Early prediction of Alzheimer's disease (AD) is crucial for timely intervention and treatment. This study aims to use machine learning approaches to analyze longitudinal electronic health records (EHRs) of patients with AD and identify signs and symptoms that can predict AD onset earlier. We used a case-control design with longitudinal EHRs from the U.S. Department of Veterans Affairs Veterans Health Administration (VHA) from 2004 to 2021. Cases were VHA patients with AD diagnosed after 1/1/2016 based on ICD-10-CM codes, matched 1:9 with controls by age, sex and clinical utilization with replacement. We used a panel of AD-related keywords and their occurrences over time in a patient's longitudinal EHRs as predictors for AD prediction with four machine learning models. We performed subgroup analyses by age, sex, and race/ethnicity, and validated the model in a hold-out and "unseen" VHA stations group. Model discrimination, calibration, and other relevant metrics were reported for predictions up to ten years before ICD-based diagnosis. The study population included 16,701 cases and 39,097 matched controls. The average number of AD-related keywords (e.g., "concentration", "speaking") per year increased rapidly for cases as diagnosis approached, from around 10 to over 40, while remaining flat at 10 for controls. The best model achieved high discriminative accuracy (ROCAUC 0.997) for predictions using data from at least ten years before ICD-based diagnoses. The model was well-calibrated (Hosmer-Lemeshow goodness-of-fit p-value = 0.99) and consistent across subgroups of age, sex and race/ethnicity, except for patients younger than 65 (ROCAUC 0.746). Machine learning models using AD-related keywords identified from EHR notes can predict future AD diagnoses, suggesting its potential use for identifying AD risk using EHR notes, offering an affordable way for early screening on large population.

Prognostic and Health Management (PHM) has been widely applied to hardware systems in the electronics and non-electronics domains but has not been explored for software. While software does not decay over time, it can degrade over release cycles. Software health management is confined to diagnostic assessments that identify problems, whereas prognostic assessment potentially indicates when in the future a problem will become detrimental. Relevant research areas such as software defect prediction, software reliability prediction, predictive maintenance of software, software degradation, and software performance prediction, exist, but all of these represent diagnostic models built upon historical data, none of which can predict an RUL for software. This paper addresses the application of PHM concepts to software systems for fault predictions and RUL estimation. Specifically, this paper addresses how PHM can be used to make decisions for software systems such as version update and upgrade, module changes, system reengineering, rejuvenation, maintenance scheduling, budgeting, and total abandonment. This paper presents a method to prognostically and continuously predict the RUL of a software system based on usage parameters (e.g., the numbers and categories of releases) and performance parameters (e.g., response time). The model developed has been validated by comparing actual data, with the results that were generated by predictive models. Statistical validation (regression validation, and k-fold cross validation) has also been carried out. A case study, based on publicly available data for the Bugzilla application is presented. This case study demonstrates that PHM concepts can be applied to software systems and RUL can be calculated to make system management decisions.

Opioid related aberrant behaviors (ORAB) present novel risk factors for opioid overdose. Previously, ORAB have been mainly assessed by survey results and by monitoring drug administrations. Such methods however, cannot scale up and do not cover the entire spectrum of aberrant behaviors. On the other hand, ORAB are widely documented in electronic health record notes. This paper introduces a novel biomedical natural language processing benchmark dataset named ODD, for ORAB Detection Dataset. ODD is an expert-annotated dataset comprising of more than 750 publicly available EHR notes. ODD has been designed to identify ORAB from patients' EHR notes and classify them into nine categories; 1) Confirmed Aberrant Behavior, 2) Suggested Aberrant Behavior, 3) Opioids, 4) Indication, 5) Diagnosed opioid dependency, 6) Benzodiapines, 7) Medication Changes, 8) Central Nervous System-related, and 9) Social Determinants of Health. We explored two state-of-the-art natural language processing (NLP) models (finetuning pretrained language models and prompt-tuning approaches) to identify ORAB. Experimental results show that the prompt-tuning models outperformed the finetuning models in most cateogories and the gains were especially higher among uncommon categories (Suggested aberrant behavior, Diagnosed opioid dependency and Medication change). Although the best model achieved the highest 83.92% on area under precision recall curve, uncommon classes (Suggested Aberrant Behavior, Diagnosed Opioid Dependence, and Medication Change) still have a large room for performance improvement.

The system log generated in a computer system refers to large-scale data that are collected simultaneously and used as the basic data for determining errors, intrusion and abnormal behaviors. The aim of system log anomaly detection is to promptly identify anomalies while minimizing human intervention, which is a critical problem in the industry. Previous studies performed anomaly detection through algorithms after converting various forms of log data into a standardized template using a parser. Particularly, a template corresponding to a specific event should be defined in advance for all the log data using which the information within the log key may get lost. In this study, we propose LAnoBERT, a parser free system log anomaly detection method that uses the BERT model, exhibiting excellent natural language processing performance. The proposed method, LAnoBERT, learns the model through masked language modeling, which is a BERT-based pre-training method, and proceeds with unsupervised learning-based anomaly detection using the masked language modeling loss function per log key during the test process. In addition, we also propose an efficient inference process to establish a practically applicable pipeline to the actual system. Experiments on three well-known log datasets, i.e., HDFS, BGL, and Thunderbird, show that not only did LAnoBERT yield a higher anomaly detection performance compared to unsupervised learning-based benchmark models, but also it resulted in a comparable performance with supervised learning-based benchmark models.

