A tool that could suggest new personalized research directions and ideas by taking insights from the scientific literature could significantly accelerate the progress of science. A field that might benefit from such an approach is artificial intelligence (AI) research, where the number of scientific publications has been growing exponentially over the last years, making it challenging for human researchers to keep track of the progress. Here, we use AI techniques to predict the future research directions of AI itself. We develop a new graph-based benchmark based on real-world data -- the Science4Cast benchmark, which aims to predict the future state of an evolving semantic network of AI. For that, we use more than 100,000 research papers and build up a knowledge network with more than 64,000 concept nodes. We then present ten diverse methods to tackle this task, ranging from pure statistical to pure learning methods. Surprisingly, the most powerful methods use a carefully curated set of network features, rather than an end-to-end AI approach. It indicates a great potential that can be unleashed for purely ML approaches without human knowledge. Ultimately, better predictions of new future research directions will be a crucial component of more advanced research suggestion tools.

The rapid progress in clinical data management systems and artificial intelligence approaches enable the era of personalized medicine. Intensive care units (ICUs) are the ideal clinical research environment for such development because they collect many clinical data and are highly computerized environments. We designed a retrospective clinical study on a prospective ICU database using clinical natural language to help in the early diagnosis of heart failure in critically ill children. The methodology consisted of empirical experiments of a learning algorithm to learn the hidden interpretation and presentation of the French clinical note data. This study included 1386 patients' clinical notes with 5444 single lines of notes. There were 1941 positive cases (36 % of total) and 3503 negative cases classified by two independent physicians using a standardized approach. The multilayer perceptron neural network outperforms other discriminative and generative classifiers. Consequently, the proposed framework yields an overall classification performance with 89 % accuracy, 88 % recall, and 89 % precision. This study successfully applied learning representation and machine learning algorithms to detect heart failure from clinical natural language in a single French institution. Further work is needed to use the same methodology in other institutions and other languages.

Applicability of Machine Learning (ML) algorithms -- in the industry, tutorials, and courses -- is heavily biased towards building the ML models themselves. From our point of view, however, the data preprocessing step (i.e., transforming textual system logging to numerical arrays that capture valuable insights from the data) possesses the highest psychological and epistemic gap for security engineers and analysts trying to weaponize their data. There are enormous log collection hubs that lack qualitative analytics to infer necessary visibility out of acquired data. TeraBytes of logs are often collected to perform only basic analytics (e.g., basic signature-based rules) and are considered to be used in an ad hoc, reactive manner -- if an investigation is needed. Many valuable inferences can be acquired by defining manual heuristics on top of this data.

For Head and Neck Cancers (HNC) patient management, automatic gross tumor volume (GTV) segmentation and accurate pre-treatment cancer recurrence prediction are of great importance to assist physicians in designing personalized management plans, which have the potential to improve the treatment outcome and quality of life for HNC patients. In this paper, we developed an automated primary tumor (GTVp) and lymph nodes (GTVn) segmentation method based on combined pre-treatment positron emission tomography/computed tomography (PET/CT) scans of HNC patients. We extracted radiomics features from the segmented tumor volume and constructed a multi-modality tumor recurrence-free survival (RFS) prediction model, which fused the prediction results from separate CT radiomics, PET radiomics, and clinical models. We performed 5-fold cross-validation to train and evaluate our methods on the MICCAI 2022 HEad and neCK TumOR segmentation and outcome prediction challenge (HECKTOR) dataset. The ensemble prediction results on the testing cohort achieved Dice scores of 0.77 and 0.73 for GTVp and GTVn segmentation, respectively, and a C-index value of 0.67 for RFS prediction. The code is publicly available (https://github.com/wangkaiwan/HECKTOR-2022-AIRT). Our team's name is AIRT.

Freezing of gait (FoG) is one of the most common symptoms of Parkinson's disease, which is a neurodegenerative disorder of the central nervous system impacting millions of people around the world. To address the pressing need to improve the quality of treatment for FoG, devising a computer-aided detection and quantification tool for FoG has been increasingly important. As a non-invasive technique for collecting motion patterns, the footstep pressure sequences obtained from pressure sensitive gait mats provide a great opportunity for evaluating FoG in the clinic and potentially in the home environment. In this study, FoG detection is formulated as a sequential modelling task and a novel deep learning architecture, namely Adversarial Spatio-temporal Network (ASTN), is proposed to learn FoG patterns across multiple levels. A novel adversarial training scheme is introduced with a multi-level subject discriminator to obtain subject-independent FoG representations, which helps to reduce the over-fitting risk due to the high inter-subject variance. As a result, robust FoG detection can be achieved for unseen subjects. The proposed scheme also sheds light on improving subject-level clinical studies from other scenarios as it can be integrated with many existing deep architectures. To the best of our knowledge, this is one of the first studies of footstep pressure-based FoG detection and the approach of utilizing ASTN is the first deep neural network architecture in pursuit of subject-independent representations. Experimental results on 393 trials collected from 21 subjects demonstrate encouraging performance of the proposed ASTN for FoG detection with an AUC 0.85.

