In the task of comparing two classification algorithms, the widely-used McNemar's test aims to infer the presence of a significant difference between the error rates of the two classification algorithms. However, the power of the conventional McNemar's test is usually unpromising because the hold-out (HO) method in the test merely uses a single train-validation split that usually produces a highly varied estimation of the error rates. In contrast, a cross-validation (CV) method repeats the HO method in multiple times and produces a stable estimation. Therefore, a CV method has a great advantage to improve the power of McNemar's test. Among all types of CV methods, a block-regularized 5$\times$2 CV (BCV) has been shown in many previous studies to be superior to the other CV methods in the comparison task of algorithms because the 5$\times$2 BCV can produce a high-quality estimator of the error rate by regularizing the numbers of overlapping records between all training sets. In this study, we compress the 10 correlated contingency tables in the 5$\times$2 BCV to form an effective contingency table. Then, we define a 5$\times$2 BCV McNemar's test on the basis of the effective contingency table. We demonstrate the reasonable type I error and the promising power of the proposed 5$\times$2 BCV McNemar's test on multiple simulated and real-world data sets.

Out-of-distribution (OOD) detection has received much attention lately due to its practical importance in enhancing the safe deployment of neural networks. One of the primary challenges is that models often produce highly confident predictions on OOD data, which undermines the driving principle in OOD detection that the model should only be confident about in-distribution samples. In this work, we propose ReAct--a simple and effective technique for reducing model overconfidence on OOD data. Our method is motivated by novel analysis on internal activations of neural networks, which displays highly distinctive signature patterns for OOD distributions. Our method can generalize effectively to different network architectures and different OOD detection scores. We empirically demonstrate that ReAct achieves competitive detection performance on a comprehensive suite of benchmark datasets, and give theoretical explication for our method's efficacy. On the ImageNet benchmark, ReAct reduces the false positive rate (FPR95) by 25.05% compared to the previous best method

Clinical trials are essential to drug development but time-consuming, costly, and prone to failure. Accurate trial outcome prediction based on historical trial data promises better trial investment decisions and more trial success. Existing trial outcome prediction models were not designed to model the relations among similar trials, capture the progression of features and designs of similar trials, or address the skewness of trial data which causes inferior performance for less common trials. To fill the gap and provide accurate trial outcome prediction, we propose Sequential Predictive mOdeling of clinical Trial outcome (SPOT) that first identifies trial topics to cluster the multi-sourced trial data into relevant trial topics. It then generates trial embeddings and organizes them by topic and time to create clinical trial sequences. With the consideration of each trial sequence as a task, it uses a meta-learning strategy to achieve a point where the model can rapidly adapt to new tasks with minimal updates. In particular, the topic discovery module enables a deeper understanding of the underlying structure of the data, while sequential learning captures the evolution of trial designs and outcomes. This results in predictions that are not only more accurate but also more interpretable, taking into account the temporal patterns and unique characteristics of each trial topic. We demonstrate that SPOT wins over the prior methods by a significant margin on trial outcome benchmark data: with a 21.5\% lift on phase I, an 8.9\% lift on phase II, and a 5.5\% lift on phase III trials in the metric of the area under precision-recall curve (PR-AUC).

The shipping industry is one of the strongest anthropogenic emitters of $\text{NO}_\text{x}$ -- substance harmful both to human health and the environment. The rapid growth of the industry causes societal pressure on controlling the emission levels produced by ships. All the methods currently used for ship emission monitoring are costly and require proximity to a ship, which makes global and continuous emission monitoring impossible. A promising approach is the application of remote sensing. Studies showed that some of the $\text{NO}_\text{2}$ plumes from individual ships can visually be distinguished using the TROPOspheric Monitoring Instrument on board the Copernicus Sentinel 5 Precursor (TROPOMI/S5P). To deploy a remote sensing-based global emission monitoring system, an automated procedure for the estimation of $\text{NO}_\text{2}$ emissions from individual ships is needed. The extremely low signal-to-noise ratio of the available data as well as the absence of ground truth makes the task very challenging. Here, we present a methodology for the automated segmentation of $\text{NO}_\text{2}$ plumes produced by seagoing ships using supervised machine learning on TROPOMI/S5P data. We show that the proposed approach leads to a more than a 20\% increase in the average precision score in comparison to the methods used in previous studies and results in a high correlation of 0.834 with the theoretically derived ship emission proxy. This work is a crucial step toward the development of an automated procedure for global ship emission monitoring using remote sensing data.

Flower breed detection and giving details of that breed with the suggestion of cultivation processes and the way of taking care is important for flower cultivation, breed invention, and the flower business. Among all the local flowers in Bangladesh, the rose is one of the most popular and demanded flowers. Roses are the most desirable flower not only in Bangladesh but also throughout the world. Roses can be used for many other purposes apart from decoration. As roses have a great demand in the flower business so rose breed detection will be very essential. However, there is no remarkable work for breed detection of a particular flower unlike the classification of different flowers. In this research, we have proposed a model to detect rose breeds from images using transfer learning techniques. For such work in flowers, resources are not enough in image processing and classification, so we needed a large dataset of the massive number of images to train our model. we have used 1939 raw images of five different breeds and we have generated 9306 images for the training dataset and 388 images for the testing dataset to validate the model using augmentation. We have applied four transfer learning models in this research, which are Inception V3, ResNet50, Xception, and VGG16. Among these four models, VGG16 achieved the highest accuracy of 99%, which is an excellent outcome. Breed detection of a rose by using transfer learning methods is the first work on breed detection of a particular flower that is publicly available according to the study.

