediction problem. The features are selected one by one sequentially, in an iterative loss minimization procedure. We use neural networks as predictors in the algorithm to compute the loss and hence, we refer to our method as neural greedy pursuit (NGP). NGP is efficient in selecting $N$ features when $N \ll P$, and it provides a notion of feature importance in a descending order following the sequential selection procedure. We experimentally show that NGP provides better performance than several feature selection methods such as DeepLIFT and Drop-one-out loss. In addition, we experimentally show a phase transition behavior in which perfect selection of all $N$ features without false positives is possible when the training data size exceeds a threshold.

Adverse events are a serious issue in drug development and many prediction methods using machine learning have been developed. The random split cross-validation is the de facto standard for model building and evaluation in machine learning, but care should be taken in adverse event prediction because this approach does not match to the real-world situation. The time split, which uses the time axis, is considered suitable for real-world prediction. However, the differences in model performance obtained using the time and random splits are not clear due to the lack of the comparable studies. To understand the differences, we compared the model performance between the time and random splits using nine types of compound information as input, eight adverse events as targets, and six machine learning algorithms. The random split showed higher area under the curve values than did the time split for six of eight targets. The chemical spaces of the training and test datasets of the time split were similar, suggesting that the concept of applicability domain is insufficient to explain the differences derived from the splitting. The area under the curve differences were smaller for the protein interaction than for the other datasets. Subsequent detailed analyses suggested the danger of confounding in the use of knowledge-based information in the time split. These findings indicate the importance of understanding the differences between the time and random splits in adverse event prediction and strongly suggest that appropriate use of the splitting strategies and interpretation of results are necessary for the real-world prediction of adverse events. We provide analysis code and datasets used in the present study (https://github.com/mizuno-group/AE_prediction).

As opaque predictive models increasingly impact many areas of modern life, interest in quantifying the importance of a given input variable for making a specific prediction has grown. Recently, there has been a proliferation of model-agnostic methods to measure variable importance (VI) that analyze the difference in predictive power between a full model trained on all variables and a reduced model that excludes the variable(s) of interest. A bottleneck common to these methods is the estimation of the reduced model for each variable (or subset of variables), which is an expensive process that often does not come with theoretical guarantees. In this work, we propose a fast and flexible method for approximating the reduced model with important inferential guarantees. We replace the need for fully retraining a wide neural network by a linearization initialized at the full model parameters. By adding a ridge-like penalty to make the problem convex, we prove that when the ridge penalty parameter is sufficiently large, our method estimates the variable importance measure with an error rate of $O(\frac{1}{\sqrt{n}})$ where $n$ is the number of training samples. We also show that our estimator is asymptotically normal, enabling us to provide confidence bounds for the VI estimates. We demonstrate through simulations that our method is fast and accurate under several data-generating regimes, and we demonstrate its real-world applicability on a seasonal climate forecasting example.

Although a plethora of architectural variants for deep classification has been introduced over time, recent works have found empirical evidence towards similarities in their training process. It has been hypothesized that neural networks converge not only to similar representations, but also exhibit a notion of empirical agreement on which data instances are learned first. Following in the latter works$'$ footsteps, we define a metric to quantify the relationship between such classification agreement over time, and posit that the agreement phenomenon can be mapped to core statistics of the investigated dataset. We empirically corroborate this hypothesis across the CIFAR10, Pascal, ImageNet and KTH-TIPS2 datasets. Our findings indicate that agreement seems to be independent of specific architectures, training hyper-parameters or labels, albeit follows an ordering according to image statistics.

Automating machine learning has achieved remarkable technological developments in recent years, and building an automated machine learning pipeline is now an essential task. The model ensemble is the technique of combining multiple models to get a better and more robust model. However, existing automated machine learning tends to be simplistic in handling the model ensemble, where the ensemble strategy is fixed, such as stacked generalization. There have been many techniques on different ensemble methods, especially ensemble selection, and the fixed ensemble strategy limits the upper limit of the model's performance. In this article, we present a novel framework for automated machine learning. Our framework incorporates advances in dynamic ensemble selection, and to our best knowledge, our approach is the first in the field of AutoML to search and optimize ensemble strategies. In the comparison experiments, our method outperforms the state-of-the-art automated machine learning frameworks with the same CPU time in 42 classification datasets from the OpenML platform. Ablation experiments on our framework validate the effectiveness of our proposed method.

Continuously learning new classes without catastrophic forgetting is a challenging problem for on-device environmental sound classification given the restrictions on computation resources (e.g., model size, running memory). To address this issue, we propose a simple and efficient continual learning method. Our method selects the historical data for the training by measuring the per-sample classification uncertainty. Specifically, we measure the uncertainty by observing how the classification probability of data fluctuates against the parallel perturbations added to the classifier embedding. In this way, the computation cost can be significantly reduced compared with adding perturbation to the raw data. Experimental results on the DCASE 2019 Task 1 and ESC-50 dataset show that our proposed method outperforms baseline continual learning methods on classification accuracy and computational efficiency, indicating our method can efficiently and incrementally learn new classes without the catastrophic forgetting problem for on-device environmental sound classification.

High-end vehicles have been furnished with a number of electronic control units (ECUs), which provide upgrading functions to enhance the driving experience. The controller area network (CAN) is a well-known protocol that connects these ECUs because of its modesty and efficiency. However, the CAN bus is vulnerable to various types of attacks. Although the intrusion detection system (IDS) is proposed to address the security problem of the CAN bus, most previous studies only provide alerts when attacks occur without knowing the specific type of attack. Moreover, an IDS is designed for a specific car model due to diverse car manufacturers. In this study, we proposed a novel deep learning model called supervised contrastive (SupCon) ResNet, which can handle multiple attack identification on the CAN bus. Furthermore, the model can be used to improve the performance of a limited-size dataset using a transfer learning technique. The capability of the proposed model is evaluated on two real car datasets. When tested with the car hacking dataset, the experiment results show that the SupCon ResNet model improves the overall false-negative rates of four types of attack by four times on average, compared to other models. In addition, the model achieves the highest F1 score at 0.9994 on the survival dataset by utilizing transfer learning. Finally, the model can adapt to hardware constraints in terms of memory size and running time.