Automatic classification of electrocardiogram (ECG) signals plays a crucial role in the early prevention and diagnosis of cardiovascular diseases. While ECG signals can be used for the diagnosis of various diseases, their pathological characteristics exhibit minimal variations, posing a challenge to automatic classification models. Existing methods primarily utilize convolutional neural networks to extract ECG signal features for classification, which may not fully capture the pathological feature differences of different diseases. Transformer networks have advantages in feature extraction for sequence data, but the complete network is complex and relies on large-scale datasets. To address these challenges, we propose a single-layer Transformer network called Multi-Scale Shifted Windows Transformer Networks (MSW-Transformer), which uses a multi-window sliding attention mechanism at different scales to capture features in different dimensions. The self-attention is restricted to non-overlapping local windows via shifted windows, and different window scales have different receptive fields. A learnable feature fusion method is then proposed to integrate features from different windows to further enhance model performance. Furthermore, we visualize the attention mechanism of the multi-window shifted mechanism to achieve better clinical interpretation in the ECG classification task. The proposed model achieves state-of-the-art performance on five classification tasks of the PTBXL-2020 12-lead ECG dataset, which includes 5 diagnostic superclasses, 23 diagnostic subclasses, 12 rhythm classes, 17 morphology classes, and 44 diagnosis classes, with average macro-F1 scores of 77.85%, 47.57%, 66.13%, 34.60%, and 34.29%, and average sample-F1 scores of 81.26%, 68.27%, 91.32%, 50.07%, and 63.19%, respectively.

We propose an efficient abnormal event detection model based on a lightweight masked auto-encoder (AE) applied at the video frame level. The novelty of the proposed model is threefold. First, we introduce an approach to weight tokens based on motion gradients, thus avoiding learning to reconstruct the static background scene. Second, we integrate a teacher decoder and a student decoder into our architecture, leveraging the discrepancy between the outputs given by the two decoders to improve anomaly detection. Third, we generate synthetic abnormal events to augment the training videos, and task the masked AE model to jointly reconstruct the original frames (without anomalies) and the corresponding pixel-level anomaly maps. Our design leads to an efficient and effective model, as demonstrated by the extensive experiments carried out on three benchmarks: Avenue, ShanghaiTech and UCSD Ped2. The empirical results show that our model achieves an excellent trade-off between speed and accuracy, obtaining competitive AUC scores, while processing 1670 FPS. Hence, our model is between 8 and 70 times faster than competing methods. We also conduct an ablation study to justify our design.

Machine Learning as a Service (MLaaS) platforms have gained popularity due to their accessibility, cost-efficiency, scalability, and rapid development capabilities. However, recent research has highlighted the vulnerability of cloud-based models in MLaaS to model extraction attacks. In this paper, we introduce FDINET, a novel defense mechanism that leverages the feature distribution of deep neural network (DNN) models. Concretely, by analyzing the feature distribution from the adversary's queries, we reveal that the feature distribution of these queries deviates from that of the model's training set. Based on this key observation, we propose Feature Distortion Index (FDI), a metric designed to quantitatively measure the feature distribution deviation of received queries. The proposed FDINET utilizes FDI to train a binary detector and exploits FDI similarity to identify colluding adversaries from distributed extraction attacks. We conduct extensive experiments to evaluate FDINET against six state-of-the-art extraction attacks on four benchmark datasets and four popular model architectures. Empirical results demonstrate the following findings FDINET proves to be highly effective in detecting model extraction, achieving a 100% detection accuracy on DFME and DaST. FDINET is highly efficient, using just 50 queries to raise an extraction alarm with an average confidence of 96.08% for GTSRB. FDINET exhibits the capability to identify colluding adversaries with an accuracy exceeding 91%. Additionally, it demonstrates the ability to detect two types of adaptive attacks.

Obesity is a serious issue in the modern society and is often associated to significantly reduced quality of life. Current research conducted to explore obesity-related neurological evidences using electroencephalography (EEG) data are limited to traditional approaches. In this study, we developed a novel machine learning model to identify brain networks of obese females using alpha band functional connectivity features derived from EEG data. An overall classification accuracy of 0.937 is achieved. Our finding suggests that the obese brain is characterized by a dysfunctional network in which the areas that responsible for processing self-referential information and environmental context information are impaired.

Conditional independence (CI) testing is frequently used in data analysis and machine learning for various scientific fields and it forms the basis of constraint-based causal discovery. Oftentimes, CI testing relies on strong, rather unrealistic assumptions. One of these assumptions is homoskedasticity, in other words, a constant conditional variance is assumed. We frame heteroskedasticity in a structural causal model framework and present an adaptation of the partial correlation CI test that works well in the presence of heteroskedastic noise, given that expert knowledge about the heteroskedastic relationships is available. Further, we provide theoretical consistency results for the proposed CI test which carry over to causal discovery under certain assumptions. Numerical causal discovery experiments demonstrate that the adapted partial correlation CI test outperforms the standard test in the presence of heteroskedasticity and is on par for the homoskedastic case. Finally, we discuss the general challenges and limits as to how expert knowledge about heteroskedasticity can be accounted for in causal discovery.

