Cryptominers are one of the main cloud threats today. Miner attacks are low risk, low effort, and high reward for a financially motivated attacker. Moreover, this kind of malware can pass unnoticed because, with proper evasive techniques, they may not disrupt a company's business operations. Given all the possible elusive strategies, detecting cryptominers is a complex task, but machine learning could help to develop a robust detection algorithm. However, being able to assess the model performance in a reliable way is paramount.

Several researchers have focused on studying driver cognitive behavior and mental load for in-vehicle interaction while driving. Adaptive interfaces that vary with mental and perceptual load levels could help in reducing accidents and enhancing the driver experience. In this paper, we analyze the effects of mental workload and perceptual load on psychophysiological dimensions and provide a machine learning-based framework for mental and perceptual load estimation in a dual task scenario for in-vehicle interaction (https://github.com/amrgomaaelhady/MWL-PL-estimator). We use off-the-shelf non-intrusive sensors that can be easily integrated into the vehicle's system. Our statistical analysis shows that while mental workload influences some psychophysiological dimensions, perceptual load shows little effect. Furthermore, we classify the mental and perceptual load levels through the fusion of these measurements, moving towards a real-time adaptive in-vehicle interface that is personalized to user behavior and driving conditions. We report up to 89% mental workload classification accuracy and provide a real-time minimally-intrusive solution.

Cancer is a disease that stems from the disruption of cellular state. Through genetic perturbations, tumor cells attain cellular states that give them proliferative advantage over the surrounding normal tissue [1]. The inherent variability of this process has hampered efforts to find highly effective common therapies, thereby ushering the need for precision medicine [2]. The scale of single-cell experiments is poised to revolutionize personalized medicine by effective characterization of the complete heterogeneity within a tumor for each individual patient [3, 4]. Recent expansion of single-cell sequencing technologies has exponentially increased the scale of knowledge attainable through a single biological experiment [5].

This paper proposes a framework based on a causal model of safety upon which effective safety assurance cases for ML-based applications can be developed. In doing so, we build upon established principles of safety engineering as well as previous work on structuring assurance arguments for ML. The paper defines four categories of safety case evidence and a structured analysis approach within which these evidences can be effectively combined. Where appropriate, abstract formalisations of these contributions are used to illustrate the causalities they evaluate, their contributions to the safety argument and desirable properties of the evidences. Based on the proposed framework, progress in this area is re-evaluated and a set of future research directions proposed in order for tangible progress in this field to be made.

Purpose: When a learner fails to reach a milestone, educators often wonder if there had been any warning signs that could have allowed them to intervene sooner. Machine learning can predict which students are at risk of failing a high-stakes certification exam. If predictions can be made well in advance of the exam, then educators can meaningfully intervene before students take the exam to reduce the chances of a failing score. Methods: Using already-collected, first-year student assessment data from five cohorts in a Master of Physician Assistant Studies program, the authors implement an "adaptive minimum match" version of the k-nearest neighbors algorithm (AMMKNN), using changing numbers of neighbors to predict each student's future exam scores on the Physician Assistant National Certifying Examination (PANCE). Validation occurred in two ways: Leave-one-out cross-validation (LOOCV) and evaluating the predictions in a new cohort. Results: AMMKNN achieved an accuracy of 93% in LOOCV. AMMKNN generates a predicted PANCE score for each student, one year before they are scheduled to take the exam. Students can then be classified into extra support, optional extra support, or no extra support groups. The educator then has one year to provide the appropriate customized support to each category of student. Conclusions: Predictive analytics can identify at-risk students, so they can receive additional support or remediation when preparing for high-stakes certification exams. Educators can use the included methods and code to generate predicted test outcomes for students. The authors recommend that educators use this or similar predictive methods responsibly and transparently, as one of many tools used to support students.

In this paper, we study the expanding attack surface of Adversarial Machine Learning (AML) and the potential attacks against Vehicle-to-Microgrid (V2M) services. We present an anticipatory study of a multi-stage gray-box attack that can achieve a comparable result to a white-box attack. Adversaries aim to deceive the targeted Machine Learning (ML) classifier at the network edge to misclassify the incoming energy requests from microgrids. With an inference attack, an adversary can collect real-time data from the communication between smart microgrids and a 5G gNodeB to train a surrogate (i.e., shadow) model of the targeted classifier at the edge. To anticipate the associated impact of an adversary's capability to collect real-time data instances, we study five different cases, each representing different amounts of real-time data instances collected by an adversary. Out of six ML models trained on the complete dataset, K-Nearest Neighbour (K-NN) is selected as the surrogate model, and through simulations, we demonstrate that the multi-stage gray-box attack is able to mislead the ML classifier and cause an Evasion Increase Rate (EIR) up to 73.2% using 40% less data than what a white-box attack needs to achieve a similar EIR.