Entity Resolution (ER) is the problem of determining when two entities refer to the same underlying entity. The problem has been studied for over 50 years, and most recently, has taken on new importance in an era of large, heterogeneous 'knowledge graphs' published on the Web and used widely in domains as wide ranging as social media, e-commerce and search. This chapter will discuss the specific problem of named ER in the context of personal knowledge graphs (PKGs). We begin with a formal definition of the problem, and the components necessary for doing high-quality and efficient ER. We also discuss some challenges that are expected to arise for Web-scale data. Next, we provide a brief literature review, with a special focus on how existing techniques can potentially apply to PKGs. We conclude the chapter by covering some applications, as well as promising directions for future research.

Object pose estimation is a core perception task that enables, for example, object grasping and scene understanding. The widely available, inexpensive and high-resolution RGB sensors and CNNs that allow for fast inference based on this modality make monocular approaches especially well suited for robotics applications. We observe that previous surveys on object pose estimation establish the state of the art for varying modalities, single- and multi-view settings, and datasets and metrics that consider a multitude of applications. We argue, however, that those works' broad scope hinders the identification of open challenges that are specific to monocular approaches and the derivation of promising future challenges for their application in robotics. By providing a unified view on recent publications from both robotics and computer vision, we find that occlusion handling, novel pose representations, and formalizing and improving category-level pose estimation are still fundamental challenges that are highly relevant for robotics. Moreover, to further improve robotic performance, large object sets, novel objects, refractive materials, and uncertainty estimates are central, largely unsolved open challenges. In order to address them, ontological reasoning, deformability handling, scene-level reasoning, realistic datasets, and the ecological footprint of algorithms need to be improved.

Identifying Amyotrophic Lateral Sclerosis (ALS) in its early stages is essential for establishing the beginning of treatment, enriching the outlook, and enhancing the overall well-being of those affected individuals. However, early diagnosis and detecting the disease's signs is not straightforward. A simpler and cheaper way arises by analyzing the patient's facial expressions through computational methods. When a patient with ALS engages in specific actions, e.g., opening their mouth, the movement of specific facial muscles differs from that observed in a healthy individual. This paper proposes Facial Point Graphs to learn information from the geometry of facial images to identify ALS automatically. The experimental outcomes in the Toronto Neuroface dataset show the proposed approach outperformed state-of-the-art results, fostering promising developments in the area.

Misinformation on YouTube is a significant concern, necessitating robust detection strategies. In this paper, we introduce a novel methodology for video classification, focusing on the veracity of the content. We convert the conventional video classification task into a text classification task by leveraging the textual content derived from the video transcripts. We employ advanced machine learning techniques like transfer learning to solve the classification challenge. Our approach incorporates two forms of transfer learning: (a) fine-tuning base transformer models such as BERT, RoBERTa, and ELECTRA, and (b) few-shot learning using sentence-transformers MPNet and RoBERTa-large. We apply the trained models to three datasets: (a) YouTube Vaccine-misinformation related videos, (b) YouTube Pseudoscience videos, and (c) Fake-News dataset (a collection of articles). Including the Fake-News dataset extended the evaluation of our approach beyond YouTube videos. Using these datasets, we evaluated the models distinguishing valid information from misinformation. The fine-tuned models yielded Matthews Correlation Coefficient>0.81, accuracy>0.90, and F1 score>0.90 in two of three datasets. Interestingly, the few-shot models outperformed the fine-tuned ones by 20% in both Accuracy and F1 score for the YouTube Pseudoscience dataset, highlighting the potential utility of this approach -- especially in the context of limited training data.

Vision-language models such as CLIP learn a generic text-image embedding from large-scale training data. A vision-language model can be adapted to a new classification task through few-shot prompt tuning. We find that such a prompt tuning process is highly robust to label noises. This intrigues us to study the key reasons contributing to the robustness of the prompt tuning paradigm. We conducted extensive experiments to explore this property and find the key factors are: 1) the fixed classname tokens provide a strong regularization to the optimization of the model, reducing gradients induced by the noisy samples; 2) the powerful pre-trained image-text embedding that is learned from diverse and generic web data provides strong prior knowledge for image classification. Further, we demonstrate that noisy zero-shot predictions from CLIP can be used to tune its own prompt, significantly enhancing prediction accuracy in the unsupervised setting. The code is available at https://github.com/CEWu/PTNL.

Twenty20 cricket, sometimes written Twenty-20, and often abbreviated to T20, is a short form of cricket. In a Twenty20 game the two teams of 11 players have a single innings each, which is restricted to a maximum of 20 overs. This version of cricket is especially unpredictable and is one of the reasons it has gained popularity over recent times. However, in this paper we try four different machine learning approaches for predicting the results of T20 Cricket Matches. Specifically we take in to account: previous performance statistics of the players involved in the competing teams, ratings of players obtained from reputed cricket statistics websites, clustering the players' with similar performance statistics and propose a novel method using an ELO based approach to rate players. We compare the performances of each of these feature engineering approaches by using different ML algorithms, including logistic regression, support vector machines, bayes network, decision tree, random forest.