Artificial Intelligence (AI) has made impressive progress in recent years and represents a key technology that has a crucial impact on the economy and society. However, it is clear that AI and business models based on it can only reach their full potential if AI applications are developed according to high quality standards and are effectively protected against new AI risks. For instance, AI bears the risk of unfair treatment of individuals when processing personal data e.g., to support credit lending or staff recruitment decisions. The emergence of these new risks is closely linked to the fact that the behavior of AI applications, particularly those based on Machine Learning (ML), is essentially learned from large volumes of data and is not predetermined by fixed programmed rules. Thus, the issue of the trustworthiness of AI applications is crucial and is the subject of numerous major publications by stakeholders in politics, business and society. In addition, there is mutual agreement that the requirements for trustworthy AI, which are often described in an abstract way, must now be made clear and tangible. One challenge to overcome here relates to the fact that the specific quality criteria for an AI application depend heavily on the application context and possible measures to fulfill them in turn depend heavily on the AI technology used. Lastly, practical assessment procedures are needed to evaluate whether specific AI applications have been developed according to adequate quality standards. This AI assessment catalog addresses exactly this point and is intended for two target groups: Firstly, it provides developers with a guideline for systematically making their AI applications trustworthy. Secondly, it guides assessors and auditors on how to examine AI applications for trustworthiness in a structured way.

Graph Neural Networks (GNNs) are promising surrogates for quantum mechanical calculations as they establish unprecedented low errors on collections of molecular dynamics (MD) trajectories. Thanks to their fast inference times they promise to accelerate computational chemistry applications. Unfortunately, despite low in-distribution (ID) errors, such GNNs might be horribly wrong for out-of-distribution (OOD) samples. Uncertainty estimation (UE) may aid in such situations by communicating the model's certainty about its prediction. Here, we take a closer look at the problem and identify six key desiderata for UE in molecular force fields, three 'physics-informed' and three 'application-focused' ones. To overview the field, we survey existing methods from the field of UE and analyze how they fit to the set desiderata. By our analysis, we conclude that none of the previous works satisfies all criteria. To fill this gap, we propose Localized Neural Kernel (LNK) a Gaussian Process (GP)-based extension to existing GNNs satisfying the desiderata. In our extensive experimental evaluation, we test four different UE with three different backbones and two datasets. In out-of-equilibrium detection, we find LNK yielding up to 2.5 and 2.1 times lower errors in terms of AUC-ROC score than dropout or evidential regression-based methods while maintaining high predictive performance.

Detecting duplicate patient participation in clinical trials is a major challenge because repeated patients can undermine the credibility and accuracy of the trial's findings and result in significant health and financial risks. Developing accurate automated speaker verification (ASV) models is crucial to verify the identity of enrolled individuals and remove duplicates, but the size and quality of data influence ASV performance. However, there has been limited investigation into the factors that can affect ASV capabilities in clinical environments. In this paper, we bridge the gap by conducting analysis of how participant demographic characteristics, audio quality criteria, and severity level of Alzheimer's disease (AD) impact the performance of ASV utilizing a dataset of speech recordings from 659 participants with varying levels of AD, obtained through multiple speech tasks. Our results indicate that ASV performance: 1) is slightly better on male speakers than on female speakers; 2) degrades for individuals who are above 70 years old; 3) is comparatively better for non-native English speakers than for native English speakers; 4) is negatively affected by clinician interference, noisy background, and unclear participant speech; 5) tends to decrease with an increase in the severity level of AD. Our study finds that voice biometrics raise fairness concerns as certain subgroups exhibit different ASV performances owing to their inherent voice characteristics. Moreover, the performance of ASV is influenced by the quality of speech recordings, which underscores the importance of improving the data collection settings in clinical trials.

Understanding the effect of a feature vector $x \in \mathbb{R}^d$ on the response value (label) $y \in \mathbb{R}$ is the cornerstone of many statistical learning problems. Ideally, it is desired to understand how a set of collected features combine together and influence the response value, but this problem is notoriously difficult, due to the high-dimensionality of data and limited number of labeled data points, among many others. In this work, we take a new perspective on this problem, and we study the question of assessing the difference of influence that the two given features have on the response value. We first propose a notion of closeness for the influence of features, and show that our definition recovers the familiar notion of the magnitude of coefficients in the parametric model. We then propose a novel method to test for the closeness of influence in general model-free supervised learning problems. Our proposed test can be used with finite number of samples with control on type I error rate, no matter the ground truth conditional law $\mathcal{L}(Y |X)$. We analyze the power of our test for two general learning problems i) linear regression, and ii) binary classification under mixture of Gaussian models, and show that under the proper choice of score function, an internal component of our test, with sufficient number of samples will achieve full statistical power. We evaluate our findings through extensive numerical simulations, specifically we adopt the datamodel framework (Ilyas, et al., 2022) for CIFAR-10 dataset to identify pairs of training samples with different influence on the trained model via optional black box training mechanisms.

Neural networks are promising tools for high-throughput and accurate transmission electron microscopy (TEM) analysis of nanomaterials, but are known to generalize poorly on data that is "out-of-distribution" from their training data. Given the limited set of image features typically seen in high-resolution TEM imaging, it is unclear which images are considered out-of-distribution from others. Here, we investigate how the choice of metadata features in the training dataset influences neural network performance, focusing on the example task of nanoparticle segmentation. We train and validate neural networks across curated, experimentally-collected high-resolution TEM image datasets of nanoparticles under controlled imaging and material parameters, including magnification, dosage, nanoparticle diameter, and nanoparticle material. Overall, we find that our neural networks are not robust across microscope parameters, but do generalize across certain sample parameters. Additionally, data preprocessing heavily influences the generalizability of neural networks trained on nominally similar datasets. Our results highlight the need to understand how dataset features affect deployment of data-driven algorithms.