Intrusion detection is an important defensive measure for automotive communications security. Accurate frame detection models assist vehicles to avoid malicious attacks. Uncertainty and diversity regarding attack methods make this task challenging. However, the existing works have the limitation of only considering local features or the weak feature mapping of multi-features. To address these limitations, we present a novel model for automotive intrusion detection by spatial-temporal correlation features of in-vehicle communication traffic (STC-IDS). Specifically, the proposed model exploits an encoding-detection architecture. In the encoder part, spatial and temporal relations are encoded simultaneously. To strengthen the relationship between features, the attention-based convolutional network still captures spatial and channel features to increase the receptive field, while attention-LSTM builds meaningful relationships from previous time series or crucial bytes. The encoded information is then passed to detector for generating forceful spatial-temporal attention features and enabling anomaly classification. In particular, single-frame and multi-frame models are constructed to present different advantages respectively. Under automatic hyper-parameter selection based on Bayesian optimization, the model is trained to attain the best performance. Extensive empirical studies based on a real-world vehicle attack dataset demonstrate that STC-IDS has outperformed baseline methods and obtains fewer false-alarm rates while maintaining efficiency.

Estimation of treatment efficacy of real-world clinical interventions involves working with continuous outcomes such as time-to-death, re-hospitalization, or a composite event that may be subject to censoring. Counterfactual reasoning in such scenarios requires decoupling the effects of confounding physiological characteristics that affect baseline survival rates from the effects of the interventions being assessed. In this paper, we present a latent variable approach to model heterogeneous treatment effects by proposing that an individual can belong to one of latent clusters with distinct response characteristics. We show that this latent structure can mediate the base survival rates and helps determine the effects of an intervention. We demonstrate the ability of our approach to discover actionable phenotypes of individuals based on their treatment response on multiple large randomized clinical trials originally conducted to assess appropriate treatments to reduce cardiovascular risk.

With the rise of AI, algorithms have become better at learning underlying patterns from the training data including ingrained social biases based on gender, race, etc. Deployment of such algorithms to domains such as hiring, healthcare, law enforcement, etc. has raised serious concerns about fairness, accountability, trust and interpretability in machine learning algorithms. To alleviate this problem, we propose D-BIAS, a visual interactive tool that embodies human-in-the-loop AI approach for auditing and mitigating social biases from tabular datasets. It uses a graphical causal model to represent causal relationships among different features in the dataset and as a medium to inject domain knowledge. A user can detect the presence of bias against a group, say females, or a subgroup, say black females, by identifying unfair causal relationships in the causal network and using an array of fairness metrics. Thereafter, the user can mitigate bias by acting on the unfair causal edges. For each interaction, say weakening/deleting a biased causal edge, the system uses a novel method to simulate a new (debiased) dataset based on the current causal model. Users can visually assess the impact of their interactions on different fairness metrics, utility metrics, data distortion, and the underlying data distribution. Once satisfied, they can download the debiased dataset and use it for any downstream application for fairer predictions. We evaluate D-BIAS by conducting experiments on 3 datasets and also a formal user study. We found that D-BIAS helps reduce bias significantly compared to the baseline debiasing approach across different fairness metrics while incurring little data distortion and a small loss in utility. Moreover, our human-in-the-loop based approach significantly outperforms an automated approach on trust, interpretability and accountability.

Structural magnetic resonance imaging studies have shown that brain anatomical abnormalities are associated with cognitive deficits in preterm infants. Brain maturation and geometric features can be used with machine learning models for predicting later neurodevelopmental deficits. However, traditional machine learning models would suffer from a large feature-to-instance ratio (i.e., a large number of features but a small number of instances/samples). Ensemble learning is a paradigm that strategically generates and integrates a library of machine learning classifiers and has been successfully used on a wide variety of predictive modeling problems to boost model performance. Attribute (i.e., feature) bagging method is the most commonly used feature partitioning scheme, which randomly and repeatedly draws feature subsets from the entire feature set. Although attribute bagging method can effectively reduce feature dimensionality to handle the large feature-to-instance ratio, it lacks consideration of domain knowledge and latent relationship among features. In this study, we proposed a novel Ontology-guided Attribute Partitioning (OAP) method to better draw feature subsets by considering the domain-specific relationship among features. With the better partitioned feature subsets, we developed an ensemble learning framework, which is referred to as OAP-Ensemble Learning (OAP-EL). We applied the OAP-EL to predict cognitive deficits at 2 years of age using quantitative brain maturation and geometric features obtained at term equivalent age in very preterm infants. We demonstrated that the proposed OAP-EL approach significantly outperformed the peer ensemble learning and traditional machine learning approaches.