Abstract--Performance debugging in production is a fundamental activity in modern service-based systems. The diagnosis of performance issues is often time-consuming, since it requires thorough inspection of large volumes of traces and performance indices. In this paper we present DeLag, a novel automated search-based approach for diagnosing performance issues in service-based systems. DeLag identifies subsets of requests that show, in the combination of their Remote Procedure Call execution times, symptoms of potentially relevant performance issues. We call such symptoms Latency Degradation Patterns. DeLag simultaneously searches for multiple latency degradation patterns while optimizing precision, recall and latency dissimilarity. Experimentation on 700 datasets of requests generated from two microservice-based systems shows that our approach provides better and more stable effectiveness than three state-of-the-art approaches and general purpose machine learning clustering algorithms. DeLag is more effective than all baseline techniques in at least one case study (with p 0.05 and non-negligible effect size). Moreover, DeLag outperforms in terms of efficiency the second and the third most effective baseline techniques on the largest datasets used in our evaluation (up to 22%). In order to support this fastpaced issue, and initial understanding, scoping and localization release cycle, IT organizations often employ several are among the most time-consuming phases during debugging. Unfortunately, frequent software releases often service-based systems [9], [10], [11], [12], [13], [14], [15], the hamper the ability to deliver high quality software [3]. For reduction of the manual effort and the time needed is still example, widely used performance assurance techniques, critical. Also, given the complexity of these systems rely on pattern mining to spot patterns in trace attributes and their workloads [6], it is often unfeasible to proactively (e.g., request size, response size, RPCs execution times) detect performance issues in a testing environment [7].

The amount of sequencing data for SARS-CoV-2 is several orders of magnitude larger than any virus. This will continue to grow geometrically for SARS-CoV-2, and other viruses, as many countries heavily finance genomic surveillance efforts. Hence, we need methods for processing large amounts of sequence data to allow for effective yet timely decision-making. Such data will come from heterogeneous sources: aligned, unaligned, or even unassembled raw nucleotide or amino acid sequencing reads pertaining to the whole genome or regions (e.g., spike) of interest. In this work, we propose \emph{ViralVectors}, a compact feature vector generation from virome sequencing data that allows effective downstream analysis. Such generation is based on \emph{minimizers}, a type of lightweight "signature" of a sequence, used traditionally in assembly and read mapping -- to our knowledge, the first use minimizers in this way. We validate our approach on different types of sequencing data: (a) 2.5M SARS-CoV-2 spike sequences (to show scalability); (b) 3K Coronaviridae spike sequences (to show robustness to more genomic variability); and (c) 4K raw WGS reads sets taken from nasal-swab PCR tests (to show the ability to process unassembled reads). Our results show that ViralVectors outperforms current benchmarks in most classification and clustering tasks.

With the development of the Internet of Things (IoT), network intrusion detection is becoming more complex and extensive. It is essential to investigate an intelligent, automated, and robust network intrusion detection method. Graph neural networks based network intrusion detection methods have been proposed. However, it still needs further studies because the graph construction method of the existing methods does not fully adapt to the characteristics of the practical network intrusion datasets. To address the above issue, this paper proposes a graph neural network algorithm based on behavior similarity (BS-GAT) using graph attention network. First, a novel graph construction method is developed using the behavior similarity by analyzing the characteristics of the practical datasets. The data flows are treated as nodes in the graph, and the behavior rules of nodes are used as edges in the graph, constructing a graph with a relatively uniform number of neighbors for each node. Then, the edge behavior relationship weights are incorporated into the graph attention network to utilize the relationship between data flows and the structure information of the graph, which is used to improve the performance of the network intrusion detection. Finally, experiments are conducted based on the latest datasets to evaluate the performance of the proposed behavior similarity based graph attention network for the network intrusion detection. The results show that the proposed method is effective and has superior performance comparing to existing solutions.

Two theorems and a lemma are presented about the use of jackknife es(cid:173) timator and the cross-validation method for model selection. Theorem 1 gives the asymptotic form for the jackknife estimator. Combined with the model selection criterion, this asymptotic form can be used to obtain the fit of a model. The model selection criterion we used is the negative of the average predictive likehood, the choice of which is based on the idea of the cross-validation method. Lemma 1 provides a formula for further explo(cid:173) ration of the asymptotics of the model selection criterion.

We show how randomly scrambling the output classes of various fractions of the training data may be used to improve predictive accuracy of a classification algorithm. We present a method for calculating the "noise sensitivity signature" of a learning algorithm which is based on scrambling the output classes. This signature can be used to indicate a good match between the complexity of the classifier and the complexity of the data. Use of noise sensitivity signatures is distinctly different from other schemes to avoid over(cid:173) training, such as cross-validation, which uses only part of the train(cid:173) ing data, or various penalty functions, which are not data-adaptive. Noise sensitivity signature methods use all of the training data and are manifestly data-adaptive and non-parametric.