Evaluation of generative models has been an underrepresented field despite the surge of generative architectures. Most recent models are evaluated upon rather obsolete metrics which suffer from robustness issues, while being unable to assess more aspects of visual quality, such as compositionality and logic of synthesis. At the same time, the explainability of generative models remains a limited, though important, research direction with several current attempts requiring access to the inner functionalities of generative models. Contrary to prior literature, we view generative models as a black box, and we propose a framework for the evaluation and explanation of synthesized results based on concepts instead of pixels. Our framework exploits knowledge-based counterfactual edits that underline which objects or attributes should be inserted, removed, or replaced from generated images to approach their ground truth conditioning. Moreover, global explanations produced by accumulating local edits can also reveal what concepts a model cannot generate in total. The application of our framework on various models designed for the challenging tasks of Story Visualization and Scene Synthesis verifies the power of our approach in the model-agnostic setting.

Learning high-quality, self-supervised, visual representations is essential to advance the role of computer vision in biomedical microscopy and clinical medicine. Previous work has focused on self-supervised representation learning (SSL) methods developed for instance discrimination and applied them directly to image patches, or fields-of-view, sampled from gigapixel whole-slide images (WSIs) used for cancer diagnosis. However, this strategy is limited because it (1) assumes patches from the same patient are independent, (2) neglects the patient-slide-patch hierarchy of clinical biomedical microscopy, and (3) requires strong data augmentations that can degrade downstream performance. Importantly, sampled patches from WSIs of a patient's tumor are a diverse set of image examples that capture the same underlying cancer diagnosis. This motivated HiDisc, a data-driven method that leverages the inherent patient-slide-patch hierarchy of clinical biomedical microscopy to define a hierarchical discriminative learning task that implicitly learns features of the underlying diagnosis. HiDisc uses a self-supervised contrastive learning framework in which positive patch pairs are defined based on a common ancestry in the data hierarchy, and a unified patch, slide, and patient discriminative learning objective is used for visual SSL. We benchmark HiDisc visual representations on two vision tasks using two biomedical microscopy datasets, and demonstrate that (1) HiDisc pretraining outperforms current state-of-the-art self-supervised pretraining methods for cancer diagnosis and genetic mutation prediction, and (2) HiDisc learns high-quality visual representations using natural patch diversity without strong data augmentations.

The field of time series anomaly detection is constantly advancing, with several methods available, making it a challenge to determine the most appropriate method for a specific domain. The evaluation of these methods is facilitated by the use of metrics, which vary widely in their properties. Despite the existence of new evaluation metrics, there is limited agreement on which metrics are best suited for specific scenarios and domain, and the most commonly used metrics have faced criticism in the literature. This paper provides a comprehensive overview of the metrics used for the evaluation of time series anomaly detection methods, and also defines a taxonomy of these based on how they are calculated. By defining a set of properties for evaluation metrics and a set of specific case studies and experiments, twenty metrics are analyzed and discussed in detail, highlighting the unique suitability of each for specific tasks. Through extensive experimentation and analysis, this paper argues that the choice of evaluation metric must be made with care, taking into account the specific requirements of the task at hand.

Although home IoT (Internet of Things) devices are typically plain and task oriented, the context of their daily use may affect their traffic patterns. For this reason, anomaly-based intrusion detection systems tend to suffer from a high false positive rate (FPR). To overcome this, we propose a two-step collaborative anomaly detection method which first uses an autoencoder to differentiate frequent (`benign') and infrequent (possibly `malicious') traffic flows. Clustering is then used to analyze only the infrequent flows and classify them as either known ('rare yet benign') or unknown (`malicious'). Our method is collaborative, in that (1) normal behaviors are characterized more robustly, as they take into account a variety of user interactions and network topologies, and (2) several features are computed based on a pool of identical devices rather than just the inspected device. We evaluated our method empirically, using 21 days of real-world traffic data that emanated from eight identical IoT devices deployed on various networks, one of which was located in our controlled lab where we implemented two popular IoT-related cyber-attacks. Our collaborative anomaly detection method achieved a macro-average area under the precision-recall curve of 0.841, an F1 score of 0.929, and an FPR of only 0.014. These promising results were obtained by using labeled traffic data from our lab as the test set, while training the models on the traffic of devices deployed outside the lab, and thus demonstrate a high level of generalizability. In addition to its high generalizability and promising performance, our proposed method also offers benefits such as privacy preservation, resource savings, and model poisoning mitigation. On top of that, as a contribution to the scientific community, our novel dataset is available online.

Artificial Intelligence (AI) and Machine-Learning (ML) models have been increasingly used in medical products, such as medical device software. General considerations on the statistical aspects for the evaluation of AI/ML-enabled medical diagnostic devices are discussed in this paper. We also provide relevant academic references and note good practices in addressing various statistical challenges in the clinical validation of AI/ML-enabled medical devices in the context of their intended use.