Research in machine learning for autism spectrum disorder (ASD) classification bears the promise to improve clinical diagnoses. However, recent studies in clinical imaging have shown the limited generalization of biomarkers across and beyond benchmark datasets. Despite increasing model complexity and sample size in neuroimaging, the classification performance of ASD remains far away from clinical application. This raises the question of how we can overcome these barriers to develop early biomarkers for ASD. One approach might be to rethink how we operationalize the theoretical basis of this disease in machine learning models. Here we introduced unsupervised graph representations that explicitly map the neural mechanisms of a core aspect of ASD, deficits in dyadic social interaction, as assessed by dual brain recordings, termed hyperscanning, and evaluated their predictive performance. The proposed method differs from existing approaches in that it is more suitable to capture social interaction deficits on a neural level and is applicable to young children and infants. First results from functional near-infrared spectroscopy data indicate potential predictive capacities of a task-agnostic, interpretable graph representation. This first effort to leverage interaction-related deficits on neural level to classify ASD may stimulate new approaches and methods to enhance existing models to achieve developmental ASD biomarkers in the future.

Various structures in human physiology follow a treelike morphology, which often expresses complexity at very fine scales. Examples of such structures are intrathoracic airways, retinal blood vessels, and hepatic blood vessels. Large collections of 2D and 3D images have been made available by medical imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), Optical coherence tomography (OCT) and ultrasound in which the spatial arrangement can be observed. Segmentation of these structures in medical imaging is of great importance since the analysis of the structure provides insights into disease diagnosis, treatment planning, and prognosis. Manually labelling extensive data by radiologists is often time-consuming and error-prone. As a result, automated or semi-automated computational models have become a popular research field of medical imaging in the past two decades, and many have been developed to date. In this survey, we aim to provide a comprehensive review of currently publicly available datasets, segmentation algorithms, and evaluation metrics. In addition, current challenges and future research directions are discussed.

This paper presents our submission for the SMM4H 2022-Shared Task on the classification of self-reported intimate partner violence on Twitter (in English). The goal of this task was to accurately determine if the contents of a given tweet demonstrated someone reporting their own experience with intimate partner violence. The submitted system is an ensemble of five RoBERTa models each weighted by their respective F1-scores on the validation data-set. This system performed 13% better than the baseline and was the best performing system overall for this shared task.

Particle accelerators are complex facilities that produce large amounts of structured data and have clear optimization goals as well as precisely defined control requirements. As such they are naturally amenable to data-driven research methodologies. The data from sensors and monitors inside the accelerator form multivariate time series. With fast pre-emptive approaches being highly preferred in accelerator control and diagnostics, the application of data-driven time series forecasting methods is particularly promising. This review formulates the time series forecasting problem and summarizes existing models with applications in various scientific areas. Several current and future attempts in the field of particle accelerators are introduced. The application of time series forecasting to particle accelerators has shown encouraging results and the promise for broader use, and existing problems such as data consistency and compatibility have started to be addressed.

Robust controllers ensure stability in feedback loops designed under uncertainty but at the cost of performance. Model uncertainty in time-invariant systems can be reduced by recently proposed learning-based methods, which improve the performance of robust controllers using data. However, in practice, many systems also exhibit uncertainty in the form of changes over time, e.g., due to weight shifts or wear and tear, leading to decreased performance or instability of the learning-based controller. We propose an event-triggered learning algorithm that decides when to learn in the face of uncertainty in the LQR problem with rare or slow changes. Our key idea is to switch between robust and learned controllers. For learning, we first approximate the optimal length of the learning phase via Monte-Carlo estimations using a probabilistic model. We then design a statistical test for uncertain systems based on the moment-generating function of the LQR cost. The test detects changes in the system under control and triggers re-learning when control performance deteriorates due to system changes. We demonstrate improved performance over a robust controller baseline in a numerical example.