Recent work has reported that respiratory audio-trained AI classifiers can accurately predict SARS-CoV-2 infection status. Here, we undertake a large-scale study of audio-based AI classifiers, as part of the UK government's pandemic response. We collect a dataset of audio recordings from 67,842 individuals, with linked metadata, of whom 23,514 had positive PCR tests for SARS-CoV-2. In an unadjusted analysis, similar to that in previous works, AI classifiers predict SARS-CoV-2 infection status with high accuracy (ROC-AUC=0.846 However, after matching on measured confounders, such as selfreported symptoms, performance is much weaker (ROC-AUC=0.619 Upon quantifying the utility of audio-based classifiers in practical settings, we find them to be outperformed by predictions based on user-reported symptoms. We make best-practice recommendations for handling recruitment bias, and for assessing audio-based classifiers by their utility in relevant practical settings. Our work provides novel insights into the value of AI audio analysis and the importance of study design and treatment of confounders in AI-enabled diagnostics. The coronavirus disease 2019 (COVID-19) pandemic has been estimated by the World Health Organization (WHO) to have caused 14.9 million excess deaths over the 2020-2021 period (link). Table S1 summarises nine highly cited datasets and corresponding classification performance. Here, we analyse the largest PCR-validated dataset collected to date in the field of audio-based COVID-19 screening (ABCS). We design and specify an analysis plan in advance, to investigate whether using audio-based classifiers can improve the accuracy of COVID-19 screening over using self-reported symptoms. Our contribution is as follows: - We collect a respiratory acoustic dataset of 67,842 individuals with linked PCR test outcomes, including 23,514 who tested positive for COVID-19.

Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize and critically evaluate current applications of ML in dementia research and highlight directions for future research. Results: We present an overview of ML algorithms most frequently used in dementia research and highlight future opportunities for the use of ML in clinical practice, experimental medicine, and clinical trials. We discuss issues of reproducibility, replicability and interpretability and how these impact the clinical applicability of dementia research. Finally, we give examples of how state-of-the-art methods, such as transfer learning, multi-task learning, and reinforcement learning, may be applied to overcome these issues and aid the translation of research to clinical practice in the future. Discussion: ML-based models hold great promise to advance our understanding of the underlying causes and pathological mechanisms of dementia.

An open-ended time series refers to a series of data points indexed in time order without an end. Such a time series can be found everywhere due to the prevalence of Internet of Things. Providing lightweight and real-time anomaly detection for open-ended time series is highly desirable to industry and organizations since it allows immediate response and avoids potential financial loss. In the last few years, several real-time time series anomaly detection approaches have been introduced. However, they might exhaust system resources when they are applied to open-ended time series for a long time. To address this issue, in this paper we propose RePAD2, a lightweight real-time anomaly detection approach for open-ended time series by improving its predecessor RePAD, which is one of the state-of-the-art anomaly detection approaches. We conducted a series of experiments to compare RePAD2 with RePAD and another similar detection approach based on real-world time series datasets, and demonstrated that RePAD2 can address the mentioned resource exhaustion issue while offering comparable detection accuracy and slightly less time consumption.

Detecting Out-of-distribution (OOD) inputs have been a critical issue for neural networks in the open world. However, the unstable behavior of OOD detection along the optimization trajectory during training has not been explored clearly. In this paper, we first find the performance of OOD detection suffers from overfitting and instability during training: 1) the performance could decrease when the training error is near zero, and 2) the performance would vary sharply in the final stage of training. Based on our findings, we propose Average of Pruning (AoP), consisting of model averaging and pruning, to mitigate the unstable behaviors. Specifically, model averaging can help achieve a stable performance by smoothing the landscape, and pruning is certified to eliminate the overfitting by eliminating redundant features. Comprehensive experiments on various datasets and architectures are conducted to verify the effectiveness of our method.

In this paper we define, implement, and investigate a simplicial complex construction for computing persistent homology of Euclidean point cloud data, which we call the Delaunay-Rips complex (DR). Assigning the Vietoris-Rips weights to simplices, DR experiences speed-up in the persistence calculations by only considering simplices that appear in the Delaunay triangulation of the point cloud. We document and compare a Python implementation of DR with other simplicial complex constructions for generating persistence diagrams. By imposing sufficient conditions on point cloud data, we are able to theoretically justify the stability of the persistence diagrams produced using DR. When the Delaunay triangulation of the point cloud changes under perturbations of the points, we prove that DR-produced persistence diagrams exhibit instability. Since we cannot guarantee that real-world data will satisfy our stability conditions, we demonstrate the practical robustness of DR for persistent homology in comparison with other simplicial complexes in machine learning applications. We find in our experiments that using DR for an ML-TDA pipeline performs comparatively well as using other simplicial complex constructions.